Category: 934-34-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-34-9,Benzothiazolone,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 9.2 g, 66.6 mmol) and 1,4-dibromobutane (21.0 mL, 177.6 mmol) were added, under stirring, to a solution of benzo[d]oxazol-2(3H)-one (3.0 g, 22.2 mmol) in anhydrous DMF (30 mL). The reaction mixture was heated at 60 C for 3 h. After cooling, the reaction mixture was poured into 100 mL water and extracted with ethyl acetate (3 x 70 mL). The combined organic layers were washed with saturated aqueous NaCl and dried over sodium sulfate. The solvent was removed in vacuo, and the residue was purified by flash column chromatography (SiO2) using hexane/ethyl acetate (8:2) as eluent to give 3.6 g (62%) of 2e as a white solid. 4.2.1.3 3-(2-Bromoethyl)benzo[d]thaizol-2(3H)-one (2b) General procedure A, yield 57%, white solid. 1H NMR (400 MHz, CDCl3) delta 7.64-6.99 (m, 4H), 4.37 (t, J = 6.2, 2H), 3.82 (t, J = 6.1, 2H). 13C NMR (101 MHz, CDCl3) delta 166.07, 154.40, 142.70, 135.83, 134.62, 122.03, 120.40, 55.74, 39.59. MS (EI) m/z 258 (M++1).

934-34-9, The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abdelazeem, Ahmed H.; Khan, Shabana I.; White, Stephen W.; Sufka, Kenneth J.; McCurdy, Christopher R.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3248 – 3259;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Intermediates 19-26 were prepared following literature procedures, with slight modifications [50]. A solution of 10-14 (6.6mmol) in acetone (20mL) was mixed with K2CO3 (10mmol) and stirred at room temperature for 10min. After addition of the appropriate 1-bromo-omega-chloroalkane or 1,omega-dibromoalkane (7.3mmol), the mixture was stirred for further 24h. Inorganic materials was removed by filtration, then the solvent was removed in vacuum to obtain a residue which was used without any further purification for the next step. For analytical purpose, crude 23-26 were purified by flash chromatography or by recrystallization.

934-34-9, As the paragraph descriping shows that 934-34-9 is playing an increasingly important role.

Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Marrazzo, Agostino; Siracusa, Maria A.; Sorrenti, Valeria; Di Giacomo, Claudia; Vanella, Luca; Parayath, Neha N.; Greish, Khaled; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 162 – 172;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica