Category: 95-24-9

《Synergistic effect of copolymeric resin grafted 1,2-benzisothiazol-3(2H)-one and heterocyclic groups as a marine antifouling coating》 was published in RSC Advances in 2021. These research results belong to Dong, Miao; Liu, Zheng; Gao, Yuxing; Wang, Xuemei; Chen, Junhua; Yang, Jianxin. COA of Formula: C7H5ClN2S The article mentions the following:

In order to find a new type of antifouling coating with higher biol. activity and more environmental protection, heterocyclic compounds and benzoisothiazolinone were introduced into acrylic resin to prepare a new type of antifouling resin. In this study, a series of grafted acrylic resins simultaneously containing benzoisothiazolinone and heterocyclic monomers were prepared by the copolymerization of an allyl monomer with Me methacrylate (MMA) and Bu acrylate (BA). Inhibitory activities of the copolymers against marine fouling organisms were also investigated. Results revealed that the copolymers exhibit a clear synergistic inhibitory effect on the growth of three seaweeds: Chlorella, Isochrysis galbana and Chaetoceros curvisetus, resp., and three bacteria, Staphylococcus aureus, Vibrio coralliilyticus and Vibrio parahaemolyticus, resp. In addition, the copolymers exhibited excellent inhibition against barnacle larvae. Marine field tests indicated that the resins exhibit outstanding antifouling potency against marine fouling organisms. Moreover, the introduction of the heterocyclic group led to the significantly enhanced antifouling activities of the resins; the addition of the heterocyclic unit in copolymers led to better inhibition than that observed in the case of the resin copolymerized with only the benzoisothiazolinone active monomer. The results came from multiple reactions, including the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Flow hydrodediazoniation of aromatic heterocycles》 was published in Molecules in 2019. These research results belong to Roeder, Liesa; Nicholls, Alexander J.; Baxendale, Ian R.. SDS of cas: 95-24-9 The article mentions the following:

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles RNH2 (R = 1,3-benzoxazol-2-yl, 2-pyridyl, 4-cyano-1-phenyl-1H-1,2,3-triazol-5-yl, etc.) confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimized to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines to be deaminated in good yield using a purely organic-soluble system.6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C7H5ClN2SOn September 15, 2020 ,《Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties》 was published in ACS Omega. The article was written by Dogan, Kubra; Gulkaya, Aybuke; Forough, Mehrdad; Persil Cetinkol, Ozgul. The article contains the following contents:

Benzothiazoles are known to possess a number of biol. activities and therefore are considered to be an important scaffold in the design and synthesis of pharmacophores. In this study, an improved synthesis method for novel fluorescent benzothiazole-based cyclic azacyanine (CAC) dyes bearing different electron-donating/withdrawing groups on their scaffold is presented. The improved method enabled us to increase the synthesis yield for the previously reported CACs. More importantly, it allowed us to synthesize new CAC dyes that were not synthesizable with the previously reported method. The synthesized dyes were characterized by 1H and 13C NMR spectroscopy, elemental anal., and mass spectrometry and their optical (absorption and fluorescence) properties were investigated. All of the synthesized CACs were found to be displaying strong absorption within the range of 387-407 nm. The spectral shifts observed in the absorption and fluorescence measurements suggested that the spectroscopic and optical properties of CACs can be directly modulated by the nature of the electron-donating/withdrawing substituents. The fluorescence quantum yields (QYs) of the unsubstituted (parent CAC) and substituted CACs were also measured and compared. The fluorescence QY of CACs with electron-donating substituents (methoxy or ethoxy) was found to be at least four times higher than that of the parent CAC with no substitutions. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Testis transcriptome profiling identified genes involved in spermatogenic arrest of cattleyak》 were Wu, Shixin; Mipam, Tserang Donko; Xu, Chuanfei; Zhao, Wangsheng; Shah, Mujahid Ali; Yi, Chuanping; Luo, Hui; Cai, Xin; Zhong, Jincheng. And the article was published in PLoS One in 2020. Recommanded Product: 95-24-9 The author mentioned the following in the article:

Much attempt has been made to examine the mechanisms of male sterility caused by spermatogenic arrest, but yet there is no research systematically and precisely elucidated testis gene expression profiling between cattleyak and yak. Methods: To explore the higher resolution comparative transcriptome map between the testes of yak and cattleyak, and further analyze the mRNA expression dynamics of spermatogenic arrest in cattleyak. We characterized the comparative transcriptome profile from the testes of yak and cattleyak using high-throughput sequencing. Then we used quant. anal. to validate several differentially expressed genes (DEGs) in testicular tissue and spermatogenic cells. Results: Testis transcriptome profiling identified 6477 DEGs (2919 upregulated and 3558 downregulated) between cattleyak and yak. Further anal. revealed that the marker genes and apoptosis regulatory genes for undifferentiated spermatogonia were upregulated, while the genes for differentiation maintenance were downregulated in cattleyak. A majority of DEGs associated with mitotic checkpoint, and cell cycle progression were downregulated in cattleyak during spermatogonial mitosis. Furthermore, almost all DEGs related to synaptonemal complex assembly, and meiotic progression presented no sign of expression in cattleyak. Even worse, dozens of genes involved in acrosome formation, and flagellar development were dominantly downregulated in cattleyak. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation》 were Haroun, Michelyne; Tratrat, Christophe; Petrou, Anthi; Geronikaki, Athina; Ivanov, Marija; Ciric, Ana; Sokovic, Marina; Nagaraja, Sreeharsha; Venugopala, Katharigatta Narayanaswamy; Balachandran Nair, Anroop; Elsewedy, Heba S.; Kochkar, Hafedh. And the article was published in Molecules in 2021. Product Details of 95-24-9 The author mentioned the following in the article:

Infectious diseases still affect large populations causing significant morbidity and mortality. Bacterial and fungal infections for centuries were the main factors of death and disability of millions of humans. Despite the progress in the control of infectious diseases, the appearance of resistance of microbes to existing drugs creates the need for the development of new effective antimicrobial agents. In an attempt to improve the antibacterial activity of previously synthesized compounds modifications to their structures were performed. Nineteen thiazolidinone derivatives with 6-Cl, 4-OMe, 6-CN, 6-adamantan, 4-Me, 6-adamantan substituents at benzothiazole ring were synthesized and evaluated against panel of four bacterial strains S. aureus, L. monocytogenes, E. coli and S. typhimirium and three resistant strains MRSA, E. coli and P. aeruginosa in order to improve activity of previously evaluated 6-OCF3-benzothiazole-based thiazolidinones. The evaluation of min. inhibitory and min. bactericidal concentration was determined by microdilution method. As reference compounds ampicillin and streptomycin were used. All compounds showed antibacterial activity with MIC in range of 0.12-0.75 mg/mL and MBC at 0.25->1.00 mg/mL The most active compound among all tested appeared to be compound 18, with MIC at 0.10 mg/mL and MBC at 0.12 mg/mL against P. aeruginosa. as well as against resistant strain P. aeruginosa with MIC at 0.06 mg/mL and MBC at 0.12 mg/mL almost equipotent with streptomycin and better than ampicillin. Docking studies predicted that the inhibition of LD-carboxypeptidase is probably the possible mechanism of antibacterial activity of tested compounds The best improvement of antibacterial activity after modifications was achieved by replacement of 6-OCF3 substituent in benzothiazole moiety by 6-Cl against S. aureus, MRSA and resistant strain of E. coli by 2.5 folds, while against L. monocytogenes and S. typhimirium from 4 to 5 folds. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Product Details of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Product Details of 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Yilmaz, Mehmet; Inal, Asli Ustalar published an article in Tetrahedron. The title of the article was 《Microwave assisted synthesis of 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d] pyrimidin-4-ones by radical addition of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a] pyrimidin-4-ones to various conjugated alkenes and dienes mediated Mn(OAc)3》.Reference of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:

Synthesis of chem. important, novel 2,3-dihydro-4H-benzo [4,5]thiazolo [3,2-a]furo [2,3-d]pyrimidin-4-one derivatives, I (R1 = H, Me, F, CF3; R2 = H, Me, Ph, 4-F-C6H4; R3 = Ph, 2-thienyl, 4-F-C6H4, etc.), was approached in this work. These heterocyclic compounds were synthesized in good to excellent yields from the reaction of Mn(OAc)3 mediated radical addition of 2-hydroxy-4H-benzo [4,5]thiazolo [3,2-a]pyrimidin-4-one derivatives to various conjugated alkenes and dienes under microwave irradiation in mild conditions. Also, a different compound skeleton, 2,3-dihydrobenzo [4,5]imidazo [1,2-a]furo [2,3-d]pyrimidin-4(10H)-one, II, was obtained from the reaction of 2-hydroxy-10-methylbenzo [4,5]imidazo [1,2-a]pyrimidin-4(10H)-one and 1,1-diphenylethylene for the first time. While no product was obtained with conventional method in radical addition reactions, dihydrofuropyrimidines, I,andcompd. II were synthesized in excellent yields using microwave irradiating method at 150°C, 350 W for 60 s. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Reference of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hou, Yue; Du, Jiaorui; Hou, Jingdan; Shi, Peijun; Wang, Kai; Zhang, Shen; Han, Tianyu; Li, Zhongfeng published an article on January 31 ,2019. The article was titled 《Rewritable optical data storage based on mechanochromic fluorescence materials with aggregation-induced emission》, and you may find the article in Dyes and Pigments.Category: thiazole The information in the text is summarized as follows:

In this work, the synthesis and aggregation-induced emission (AIE) properties of a new mol. system are reported. This system composes of three positional isomers, which are fabricated by attaching a methoxy group in different locations. The isomeric effects on the AIE properties as well as the intramol. charge transfer (ICT) processes were studied. Addnl. the new isomers exhibit mechanochromic fluorescence (MCF). Among the three isomers, (E)-2-(((6-chlorobenzo[d]thiazol-2-yl)imino)methyl)-5-methoxyphenol (CHM3) exhibits the most remarkable MCF performance with emission that decreases in intensity and red-shifts in wavelength under mech. stimuli. The emission changes are caused by crystalline-amorphous transition as verified by Powder X-ray diffraction (PXRD) anal. The mechano-induced state can be easily recovered through a recrystallization process, which can be activated by solvent fumigation or solvent immersion. Furthermore, the switching between two emission states shows nice reversibility. Based on the MCF material with high fatigue resistance, a new type of rewritable optical data storage (ODS) is developed. Binary data, comprised of “”0″” and “”1″” state, can be matched well with the two emission states, resp. The data could thus be written or erased on the ODS device, demonstrating feasibility and practicability. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Category: thiazole)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Category: thiazoleThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C7H5ClN2SOn September 30, 2020 ,《A dihedral-angle-controlled mechanochromic luminescent material: Application for pressure sensing》 was published in Dyes and Pigments. The article was written by Hou, Yue; Li, Yue; Zhang, Mengyao; Zhang, Xunxue; Xu, Zhenzhen; Li, Yaping; Duan, Yuai; Han, Tianyu. The article contains the following contents:

For most of the mechanochromic luminescent (MCL) materials, their mechanisms are based on the phase transition. When they are fabricated into devices or films, the MCL cannot be fully activated due to uncontrollable phase state of the materials. In this study, a new MCL material, (E)-6-chloro-N-(4-(dimethylamino)benzylidene)benzo[d]thiazol-2-amine (CDBTA), functioning based on dihedral-angle change, was reported. The initial state of CDBTA glows green emission (520 nm), while grinding changes its color into yellow-orange (551 nm). The switching between two emission states can be stably switched with high fatigue resistance. The underlying MCL mechanism was verified by crystal analyses on two forms of single crystal, namely Green-form (G-form) and Yellow-form (Y-form), resp. Mols. in G-form crystal adopt the twisted conformation by the rotation of the donor-acceptor (D-A) biplane. The dihedral angle is thus fixed by a variety of intermol. interactions. Under mech. stimuli, these interactions are destructed and the intramol. torsional stress is released. Thus the mols. cannot maintain twisted conformation but form D-A coplane similar to the Y-form. Such dihedral-angle-controlled structural relaxation makes the π-electron highly delocalized to facilitate bathochromic-shift. The MCL stems from the changes of dihedral angle of the D-A biplane rather than that in packing mode or phase state, therefore CDBTA offers the possibility to fully activate the MCL performances when instrumented. Encouraged by this advantage, a CDBTA film sensor for pressure detection was fabricated, which exhibits a gradual red-shift with pressure and low detection limit down to 15.21 MPa. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Solvent-dependent regio- and stereo-selective reactions of 3-formylchromones with 2-aminobenzothiazoles and transacetalization efficiency of the product 3-((benzo[d]thiazol-2-ylimino)butyl)-4H-chromen-4-one》 were Ahmed, Owais; Cherkadu, Vandana; Kalavagunta, Praveen Kumar; Shang, Jing. And the article was published in RSC Advances in 2019. Application In Synthesis of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:

Using 2-propanol as the solvent, 3-formylchromones I (R = H, 6-Cl, 6-Br, 6-OH, 6-Cl-8-Br) and 2-aminobenzothiazoles II [R1 = 4-Cl, 6-Br, 4,6-(F2), etc.] formed corresponding imines, (Z)-III while 1° and 2°-alcs. R2OH [R2 = CH3, CH(CH3)2, cyclohexyl, etc.] formed the corresponding 2-alkoxy-3-enamines IV with selectivity for the Z-isomer. Changing the substrates with similar mols. such as 3-formylchromone I with quinoline-, quinolone- and indole-3-carbaldehydes, e.g., 1,4-dihydro-4-oxoquinoline-3-carbaldehyde sometimes resulted in the formation of the corresponding imines, e.g., 3-((benzo[d]thiazol-2-ylimino)methyl)quinolin-4(1H)-one, whereas replacing 2-aminobenzothiazole with amides R3C(O)NH2 (R3 = H, Me, Ph) resulted in the formation of acetals V. Considering the effect of the solvent, replacing alcs. with the aprotic solvents THF and CH2Cl2 resulted in the formation of imines and enamines, which are the characteristic reactions of 2-propanol and other 1° and 2°-alcs., resp. 2-Alkoxy-3-enamines were found to undergo transacetalization with both short and long chain alcs. The novelty of these reactions is that they did not require an external catalyst, all the reactions were performed at the same temperature, and purification was achieved by filtration. The transacetalization has been performed as a new concept, which has not been reported to date. In contrast, other similar reactions, such as transalkoxylation, transalkylation, and transetherification, are performed on a com. scale using expensive catalysts such as Otera’s catalyst. The highly sensitive nature of 3-formylchromones towards variations in the substrates and solvents to form different products and the reason behind the selective formation of the Z-isomer of 2-alkoxy-3-enamines and its transacetalization efficiency need further studies to understand the reaction mechanism and possibly other factors such as solvent effects. The experimental part of the paper was very detailed, including the reaction process of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application In Synthesis of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application In Synthesis of 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lange, Karen I.; Suleman, Aly; Srayko, Martin published an article in Genetics. The title of the article was 《Kinetochore recruitment of the spindle and kinetochore-associated (Ska) complex is regulated by centrosomal PP2A in Caenorhabditis elegans》.SDS of cas: 95-24-9 The author mentioned the following in the article:

During mitosis, kinetochore-microtubule interactions ensure that chromosomes are accurately segregated to daughter cells. RSA-1 (regulator of spindle assembly-1) is a regulatory B”” subunit of protein phosphatase 2A that was previously proposed to modulate microtubule dynamics during spindle assembly. We have identified a genetic interaction between the centrosomal protein, RSA-1, and the spindle- and kinetochore-associated (Ska) complex in Caenorhabditis elegans. In a forward genetic screen for suppressors of rsa-1(or598) embryonic lethality, we identified mutations in ska-1 and ska-3. Loss of SKA-1 and SKA-3, as well as components of the KMN (KNL-1/MIS-12/NDC-80) complex and the microtubule end-binding protein EBP-2, all suppressed the embryonic lethality of rsa-1(or598). These suppressors also disrupted the intracellular localization of the Ska complex, revealing a network of proteins that influence Ska function during mitosis. In rsa-1(or598) embryos, SKA-1 is excessively and prematurely recruited to kinetochores during spindle assembly, but SKA-1 levels return to normal just prior to anaphase onset. Loss of the TPX2 homolog, TPXL- 1, also resulted in overrecruitment of SKA-1 to the kinetochores and this correlated with the loss of Aurora A kinase on the spindle microtubules. We propose that rsa-1 regulates the kinetochore localization of the Ska complex, with spindle-associated Aurora A acting as a potential mediator. These data reveal a novel mechanism of protein phosphatase 2A function during mitosis involving a centrosome-based regulatory mechanism for Ska complex recruitment to the kinetochore. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica