With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93-85-6,2-Aminobenzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
93-85-6, General procedure: In a flask charged with 50 mL of CH3CN was added2.5 mmol of compound 5 andappropriate benzothiazole derivatives (2a-r,1.5 eq.) and the reaction mixture was refluxed for 10-38 h until the completeconsumption of starting material as detected by TLC.After the completion of the reaction, the reactionmixture was treated with ice and the resulting solid was filtered and washedwith water (2 x 25 mL). The residue was purifiedby a silica gel column chromatography andwas eluted with dichloromethane: methanol (40:1) to afford correspondingproducts 6a-r in 49-82% of yields.
As the paragraph descriping shows that 93-85-6 is playing an increasingly important role.
Reference£º
Article; Mistry, Bhupendra M.; Patel, Rahul V.; Keum, Young-Soo; Kim, Doo Hwan; Bioorganic and Medicinal Chemistry Letters; vol. 25; 23; (2015); p. 5561 – 5565;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica