Category: 96-53-7

Liu, Jianhua; Kotrchova, Lenka; Lecuyer, Thomas; Corvis, Yohann; Seguin, Johanne; Mignet, Nathalie; Etrych, Tomas; Scherman, Daniel; Randarova, Eva; Richard, Cyrille published the artcile< Coating persistent luminescence nanoparticles with hydrophilic polymers for in vivo imaging>, Name: 4,5-Dihydrothiazole-2-thiol, the main research area is zinc gallium oxide chromium hydrophilic polymer optical property; HPMA polymer; imaging; in vivo; nanoparticles; persistent luminescence; surface coating.

Persistent luminescence nanoparticles (PLNPs) are innovative nanomaterials highly useful for bioimaging applications. Indeed, due to their particular optical properties, i.e., the ability to store the excitation energy before slowly releasing it for a prolonged period of time, they allow in vivo imaging without auto-fluorescence and with a high target to background ratio. However, as for most nanoparticles (NPs), without any special surface coating, they are rapidly opsonized and captured by the liver after systemic injection into small animals. To overcome this issue and prolong nanoparticle circulation in the bloodstream, a new stealth strategy was developed by covering their surface with poly(N-2-hydroxypropyl)methacrylamide (pHPMA), a highly hydrophilic polymer widely used in nanomedicine. Preliminary in vivo imaging results demonstrated the possibility of pHPMA as an alternative strategy to cover ZnGa2O4:Cr NPs to delay their capture by the liver, thereby providing a new perspective for the formulation of stealth NPs.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Biological imaging. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Name: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lee, Hyojin; Kim, Ki Hun; Lee, Kwan Hyi published the artcile< Non-invasive molecular barcode assay for diagnosis of sex hormones correlated with precocious puberty>, Reference of 96-53-7, the main research area is testosterone estradiol diagnosis noninvasive mol barcode assay precocious puberty.

Precocious puberty treatment in children faces several diagnostic and therapeutic challenges. For an efficient prognosis of the disease, early diagnosis must be accompanied by properly timed treatment. Sex hormones are markers that are used to diagnose precocious puberty. Detection methods usually require multiple blood samples from the patient over a 90-120-min time interval. The test is painful and uncomfortable for children, and is relatively expensive and time-consuming. Herein, we introduce a new bio-barcode method that is a non-invasive, fast, highly-sensitive, and is capable of multiplex detection of steroid sex hormones in urine using gold nanoparticles. We compared three different barcode assay approaches to determine the barcode mols.: gel electrophoresis, fluorescence-based solution assay, and liquid chromatog.-mass spectrometry (LC-MS). The gel electrophoresis approach was cost-effective but could not quantify the absolute levels of hormones. The other methods permitted quant. comparison between samples. LC-MS displayed the highest sensitivity. For the LC-MS anal., we grafted two chem. compounds as surrogate mols. onto the surface of 50-nm gold nanoparticles. Approx. 7-9 million chem. mols. were loaded on each nanoparticle, which amplified the LC-MS signal. The LC-MS could detect hormones levels which were 10,000-fold lower than the levels detected by the conventional method. The barcode assay could determine multiple analytes simultaneously without any sample preparation step. Importantly, this is first finding that uses barcode mols.-conjugated nanoparticles to amplify the mass spectrometer signal. The result is significant as it has implications for its principle and methodol., which utilizes non-invasive procurement protocols, can be applied to not only sex hormones, but other hormones which require will ultrasensitive detection. We anticipate that our research findings, which use a painless and economic detection method, can contribute to the early and accurate diagnosis of precocious puberty.

Sensors and Actuators, B: Chemical published new progress about Diagnosis Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Reference of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hoseinzadeh, A. R.; Javadpour, S. published the artcile< Formulation of a smart nanocomposite coating with pH-responsive loaded halloysite and investigation of its anticorrosion behaviour>, Recommanded Product: 4,5-Dihydrothiazole-2-thiol, the main research area is ethylene acrylic acid copolymer halloysite nanocomposite anticorrosion property.

In this research study, halloysite nanotubes (HNTs) were applied as nanocontainers to encapsulate the synthesized 3,4′-dihydro-3-[2′-mercaptothiazolidine]indol-2-one (DMI) mols. for corrosion protection of carbon steel in a 3.5% NaCl solution Fourier transform IR anal. was used to prove the loading of HNTs with DMI. Poly(ethylene-co-acrylic acid) and branched polyethylenimine polyelectrolyte layers were deposited on the surface of DMI-loaded HNTs by a layer by layer (LbL) method. The LbL deposition technique was verified by a zeta potential test. Release of DMI corrosion inhibitors from HNTs in alk. pH was verified by using UV-visible spectroscopy results. Electrochem. impedance spectroscopy technique was applied to consider the anticorrosion ability of 1, 2.5 and 5 weight% DMI-loaded HNTs as smart epoxy coatings.

Bulletin of Materials Science published new progress about Anticorrosive coating materials. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Recommanded Product: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bonnevide, Marine; Jimenez, Andrew M.; Dhara, Deboleena; Phan, Trang N. T.; Malicki, Nicolas; Abbas, Zaid M.; Benicewicz, Brian; Kumar, Sanat K.; Couty, Marc; Gigmes, Didier; Jestin, Jacques published the artcile< Morphologies of Polyisoprene-Grafted Silica Nanoparticles in Model Elastomers>, Synthetic Route of 96-53-7, the main research area is morphol polyisoprene grafted silica nanoparticle model elastomer.

We control nanoparticle (NP) dispersion by leveraging the entropic and enthalpic effects associated with mixing silica NPs grafted with polyisoprene (PI) chains into matrixes of varying degrees of chem. dissimilarity. Previous work in this area has primarily focused on entropic factors alone, and hence, this work represents a significant advance over the current state-of-the-art. We show using a combination of transmission electron microscopy/small-angle X-ray scattering that mixing grafted particles with PI matrixes of identical microstructure yields dispersion states as found in the literature for such entropic systems. However, replacing the PI matrix chains with dissimilar matrixes leads to an introduction of enthalpic interactions that, in some cases, can drastically change the resulting morphol. In particular, while slightly different PI microstructures for the grafted and free chains only yield moderated differences, using styrene-butadiene copolymers as a matrix leads to a completely different behavior. In the last case, phase separation becomes more likely with the increasing graft length, while the PI system (whose behavior is dominated by entropic factors) shows the opposite behavior. Tuning the relative importance of enthalpic vs. entropic factors is thus another tool in controlling the self-assembled structure of NPs, which gives rise to enhanced macroscopic properties in the composite.

Macromolecules (Washington, DC, United States) published new progress about Agglomeration. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Synthetic Route of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bilchak, Connor R.; Jhalaria, Mayank; Adhikari, Sabin; Midya, Jiarul; Huang, Yucheng; Abbas, Zaid; Nikoubashman, Arash; Benicewicz, Brian C.; Rubinstein, Michael; Kumar, Sanat K. published the artcile< Understanding Gas Transport in Polymer-Grafted Nanoparticle Assemblies>, Formula: C3H5NS2, the main research area is gas transport polymer grafted nanoparticle.

We rationalize the unusual gas transport behavior of polymer-grafted nanoparticle (GNP) membranes. While gas permeabilities depend specifically on the chem. of the polymers considered, we focus here on permeabilities relative to the corresponding pure polymer, which show interesting, “”universal”” behavior. For a given NP radius, Rc, and for large enough areal grafting densities, σ, to be in the dense brush regime, we find that gas permeability enhancements display a maximum as a function of the graft chain mol. weight, Mn. Based on a recently proposed theory for the structure of a spherical brush in a melt of GNPs, we conjecture that this peak permeability occurs when the densely grafted polymer brush has the highest, packing-induced extension free energy per chain. The corresponding brush thickness is predicted to be hmax = sqr3Rc, independent of chain chem. and σ, i.e., at an apparently universal value of the NP volume fraction (or loading), ϕNP, ϕNP,max = [Rc/(Rc + hmax)]3 ≈ 0.049. Motivated by this conclusion, we measured CO2 and CH4 permeability enhancements across a variety of Rc, Mn, and σ and find that they behave in a similar manner when considered as a function of ϕNP, with a peak in the near vicinity of the predicted ϕNP,max. Thus, the chain length-dependent extension free energy appears to be the critical variable in determining the gas permeability for these hybrid materials. The emerging picture is that these curved polymer brushes, at high enough σ, behave akin to a two-layer transport medium-the region in the near vicinity of the NP surface is comprised of extended polymer chains that speed up gas transport relative to the unperturbed melt. The chain extension free energy increases with increasing chain length, up to a maximum, and apparently leads to an increasing gas permeability. For long enough grafts, there is an outer region of chain segments that is akin to an unperturbed melt with slow gas transport. The permeability maximum and decreasing permeability with increasing chain length then follow naturally.

Macromolecules (Washington, DC, United States) published new progress about Annealing. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Formula: C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

da Silva, Monize M.; Ribeiro, Gabriel H.; de Camargo, Mariana S.; Ferreira, Antonio G.; Ribeiro, Leandro; Barbosa, Marilia I. F.; Deflon, Victor M.; Castelli, Silvia; Desideri, Alessandro; Correa, Rodrigo S.; Ribeiro, Arthur B.; Nicolella, Heloiza D.; Ozelin, Saulo D.; Tavares, Denise C.; Batista, Alzir A. published the artcile< Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo>, HPLC of Formula: 96-53-7, the main research area is melanoma antitumor lung breast cancer hTopIB docking ruthenium complexes.

Ruthenium(II) complexes (Ru1-Ru5), with the general formula [Ru(N-S)(dppe)2]PF6, bearing two 1,2-bis(diphenylphosphino)ethane (dppe) ligands and a series of mercapto ligands (N-S), have been developed. The combination of these ligands in the complexes endowed hydrophobic species with high cytotoxic activity against five cancer cell lines. For the A549 (lung) and MDA-MB-231 (breast) cancer cell lines, the IC50 values of the complexes were 288- to 14-fold lower when compared to cisplatin. Furthermore, the complexes were selective for the A549 and MDA-MB-231 cancer cell lines compared to the MRC-5 nontumor cell line. The multitarget character of the complexes was investigated by using calf thymus DNA (CT DNA), human serum albumin, and human topoisomerase IB (hTopIB). The complexes potently inhibited hTopIB. In particular, complex [Ru(dmp)(dppe)2]PF6 (Ru3) (I), bearing the 4,6-diamino-2-mercaptopyrimidine (dmp) ligand, effectively inhibited hTopIB by acting on both the cleavage and religation steps of the catalytic cycle of this enzyme. Mol. docking showed that the Ru1-Ru5 complexes have binding affinity by active sites on the hTopI and hTopI-DNA, mainly via π-alkyl and alkyl hydrophobic interactions, as well as through hydrogen bonds. Complex Ru3 displayed significant antitumor activity against murine melanoma in mouse xenograph models, but this complex did not damage DNA, as revealed by Ames and micronucleus tests.

Inorganic Chemistry published new progress about Antitumor agents. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, HPLC of Formula: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sarkar, Sudeep; Wojciechowska, Natalia; Rajkiewicz, Adam A.; Kalek, Marcin published the artcile< Synthesis of Aryl Sulfides by Metal-Free Arylation of Thiols with Diaryliodonium Salts under Basic Conditions>, Electric Literature of 96-53-7, the main research area is aryl sulfide preparation DFT; thiol diaryliodonium salt arylation.

Metal-free arylation of thiols RSH (R = n-Bu, Bn, 2,3-dihydro-1,3-benzothiazol-2-yl, etc.) with diaryliodonium salts (Ar)2I+TfO-(Ar = 2,4,6-trimethylphenyl, 2-fluorophenyl, 4-nitrophenyl, etc.) have been developed. The application of a strong organic base enables the C-S bond formation under mild and exptl. simple conditions. The method allows for the synthesis of aryl sulfides R1SAr containing a broad range of aryl groups from an array of thiols, including aryl, heteroaryl, and alkyl ones. The mechanism of the reaction was studied by DFT calculations, demonstrating that it proceeds via the inner sphere pathway involving formation of an Ar2I(SR) intermediate, followed by reductive elimination.

European Journal of Organic Chemistry published new progress about Arylation. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Khan, Muhammad Amir; Ali, Shaukat; Shamim, Sumbul; Ahmed, Nazia; Hussain, Mushtaq; Farooq, Saba; Khan, Sadaf published the artcile< Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples>, Product Details of C3H5NS2, the main research area is staphylococcus aureus thiazoline antimicrobial drainage sample.

Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three com. available thiazoline derivatives (2-amino-2-thiazoline, 2-thiazoline-2-thiol and 2-acetyl-2-thiazoline) against MDR Staphylococcus aureus strains isolated from abscess drainage samples (n = 20). MDR Staphylococcus aureus isolates were identified by Kirby-Bauer disk diffusion assay and were further subjected to mol. identification by 16srRNA amplification and DNA sequencing. Min. Inhibitory Concentration (MIC) values of test compounds and antibiotics (0.25-512μg/mL) were measured and subsequently, synergism assay was performed to calculate Fractional Inhibitory Concentration (FIC) index. Out of twenty Staphylococcus aureus isolates, sixteen (80%) were found to be MDR whereas four (20%) were Non-MDR. Moxifloxacin and vancomycine were found most effective antibiotics, inhibiting 100% (n = 20) and 95% (n = 19) strains resp. Antimicrobial activity of 2-amino-2-thiazoline (MIC: 32μg/mL), 2-thiazoline-2-thiol (MIC: 64μg/mL) and 2-acetyl-2-thiazoline (MIC: 32μg/mL) was found significant against all ten tested MDR strains. Synergistic combinations of thiazoline derivatives with test antibiotics reduced MIC values significantly. Therefore, combination of tested thiazoline derivatives with antibiotics could be used as alternative therapeutic approach to treat soft tissue infections caused by MDR Staphylococcus aureus after further pre-clin. and clin. studies.

Pakistan Journal of Pharmaceutical Sciences published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Product Details of C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Guimaraes, Daniel Silqueira Martins; Luz, Leticia Silveira de Sousa; Batista do Nascimento, Sara; Silva, Lorena Rabelo; Martins, Natalia Rezende de Miranda; Goncalves de Almeida, Heloisa; Reis, Vitoria de Souza; Maluf, Sarah El Chamy; Budu, Alexandre; Marinho, Juliane Aparecida; Abramo, Clarice; Carmona, Adriana Karaoglanovic; Goulart da Silva, Marina; Rodrigues da Silva, Gisele; Kemmer, Victor Matheus; Butera, Anna Paola; Ribeiro-Viana, Renato Marcio; Gazarini, Marcos Leoni; Nascimento, Clebio Soares Jr.; Guimaraes, Luciana; Vieira dos Santos, Fabio; Victor de Castro, Whocely; Viana, Gustavo Henrique Ribeiro; Alves de Brito, Cristiana Ferreira; Varotti, Fernando de Pilla published the artcile< Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability>, Application In Synthesis of 96-53-7, the main research area is colorectal adenocarcinoma cell permeability mutagenicity alkylpiridine alkaloid analog antimalarial; 3-Alkylpyridine marine alkaloid analogs; Antiplasmodial activity; Ferriprotoporphyrin-IX; Malaria; Plasmodium falciparum; Thiazole.

The development of new antimalarial drugs is urgent to overcome the spread of resistance to the current treatment. Herein we synthesized the compound 3, a hit-to-lead optimization of a thiazole based on the most promising 3-alkylpyridine marine alkaloid analog. Compound 3 was tested against Plasmodium falciparum and has shown to be more potent than its precursor (IC50 values of 1.55 and 14.7μM, resp.), with higher selectivity index (74.7) for noncancerous human cell line. This compound was not mutagenic and showed genotoxicity only at concentrations four-fold higher than its IC50. Compound 3 was tested in vivo against Plasmodium berghei NK65 strain and inhibited the development of parasite at 50 mg/kg. In silico and UV-vis approaches determined that compound 3 acts impairing hemozoin crystallization and confocal microscopy experiments corroborate these findings as the compound was capable of diminishing food vacuole acidity. The assay of uptake using human intestinal Caco-2 cell line showed that compound 3 is absorbed similarly to chloroquine, a standard antimalarial agent. Therefore, we present here compound 3 as a potent new lead antimalarial compound

European Journal of Pharmaceutical Sciences published new progress about Antimalarials. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Application In Synthesis of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fereidoonnezhad, Masood; Ahmadi Mirsadeghi, Hasti; Abedanzadeh, Sedigheh; Yazdani, Alireza; Alamdarlou, Arsalan; Babaghasabha, Mojgan; Almansaf, Zainab; Faghih, Zeinab; McConnell, Zachary; Shahsavari, Hamid R.; Beyzavi, M. Hassan published the artcile< Synthesis and biological evaluation of thiolate gold(I) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors>, COA of Formula: C3H5NS2, the main research area is gold thiolate complex preparation antitumor thioredoxin glutathione reductase; crystal structure gold thiolate complex.

New gold(I) thiolate complexes [(PPh2py)Au(SR)] (PPh2py = 2-(diphenylphosphino)pyridine and SR = the deprotonated form of pyridine-2-thiol (HSpy, 1a), pyrimidine-2 thiol (HSpyN, 1b), benzothiazole-2-thiol (HSbt, 1c) and 2-thiazoline-2-thiol (HSt, 1d)) were prepared by the reaction of chloro gold complex [(PPh2py)AuCl], A, with the corresponding in situ generated thiolate salt (through a nucleophilic substitution reaction) under inert conditions. All complexes were characterized by NMR spectroscopy and the structures of 1b and 1d were further identified by single crystal x-ray determination An in vitro cytotoxicity evaluation against five human cancer cell lines including A549 (nonsmall cell lung cancer), SKOV3 (human ovarian cancer), MCF-7 (human breast cancer), SW1116 (colon cancer) and HeLa (cervical cancer) demonstrated the promising antitumor effects of 1b in comparison with standard auranofin and cisplatin. The effects of these compounds on the proliferation of nontumoral breast cell line MCF-12A showed good selectivity among tumorigenic and nontumorigenic cell lines. 1B effectively produces cell death by inducing apoptosis in the MCF-7 human breast cancer cell line. These complexes inhibit both cytosolic (TrxR1) and mitochondrial (TrxR2) thioredoxin reductases as well as glutathione reductase (GR).

New Journal of Chemistry published new progress about Colon neoplasm. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, COA of Formula: C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica