Category: 95-24-9

《Antibacterial activity and greener method of synthesis of heterocyclic compounds incorporating benzothiazole moiety using ionic liquid as solvent》 was published in Rasayan Journal of Chemistry in 2019. These research results belong to Toshniwal, Madhu; Bundel, Mahendra; Kriplani, Prashant; Ravikant; Pareek, Rashmi; Pareek, Arun. HPLC of Formula: 95-24-9 The article mentions the following:

A novel series of substituted dimethylimidazo{2,1-b}[1,3]benzothiazoles have been synthesized by reaction of 2-amino-6-substituted benzothiazoles with halo ketone by conventional method as well as microwave conditions using ionic liquids The yield of products obtained by microwave synthesis with ionic liquids is much better than the conventional method. The reported compounds were further screened for their antibacterial activity using ampicillin as standard drug. The compounds showed excellent activity against Pseudomonas Aeruginosa, Klebsiella pneumonia and Staphylococcus aureus. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

B, Manjunatha; Bodke, Yadav D.; O, Nagaraja; N, Lohith T.; G, Nagaraju; Ma, Sridhar published their research in Journal of Molecular Structure on December 15 ,2021. The article was titled 《Coumarin-Benzothiazole Based Azo Dyes: Synthesis, Characterization, Computational, Photophysical and Biological Studies》.COA of Formula: C7H5ClN2S The article contains the following contents:

In this paper, we have reported the synthesis of some coumarin-benzothiazole based azo dyes (C1-C5). The structure of the synthesized dyes was precisely established from their IR, NMR and HRMS spectra. The synthesized dyes were photophys. characterized by UV-Vis and Photoluminescence studies. Through the computational study, the optimized mol. geometry, and reactive parameters were investigated to get a better insight into the mol. properties. Mol. electrostatic potential (MEP) and Reduced d. gradient (RDG) were also studied for all the compounds Diffuse reflectance study was carried out to determine the energy gap (Eg) of the synthesized dyes. Addnl., the synthesized compounds were screened for their pharmacol. property against Mycobacterium tuberculosis (H37 RV strain). The in silico mol. docking study was also performed with enoyl-ACP reductase.6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 6-Chlorobenzothiazol-2-ylamineOn October 31, 2021 ,《Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound》 appeared in Cell Death & Disease. The author of the article were Giovannucci, Tatiana A.; Salomons, Florian A.; Haraldsson, Martin; Elfman, Lotta H. M.; Wickstroem, Malin; Young, Patrick; Lundbaeck, Thomas; Eirich, Jurgen; Altun, Mikael; Jafari, Rozbeh; Gustavsson, Anna-Lena; Johnsen, John Inge; Dantuma, Nico P.. The article conveys some information:

Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irreversible collapse of the UPS, accompanied by a general accumulation of ubiquitylated proteins and caspase-dependent cell death. CBK77 caused accumulation of ubiquitin-dependent, but not ubiquitin-independent, reporter substrates of the UPS, suggesting a selective effect on ubiquitin-dependent proteolysis. In a genome-wide CRISPR interference screen, we identified the redox enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) as a critical mediator of CBK77 activity, and further demonstrated its role as the compound bioactivator. Through affinity-based proteomics, we found that CBK77 covalently interacts with ubiquitin. In vitro experiments showed that CBK77-treated ubiquitin conjugates were less susceptible to disassembly by deubiquitylating enzymes. In vivo efficacy of CBK77 was validated by reduced growth of NQO1-proficient human adenocarcinoma cells in nude mice treated with CBK77. This first-in-class NQO1-activatable UPS inhibitor suggests that it may be possible to exploit the intracellular environment in malignant cells for leveraging the impact of compounds that impair the UPS. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Reference of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Silica-Supported P2O5 as an Efficient Heterogeneous Catalyst for the One Pot Synthesis of 3-Amino-imidazo[2,1-b](1,3)benzothiazole under Green Conditions》 were Khan, Takallum; Yadav, Ritu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Quality Control of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:

The new approach involving the solid supported catalyst for the formation of C-N bond followed by cyclization has been reported. In this work we have reported a facile, efficient, and environment-friendly protocol for the synthesis of some new 3-amino-imidazo[2,1-b](1,3)benzothiazole derivatives by one-pot condensation of 2-aminobenzothiazole, indole-3-carbaldehyde, and aryl isocyanide in the presence of silica-supported P2O5 as a heterogeneous solid acid catalyst. The reaction was performed using conventional method under green conditions. The present approach offers the advantages of simple methodol., inexpensive acid catalyst, short reaction time, easy work up with excellent yield, simple purification and use of green solvent. All the newly synthesized compounds were characterized in details using phys. and chem. techniques such as m.p., 1H NMR, 13C NMR, and FTIR spectroscopy. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Quality Control of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Quality Control of 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Safety of 6-Chlorobenzothiazol-2-ylamineOn May 15, 2019 ,《Design, synthesis, biological evaluation and computational study of novel triazolo[4,3-a]pyrazine analogues》 appeared in Journal of Molecular Structure. The author of the article were Jethava, Divya J.; Acharya, Prachi T.; Vasava, Mahesh S.; Bhoi, Manoj N.; Bhavsar, Zeel A.; Rathwa, Sanjay K.; Rajani, Dhanji P.; Patel, Hitesh D.. The article conveys some information:

In search of suitable potent drug candidate, the design, synthesis, characterization, biol. activities and computation study of novel triazolo[4,3-a]pyrazine analogs was reported. The newly synthesized compounds were evaluated for their in vitro biol. activities such as anti-malarial, anti-tuberculosis, anti-bacterial and anti-fungal activities against plasmodium falciparum, H37Rv, various bacterial and fungal strains, resp. The mol. docking study was carried out with enzyme aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum to analyze their binding orientation in the active site of the aspartic proteinase enzyme. The best docking complex was subjected to mol. dynamics simulation to illustrate the stability of these complexes and the most prominent interactions during the simulated trajectory. ADMET properties of all the synthesized compounds to predict the pharmacokinetic properties for the selection of the active and bioavailability of compounds has been calculated In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Safety of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Safety of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 95-24-9On March 1, 2019, Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Adil Md.; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed published an article in Bioorganic & Medicinal Chemistry. The article was 《Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability》. The article mentions the following:

A series of new pyrazole linked benzothiazole-β-naphthol derivatives were designed and synthesized using a simple, efficient and ecofriendly route under catalyst-free conditions in good to excellent yields. These derivatives were evaluated for their cytotoxicity on selected human cancer cell lines. Among those, the derivatives 4j, 4k and 4l exhibited considerable cytotoxicity with IC50 values ranging between 4.63 and 5.54 μM against human cervical cancer cells (HeLa). Structure activity relationship was elucidated by varying different substituents on benzothiazoles and pyrazoles. Further, flow cytometric anal. revealed that these derivatives induced cell cycle arrest in G2/M phase and spectroscopic studies such as UV-visible, fluorescence and CD studies showed that these derivatives exhibited good DNA binding affinity. Addnl., these derivatives can effectively inhibit the topoisomerase I activity. Viscosity studies and mol. docking studies demonstrated that the derivatives bind with the minor groove of the DNA. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes》 was published in European Journal of Organic Chemistry in 2019. These research results belong to Zheng, Jun; Woerl, Benjamin; Breit, Bernhard. Recommanded Product: 95-24-9 The article mentions the following:

A rhodium-catalyzed chemo-, regio- and enantioselective intermol. coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodol. was further applied in an efficient synthesis of chiral isothiourea. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity》 was written by Jakopec, Silvio; Pantalon Juraj, Natalija; Brozovic, Anamaria; Jadresko, Dijana; Peric, Berislav; Kirin, Srecko I.; Raic-Malic, Silvana. HPLC of Formula: 95-24-9 And the article was included in Applied Organometallic Chemistry on April 30 ,2022. The article conveys some information:

Ferrocene derivatives with mono- Py2NCH2Trz-1-R (8a-c; Py = 2-pyridyl, Trz = 1,2,3-triazol-5-yl; R = Fc, FcCH2, FcCHMe) and bis-1,2,3-triazolyl fc(CH2-1-TrzCH2NPy2)2(9, fc = 1,1′-ferrocenediyl) and ArN(CH2Trz-1-R)2 (10a-13c; R = Fc, FcCH2, FcCHMe; Ar = Ph, 2-benzothiazolyl, 6-chloro-2-benzothiazolyl, 6-nitro-2-benzothiazolyl) chelating groups were synthesized by regioselective copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)2](CF3SO3)2 (8a-Cu) and [Cu(8c)2(MeOH)2](BF4)2 (8c-Cu). In addition to NMR and UV-Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle anal. was performed. The complex [Cu(8c)2](CF3SO3)2 showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB-231) cells. This complex increased cell population in the S and G2/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G0/G1 fraction. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Maliyappa, M. R.; Keshavayya, J.; Mahanthappa, Mallappa; Shivaraj, Y.; Basavarajappa, K. V. published an article on January 5 ,2020. The article was titled 《6-Substituted benzothiazole based dispersed azo dyes having pyrazole moiety: Synthesis, characterization, electrochemical and DFT studies》, and you may find the article in Journal of Molecular Structure.Computed Properties of C7H5ClN2S The information in the text is summarized as follows:

In the present work discusses synthesis, structural characterization and electrochem. investigation on some azo dyes derived from substituted benzothiazoles. The conventional diazo-coupling method was adopted to afford the heterocyclic azo dyes of benzothiazoles having pyrazole moiety. The obtained azo dyes were characterized by FT-IR, UV-visible, fluorescence, 1HNMR and, mass spectrometric techniques. The quantum chem. studies (DFT) was also used to interpret the structural properties of the compounds by using B3LYP program at 6-311++ (d, p) basis set. Further, the cyclic voltammetry was used to study the electrochem. behavior of the synthesized azo dyes in 0.1 M H2SO4 solution on a glassy carbon electrode at different scan rates. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Computed Properties of C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C7H5ClN2SOn November 27, 2019 ,《Chagas Disease Drug Discovery: Multiparametric Lead Optimization against Trypanosoma cruzi in Acylaminobenzothiazole Series》 appeared in Journal of Medicinal Chemistry. The author of the article were Fleau, Charlotte; Padilla, Angel; Miguel-Siles, Juan; Quesada-Campos, Maria T.; Saiz-Nicolas, Isabel; Cotillo, Ignacio; Cantizani Perez, Juan; Tarleton, Rick L.; Marco, Maria; Courtemanche, Gilles. The article conveys some information:

Acylaminobenzothiazole hits were identified as potential inhibitors of T. cruzi replication, a parasite responsible for Chagas Disease. We selected compound 1, N-(6-chlorobenzo[d]thiazol-2-yl)cyclopropanecarboxamide, for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (IC50 = 0.630μM) and its human metabolic stability (human clearance = 9.57mL/min/g). A total of 39 analogs of 1 were synthesized and tested in vitro. We established a multiparametric structure activity relationship, allowing optimization of both anti-parasite activity, physicochem. parameters and ADME properties. We identified compound 50, N-(5-Fluoro-6-(trifluoromethyl)benzothiazol-2-yl)cyclopropanecarboxamide, as an advanced lead with an improved anti-T. cruzi activity in vitro (IC50 = 0.079μM), an enhanced metabolic stability (Human Clearance = 0.413mL/min/g) and opportunity for oral route of administration. After tolerability assessment, compound 50 demonstrated a promising in vivo efficacy. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica