Category: 944804-88-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.944804-88-0,tert-Butyl 4-bromothiazol-2-ylcarbamate,as a common compound, the synthetic route is as follows.

944804-88-0, General procedure: To a solution of 51 (0.5g, 1.8mmol), 48 (0.381g, 2.7mmol) and triphenylphosphine (0.707g, 2.7mmol) in anhydrous THF (20mL) at 0C was added diisopropyl azodicarboxylate (DIAD) (0.545g, 2.7mmol) dropwise. The reaction mixture was allowed to stir at room temperature for 10min and then stirred at 40C overnight. The resulting mixture was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in 74 petroleum ether 2-5%) to give the 172 product 52a as a white solid (0.365g, yield=50%).

The synthetic route of 944804-88-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

944804-88-0, A mixture of 48 (3.61g, 12.9mmol) and 70 Na2CO3 (3.4g, 32.3mmol) in DME/H2O/dioxane (240/48/48mL) was exchanged with N2 twice, and 5-chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (45a) (6.6g, 25.9mmol) and Pd(PPh3)4 (1.45g, 1.25mmol) were added to the mixture. The reaction mixture was heated to 100C and stirred for 6h under N2 atmosphere. The solid was removed by centrifugation at 3000rpm, 25C for 20min. The supernatant was concentrated and the crude product was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2-5%) to give 11 as a white solid (1.57g, yield=37%). 1H NMR (400MHz, DMSO-d6) delta 11.79 (s, 1H), 8.44 (s, 1H), 8.11 (s, 1H), 7.61 (s, 1H), 1.50 (s, 9H); LC/MS (ESI, m/z) 274.05 [M+H]+.

The synthetic route of 944804-88-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Methoxybenzyl chloride (2.72 mL, 20.09 mmol) was added to a solution of terEbutyl (4-bromothiazol- 2-yl)carbamate (5.10 g, 18.26 mmol) and CS2CO3 (11.90 g, 36.53 mmol) in DMF (40 mL) and the mixture was stirred at 80 C for 1 h. The reaction mixture was cooled to 25 C, quenched with water (100 mL), and extracted with EtOAc (3 x 300 mL). The organic extracts were dried over MgSCL, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (hexane: EtOAc; 1 :0 to 9.5:0.5) to afford the product (7.20 g, 99%) as a pale yellow wax. (0183) NMR (500 MHz, CDCL) (ppm) 7.36 – 7.31 (m, 2H), 6.85 – 6.81 (m, 2H), 6.81 (s, 1H), 5.21 (s, 2H), 3.78 (s, 3H), 1.52 (s, 9H); 13C NMR (126 MHz, CDCl3) (ppm) 161.9, 159.1, 153.0, 129.7, 129.6, 120.5, 113.8, 112.1, 84.1, 55.4, 49.7, 28.3; (0184) HRMS calcd for ( VJ hoBr^CkS [M+H]+ 401.0353, found 401.0359, 944804-88-0

944804-88-0 tert-Butyl 4-bromothiazol-2-ylcarbamate 45117837, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MASARYKOVA UNIVERZITA; PARUCH, Kamil; CARBAIN, Benoit; HAVEL, Stepan; VSIANSKY, Vit; NIKULENKOV, Fedor; KREJCI, Lumir; (133 pag.)WO2019/201867; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica