Category: 942631-50-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942631-50-7,tert-Butyl thiazol-5-ylcarbamate,as a common compound, the synthetic route is as follows.

942631-50-7, 1.2 thiazo 1-5 -amine hydrochloride To a solution of tert-butyl thiazo 1-5 -ylcarbamate from example 1.1 (20 g, 100 mmol) in methanol (100 mL) was added HCl/dioxane (50 mL). The solution was stirred at room temperature for 2 h. The solution was concentrated to give the title compound as a pale yellow solid (10.9 g, 0.80 mmol, 80%). It was used directly for next step without further purification. LC-MS: m/z 137 (M+H), RT=0.05 min

The synthetic route of 942631-50-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ABBOTT GMBH & CO. KG; ABBVIE INC.; GENESTE, Herve; OCHSE, Michael; DRESCHER, Karla; JAKOB, Clarissa; TORRENT, Maricel; YAO, Shanshan; ZHAO, Xiaoling; WANG, Liang; WO2014/41175; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

942631-50-7, tert-Butyl thiazol-5-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

942631-50-7, [0003 10] Synthesis of thiazol-5-amine hydrochloride (380): To a stirred solution of compound 379 (300 mg, 1.5 mmol) in MeOH (5 mL) was added 4 N HC1 in 1, 4-Dioxane (5 mL) under argon atmosphere at 0 C; warmed to RT and stirred for 3 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo to obtain the crude. The crude was washed with n-pentane (2 x 5 mL) and dried in vacuo to afford compound 380 (150 mg, HC1 salt) as pale yellow solid. TLC: 50% EtOAc/ hexanes (R 0.1); 1H-NMR (DMSO-d6, 500 MHz): oe 9.10 (s, 1H), 7.22 (s, 1H).

942631-50-7 tert-Butyl thiazol-5-ylcarbamate 53432624, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ASSEMBLY BIOSCIENCES, INC.; TURNER, William W.; ARNOLD, Lee Daniel; MAAG, Hans; ZLOTNICK, Adam; WO2015/138895; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica