933720-87-7,933720-87-7, 2-Bromo-4-methylthiazole-5-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
PREPARATION 991-(2-Bromo-4-meth lthiazol-5-yl)ethanolTo a mixture of 2-bromo-4-methylthiazole-5-carbaldehyde of preparation 98 (1.8 g, 8.8 mmol) in dry THF (50 mL) was added dropwise MeMgBr in EfeO (3M, 2.9 mL, 8.8 mmol) at -40C under N2. After the addition, the mixture was stirred at room temperature for 1 hr. TLC (petroleum ether/EtOAc = 5:1 ) showed most of the starting material was consumed. To the reaction mixture was added saturated NH4CI (60 mL). The mixture was extracted with EtOAc (50 ml_x2). The combined organic layers were washed with brine (80 mL), dried over sodium sulfate and concentrated in vacuum. The residue was purified by a Biotage silica gel cartridge (EA/PE 48%, Rf = 0.5) to give the titlecompound as a yellow oil (1.7 g, 87%).1H NMR (400 MHz, CDCI3): delta ppm 5.09-5.06 (q, 1 H), 2.29-2.28 (d, 4H), 1.46-1.45 (d, 3H). MS: m/z 223.6 [MH]+.
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Reference：
Patent; PFIZER INC.; BUNNAGE, Mark, Edward; COOK, Andrew, Simon; CUI, Jingrong, Jean; DACK, Kevin, Neil; DEAL, Judith, Gail; GU, Danlin; HE, Mingying; JOHNSON, Patrick, Stephen; JOHNSON, Ted, William; LE, Phuong, Thi, Quy; PALMER, Cynthia, Louise; SHEN, Hong; WO2011/138751; (2011); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica