Category: 96929-05-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, 33.5 g (0.18 mol) of thiazolyl ester are dissolved in 140 ml of methanol and 3 ml of water and, at 5-10 C., ammonia is introduced until the solution is saturated. The reaction mixture is stirred at room temperature overnight. The solvent is evaporated and the residue is, at 80 C., taken up in 100 ml of n-butanol. The mixture is cooled to 0 C. The precipitate is filtered off with suction, washed twice with in each case 35 ml of n-butanol and twice with in each case 35 ml of MTBE and dried under reduced pressure. Yield 17.3 g (58%), yield corrected for purity: 55% based on the thiazolidine employed. 1H-NMR (DMSO-d6): delta=8.2 (s, 1H, SCHCOOEt), 7.6, 7.7, 7.8 (3*s, 3*1H, 3*NH), 4.4 (s, 2H, CH2NH), 1.4 (s, 9H, tert-butyl) ppm.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Patent; Abbott GmbH & Ci, KG; US6639081; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Tert-butyl N-[[4-(hydrazinecarbonyl)thiazol-2-yl]methyl]carbamate To a stirred solution of ethyl 2-(((tert-butoxycarbonyl) amino) methyl) thiazole-4-carboxylate (500 mg, 1.74 mmol) in dioxane (10 mL) was added hydrazine hydrate (3 mL) at room temperature and stirred for 3 h. The reaction mixture was diluted with water (30 mL), extracted with EtOAc (2 x 60 mL) and combined organic layer was dried, filtered and evaporated affording a pale yellow solid (520 mg, crude). M/z 273.1 (M+H)+., 96929-05-4

The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Antabio SAS; The designation of the inventor has not yet been filed; (149 pag.)EP3628672; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

96929-05-4, General procedure: An aqueous KOH (10%) solution was added to an ester solution in THF. The reaction mixture was stirred at rt until reagent disappearance was confirmed by TLC. HCl 1M was added until pH 4 and the solution was extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated in vacuo to afford the acid.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Article; Pena, Stella; Scarone, Laura; Manta, Eduardo; Serra, Gloria; Tetrahedron Letters; vol. 54; 22; (2013); p. 2806 – 2808;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica