Category: 99171-11-6

In an article, published in an article, once mentioned the application of 99171-11-6, Name is 5-(Methylthio)thiazol-2-amine,molecular formula is C4H6N2S2, is a conventional compound. this article was the specific content is as follows.Computed Properties of C4H6N2S2

Sulfonylureido thiazoles were identified from a HTS campaign and optimized through a combination of structure-activity studies, X-ray crystallography and molecular modeling to yield potent inhibitors of fructose-1,6-bisphosphatase. Compound 12 showed favorable ADME properties, for example, F = 70%, and a robust 32% glucose reduction in the acute db/db mouse model for Type-2 diabetes.

Do you like my blog? If you like, you can also browse other articles about this kind. Computed Properties of C4H6N2S2. Thanks for taking the time to read the blog about 99171-11-6

Reference：
Thiazole | C3H6020NS – PubChem,
Thiazole | chemical compound | Britannica

99171-11-6, Name is 5-(Methylthio)thiazol-2-amine, molecular formula is C4H6N2S2, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 99171-11-6, Formula: C4H6N2S2

Various fused 3H-1,2,4-thiadiazoles were prepared. Significant in vitro Gram-positive antibacterial and antifungal activities were observed for certain members of the series.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C4H6N2S2. In my other articles, you can also check out more blogs about 99171-11-6

Reference：
Thiazole | C3H6018NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 99171-11-6. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 99171-11-6, Name is 5-(Methylthio)thiazol-2-amine

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

High-throughput screening with cyclin-dependent kinase 5 (cdk5)/p25 led to the discovery of N-(5-isopropyl-thiazol-2-yl)isobutyramide (1). This compound is an equipotent inhibitor of cdk5 and cyclin-dependent kinase 2 (cdk2)/cyclin E (IC50 = ca. 320 nM). Parallel and directed synthesis techniques were utilized to explore the SAR of this series. Up to 60-fold improvements in potency at cdk5 and 12-fold selectivity over cdk2 were achieved.

If you are hungry for even more, make sure to check my other article about 99171-11-6. Electric Literature of 99171-11-6

Reference：
Thiazole | C3H6021NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 99171-11-6, Name is 5-(Methylthio)thiazol-2-amine, molecular formula is C4H6N2S2. In a Article£¬once mentioned of 99171-11-6, Safety of 5-(Methylthio)thiazol-2-amine

We report the syntheses and activities of a wide range of thiazolides [viz., 2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis B virus replication, with QSAR analysis of our results. The prototypical thiazolide, nitazoxanide [2-hydroxybenzoyl-N-(5-nitrothiazol-2-yl)amide, NTZ] 1 is a broad spectrum antiinfective agent effective against anaerobic bacteria, viruses, and parasites. By contrast, 2-hydroxybenzoyl-N-(5-chlorothiazol-2-yl)amide 3 is a novel, potent, and selective inhibitor of hepatitis B replication (EC 50 = 0.33 mum) but is inactive against anaerobes. Several 4?- and 5?-substituted thiazolides show good activity against HBV; by contrast, some related salicyloylanilides show a narrower spectrum of activity. The ADME properties of 3 are similar to 1; viz., the O-acetate is an effective prodrug, and the O-aryl glucuronide is a major metabolite. The QSAR study shows a good correlation of observed EC90 for intracellular virions with thiazolide structural parameters. Finally we discuss the mechanism of action of thiazolides in relation to the present results.

We report the syntheses and activities of a wide range of thiazolides [viz., 2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis B virus replication, with QSAR analysis of our results. The prototypical thiazolide, nitazoxanide [2-hydroxybenzoyl-N-(5-nitrothiazol-2-yl)amide, NTZ] 1 is a broad spectrum antiinfective agent effective against anaerobic bacteria, viruses, and parasites. By contrast, 2-hydroxybenzoyl-N-(5-chlorothiazol-2-yl)amide 3 is a novel, potent, and selective inhibitor of hepatitis B replication (EC 50 = 0.33 mum) but is inactive against anaerobes. Several 4?- and 5?-substituted thiazolides show good activity against HBV; by contrast, some related salicyloylanilides show a narrower spectrum of activity. The ADME properties of 3 are similar to 1; viz., the O-acetate is an effective prodrug, and the O-aryl glucuronide is a major metabolite. The QSAR study shows a good correlation of observed EC90 for intracellular virions with thiazolide structural parameters. Finally we discuss the mechanism of action of thiazolides in relation to the present results.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 5-(Methylthio)thiazol-2-amine. In my other articles, you can also check out more blogs about 99171-11-6

Reference£º
Thiazole | C3H6017NS – PubChem,
Thiazole | chemical compound | Britannica