Category: 94641-22-2

In 1989,Dyes and Pigments included an article by Rangnekar, D. W.; Chaudhari, M. B.. Computed Properties of C11H13N3OS. The article was titled 《Synthesis of disperse azo dyes from 2-amino-4- and 6-N,N-dialkylaminobenzothiazoles and their application》. The information in the text is summarized as follows:

2-Amino-6-(dialkylamino)benzothiazole and 2-amino-4-(dialkylamino)-6-thiocyanatobenzothiazoles were prepared by condensation of 4-(dialkylamino)anilines and 2-(dialkylamino)anilines, resp., with NH4SCN and bromine in HOAc. These amines were diazotized and coupled with substituted N,N-dialkylanilines to give 2-[substituted-4-(dialkylamino)phenylazo]-6-(dialkylamino)benzothiazole dyes (I; NR1R2 = NEt2, morpholino, piperidino; R3 = Me, Et, 2-hydroxyethyl; R4 = Me, 2-cyanoethyl; X = H, OMe; Y = H, AcNH) and 2-[substituted-4-(dialkylamino)phenylazo]-6-thiocyanato-4-(dialkylamino)benzothiazole dyes (II; NR1R2, R3, R4, X, Y as for I). I and II were applied to polyester and polyamide fibers and their dyeing properties assessed. In the experiment, the researchers used 6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Computed Properties of C11H13N3OS)

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C11H13N3OSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 1989,Dyes and Pigments included an article by Rangnekar, D. W.; Chaudhari, M. B.. Computed Properties of C11H13N3OS. The article was titled 《Synthesis of disperse azo dyes from 2-amino-4- and 6-N,N-dialkylaminobenzothiazoles and their application》. The information in the text is summarized as follows:

2-Amino-6-(dialkylamino)benzothiazole and 2-amino-4-(dialkylamino)-6-thiocyanatobenzothiazoles were prepared by condensation of 4-(dialkylamino)anilines and 2-(dialkylamino)anilines, resp., with NH4SCN and bromine in HOAc. These amines were diazotized and coupled with substituted N,N-dialkylanilines to give 2-[substituted-4-(dialkylamino)phenylazo]-6-(dialkylamino)benzothiazole dyes (I; NR1R2 = NEt2, morpholino, piperidino; R3 = Me, Et, 2-hydroxyethyl; R4 = Me, 2-cyanoethyl; X = H, OMe; Y = H, AcNH) and 2-[substituted-4-(dialkylamino)phenylazo]-6-thiocyanato-4-(dialkylamino)benzothiazole dyes (II; NR1R2, R3, R4, X, Y as for I). I and II were applied to polyester and polyamide fibers and their dyeing properties assessed. In the experiment, the researchers used 6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Computed Properties of C11H13N3OS)

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C11H13N3OSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 6-Morpholinobenzo[d]thiazol-2-amineOn October 30, 2014 ,《Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents》 was published in European Journal of Medicinal Chemistry. The article was written by Ma, Junjie; Chen, Dong; Lu, Kuan; Wang, Lihui; Han, Xiaoqi; Zhao, Yanfang; Gong, Ping. The article contains the following contents:

A series of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety were designed and synthesized and their cytotoxic activities against five cancer cell lines (NCI-H226, SK-N-SH, HT29, MKN45, and MDA-MB-231) were screened in vitro. Most of them showed moderate to excellent activity against all the tested cell lines. Two compounds (procaspase-3 EC50 = 1.42 μM and procaspase-3 EC50 = 0.25 μM) exhibited excellent antitumor activity with IC50 values ranging from 0.14 μM to 0.98 μM against all cancer cell lines, which were 1.8-8.7 times more active than the first procaspase activating compound (PAC-1) (procaspase-3 EC50 = 4.08 μM). The structure-activity relationship analyses indicated that the introduction of a lipophilic group (a benzyloxy or heteroaryloxy group) at the 4-position of the 2-hydroxyphenyl ring was beneficial to antitumor activity, and the presence of substituents containing nitrogen that are pos. charged at physiol. pH could also improve antitumor activity. It was also confirmed that the steric effect of the 4-position substituent of the benzyloxy group had a significant influence on cytotoxic activity.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Reference of 6-Morpholinobenzo[d]thiazol-2-amine) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Morpholinobenzo[d]thiazol-2-amineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pollack, Scott J.; Beyer, Kim S.; Lock, Christopher; Mueller, Ilka; Sheppard, David; Lipkin, Mike; Hardick, David; Blurton, Peter; Leonard, Philip M.; Hubbard, Paul A.; Todd, Daniel; Richardson, Christine M.; Ahrens, Thomas; Baader, Manuel; Hafenbradl, Doris O.; Hilyard, Kate; Buerli, Roland W. published an article in Journal of Computer-Aided Molecular Design. The title of the article was 《A comparative study of fragment screening methods on the p38α kinase: new methods, new insights》.Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amine The author mentioned the following in the article:

The stress-activated kinase p38α was used to evaluate a fragment-based drug discovery approach using the BioFocus fragment library. Compounds were screened by surface plasmon resonance (SPR) on a Biacore T100 against p38α and two selectivity targets. A sub-set of the library was the focus of detailed follow-up analyses that included hit confirmation, affinity determination on 24 confirmed, selective hits and competition assays of these hits with respect to a known ATP binding site inhibitor. In addition, functional activity against p38α was assessed in a biochem. assay using a mobility shift platform (LC3000, Caliper LifeSciences). A selection of fragments was also evaluated using fluorescence lifetime (FLEXYTE) and microscale thermophoresis (Nanotemper) technologies. A good correlation between the data for the different assays was found. Crystal structures were solved for four of the small mols. complexed to p38α. Interestingly, as determined both by X-ray anal. and SPR competition experiments, three of the complexes involved the fragment at the ATP binding site, while the fourth compound bound in a distal site that may offer potential as a novel drug target site. A first round of optimization around the remotely bound fragment has led to the identification of a series of triazole-containing compounds This approach could form the basis for developing novel and active p38α inhibitors. More broadly, it illustrates the power of combining a range of biophys. and biochem. techniques to the discovery of fragments that facilitate the development of novel modulators of kinase and other drug targets.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amine) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application In Synthesis of 6-Morpholinobenzo[d]thiazol-2-amineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Design, Synthesis and Antiproliferative Activity of Novel Benzothiazole Derivatives Conjugated with Semicarbazone Scaffold》 was written by Bao, Guanglong; Du, Baoquan; Ma, Yuxiu; Zhao, Meng; Gong, Ping; Zhai, Xin. Category: thiazole And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) on August 31 ,2016. The article conveys some information:

Two series of novel benzothiazole derivatives conjugated with semicarbazone scaffold were designed and synthesized through a structure-based mol. hybridization strategy. All the target compounds were evaluated for their cytotoxicity in vitro against three cancer cell lines (HT-29, MKN-45 and H460) by standard MTT assay. The pharmacol. results indicated that seven compounds (17h-n) exhibited comparable or even better antiproliferative activity in comparison with reference drugs Sorafenib and PAC-1. Particularly, compound 17i displayed remarkable cytotoxicity against tested three cancer cell lines with IC50 values of 0.84, 0.06 and 0.52 μM, which were 4.3-, 36.6-, 4.2-folds more potent than Sorafenib and 1.2-, 13.7-, 6.9-times more active than PAC-1, resp.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Category: thiazole) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Category: thiazoleTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pollack, Scott J.; Beyer, Kim S.; Lock, Christopher; Mueller, Ilka; Sheppard, David; Lipkin, Mike; Hardick, David; Blurton, Peter; Leonard, Philip M.; Hubbard, Paul A.; Todd, Daniel; Richardson, Christine M.; Ahrens, Thomas; Baader, Manuel; Hafenbradl, Doris O.; Hilyard, Kate; Buerli, Roland W. published an article in Journal of Computer-Aided Molecular Design. The title of the article was 《A comparative study of fragment screening methods on the p38α kinase: new methods, new insights》.Synthetic Route of C11H13N3OS The author mentioned the following in the article:

The stress-activated kinase p38α was used to evaluate a fragment-based drug discovery approach using the BioFocus fragment library. Compounds were screened by surface plasmon resonance (SPR) on a Biacore T100 against p38α and two selectivity targets. A sub-set of the library was the focus of detailed follow-up analyses that included hit confirmation, affinity determination on 24 confirmed, selective hits and competition assays of these hits with respect to a known ATP binding site inhibitor. In addition, functional activity against p38α was assessed in a biochem. assay using a mobility shift platform (LC3000, Caliper LifeSciences). A selection of fragments was also evaluated using fluorescence lifetime (FLEXYTE) and microscale thermophoresis (Nanotemper) technologies. A good correlation between the data for the different assays was found. Crystal structures were solved for four of the small mols. complexed to p38α. Interestingly, as determined both by X-ray anal. and SPR competition experiments, three of the complexes involved the fragment at the ATP binding site, while the fourth compound bound in a distal site that may offer potential as a novel drug target site. A first round of optimization around the remotely bound fragment has led to the identification of a series of triazole-containing compounds This approach could form the basis for developing novel and active p38α inhibitors. More broadly, it illustrates the power of combining a range of biophys. and biochem. techniques to the discovery of fragments that facilitate the development of novel modulators of kinase and other drug targets.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Synthetic Route of C11H13N3OS) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Synthetic Route of C11H13N3OSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Design, Synthesis and Antiproliferative Activity of Novel Benzothiazole Derivatives Conjugated with Semicarbazone Scaffold》 was written by Bao, Guanglong; Du, Baoquan; Ma, Yuxiu; Zhao, Meng; Gong, Ping; Zhai, Xin. Related Products of 94641-22-2 And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) on August 31 ,2016. The article conveys some information:

Two series of novel benzothiazole derivatives conjugated with semicarbazone scaffold were designed and synthesized through a structure-based mol. hybridization strategy. All the target compounds were evaluated for their cytotoxicity in vitro against three cancer cell lines (HT-29, MKN-45 and H460) by standard MTT assay. The pharmacol. results indicated that seven compounds (17h-n) exhibited comparable or even better antiproliferative activity in comparison with reference drugs Sorafenib and PAC-1. Particularly, compound 17i displayed remarkable cytotoxicity against tested three cancer cell lines with IC50 values of 0.84, 0.06 and 0.52 μM, which were 4.3-, 36.6-, 4.2-folds more potent than Sorafenib and 1.2-, 13.7-, 6.9-times more active than PAC-1, resp.6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2Related Products of 94641-22-2) was used in this study.

6-Morpholinobenzo[d]thiazol-2-amine(cas: 94641-22-2) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Related Products of 94641-22-2Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica