Category: 99822-80-7

Nagashima, Shinya’s team published research in Bioorganic & Medicinal Chemistry in 2014-07-01 | CAS: 99822-80-7

Bioorganic & Medicinal Chemistry published new progress about Bronchodilators. 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, Safety of Ethyl 4-phenylthiazole-5-carboxylate.

Nagashima, Shinya published the artcileNovel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists, Safety of Ethyl 4-phenylthiazole-5-carboxylate, the main research area is quinuclidinyl heteroarylcarbamate derivative preparation muscarinic receptor antagonist; ASP9133; COPD; In vivo selectivity; Long acting muscarinic receptor antagonist.

Herein, we describe the synthesis and pharmacol. profiles of novel quinuclidinyl heteroarylcarbamate derivatives Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.

Bioorganic & Medicinal Chemistry published new progress about Bronchodilators. 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, Safety of Ethyl 4-phenylthiazole-5-carboxylate.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Yamaguchi, Kohji’s team published research in Bioorganic & Medicinal Chemistry Letters in 1999-04-05 | CAS: 99822-80-7

Bioorganic & Medicinal Chemistry Letters published new progress about Interleukin 6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, SDS of cas: 99822-80-7.

Yamaguchi, Kohji published the artcile4-phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice, SDS of cas: 99822-80-7, the main research area is phenylthiazole derivative osteoblast interleukin6 secretion; osteoporosis phenylthiazole derivative structure.

A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteoblastic cells. SCRC2941-18, 2-amino-4-(4-chlorophenyl)-5-methylthiazole, was found to be the most potent inhibitor in the derivatives Furthermore, SCRC2941-18 significantly suppressed the bone weight loss in the ovariectomized mice, an osteoporosis model.

Bioorganic & Medicinal Chemistry Letters published new progress about Interleukin 6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 99822-80-7 belongs to class thiazole, name is Ethyl 4-phenylthiazole-5-carboxylate, and the molecular formula is C12H11NO2S, SDS of cas: 99822-80-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica