Category: thiazole

Vipotnik, Ziva published the artcileRehabilitation of a historically contaminated soil by different laccases and laccase-mediator system, HPLC of Formula: 30931-67-0, the publication is Journal of Soils and Sediments (2022), 22(5), 1546-1554, database is CAplus.

In this study, the degradation of polyaromatic hydrocarbons (PAH) present in naturally contaminated soil by laccases was evaluated. For that purpose, laccase was produced by solid-state fermentation (SSF) on agroindustrial residues by Trametes versicolor and Agrocybe aegerita. At the same time, com. laccases from T. versicolor and Aspergillus sp. (Novozym 51,003) were used. Material and methods: Contaminated soil was collected at a dumping site in Lagos, Nigeria, 15-30 cm depth, with a total measurement of 74.87 mg kg-1 of PAH (UHPLC) and 235.26 mg kg-1 of metals (ICP). Soil rehabilitation was evaluated in amber bottles containing 20 g contaminated soil, 20 mL of 10 U g-1 of different laccases and 1 mM of mediators (ABTS, ferulic and coumaric acid) for 12 days. Results and discussion: After 12 days of treatment with laccases and mediators, the total PAH in soil was reduced to 28.20 mg kg-1 and 33.40 mg kg-1 by the laccases from A. aegerita and T. versicolor strains studied in this work, resp., and to 42.23 mg kg-1 and 39.46 mg kg-1 by the action of the com. laccases from T. versicolor laccase and Aspergillus sp., resp. Despite redox mediators such as 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), ferulic acid and coumaric acid were studied; it was observed that laccase alone could also achieve high degradation of the contaminants load. In general, ABTS and ferulic acid were the most effective mediators in PAH degradation Despite the high price, laccases and laccase-mediator system (LMS) may degrade or transform different pollutants in real environment and work very efficiently in a first approach to the rehabilitation of soil.

Journal of Soils and Sediments published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C5H6N2O2, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chenard, B. L. published the artcileBenzopentathiepins: synthesis via thermolysis of benzothiadiazoles with sulfur, Application of Benzo[d][1,2,3]thiadiazol-5-amine, the publication is Journal of Organic Chemistry (1984), 49(7), 1221-4, database is CAplus.

A general synthesis of benzopentathiepins I (R = H, 6-Cl, 6-CF₃, 5-MeO, 5-Me₂N, 4-Br, 4-CF₃) has been developed by the thermolysis of benzothiadiazoles II with S. Diazabicyclooctane enhances the yield of benzopentathiepin by approx. 2-fold. The scope and limitations of the method are also discussed.

Journal of Organic Chemistry published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, Application of Benzo[d][1,2,3]thiadiazol-5-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Evans, David L. published the artcileNickel peroxide dehydrogenation of oxygen-, sulfur-, and nitrogen-containing heterocycles, Synthetic Route of 5053-24-7, the publication is Journal of Organic Chemistry (1979), 44(4), 497-501, database is CAplus.

Twenty-seven partially reduced O-, S-, and N-containing heterocycles were oxidized by NiO₂. Of particular interest were the conversions of several oxazolines to the corresponding oxazoles, a conversion apparently without precedent in the chem. literature, and the efficient oxidation of thiazolines to thiazoles. Since NiO₂ can effect thiazoline dehydrogenations in the presence of other functionalities, as may be judged by the successful oxidation of phleomycin A₂ to bleomycin A₂, the oxidant should be of utility for the preparation of natural products containing thiazoles.

Journal of Organic Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Synthetic Route of 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wu, Shixin published the artcileTestis transcriptome profiling identified genes involved in spermatogenic arrest of cattleyak, Product Details of C7H5ClN2S, the publication is PLoS One (2020), 15(2), e0229503, database is CAplus and MEDLINE.

Much attempt has been made to examine the mechanisms of male sterility caused by spermatogenic arrest, but yet there is no research systematically and precisely elucidated testis gene expression profiling between cattleyak and yak. Methods: To explore the higher resolution comparative transcriptome map between the testes of yak and cattleyak, and further analyze the mRNA expression dynamics of spermatogenic arrest in cattleyak. We characterized the comparative transcriptome profile from the testes of yak and cattleyak using high-throughput sequencing. Then we used quant. anal. to validate several differentially expressed genes (DEGs) in testicular tissue and spermatogenic cells. Results: Testis transcriptome profiling identified 6477 DEGs (2919 upregulated and 3558 downregulated) between cattleyak and yak. Further anal. revealed that the marker genes and apoptosis regulatory genes for undifferentiated spermatogonia were upregulated, while the genes for differentiation maintenance were downregulated in cattleyak. A majority of DEGs associated with mitotic checkpoint, and cell cycle progression were downregulated in cattleyak during spermatogonial mitosis. Furthermore, almost all DEGs related to synaptonemal complex assembly, and meiotic progression presented no sign of expression in cattleyak. Even worse, dozens of genes involved in acrosome formation, and flagellar development were dominantly downregulated in cattleyak.

PLoS One published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C30H42NOP, Product Details of C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tomasic, Tihomir published the artcileDesign, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors, Application of Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Bioorganic & Medicinal Chemistry (2017), 25(1), 338-349, database is CAplus and MEDLINE.

Two new series of Escherichia coli DNA gyrase inhibitors bearing the 4,5-dibromopyrrolamide moiety was designed and synthesized. 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole-2,6-diamine derivatives inhibited E. coli DNA gyrase in the submicromolar to low micromolar range (IC₅₀ values between 0.891 and 10.4 μM). Their “ring-opened” analogs, based on the 2-(2-aminothiazol-4-yl)acetic acid scaffold, displayed weaker DNA gyrase inhibition with IC₅₀ values between 15.9 and 169 μM. Mol. docking experiments were conducted to study the binding modes of inhibitors.

Bioorganic & Medicinal Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C13H15NO6S, Application of Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Maurya, R. C. published the artcileMagneto, spectral and thermal studies of some mixed-ligand cyanonitrosyl chromium (CrNO)⁵ complexes involving benzothiazole derivatives, COA of Formula: C14H12N2S, the publication is Journal of the Institution of Chemists (India) (1992), 64(1), 7-8, database is CAplus.

[Cr(NO)(CN)₂L₂(H₂O)] (L = 2-amino-6-ethoxy-, 2-amino-4-chloro-, 2-amino-6-nitro-, 2-amino-5,6-dimethyl-, 2-(2-tolyl)-, 2-(4-aminophenyl)-6-methylbenzothiazoles) were prepared and characterized by elemental anal., magnetic, molar conductance, TGA, and IR and ESR spectral methods. The benzothiazoles act as monodentate ligands coordinating through tertiary N.

Journal of the Institution of Chemists (India) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Muri, E. M. F. published the artcileMolecular modeling, synthesis and biological evaluation of heterocyclic hydroxamic acids designed as Helicobacter pylori urease inhibitors, Computed Properties of 64987-16-2, the publication is Letters in Drug Design & Discovery (2004), 1(1), 30-34, database is CAplus.

A computer-generated homol. model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.

Letters in Drug Design & Discovery published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Computed Properties of 64987-16-2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Muri, Estela Maris F. published the artcileDesign and synthesis of heterocyclic hydroxamic acid derivatives as inhibitors of Helicobacter pylori urease, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Synthetic Communications (2003), 33(12), 1977-1995, database is CAplus.

Helicobacter pylori produces ammonia to help counter the acidic environment in the human stomach. The production of ammonia, essential for the microorganism’s survival and virulence, is the product of enzymic conversion of urea by the H. pylori’s urease. Inhibition of urease activity by dipeptide hydroxamic acids has previously been demonstrated using a variety of fluorides, thiols and hydroxamic acids. Studies employing computer-aided drug design techniques have been utilized to suggest a novel series of heterocyclic hydroxamic acid derivatives as potential urease inhibitors. Heterocyclic compounds such as I, II, III, and IV have been designed, synthesized, and preliminarily tested as dipeptide mimics which offer a structure that is more biol. stable than that of the reported dipeptide inhibitors.

Synthetic Communications published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Recommanded Product: Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ahdenov, Reza published the artcileEelectrosynthesis of benzothiazole derivatives via C-H thiolation, Computed Properties of 95-24-9, the publication is Heterocyclic Communications (2022), 28(1), 67-74, database is CAplus.

Benzothiazole derivatives are essential intermediates in synthesizing a wide variety of medical and pharmaceutical compounds, and there is a great demand for a simple and efficient method to synthesize benzothiazoles under mild reaction conditions. Organic electrosynthesis as an energy-efficient process represents an environmentally benign and safer method than traditional methods for organic synthesis. Herein, authors present bromine-free and straightforward synthesis of 2-amino benzothiazole derivatives via the reaction of aniline derivatives and ammonium thiocyanate using electrosynthesis in the presence of sodium bromide both as an electrolyte and as a brominating agent at room temperature in iso-Pr alc. (i-PrOH) as a solvent. The reaction of ammonium thiocyanate via C-H thiolation routes, using various aniline derivatives, resulted in a simple, green, and bromine-free synthesis of 2-amino benzothiazole in moderate to good yields under mild reaction conditions. Riluzole drug can be produced using the same procedure in moderate yields.

Heterocyclic Communications published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mohinuddin, Pinjari K. Md. published the artcileMontmorillonite K-10 Clay Mediated Green Synthesis of 2-Amino-4-aryl thiazole Derivatives from α-Brominated Aralkyl Ketones in Water, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Current Green Chemistry (2015), 2(2), 163-169, database is CAplus.

Montmorillonite K-10 clay has been identified as an efficient and green catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives I (R = 4-H₃CC₆H₄, 1-naphthyl, 2-naphthyl, etc.; R¹ = H, CH₃) in good to excellent isolated yields (80-96%) from α-brominated aralkyl ketones RC(O)C(R¹)Br and thiourea in aqueous medium at 25-30 °C. The present procedure offers advantages of short reaction time, simple work-up, high yields of products and the catalyst is environmentally benign and exhibits remarkable reusable activity by four times.

Current Green Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica