Category: 99073-88-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

Step 3 6-Ethoxycarbonyl-2-mercaptobenzothiazole The crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g, 6.64 mmol) from Step 2 was suspended in absolute ethanol (35 mL) and treated with potassium hydrogen sulfide (0.96 g, 13.3 mmol). The mixture was placed under a nitrogen atmosphere, stirred, and heated in an oil bath at 80 C. The benzothiazole starring material gradually went into solution. After hearing for 30 minutes, the mixture was cooled in an ice bath, treated with 1N hydrochloric acid (13.5 mL), and evaporated under vacuum. The residue was partitioned between ethyl acetate (100 mL) and water (100 mL) and the aqueous phase extracted with more ethyl acetate (50 mL). The combined ethyl acetate solution was washed with brine (50 mL), dried over sodium sulfate, filtered and evaporated under vacuum to a yellow-tan solid (1.56 g). This material was triturated with diethyl ether and dried under vacuum to provide 6-ethoxycarbonyl-2-mercaptobenzothiazole (1.14 g) as a pale tan powder. 1 H NMR (DMSO-d6, 500 MHz) delta1.31 (t, CH3), 3.33 (br s, SH), 4.30(q, CH2), 7.35 (d, H-4), 7.94 (d, H-5), and 8.29 (s, H-7). 13 C NMR (DMSO-d6, 125.7 MHz) delta14.1, 60.9, 112.1,123.2, 125.5, 128.4, 129.7, 144.6, 165.0, and 191.8., 99073-88-8

As the paragraph descriping shows that 99073-88-8 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US5538964; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

99073-88-8, Ethyl 2-bromo-6-benzothiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,99073-88-8

Under nitrogen atmosphere, to a solution of this compound (4.00 g) in DMSO (100 mL)-CH3CN (100 mL) were added successively Pd(PPh3)4(485 mg) and sodium formate (4.76 g), and the mixture was stirred at 100 C. for 75 minutes. The solvent was evaporated under reduced pressure, and thereto was added water, and the mixture was extracted four times with Et2O, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate=10/1) to give ethyl 1,3-benzothiazole-6-carboxylate (1.21 g, 42%). 1H NMR (CDCl3, 400 MHz) delta 9.15 (s, 1H), 8.71 (dd, 1H, J=1.6, 0.5 Hz), 8.21 (dd, 1H, J=8.6, 1.6 Hz), 8.17 (dd, 1H, J=8.6, 0.5 Hz), 4.44 (q, 2H, J=7.1 Hz), 1.44 (t, 3H, J=7.1 Hz).

As the paragraph descriping shows that 99073-88-8 is playing an increasingly important role.

Reference：
Patent; Tokunaga, Teruhisa; Hume, William Ewan; Kitoh, Makoto; Nagata, Ryu; US2003/181496; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

Heat a degassed solution of ethyl 2-bromobenzothiazole-6- carboxylate (Step 1, 7.75 G, 27.1 mmol), tetrakis (TRIPHENYLPHOSPHINE) palladium (0) (1.7 g, 1.5 mmol), 4- (trifluoromethyl) phenylboronic acid (6.2 g, 32.6 mmol) and 2 M aqueous sodium carbonate solution (120 mL) in DME (90 mL) at reflux under nitrogen for 19 h. Dilute the cooled mixture with 1 N NAOH (1.2 L) and extract with methylene chloride (2 x 500 ML). Dry the combined organic extracts over MGS04, remove the solvents under reduced pressure and purify the residue by flash column chromatography on silica gel, eluting with hexanes/ethyl acetate (98: 2), to afford ethyl 2- (4-trifluoromethylphenyl) benzothiazole-6-carboxylate as a white solid (2.62 g, 27%) : 1H NMR (CDC13) 5 1.40 (t, 3H), 4.40 (q, 2H), 7.80 (d, 2H), 8.10 (d, 1H), 8.20 (m, 3H), 8.60 (s, 1H)., 99073-88-8

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

99073-88-8, Under nitrogen atmosphere, to a solution of this compound (4.00 g) in DMSO (100 mL)-CH3CN (100 mL) were added successively Pd(PPh3)4 (485 mg) and sodium formate (4.76 g), and the mixture was stirred at 100C for 75 minutes. The solvent was evaporated under reduced pressure, and thereto was added water, and the mixture was extracted four times with Et2O, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate = 10/1) to give ethyl 1,3-benzothiazole-6-carboxylate (1.21 g, 42 %). 1H NMR (CDCl3, 400MHz) delta 9.15 (s, 1H), 8.71 (dd, 1H, J=1.6, 0.5Hz), 8.21 (dd, 1H, J=8.6, 1.6Hz), 8.17 (dd, 1H, J=8.6, 0.5Hz), 4.44 (q, 2H, J=7.1Hz), 1.44 (t, 3H, J=7.1Hz).

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1479384; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

99073-88-8,99073-88-8, Ethyl 2-bromo-6-benzothiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 6-Ethoxycarbonyl-2-mercaptobenzothiazole The crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g, 6.64 mmol) from Step 2 was suspended in absolute ethanol (35 mL) and treated with potassium hydrogen sulfide (0.96 g, 13.3 mmol). The mixture was placed under a nitrogen atmosphere, stirred, and heated in an oil bath at 80 C. The benzothiazole starting material gradually went into solution. After heating for 30 minutes,the mixture was cooled in an ice bath, treated with IN hydrochloric acid (13.5 mL), and evaporated under vacuum. The residue was partitioned between ethyl acetate (100 mL) and water (100 mL) and the aqueous phase extracted with more ethyl acetate (50 mL). The combined ethyl acetate solution was washed with brine (50 mL), dried over sodium sulfate, filtered and evaporated under vacuum to a yellow-tan solid (1.56 g). This material was triturated with diethyl ether and dried under vacuum to provide 6-ethoxycarbonyl-2-mercaptobenzothiazole (1.14 g) as a pale tan powder. 1 H NMR (DMSO-d6, 500 MHz) delta1.31 (t, CH3), 3.33 (br s, SH), 4.30(q, CH2), 7.35 (d, H-4), 7.94 (d, H-5), and 8.29 (s, H-7). 13 C NMR (DMSO-d6, 125.7 MHz) delta14.1, 60.9, 112.1,123.2, 125.5, 128.4, 129.7, 144.6, 165.0, and 191.8.

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Merck & Co., Inc.; US5498777; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica