Category: 92-36-4

Shaikh, Asif R. published the artcileAntimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones, HPLC of Formula: 92-36-4, the publication is Indian Journal of Research in Pharmacy and Biotechnology (2014), 2(1), 935-942, 8 pp., database is CAplus.

The 7-chloro-2-(substituted)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) quinazolin-4(3H)-ones e.g., I (R = furan-2-yl) have been prepared from the substituted acids, which were converted to substituted acetyl chlorides and cyclized with 4-chloro anthranilic acid afforded substituted benzoxazines 4(3H)-ones e.g., II and its further reaction with 4-(6-methylbenzo[d]thiazol-2-yl)aniline a gives desired compounds I. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H₃₇Rv strain using Lowenstein-Jensen medium (conventional method) and antimicrobial activity against various bacteria and fungi using broth microdilution method. The compounds II, I were emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. The compounds II, I showed better antitubercular activities compared to rifampicin and isoniazid.

Indian Journal of Research in Pharmacy and Biotechnology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C7H6Cl2, HPLC of Formula: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Blackwell, Helen E. published the artcileDecoding products of diversity pathways from stock solutions derived from single polymeric macrobeads, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Angewandte Chemie, International Edition (2001), 40(18), 3421-3425, database is CAplus and MEDLINE.

A combinatorial library of nonracemic dihydropyrancarboxamides such as I [prepared on solid phase by the enantioselective Diels-Alder cycloaddition of resin-bound vinyl ethers with allyl β,γ-unsaturated-α-ketoesters in the presence of nonracemic bisoxazoline ligands and copper (II) triflate] using a novel tagging technique for the labeling and identification of members of combinatorial libraries. Chloroarom. diazoketones II (n = 1, 7, 14; R = H, Cl) were used as tagging agents to identify the sequence of reactions to which a resin bead had been subjected; treatment of a resin bead with II in the presence of dirhodium tetrakis(triphenylacetate) yielded a polystyrene resin containing a fraction of chloroaralkyl cycloheptatriene moieties (formed by ring expansion of the polystyrene Ph groups). Oxidative cleavage of the tags with ceric ammonium nitrate liberated the chloroarom. portion of the tags; treatment of the tags with N,O-bis(trimethylsilyl)acetamide and gas chromatog. yielded masses corresponding to the sequence of reactions to which beads were subjected and thus their identities. The tags could be decoded either directly from a bead before compound cleavage, from a bead after compound cleavage, or from compound stock solutions (generated by compound cleavage and dissolution of a fraction of the liberated compounds in THF/H₂O). Decoding compound stock solutions was the most effective method of identifying library members; compounds were identified by tag cleavage of solutions containing 1 or 5% of the compound cleaved from a single bead. Stock solutions were decoded most effectively because a fraction of the library member on a given bead was tagged with the chloroarom. diazoketone in addition to the polystyrene resin (due to the high-loading resin used) and because oxidative cleavage of the tags with CAN proceeded more readily in solution than on solid support. A sublibrary of 108 beads chosen from the larger combinatorial library was decoded by this procedure; of the 108 compounds, 107 were successfully decoded. Four different synthetic pathways were found to be compatible with the diazoketone tagging methodol. (no data). The use of stock solutions for the decoding and deconvolution of combinatorial libraries is amenable to robotic methods for combinatorial library synthesis and testing, minimizes the storage requirements for combinatorial libraries, and allows for simpler and faster compound identification.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gadre, J. N. published the artcileSynthesis of pyridone based azo disperse dyes, COA of Formula: C14H12N2S, the publication is Indian Journal of Heterocyclic Chemistry (2006), 16(1), 43-46, database is CAplus.

Pyridone derivatives have proved to be the best heterocyclic couplers as they provide proper nucleophilic center. In the present project N-aryl imides (pyridine-2,6-dione) were coupled with diazotized substituted aniline derivatives to yield azo disperse dyes.

Indian Journal of Heterocyclic Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lopez, Rosana published the artcileThe apparent dipole moments and molar volumes of 1,3-benzothiazole and some derivatives, in nonpolar solvents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1999), 2225-2229, database is CAplus.

The apparent mol. polarizations at infinite dilution, P_2∞, mol. refractions, R_D, dipole moments, μ₂, polarizabilities, α, partial molar volumes, V ⁰_2,m, of 1,3-benzothiazole and some derivatives at position 2 or 3, were determined from relative permittivity, d. and refractive index measurements in n-hexane or 1,4-dioxane solutions at 25°. The R_D and V ⁰_2,m values correlate well for all substances studied, independently of the solvent used. The P_2∞ values appear to be slightly dependent on the solvent showing the presence of specific interactions as H bond. The apparent relative permittivity, ε₂‘, and the refraction index extrapolated at the IR region, n_IR, were estimated for all solutes. In the case of 1,3-benzothiazole and its 2-Me derivative, these results were compared with the relative permittivities measured at 25° at low and high frequencies, resp., by the Cole-Cole dynamic method, showing a good agreement. The apparent dipole moments and their changes with the corresponding substituent group were determined by 3 different methods. From the measurement of dipole moment it was unambiguously established that the tautomeric equilibrium between 2-mercapto-1,3-benzothiazole and 2-thioxo-3H-1,3-benzothiazole is strongly displaced to the latter. Changes in the apparent molar solution volumes and apparent molar polarizations of the solutes in the considered solvents are qual. discussed. Comparison between pK_a values reported in the literature and the corresponding μ values for free base benzothiazole derivatives were carried out as well as the appropriate qual. discussion.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ukrainets, I. V. published the artcile4-hydroxy-2-quinolones. 122. 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2007), 43(7), 863-870, database is CAplus.

An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides, e.g., I. The antitubercular activity of all of the compounds prepared has been studied. The structure-biol. activity dependence revealed is discussed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C40H35N7O8, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hazra, Dipak K. published the artcileAb initio powder structure analysis and theoretical study of two thiazole derivatives, Related Products of thiazole, the publication is Journal of Molecular Structure (2013), 153-159, database is CAplus.

Crystal structures of 2-amino-5-methylthiazole (1) and 4-(6-methyl-2-benzothiazolyl) aniline (2) have been determined from laboratory X-ray powder diffraction data along with an anal. of the Hirshfeld surfaces and 2D-fingerprint plots, facilitating a comparison of intermol. interactions. The DFT optimized mol. geometries in (1) and (2) agree closely with those obtained from the crystallog. studies. An interplay of NH···N/S hydrogen bonds and C/NH···π interactions connects the mols. of (1) and (2) into two-dimensional framework. Hirshfeld surface anal. of (1) indicates that the H···H and H···π contacts can account for 56.9% of the Hirshfeld surface area, whereas the corresponding fraction in (2) is 80.5%.

Journal of Molecular Structure published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Katritzky, Alan R. published the artcileAqueous high-temperature chemistry of carbo- and heterocycles. 11. Aquathermolysis of arylamines in the presence and absence of sodium bisulfite, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Energy & Fuels (1990), 4(5), 547-55, database is CAplus.

Thermolysis and neutral aqueous thermolysis of ring- and N-substituted anilines showed either no reaction or little conversion. In aqueous 10% H₃PO₄ the anilines underwent denitrogenation to give phenols. Friedel-Crafts alkylations and dealkylations were observed for alkyl-substituted anilines, together with the formation of diarylamines and carbazoles, both in runs with H₃PO₄ and in runs with an aqueous sulfite/bisulfite mixture Mechanistic pathways are suggested for the formation of all products. The foregoing has relevance to heteroatom elimination from coal, kerogen, and heavy oils.

Energy & Fuels published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Phoon, C. W. published the artcileBiological evaluation of hepatitis C virus helicase inhibitors, Category: thiazole, the publication is Bioorganic & Medicinal Chemistry Letters (2001), 11(13), 1647-1650, database is CAplus and MEDLINE.

A small chem. library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biol. activity. The development of a robust HCV helicase assay is also described.

Bioorganic & Medicinal Chemistry Letters published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tomoshige, Shusuke published the artcileDiscovery of Small Molecules that Induce the Degradation of Huntingtin, COA of Formula: C14H12N2S, the publication is Angewandte Chemie, International Edition (2017), 56(38), 11530-11533, database is CAplus and MEDLINE.

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. The authors designed two small hybrid mols. by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C10H12O5, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Maurya, R. C. published the artcileMagneto, spectral and thermal studies of some mixed-ligand cyanonitrosyl chromium (CrNO)⁵ complexes involving benzothiazole derivatives, COA of Formula: C14H12N2S, the publication is Journal of the Institution of Chemists (India) (1992), 64(1), 7-8, database is CAplus.

[Cr(NO)(CN)₂L₂(H₂O)] (L = 2-amino-6-ethoxy-, 2-amino-4-chloro-, 2-amino-6-nitro-, 2-amino-5,6-dimethyl-, 2-(2-tolyl)-, 2-(4-aminophenyl)-6-methylbenzothiazoles) were prepared and characterized by elemental anal., magnetic, molar conductance, TGA, and IR and ESR spectral methods. The benzothiazoles act as monodentate ligands coordinating through tertiary N.

Journal of the Institution of Chemists (India) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica