Category: 92-36-4

Chen, Yen Ting published the artcileParallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Bioorganic & Medicinal Chemistry (2004), 12(12), 3289-3298, database is CAplus and MEDLINE.

Protein tyrosine phosphatases (PTPases) regulate intracellular signal transduction pathways by controlling the level of tyrosine phosphorylation in cells. These enzymes play an important role in a variety of diseases including type II diabetes and infection by the bacterium Yersinia pestis, which is the causative agent of bubonic plague. This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases. The library members are based on the bis(aryl α-ketocarboxylic acid) motif that incorporates a carboxylic acid on the central benzene linker. This carboxylic acid was coupled with a variety of different aromatic amines through an amide linkage. The aromatic component of the resulting amides is designed to make contacts with residues that surround the active site of the PTPase. The library was screened against the Yersinia PTPase and PTP1B. Based upon the screening results, four members of the library were selected for further study. These four compounds were evaluated against the Yersinia PTPase, PTP1B, TCPTP, CD45, and LAR. Compound 14 has an IC₅₀ value of 590 nM against PTP1B and is a reversible competitive inhibitor. This affinity represents a greater than 120-fold increase in potency over compound 2, the parent structure upon which the library was based. A second inhibitor, compound 12, has an IC₅₀ value of 240 nM against the Yersinia PTPase. In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45.

Bioorganic & Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Akerfeldt, Stig published the artcileIn vivo antiviral effects of benzothiazole derivatives against various influenza A2 strains, Application In Synthesis of 92-36-4, the publication is Journal of Medicinal Chemistry (1970), 13(5), 1012-13, database is CAplus and MEDLINE.

Seventeen derivatives of benzothiazole were investigated for antiviral activity against various influenza A2 strains in mice. Aminoadamantane was used as an internal standard in the experiments 2-Aminobenzothiazole and 2-amino-4-chlorobenzothiazole gave a protective effect comparable to, or better than, that found for aminoadamantane. Small variations in the structure of these 2 compounds caused a complete disappearance of the antiviral effect. To be effective the active compounds had to be administered in near-toxic doses. All 17 compounds were also tested for antiviral effect against rhino virus 33342, adeno virus 3, and herpes simplex virus. Significant antiviral effect could not be demonstrated for any compound in vitro.

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Anonymous published the artcilePreparation of amino substituted hydroxyphenyl benzophenone derivatives and their uses as UV filters in sunscreen formulations, Category: thiazole, the publication is IP.com Journal (2003), 3(8), 40, database is CAplus.

Described are synthesis of amino substituted hydroxyphenyl benzophenone derivatives The compounds are useful as UV filters in sunscreen applications. For example, comound I synthesized by reacting anhydrous 4-diethylamino 2-hydroxy benzophenone carboxylic acid with 2,2-dimethyl-1,3-propanediol was found to be a good UV absorber and was incorporated into sunscreen formulations.

IP.com Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Azzem, M. Abdel published the artcileElectroactive film of polyaniline substituted with heterocyclic benzothiazole ring, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is European Polymer Journal (1995), 31(2), 205-8, database is CAplus.

Voltammetric studies of 2-(4-aminophenyl)-6-methylbenzothiazole (ABT) were carried out in MeCN and acidic aqueous solutions Potential sweep electrolysis of 0.05 M ABT at a glassy C electrode in MeCN containing 0.1 M LiClO₄ and 0.05 M pyridine produced a polymeric film. The film coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of poly-ABT prepared by constant current electrolysis was 3.8 × 10^-5 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

European Polymer Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Law, K. P. published the artcileSurface-assisted laser desorption/ionization mass spectrometry on nanostructured silicon substrates prepared by iodine-assisted etching, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is International Journal of Mass Spectrometry (2010), 290(1), 47-59, database is CAplus.

Surface-assisted laser desorption/ionization (SALDI) is a matrix-free mass spectrometry (MS) approach that utilizes the unique properties of a nanostructured surface to promote desorption and ionization. However, there are still questions on what constitutes a suitable SALDI substrate for mass spectrometric application. A range of SALDI substrates prepared by anodization with an oxidizing electrolyte was investigated. The laser desorption/ionization (LDI) performance was examined on a reflectron time-of-flight (ToF) mass spectrometer. The physicochem. properties of the substrates were characterized by a number of surface anal. techniques including SEM, at. force microscopy (AFM), secondary ion mass spectrometry (SIMS), XPS and water contact angle measurement. Examination of surface cleaning technologies and methods for surface chem. modification were carried out. Correlation between the substrate physicochem. properties and the LDI performance was determined It was found that only the substrate, which had a thick nanostructured layer, was effective for LDI-MS. SALDI substrate was found to have a high surface potential. However, this unique property offered no advantage for the application of LDI-MS. Surface chem. is also an important factor in affecting the LDI performance. Plasma etching can effectively remove the surface contamination but it also increases the thickness of the oxide layer. Fluorine and hydroxyl termination is advantageous. Fluorine passivation increases the surface hydrophobicity, which confines the analyte solution droplet to a smaller area and also withdraws the electronic d. from the surface, and acidifies the surface Si-OH moieties, which is believed a major proton source. The effect of laser etching was investigated by SIMS and XPS imaging and provided new insight of the SALDI ionization mechanism.

International Journal of Mass Spectrometry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Riesz, E. published the artcileSome new benzothiazole derivatives and comparison dyeing with such compounds, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Textilveredlung (1991), 26(12), 403-5, database is CAplus.

The yellow dye primuline, prepared by heating p-toluidine with S, was separated into 3 bases, having the structure I (x = 0, 1, or 2), which were then converted into the corresponding Na sulfonate salts and used to dye viscose and cotton fabrics. For the I (x = 0) Na sulfonate, the fibers remained practically undyed, displaying only a light yellow tinge; with the sulfonates of I (x = 2) and I (x = 3) yellow and deep yellow dyeings were produced, resp. To evaluate the shade-deepening and affinity effects of the benzothiazole (II) groups, the 3 Na sulfonates were diazotized and coupled with β-naphthol on the fibers. Most of the dye was taken up by the fibers because of an increase in affinity, but a certain contribution by the shade-deepening effect of the II groups could not be excluded. Reaction of the 3 sulfonates with p-dimethylaminobenzaldehyde produced dyes containing a weaker chromophore, i.e., azomethine, than the azo group. These compounds dyed cellulosic fibers widely different shades of yellow and orange and, as free bases, gave basic dyes which dyed fibers from an HOAc solution without pretreatment. Conversion of the amino groups of the 3 bases into SH groups yielded the 1st purely synthetic S dyes for dyeing cellulosic fibers yellow shades.

Textilveredlung published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sekar, N. published the artcileThiazole – containing monoazo direct dyes, Formula: C14H12N2S, the publication is Colourage (2005), 52(3), 95-98, database is CAplus.

A review. Chem. of monoazo direct dyes based on dehydrothio-p-toluidine and its higher analogs and the others containing thiazolyl residue is discussed in the light of structures documented in color index.

Colourage published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C8H5F3O2S, Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Du, Zhi published the artcileSelf-triggered click reaction in an Alzheimer’s disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-beta plaques, Category: thiazole, the publication is Chemical Science (2019), 10(44), 10343-10350, database is CAplus and MEDLINE.

Cu is one of the essential elements for life. Its dyshomeostasis has been demonstrated to be closely related to neurodegenerative disorders, such as Alzheimer’s disease (AD), which is characterized by amyloid-beta (Abeta) aggregation and Cu accumulation. It is a great challenge as to how to take advantage of neurotoxic Cu to fight disease and make it helpful. Herein, we report that the accumulated Cu in Abeta plaques can effectively catalyze an azide-alkyne bioorthogonal cycloaddition reaction for fluorophore activation and drug synthesis in living cells, a transgenic AD model of Caenorhabditis elegans CL2006, and brain slices of triple transgenic AD mice. More importantly, the in situ synthesized bifunctional drug 6 can disassemble Abeta-Cu aggregates by extracting Cu and photo-oxygenating Abeta synergistically, suppressing Abeta-mediated paralysis and diminishing the locomotion defects of the AD model CL2006 strain. Our results demonstrate that taking the accumulated Cu ions in the Abeta plaque for an in situ click reaction can achieve both a self-triggered and self-regulated drug synthesis for AD therapy. To the best of our knowledge, a click reaction catalyzed by local Cu in a physiol. environment has not been reported. This work may open up a new avenue for in situ multifunctional drug synthesis by using endogenous neurotoxic metal ions for the treatment of neurodegenerative diseases.

Chemical Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Guan, Ai-jiao published the artcileEthyl-substitutive Thioflavin T as a highly-specific fluorescence probe for detecting G-quadruplex structure, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Scientific Reports (2018), 8(1), 1-12, database is CAplus and MEDLINE.

G-quadruplex has attracted considerable attention due to their prevalent distribution in functional genomic regions and transcripts, which can importantly influence biol. processes such as regulation of telomere maintenance, gene transcription and gene translation. Artificial receptor study has been developed for accurate identification of G-quadruplex from DNA species, since it is important for the G-quadruplex related basic research, clin. diagnosis, and therapy. Herein, fluorescent dye ThT-E, a derivative of the known fluorescence probe Thioflavin T (ThT), was designed and synthesized to effectively differentiate various G-quadruplex structures from other nucleic acid forms. Compared with Me groups in ThT, three Et groups were introduced to ThT-E, which leads to strengthened affinity, selectivity and little inducing effect on the G-quadruplex formation. More importantly, ThT-E could be served as a visual tool to directly differentiate G-quadruplex solution even with naked eyes under illumination of UV light. Thus, this probe reported herein may hold great promise for high-throughput assay to screen G-quadruplex, which may widely apply to G-quadruplex-based potential diagnosis and therapy.

Scientific Reports published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Abdel Azzem, M. published the artcileElectroactive film of polyaniline substituted with the benzothiazole ring, Application In Synthesis of 92-36-4, the publication is Delta Journal of Science (1993), 17(3), 127-140, database is CAplus.

Voltammetric studies of ring-substituted aniline with a heterocyclic ring , i.e., 2-(4-aminophenyl)-6-methylbenzothiazole (ABT), were carried out in acetonitrile and acidic aqueous solutions Potential sweep electrolysis of 0.05M ABT at a glassy carbon electrode in CH₃CN containing 0.1M LiC10₄ and 0.05M pyridine produced a polymeric film. The film-coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of PABT prepared by constant current electrolysis was 3.8 × 10 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

Delta Journal of Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica