Category: thiazole

Rajitha, Kamalon’s team published research in Diamond and Related Materials in 108 | CAS: 56503-96-9

Diamond and Related Materials published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, COA of Formula: C13H10N2S.

Rajitha, Kamalon published the artcileSynthesis of graphene oxide-based nanofillers and their influence on the anticorrosion performance of epoxy coating in saline medium, COA of Formula: C13H10N2S, the publication is Diamond and Related Materials (2020), 107974, database is CAplus.

The present study investigated the anticorrosion performance of epoxy coating by the incorporation of two different functionalized graphene oxides as nanofillers in saline media. GO was functionalized with 2-aminothiazole (AT) and 2-amino-4-(1-Naphthyl)Thiazole (ANT) and modified compounds were characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), Thermogravimetric anal. (TGA), Raman spectroscopy, and SEM. 0.2 Weight% of neat epoxy and epoxy nanocomposites (GO-AT/EP and GO-ANT/EP) were coated on mild steel substrate by a spin coating method and the formation of a protective film on the steel surface was confirmed using SEM, Atomic Force Microscopy (AFM) and contact angle test. The electrochem. impedance spectroscopy was employed to study the corrosion protection properties of nanocomposite coatings in 3.5% NaCl medium. The results signify the better anticorrosion performance of nanocomposite coatings due to their two-dimensional sheet structures, uniform dispersion and exfoliation in the epoxy matrix, hydrophobic nature and stopping up tiny pores properties. The GO-ANT/EP coating exhibited higher coating resistance (6.598 x 107 Ω cm2) than GO-AT/EP (1.017 x 105 Ω cm2) and pure epoxy (1270 Ω cm2) coating. The crowded structure of GO-ANT helps in forming highly crosslinked compact epoxy coating and therefore displays excellent corrosion protection efficiency than other coatings.

Diamond and Related Materials published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, COA of Formula: C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kar, Soumya Ranjan’s team published research in Polymer Bulletin (Heidelberg, Germany) in | CAS: 95-24-9

Polymer Bulletin (Heidelberg, Germany) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Category: thiazole.

Kar, Soumya Ranjan published the artcileGreen synthesis, characterization and antibacterial activity studies of new multifunctional nano polymeric material, which may have multidimensional application in water purification, Category: thiazole, the publication is Polymer Bulletin (Heidelberg, Germany), database is CAplus.

A novel polymeric resin was synthesized by condensing a Schiff base of 6-chloro-2-aminobenzothiazole and salicyldehyde with formaldehyde, which may have multidimensional application. First step of the synthesis of novel polymeric material is synthesis of Schiff base, which is the monomer of the resin. The Schiff base was synthesize by using greener method to reduce hazardous chem. waste and reaction time, so that reduction of environmental pollution and conservation of energy can be achieved. The greener method is compared with the conventional method. The metal polychelates of the polymeric resin with Cu2+ and Fe3+ were synthesized. The Schiff base, resin and its polychelates were converted to nanodimension and its dimension is measured by DLS method. The structure of the Schiff base, resin and polychelates are ascertained by FTIR, 1H NMR spectroscopy. The exptl. data are compared with the computational data obtained from Gaussian software to ascertain the synthesis of these materials. These materials have a very wide range of application starting from anal. chem. to biochem. The antibacterial activities of Schiff base, resin and metal polychelates were studied against pathogenic bacteria Escherichia coli by turbidity measurement method. All these materials are found to be effective against the tested bacterial species, whereas the polychelates are shown exceptional results.

Polymer Bulletin (Heidelberg, Germany) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sexton, Karen E. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Pantolactams as androgen receptor antagonists for the topical suppression of sebum production was written by Sexton, Karen E.;Barrett, Stephen;Bridgwood, Katy;Carroll, Matthew;Dettling, Danielle;Du, Daniel;Fakhoury, Stephen;Fedij, Victor;Hu, Lain-Yen;Kostlan, Catherine;Pocalyko, David;Raheja, Neil;Smith, Yvonne;Shanmugasundaram, Veerabahu;Wade, Kimberly. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Category: thiazole The following contents are mentioned in the article:

A series of pantolactam based compounds were identified as potent antagonists for the androgen receptor (AR). Those that possessed properties suitable for topical delivery were evaluated in the validated Hamster Ear Model. Several compounds were found to be efficacious in reducing wax esters, a major component of sebum, initiating further preclin. work on these compounds This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Category: thiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cupido, Tommaso et al. published their research in Angewandte Chemie, International Edition in 2009 | CAS: 315703-52-7

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling was written by Cupido, Tommaso;Rack, Paul G.;Firestone, Ari J.;Hyman, Joel M.;Han, Kyuho;Sinha, Surajit;Ocasio, Cory A.;Chen, James K.. And the article was included in Angewandte Chemie, International Edition in 2009.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine The following contents are mentioned in the article:

Eradicating hedgehogs: The title mol. has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This mol. is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Brands, Michael et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2005 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis was written by Brands, Michael;Ergueden, Jens-Kerim;Hashimoto, Kentaro;Heimbach, Dirk;Schroeder, Christian;Siegel, Stephan;Stasch, Johannes-Peter;Weigand, Stefan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Electric Literature of C5H6BrNS The following contents are mentioned in the article:

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. Systematic optimization of this compound class by means of classical and solid-phase chem. is reported. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Electric Literature of C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hunt, Fraser et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2007 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 74704-39-5

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction was written by Hunt, Fraser;Austin, Caroline;Austin, Rupert;Bonnert, Roger;Cage, Peter;Christie, Jadeen;Christie, Mark;Dixon, Clare;Hill, Steven;Jewell, Robert;Martin, Ian;Robinson, David;Willis, Paul. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 74704-39-5 The following contents are mentioned in the article:

As part of a Lead Optimization program to identify small mol. antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction. E.g., thiazolo[4,5-d]pyrimidine I was prepared from II via a tandem amination. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lee, Jongkook et al. published their research in ChemBioChem in 2007 | CAS: 315703-52-7

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 315703-52-7

A small-molecule antagonist of the Hedgehog signaling pathway was written by Lee, Jongkook;Wu, Xu;Pasca di Magliano, Marina;Peters, Eric C.;Wang, Yan;Hong, Jiyong;Hebrok, Metthias;Ding, Sheng;Cho, Charles Y.;Schultz, Peter G.. And the article was included in ChemBioChem in 2007.SDS of cas: 315703-52-7 The following contents are mentioned in the article:

Shadow the Hedgehog. JK184 (illustrated in the scheme) was identified as an antagonist of Hedgehog signaling through a cell-based screen of chem. libraries. Results from biochem. and cellular experiments suggest that JK184 functions by inhibiting ge. This mol. should serve as a useful tool for studying Hedgehog signaling. This study involved multiple reactions and reactants, such as N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7SDS of cas: 315703-52-7).

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine (cas: 315703-52-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 315703-52-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alvarez, Frederic et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2002 | CAS: 74704-39-5

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Benzimidazole-4,7-diones as Inhibitors of Protozoal (Toxoplasma gondii) Purine Nucleoside Phosphorylase was written by Alvarez, Frederic;Gherardi, Arnaud;Nebois, Pascal;Sarciron, Marie-Elizabeth;Petavy, Anne-Francoise;Walchshofer, Nadia. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Formula: C5H6BrNS The following contents are mentioned in the article:

Benzimidazole-4,7-diones substituted at the 1- and/or 2-position, e.g., I (R1 = H, Me), have been synthesized and tested as inhibitors of purine nucleoside phosphorylase isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Formula: C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alaimo, Robert J. et al. published their research in Journal of Heterocyclic Chemistry in 1973 | CAS: 15850-81-4

6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Synthesis of some 4H-pyrimido[2,1-b]benzothiazol-4-ones was written by Alaimo, Robert J.. And the article was included in Journal of Heterocyclic Chemistry in 1973.Category: thiazole The following contents are mentioned in the article:

A series of 8-substituted and 7,8-disubstituted-4-oxo-3-(4H-pyrimido[2,1-b]benzothiazole)carboxylic acids (I) and esters including a 9-aza analog were synthesized from substituted 2-aminobenzothiazoles and di-Et ethoxymethylenemalonate. No significant antiparasitic activity was detected. This study involved multiple reactions and reactants, such as 6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4Category: thiazole).

6-Isopropoxybenzo[d]thiazol-2-amine (cas: 15850-81-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alaimo, Robert J. et al. published their research in Journal of Heterocyclic Chemistry in 1973 | CAS: 14372-65-7

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 14372-65-7

Synthesis of some 4H-pyrimido[2,1-b]benzothiazol-4-ones was written by Alaimo, Robert J.. And the article was included in Journal of Heterocyclic Chemistry in 1973.Application of 14372-65-7 The following contents are mentioned in the article:

A series of 8-substituted and 7,8-disubstituted-4-oxo-3-(4H-pyrimido[2,1-b]benzothiazole)carboxylic acids (I) and esters including a 9-aza analog were synthesized from substituted 2-aminobenzothiazoles and di-Et ethoxymethylenemalonate. No significant antiparasitic activity was detected. This study involved multiple reactions and reactants, such as 6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7Application of 14372-65-7).

6-Butoxybenzo[d]thiazol-2-amine (cas: 14372-65-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Application of 14372-65-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica