Category: thiazole

On June 15, 1983, Kamiya, Takashi published a patent.Synthetic Route of 64987-16-2 The title of the patent was Thiazole derivatives. And the patent contained the following:

The title compds I and II (R = COCO2H; R1 = protected amino, alkylamino; R2 = H, halo) were prepared Thus, 14 g I (R = 4-EtO2CCH2, R1 = 2-NH2, R2 = H) was acylated with EtCMe2O2CCl to give 12 g III (R3 = CH2CO2Et). This (0.3 g) was oxidized with SeO2 to give 0.22 g III (R3 = COCO2Et), which (2.8 g) was saponified to give 1.75 g III (R3 = COCO2H). I and II are intermediates in preparation of antibiotic 3-cephem-4-carboxylic acid derivatives The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Synthetic Route of 64987-16-2

The Article related to aminothiazoleglycolate, thiazoleglycolate amino, thiazoleacetate amino oxo, cephalosporin intermediate aminothiazoleglycolate, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Synthetic Route of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 7, 2013, Baloglu, Erkan; Ghosh, Shomir; Lobera, Mercedes; Schmidt, Darby R. published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted phenylacetamides as novel retinoid-related orphan receptor gamma (RORγ) modulators. And the patent contained the following:

The title compounds I [m = 0-2; n = 1-3; X1-X5 = N, N(O), CH, CR5; one of Y1 and Y2 = O or NR8 and the other is bond; or X1 = CR5, Y1 = NR8, Y2 = a bond, and R5 and R8, taken together with the atoms to which they are attached, form (un)substituted 5-7 membered ring, optionally containing an addnl. heteroatom selected from O, N and S; Cy = (un)substituted cycloalkyl, hetreocycloalkyl, Ph or 5-6 membered heteroaryl; Z = O, S, SO2, C(O), NR6, a bond; A1-A5 = N, N(O), CH, CR10; R1 = alkyl, haloalkyl, cycloalkyl, etc.; R2 = H, alkyl, haloalkyl; or R1 and R2 taken together with the carbon atom to which they are attached form (un)substituted 3-8 membered ring, optionally containing a heteroatom selected from O, N, and S; R3 and R31 = H, OH, alkyl, etc.; R4 = H, halo, alkyl, etc.; R41 = H, halo, OH, NH2, alkyl; or R4 and R41 taken together with the carbon atom to which they are attached form (un)substituted 3-8 membered ring, optionally containing a heteroatom selected from O, N, and S; R5 = alkyl, haloalkyl, cycloalkyl, etc.; R6 = H, alkyl, haloalkyl, etc.; R8 = H, alkyl, haloalkyl; R10 = alkyl, haloalkyl, cycloalkyl, etc.; with the provisos], useful as novel retinoid-related orphan receptor gamma (RORγ) modulators in the treatment of diseases mediated by RORγ, were prepared E.g., a multi-step synthesis of II, starting from 2-chloro-4-methylbenzonitrile and phenylmagnesium bromide, was described. Exemplified compounds I were tested in the dual FRET assay and were found to have a pIC50 between 5 and 9. Pharmaceutical composition comprising the compound I was disclosed. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to phenylacetamide preparation retinoid related orphan receptor gamma rorgamma modulator, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 24, 1999, Hirota, Yoshihiro; Matsunaga, Tomonori published a patent.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of chloroacetylamino thiazoleacetic acid ester derivatives. And the patent contained the following:

The title cephalosporin intermediates of formula I [X = alkyl, aralkyl; Y = H2, O, alkoxyimino, carbalkoxy-alkoxyimino] are prepared Thus, chloroacetyl chloride was added slowly to Et 2-(2-aminothiazol-4-yl)-2(Z)-methoxyiminoacetate and propylene oxide acid capture agent in THF to give II in 84% yield. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazoleacetic acid ester chloroacetylamino preparation cephalosporin intermediate, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 26, 1983, Kinast, Guenther published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Intermediates useful in the preparation of cephalosporins. And the patent contained the following:

Thiazolines I [R = protective group; R1, R2 = (un)substituted alkyl, cycloalkyl, aryl, heterocyclic], useful as intermediates for cephalosporins II [R3 = (un)substituted alkyl, cycloalkyl, aryl, heterocyclic; R4 = appropriate substituent], were prepared Thus Et 2-amino-4-thiazolylacetate was treated with (Me3CO2C)2O to give I (R = Me3CO2C, R1 = CMe3, R2 = Et) which was treated with MeCHO to give III. Saponification of III to the acid, successive reaction with MeSO2Cl and 7-aminocephalosporanic acid, and deblocking gave II (R3 = Me, R4 = CH2OAc). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to aminothiazolylalkenamidocephem, cephem aminothiazolylalkenamido, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2007, Ukrainets, I. V.; Mospanova, E. V.; Sidorenko, L. V. published an article.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was 4-hydroxy-2-quinolones. 122. 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents. And the article contained the following:

An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides, e.g., I. The antitubercular activity of all of the compounds prepared has been studied. The structure-biol. activity dependence revealed is discussed. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to hydroxyoxodihydropyrroloquinoline carboxylic acid heteroaryl amine amidation, pyrroloquinoline amide hydroxyoxodihydro derivative preparation tuberculostatic activity, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 5, 2021, Chen, Jin-Ping; Battini, Narsaiah; Ansari, Mohammad Fawad; Zhou, Cheng-He published an article.Application of 24295-03-2 The title of the article was Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. And the article contained the following:

A novel class of 7-thiazoxime quinolones was developed as potential antimicrobial agents for the sake of bypassing resistance of quinolones. Biol. assays revealed that some constructed 7-thiazoxime quinolones possessed effective antibacterial efficiency. Me acetate oxime derivative I exhibited 32-fold more active than ciprofloxacin against MRSA, which also possessed rapidly bactericidal ability and low toxicity towards mammalian cells. The combination use of 7-thiazoxime quinolone I and ciprofloxacin was able to improve antibacterial potency and effectively alleviate bacterial resistance. The preliminarily mechanism exploration revealed that compound I could destroy the cell membrane and insert into MRSA DNA to bind with DNA gyrase, then decrease the expression of gyrB and femB genes. The above results strongly suggested that Me acetate oxime derivative I held a promise for combating MRSA infection. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to membrane active thiazoxime quinolone preparation mrsa antibacterial dna binding, cell membrane, drug-resistance, gene, mrsa dna, quinolone, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2020, Hussein, Essam M.; Al-Rooqi, Munirah M.; Elkhawaga, Amal A.; Ahmed, Saleh A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Tailoring of novel biologically active molecules based on N4-substituted sulfonamides bearing thiazole moiety exhibiting unique multi-addressable biological potentials. And the article contained the following:

In the present study, a new series of 2-(4-substituted-thiazol-2-ylamino)acetamides and N-(4-substituted-thiazol-2-yl)acetamides incorporating sulfonamide moieties I (R = H, 4-bromophenyl, pyren-1-yl, etc.; R1 = CH2C(O), C(O)CH2; X = CH2, O) was designed, synthesized, well-characterized and successfully evaluated for their antimicrobial activity against multidrug resistant strains and screened for cytotoxic activity against normal lung fibroblast (WI-38), human lung carcinoma (A549), and human breast carcinoma (MDA-MB-231) cell lines. Fluorescence-activated cell sorting (FACS) anal. and mol. modeling study were performed to identify the mode of action of the novel synthesized compounds and their binding interactions with the active sites of dihydrofolate reductase enzyme (DHFR). The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to acetamide aminothiazolyl sulfonyl preparation docking antibacterial antifungal antitumor activity, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2021, Zhang, Qian; Wu, Jiefei; Pan, Zexi; Zhang, Wen; Zhou, Wei published an article.Quality Control of 4-Phenylthiazol-2-amine The title of the article was A one-pot synthesis of 2-aminothiazoles via the coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. And the article contained the following:

A series of 2-aminothiazoles was prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic α-haloketones and the use of an acid-binding agent, thus provided a more convenient approach to 2-aminothiazoles compared to the Hantzsch reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to ketone thiourea iodine catalyst dimethyl sulfoxide oxidative coupling, aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2011, Hathoot, A. A.; El-Maghrabi, S.; Abdel-Azzem, M. published an article.Recommanded Product: 92-36-4 The title of the article was Electrochemical and electrocatalytic properties of hybrid films composed of conducting polymer and metal hexacyanoferrate. And the article contained the following:

Hybrid organic/inorganic modified electrode, composed of poly(2-(4-aminophenyl)-6-methylbenzothiazole) (PABT) matrix and Prussian blue (PB) like Ni hexacyanoferrate redox centers (PABT/NiHcF), showed reversible electrochem. behavior in aqueous electrolytes. Pt disk (Pt) was used as a conductive substrate onto which the composite film was electrodeposited by potential cycling. Electrochem. behavior of the modified electrode was well characterized using cyclic voltammetry (CV). The voltammetric characteristics of the composite modified electrodes were also studied in presence of different alkali metal cations (Li+, Na+, K+ ,Ce+ and NH4+). The heterogeneous electron transfer processes involving the composite and their stability were examined by subjecting the system to the long term cyclic voltammetric potential, cycling in 0.2 M NaCl electrolyte. Bilayer composite electrodes exhibit higher ionic conductivity, higher stability in comparison with pure inorganic (MeHcF) films. The inner electro active polymer chains in the film cause enhancement in the elec. conductivity of the composite electrodes. The modified electrode presented a good electrocatalytic activity towards the oxidation of MeOH, and oxalic acid (COOH)2. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 92-36-4

The Article related to electrochem electrocatalysis hybrid film composed conducting polymer metal hexacyanoferrate, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Recommanded Product: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 5, 2018, Ma, Chunhua; Miao, Yuqi; Zhao, Minghao; Wu, Ping; Zhou, Jianglu; Li, Zhi; Xie, Xilei; Zhang, Wei published an article.Recommanded Product: 31699-14-6 The title of the article was Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydantoin (DBH). And the article contained the following:

An efficient procedure for the synthesis of 2-aminothiazoles via DBH-mediated oxidative cyclization of styrenes and thioureas is reported. Various alkenes were successfully transformed to the corresponding 2-aminothiazoles in yields of 10-81% via a two-step one-pot manner using DBH as both the bromine source and oxidant. The method can be readily carried out in gram-scale and successfully applied to the synthesis of anti-inflammatory drug fanetizole using styrene as starting material. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Recommanded Product: 31699-14-6

The Article related to aminothiazole preparation, styrene thiourea oxidative cyclization dibromo dimethylhydantoin, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica