92-36-4归档 - Page 15 of 18 - Heterocyclic Building Blocks-Thiazole

Song, Jung Min et al. published their research in Experimental Neurology in 2014 |CAS: 92-36-4

The Article related to tetraethylene glycol derivative bta dendritic spine alzheimers disease neuroprotectant, cognition cortex, 3xtg ad mice, ad, alzheimer’s disease, aβ, bta-eg(4), dendritic spine, ras signaling, amyloid-β and other aspects.HPLC of Formula: 92-36-4

On February 28, 2014, Song, Jung Min; DiBattista, Amanda Marie; Sung, You Me; Ahn, Joo Myung; Turner, R. Scott; Yang, Jerry; Pak, Daniel T. S.; Lee, Hey-Kyoung; Hoe, Hyang-Sook published an article.HPLC of Formula: 92-36-4 The title of the article was A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer’s disease. And the article contained the following:

We recently reported that the tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, acts as an amyloid-binding small mol. that promotes dendritic spine d. and cognitive function in wild-type mice. This raised the possibility that BTA-EG4 may benefit the functional decline seen in Alzheimer’s disease (AD). In the present study, we directly tested whether BTA-EG4 improves dendritic spine d. and cognitive function in a well-established mouse model of AD carrying mutations in APP, PS1 and tau (APPswe;PS1M146V;tauP301L, 3xTg AD mice). We found that daily injections of BTA-EG4 for 2 wk improved dendritic spine d. and cognitive function of 3xTg AD mice in an age-dependent manner. Specifically, BTA-EG4 promoted both dendritic spine d. and morphol. alterations in cortical layers II/III and in the hippocampus at 6-10 mo of age compared to vehicle-injected mice. However, at 13-16 mo of age, only cortical spine d. was improved without changes in spine morphol. The changes in dendritic spine d. correlated with Ras activity, such that 6-10 mo old BTA-EG4 injected 3xTg AD mice had increased Ras activity in the cortex and hippocampus, while 13-16 mo old mice only trended toward an increase in Ras activity in the cortex. Finally, BTA-EG4 injected 3xTg AD mice at 6-10 mo of age showed improved learning and memory; however, only minimal improvement was observed at 13-16 mo of age. This behavioral improvement corresponds to a decrease in soluble Aβ 40 levels. Taken together, these findings suggest that BTA-EG4 may be beneficial in ameliorating the synaptic loss seen in early AD. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lee, Nathanael J. et al. published their research in Biochimica et Biophysica Acta, Molecular Basis of Disease in 2016 |CAS: 92-36-4

The Article related to bta eg6 preparation dendritic spine rasgrf1 erk signaling, hexaethylene glycol benzothiazole aniline derivative preparation dendritic spine, bta-eg6, dendritic spine, rap signaling, ras signaling and other aspects.Product Details of 92-36-4

On February 29, 2016, Lee, Nathanael J.; Song, Jung Min; Cho, Hyun-Ji; Sung, You Me; Lee, Taehee; Chung, Andrew; Hong, Sung-Ha; Cifelli, Jessica L.; Rubinshtein, Mark; Habib, Lila K.; Capule, Christina C.; Turner, R. Scott; Pak, Daniel T. S.; Yang, Jerry; Hoe, Hyang-Sook published an article.Product Details of 92-36-4 The title of the article was Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway. And the article contained the following:

The authors’ recent study demonstrated that an amyloid-β binding mol., BTA-EG4, increases dendritic spine number via Ras-mediated signaling. To potentially optimize the potency of the BTA compounds, the authors synthesized and evaluated an amyloid-β binding analog of BTA-EG4 with increased solubility in aqueous solution, BTA-EG6. The authors initially examined the effects of BTA-EG6 on dendritic spine formation and found that BTA-EG6-treated primary hippocampal neurons had significantly increased dendritic spine number compared to control treatment. In addition, BTA-EG6 significantly increased the surface level of AMPA receptors. Upon investigation into the mol. mechanism by which BTA-EG6 promotes dendritic spine formation, the authors found that BTA-EG6 may exert its effects on spinogenesis via RasGRF1-ERK signaling, with potential involvement of other spinogenesis-related proteins such as Cdc42 and CDK5. Taken together, the authors’ data suggest that BTA-EG6 boosts spine and synapse number, which may have a beneficial effect of enhancing neuronal and synaptic function in the normal healthy brain. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Product Details of 92-36-4

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tomoshige, Shusuke et al. published their research in Angewandte Chemie, International Edition in 2017 |CAS: 92-36-4

The Article related to huntington disease treatment huntingtin protein ciap1 hybrid mol preparation, bestatin hybrid preparation ciap1 mhtt interaction inhibitor huntington disease, huntington’s disease, drug design, medicinal chemistry, protein degradation, small-molecule protein degraders and other aspects.Computed Properties of 92-36-4

Tomoshige, Shusuke; Nomura, Sayaka; Ohgane, Kenji; Hashimoto, Yuichi; Ishikawa, Minoru published an article in 2017, the title of the article was Discovery of Small Molecules that Induce the Degradation of Huntingtin.Computed Properties of 92-36-4 And the article contains the following content:

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. The authors designed two small hybrid mols. by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Computed Properties of 92-36-4

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Meltzer-Mats, Ella et al. published their research in Journal of Medicinal Chemistry in 2013 |CAS: 92-36-4

The Article related to denzothiazole derivative preparation hypoglycemic mechanism ampk antidiabetic target diabetes, plasma glut4 myotube ampk antidiabetic denzothiazole derivative preparation diabetes, mol modeling pharmacophore model food intake denzothiazole derivative preparation and other aspects.Related Products of 92-36-4

On July 11, 2013, Meltzer-Mats, Ella; Babai-Shani, Gali; Pasternak, Lily; Uritsky, Neta; Getter, Tamar; Viskind, Olga; Eckel, Jurgen; Cerasi, Erol; Senderowitz, Hanoch; Sasson, Shlomo; Gruzman, Arie published an article.Related Products of 92-36-4 The title of the article was Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives. And the article contained the following:

AMP activated protein kinase (AMPK) has emerged as a major potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-4-oxothiazolidin-2-ylidene)amino)benzoic acid (PT-1), which attenuates the autoinhibition of the enzyme AMPK, for the design and synthesis of different benzothiazoles with potential antidiabetic activity. We synthesized several structurally related benzothiazole derivatives that increased the rate of glucose uptake in L6 myotubes in an AMPK-dependent manner. One compound, 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole , augmented the rate of glucose uptake up to 2.5-fold compared with vehicle-treated cells and up to 1.1-fold compared to PT-1. Concomitantly, it elevated the abundance of GLUT4 in the plasma membrane of the myotubes and activated AMPK. S.c. administration of 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole to hyperglycemic Kuo Kondo rats carrying the Ay-yellow obese gene (KKAy) mice lowered blood glucose levels toward the normoglycemic range. In accord with its activity, compound 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole showed a high fit value to a pharmacophore model derived from the PT-1. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Related Products of 92-36-4

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Prasanna, Gutta Lakshmi et al. published their research in Journal of Applicable Chemistry (Lumami, India) in 2018 |CAS: 92-36-4

The Article related to benzothiazole preparation antibacterial, benzothiazolyl benzenamine preparation diketone potassium bisulfate catalyst paal knorr, thiobenzanilide preparation, benzanilide preparation, nitrobenzoyl chloride aniline reactant benzanilide preparation and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Prasanna, Gutta Lakshmi; Bharat, Y.; Sreenivasulu, Reddymasu; Rao, Mandava Venkata Basaveswara published an article in 2018, the title of the article was Synthesis and antibacterial activity of benzothiazole analogues.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

A series of novel benzothiazole fused derivatives I [R = Me, Cl, Br, I; R1 = Me, OMe] was designed, synthesized and screened for their antibacterial activity against Escherichia coli (MTCC 40) (Gram-neg.) and Staphylococcus aureus (MTCC 96)(Gram-pos.) bacteria. Among them, derivative I [R = Cl; R1 = Me] showed highest antibacterial activity against Gram-pos. and Gram-neg. bacteria. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Moloney, Gerard P. et al. published their research in European Journal of Medicinal Chemistry in 2004 |CAS: 92-36-4

The Article related to 5-ht antagonists (type 5-ht1b), 5-ht1b receptors role: bsu (biological study, unclassified), biol (biological study) (antagonists), molecular modeling, pharmacophores, structure-activity relationship, serotoninergic antagonist and other aspects.Category: thiazole

On April 30, 2004, Moloney, Gerard P.; Garavelas, Agatha; Martin, Graeme R.; Maxwell, Miles; Glen, Robert C. published an article.Category: thiazole The title of the article was Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor. And the article contained the following:

The synthesis and vascular 5-HT1B receptor activity of a novel series of substituted 3-amido phenylpiperazine and 4-(4-methyl-1-piperazinyl)-1-benzo[b]thiophene derivatives is described. Modifications to the amido linked sidechains of the 3-amidophenyl piperazine derivatives and to the 2-side-chain of the 1-benzo[b]thiophene derivatives have been explored. Several compounds were identified which exhibited affinity at the vascular 5-HT1B receptor of pKB > 7.0. From the 3-amidophenyl-piperazine series, N-[5-(4-chlorophenyl)-2-thiazolyl]-3-(4-methyl-1-piperazinyl)benzamide (I) and from the benzo[b]thiophene-4-piperazine series N-(2-ethylphenyl)-4-(4-methyl-1-piperazinyl)benzo[b]thiophene-2-carboxamide (II) were identified as a highly potent, silent (as judged by the inability of angiotensin II to unmask 5-HT1B receptor mediated agonist activity in the rabbit femoral artery) and competitive vascular 5-HT1B receptor antagonist. The affinity of compounds from these two series of compounds for the vascular 5-HT1B receptor is discussed as well as a proposed mode of binding to the receptor pharmacophore. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Category: thiazole

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sagnou, Marina et al. published their research in European Journal of Inorganic Chemistry in 2012 |CAS: 92-36-4

The Article related to radiolabeled benzothiazole chelate conjugate spect imaging amyloid alzheimers, crystal structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex, mol structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex and other aspects.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

Sagnou, Marina; Tzanopoulou, Stamatia; Raptopoulou, Catherine P.; Psycharis, Vassilis; Braband, Henrik; Alberto, Roger; Pirmettis, Ioannis C.; Papadopoulos, Minas; Pelecanou, Maria published an article in 2012, the title of the article was A Phenylbenzothiazole Conjugate with the Tricarbonyl fac-[M(I)(CO)3]+ (M = Re, 99Tc, 99mTc) Core for Imaging of β-Amyloid Plaques.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

The 2-(4′-aminophenyl)-6-methylbenzothiazole that is known to display affinity and specificity toward the amyloid plaques of Alzheimer’s disease (AD) has been joined to the tricarbonyl [M(CO)3NNO] chelate (M = Re, 99Tc, and 99mTc) through a five-carbon linker chain to generate the neutral complex (1) (namely, Re-1 for M = Re; 99Tc-1 for M = 99Tc; and 99mTc-1 for M = 99mTc) with the aim of developing a single-photon emission computed tomog. (SPECT) radiodiagnostic agent for AD. Re-1 was characterized by spectroscopic methods and x-ray crystallog., whereas the detailed NMR spectroscopic anal. of 99Tc-1 demonstrated its structural similarity to Re-1. Complexes Re-1 and 99Tc-1 display selective binding affinity for amyloid plaques as evidenced by fluorescence spectroscopy, whereas the biodistribution data of 99mTc-1 characterized by relatively low brain uptake, fast clearance from brain and blood, and in vivo stability are considered encouraging for further elaboration on the structural features of 1 in the direction of increased brain uptake. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sep-21 News Final Thoughts on Chemistry for 2-(4-Aminophenyl)-6-methylbenzothiazole

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Application In Synthesis of 2-(4-Aminophenyl)-6-methylbenzothiazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 92-36-4, in my other articles.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92-36-4, Name is 2-(4-Aminophenyl)-6-methylbenzothiazole, molecular formula is C14H12N2S. In a Article，once mentioned of 92-36-4, Application In Synthesis of 2-(4-Aminophenyl)-6-methylbenzothiazole

Surface-assisted laser desorption/ionization (SALDI) is a matrix-free mass spectrometry (MS) approach that utilizes the unique properties of a nanostructured surface to promote desorption and ionization. However, there are still questions on what constitutes a suitable SALDI substrate for mass spectrometric application. A range of SALDI substrates prepared by anodization with an oxidizing electrolyte was investigated. The laser desorption/ionization (LDI) performance was examined on a reflectron time-of-flight (ToF) mass spectrometer. The physicochemical properties of the substrates were characterized by a number of surface analysis techniques including scanning electron microscopy (SEM), atomic force microscopy (AFM), secondary ion mass spectrometry (SIMS), X-ray photoelectron spectroscopy (XPS) and water contact angle measurement. Examination of surface cleaning technologies and methods for surface chemical modification were carried out. Correlation between the substrate physicochemical properties and the LDI performance was determined. It was found that only the substrate, which had a thick nanostructured layer, was effective for LDI-MS. SALDI substrate was found to have a high surface potential. However, this unique property offered no advantage for the application of LDI-MS. Surface chemistry is also an important factor in affecting the LDI performance. Plasma etching can effectively remove the surface contamination but it also increases the thickness of the oxide layer. Fluorine and hydroxyl termination is advantageous. Fluorine passivation increases the surface hydrophobicity, which confines the analyte solution droplet to a smaller area and also withdraws the electronic density from the surface, and acidifies the surface Si-OH moieties, which is believed a major proton source. The effect of laser etching was investigated by SIMS and XPS imaging and provided new insight of the SALDI ionization mechanism.

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Thiazole | C3H530NS – PubChem,
Thiazole | chemical compound | Britannica

Extracurricular laboratory:new discovery of 2-(4-Aminophenyl)-6-methylbenzothiazole

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.HPLC of Formula: C14H12N2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 92-36-4, in my other articles.

This paper evaluates the use of oligovalent amyloid-binding molecules as potential agents that can reduce the enhancement of human immunodeficiency virus-1 (HIV-1) infection in cells by semen-derived enhancer of virus infection (SEVI) fibrils. These naturally occurring amyloid fibrils found in semen have been implicated as mediators that can facilitate the attachment and internalization of HIV-1 virions to immune cells. Molecules that are capable of reducing the role of SEVI in HIV-1 infection may, therefore, represent a novel strategy to reduce the rate of sexual transmission of HIV-1 in humans. Here, we evaluated a set of synthetic, oligovalent derivatives of benzothiazole aniline (BTA, a known amyloid-binding molecule) for their capability to bind cooperatively to aggregated amyloid peptides and to neutralize the effects of SEVI in HIV-1 infection. We demonstrate that these BTA derivatives exhibit a general trend of increased binding to aggregated amyloids as a function of increasing valence number of the oligomer. Importantly, we find that oligomers of BTA show improved capability to reduce SEVI-mediated infection of HIV-1 in cells compared to a BTA monomer, with the pentamer exhibiting a 65-fold improvement in efficacy compared to a previously reported monomeric BTA derivative. These results, thus, support the use of amyloid-targeting molecules as potential supplements for microbicides to curb the spread of HIV-1 through sexual contact.

Reference：
Thiazole | C3H509NS – PubChem,
Thiazole | chemical compound | Britannica

Simple exploration of 92-36-4

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Product Details of 92-36-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 92-36-4, in my other articles.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92-36-4, Name is 2-(4-Aminophenyl)-6-methylbenzothiazole, molecular formula is C14H12N2S. In a Patent，once mentioned of 92-36-4, Product Details of 92-36-4

Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1,-C20alkyl; C2-C20alkenyl; C3-C10,cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1,-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; wenn n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; wenn n1 is 4, R3 is an alkanetetrayl radical; A is -O-; or -N(R5)-; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.

Reference：
Thiazole | C3H553NS – PubChem,
Thiazole | chemical compound | Britannica