Category: 96-53-7

Chadha, Ridhima; Das, Abhishek; Kapoor, Sudhir; Maiti, Nandita published the artcile< Surface-induced dimerization of 2-thiazoline-2-thiol on silver and gold nanoparticles: A surface enhanced Raman scattering (SERS) and density functional theoretical (DFT) study>, SDS of cas: 96-53-7, the main research area is surface induced dimerization silver gold nanoparticles enhanced Raman scattering.

The adsorption behavior of an anti-thyroid agent, 2-thiazoline-2-thiol (TT) on silver (Ag) and gold (Au) nanoparticles (NPs) was studied using surface enhanced Raman scattering (SERS) and d. functional theory (DFT). The tautomers of TT involved in the surface adsorption processes were identified. Raman scattering studies indicated the predominance of the thione form in solid and the thiol tautomer in aqueous solution SERS studies of TT functionalized Ag (TT-Ag) and Au NPs (TT-Au) showed maximum enhancement for 1μM concentration, suggesting monolayer coverage. Surface induced dimerization of TT was evident from SERS and DFT. The appearance of prominent peaks at 484 (S-S stretch) and 317 (CSS bend) cm-1 for TT-Ag revealed the formation of disulfide dimer, while the emergence of a distinct band at 2124 cm-1 (H-bonded S-H stretch) for TT-Au indicated the development of H-bonded dimer. Thus, in the present study, selective formation of disulfide dimer and the H-bonded dimer was observed on the surface of Ag and Au NPs, resp. In Inaddn., the thiol tautomer was found to be exclusively bound to the metal surface, via the thiazoline ring N atom. In this work, a qual. relation between the strength of TT-metal charge transfer complex and inter-mol. association of TT on the surface of metal NPs was established. This study, thus paves the way for designing novel metal nanosubstrates that can be exploited for studying interesting surface phenomenon, viz. surface induced dimerization or rearrangement reactions, surface catalysis, etc. as well as for designing valuable drugs suitable for chelation therapy.

Journal of Molecular Liquids published new progress about Adsorption. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Subr, Vladimir; Ormsby, Tereza; Sacha, Pavel; Konvalinka, Jan; Etrych, Tomas; Kostka, Libor published the artcile< The role of the biotin linker in polymer antibody mimetics, iBodies, in biochemical assays>, Reference of 96-53-7, the main research area is biotin linker polymer antibody mimetics iBody biochem assay.

Recently, we have developed synthetic polymer-based antibody mimetics called iBodies that can successfully replace antibodies in many biochem. applications including ELISA (ELISA), flow cytometry, immunocytochem., affinity purification, and confocal microscopy. In this study, we focused primarily on the effect of a linker between the polymer backbone and biotin, and then on the influence of the number of biotins per polymer chain on the efficacy of the ELISA or pull-down assays. In addition, the biotin position on the polymer chain was investigated. Moreover, we developed a novel chain transfer agent suitable for RAFT polymerization, which enables the functionalization of specifically the polymer precursors and simplifies the synthesis of semitelechelic antibody mimetic materials. By employing optimized iBodies the sensitivity of the ELISA with a lengthened linker between the polymer backbone and biotin was increased up to 5 times. Importantly, we found that one biotin at the end of the polymer chain can replace up to 12 biotins located along the polymer chain and maintain the signal level in the ELISA, as well as in the pull-down assay.

Polymer Chemistry published new progress about Affinity purification. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Reference of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mann, Joseph L.; Grosskopf, Abigail K.; Smith, Anton A. A.; Appel, Eric A. published the artcile< Highly Branched Polydimethylacrylamide Copolymers as Functional Biomaterials>, Application of C3H5NS2, the main research area is branched polydimethylacrylamide copolymer biomaterial.

Controlled radical polymerization of vinyl monomers with multivinyl cross-linkers leads to the synthesis of highly branched polymers with controlled spatial d. of functional chain ends. The resulting polymers synthesized in this manner have large dispersities resulting from a mixture of unreacted primary chains, low mol. weight branched species, and high mol. weight highly branched species. Through the use of fractional precipitation, we present a synthetic route to high mol. weight highly branched polymers that are absent of low mol. weight species and that contain reactivity toward amines for controlled postpolymn. modification. The controlled spatial d. of functional moieties on these high mol. weight macromol. constructs enable new functional biomaterials with the potential for application in regenerative medicine, immunoengineering, imaging, and controlled drug delivery.

Biomacromolecules published new progress about Biocompatibility. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Application of C3H5NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Teloxa, Saul F.; Kennington, Stuart C. D.; Camats, Marc; Romea, Pedro; Urpi, Felix; Aullon, Gabriel; Font-Bardia, Merce published the artcile< Direct, Enantioselective, and Nickel(II) Catalyzed Reactions of N-Azidoacetyl Thioimides with Trimethyl Orthoformate: A New Combined Methodology for the Rapid Synthesis of Lacosamide and Derivatives>, Electric Literature of 96-53-7, the main research area is Lacosamide derivative enantioselective preparation; azidoacetyl thioimide trimethyl orthoformate nickel catalyst addition reduction acylation; C−C bond forming reactions; asymmetric synthesis; catalysis; lacosamide; synthetic methods.

A direct and highly enantioselective reaction of N-azidoacetyl-1,3-thiazolidine-2-thione with tri-Me orthoformate catalyzed by Tol-BINAPNiCl2 in the presence of TESOTf and 2,6-lutidine was reported. The heterocyclic scaffold could be easily removed by addition of a wide array of amines to give the corresponding enantiomerically pure 2-azido-3,3-dimethoxypropanamides R1R2NC(O)CHN3CH(OMe)2 [R1 = n-hexyl, Ph, Bn, etc.; R2 = H; R1R2 = (CH2)4, (CH2)2O(CH2)2] in high yields. Appropriate manipulation of the N-benzyl amide derivative provided an efficient access to the antiepileptic agent lacosamide through a new enantioselective C-C bond-forming process. DFT computational studies uncover clues for the understanding of the remarkable stereocontrol of the addition of a nickel(II) enolate to a putative oxocarbenium intermediate from tri-Me orthoformate.

Chemistry – A European Journal published new progress about Acylation. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Ruixin; Xie, Hongguo; Zhang, Chunguang; Sun, Yeqing; Yin, Heng published the artcile< ROS-Responsive Polymeric Micelle for Improving Pesticides Efficiency and Intelligent Release>, Electric Literature of 96-53-7, the main research area is ROS responsive polymeric micelle controlled release fungicide validamycin Rhizoctonia; ROS-responsive; Rhizoctonia solani; biostimulation; polymeric micelle; validamycin.

The low utilization rate of pesticides causes serious problems such as food safety and environmental pollution. Stimulus-responsive release can effectively improve the utilization rate of pesticides. Reactive oxygen species (ROS) burst, as an early event of plant-pathogen interaction, can stimulate the release of pesticides. In this work, a polymeric micelle with ROS-responsive was prepared and then Validamycin (Vail) was loaded into polymeric micelle to prepare Vail-loaded polymeric micelle. The Vail-loaded polymeric micelle displayed excellent ROS-dependent release kinetics. In vitro and in vivo antifungal experiments confirmed that the Vail-loaded polymeric micelle could improve antifungal efficacy against Rhizoctonia solani than with the Vail reagent. Therefore, as a biostimulation and controlled release system, ROS-responsive polymeric micelles can improve the utilization rate of pesticides and alleviate the problem of food safety and environmental pollution.

Journal of Agricultural and Food Chemistry published new progress about Agrochemical fungicides. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mapesa, Emmanuel U.; Street, Dayton P.; Heres, Maximilian F.; Kilbey, S. Michael; Sangoro, Joshua published the artcile< Wetting and Chain Packing across Interfacial Zones Affect Distribution of Relaxations in Polymer and Polymer-Grafted Nanocomposites>, Category: thiazole, the main research area is wetting chain packing interface distribution PMMA silica graft nanocomposite.

Polymers exhibit deviations from their bulk phys. properties in the vicinity of solid interfaces due to changes in configurations, entanglements, and relaxation dynamics at the interfacial regions. By comparing grafted and nongrafted polymer nanocomposite systems based on poly(Me methacrylate) and silica, we show that the distribution of relaxation times exhibits both commonly reported slower mobility and faster modes that depend on the nature of the interfacial zone, matrix mol. weight, and loading level of nanomaterials. These findings are derived from studies using broadband dielec. spectroscopy (BDS) and differential scanning calorimetry (DSC) to probe mol. and interfacial dynamics. By systematically examining nanocomposites based on nonfunctionalized “”bare”” Si nanoparticles (NPs) dispersed in PMMA matrixes and on PMMA-grafted Si NPs (PMMA-g-NPs) in PMMA matrixes, we probe the effects of interfacial interactions and confinement in each of these cases on the glass transition temperature, Tg, the mean time scales, and spectral shapes of the dielec. relaxation. The faster relaxation modes are attributed to the increasing importance of chain wetting and packing in the interfacial zones around nanofillers, especially in the polymer-grafted system. These insights are used to generate a unifying mol. framework that explains the enhancement in numerous macroscopic phys. properties of polymer and polymer-grafted nanocomposites, which suits them for myriad applications.

Macromolecules (Washington, DC, United States) published new progress about Dielectric loss. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Jing; Liang, Jing; Liu, Xu; Xiao, Han; Dong, Fuping; Wang, Yilin; Shu, Xin; Huang, Furong; Liu, Hai-Bo published the artcile< Thiazoline-pyrene selective and sensitive fluorescence ""turn-on"" sensor for detection of Cu2+>, Recommanded Product: 4,5-Dihydrothiazole-2-thiol, the main research area is thiazoline pyrene selective sensitive fluorescence sensor copper detection; Cu2+ detection; Fluorescence; Pyrene; Thiazoline; “Turn-on” sensor.

A thiazoline and pyrene containing sensor 1 (I) was synthesized via 1-pot reaction and used as a highly selective and sensitive fluorescence turn-on sensor for Cu2+ detection, via the fluorescence enhancement of pyrene monomer emission. The 2:1 stoichiometry of 1 and Cu2+ was calculated from Job’s plots based on fluorescent titrations, and the complexation of 1 with Cu2+ was also supported by mass spectra, FTIR spectra, 1H NMR spectra and d. functional theory anal. The fluorescence intensity of 1 at 389 nm and 410 nm increased significantly upon the addition of Cu2+. Limit of detection and association constant value of 1-Cu2+ were calculated using standard deviations and linear fittings, resp. 1 Was active for Cu2+ detection in the wide pH range of 2.0-11.0.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetry. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Recommanded Product: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ryu, Se Hwan; Ra, Jongmin; Ko, Haye Min published the artcile< Efficient Synthesis of Sulfenamides through Mitsunobu-type Coupling Reaction of Thiols with Amines using Dibenzyl Azodicarboxylate>, Quality Control of 96-53-7, the main research area is sulfenamide preparation; thiol amine Mitsunobu coupling; disulfides preparation.

S-H activation reaction of thiols employing dibenzyl azodicarboxylate (DBAD) had been developed for the preparation of sulfenamides I [R = H; R1 = Et, Bn, cyclopropyl, cyclopentyl, cyclohexyl; RR1 = (CH2)4, (CH2)6, (CH2)2O(CH2)2, etc.; X = O, S]. The dehydrogenation of thiols and amines under these reaction conditions involved the formation of dibenzyl hydrazine-1,2-dicarboxylate, which led to the S-N bond formation reaction. The reaction proceeded efficiently with release of dibenzyl hydrazine-1,2-dicarboxylate and afforded various sulfenamides I in good to excellent yields.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Quality Control of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Gang; Xin, Xiaodong; Wang, Zehua; Lu, Gang; Ma, Yudao; Liu, Lei published the artcile< Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives>, Electric Literature of 96-53-7, the main research area is ether azolidinyl alkanone preparation regioselective enantioselective cross dehydrogenative coupling.

A formal catalytic enantioselective cross-dehydrogenative coupling of saturated ethers with diverse carboxylic acid derivatives involving an initial oxidative acetal formation, followed by nickel(II)-catalyzed asym. alkylation. The one-pot, general and modular method exhibited wide compatibility of a broad range of saturated ethers not only including prevalent THF and tetrahydropyran but also including medium- and large-sized cyclic moieties and acyclic ones with excellent enantioselectivity and functional group tolerance. The application in the rapid preparation of biol. active mols. that are difficult to access with existing methods was also demonstrated.

Nature Communications published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Abas, Elisa; Pena-Martinez, Raquel; Aguirre-Ramirez, Diego; Rodriguez-Dieguez, Antonio; Laguna, Mariano; Grasa, Laura published the artcile< New selective thiolate gold(i) complexes inhibit the proliferation of different human cancer cells and induce apoptosis in primary cultures of mouse colon tumors>, Name: 4,5-Dihydrothiazole-2-thiol, the main research area is thiolate gold complex preparation cancer apoptosis thioredoxin reductase.

New thiolate gold(i) complexes with P(NMe2)3 (HMPT) as a phosphane group [Au(SR)(HMPT)] (SR = Spy, Spyrim, SMe2pyrim, Sbenzothiazole, Sthiazoline, Sbenzimidazole and 2-thiouracil) have been synthesized. All of them have been characterized, including X-ray studies of complexes with SMe2pyrim, Sbenzothiazole and 2-thiouracil moieties. In addition, their potential application as anticancer drugs has been analyzed by determining their pharmacokinetic activities (water solubility, cell permeability and BSA transport protein affinity). Based on the good results of these experiments, we carried out the studies of cell viability with our compounds on different cell lines (A2780, A2780R and Caco-2/TC7 cells), showing higher cytotoxic activity than cisplatin in all cases. Besides, two of the synthesized complexes with Sbenzimidazole and 2-thiouracil groups exhibit specific selectivity for cancerous Caco-2 cells and are considered as potential candidates for anticancer drugs. These complexes were able to induce a strong inhibition of the thioredoxin reductase (TrxR) protein and oxidative damage in membrane lipids. Addnl. studies in primary cultures of mouse colon tumors showed that these two complexes are proapoptotic upon exposure to phosphatidylserine. Based on our results, we conclude that two of our thiolate gold(I) complexes are good and effective candidates for use in chemotherapy.

Dalton Transactions published new progress about Antiproliferative agents. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Name: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica