Category: thiazole

On October 1, 2019, Shaaban, Saad; Ashmawy, Abeer M.; Negm, Amr; Wessjohann, Ludger A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma. And the article contained the following:

Nineteen organoselenides, e.g., 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione were synthesized and tested for their intrinsic cytotoxicity in hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their corresponding selective cytotoxicity (SI) was estimated using normal lung fibroblast (WI-38) cells. Most of the organic selenides exhibited good anticancer activity, and this was more pronounced in HepG2 cells. Interestingly, the 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione, Me 3-((2-amino-4-methylthiazol-5-yl)selanyl)propanoate, and 4-((4-selenocyanatophenyl)diazenyl)phenol organic selenides demonstrated promising SI (up to 76). Furthermore, 4-((2,2-diethoxyethyl)selanyl)aniline, 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione, and azo-based 4-((4-selenocyanatophenyl)diazenyl)phenol and 2-amino-5-((4-selenocyanatophenyl)diazenyl)benzoic acid organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Moreover, most of the synthesized candidates manifested good free radical-scavenging and GPx-like activities comparable to vitamin C and ebselen. The obtained results suggested that some of the presented organoselenium candidates have promising anti-HepG2 and antioxidant activities. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to organoselenide preparation anticancer antioxidant activity, antioxidant, azo coupling, breast adenocarcinoma, diselenides, hepatocellular carcinoma, michael-type reaction, selenides, selenocyanates and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 29, 2016, Lee, Nathanael J.; Song, Jung Min; Cho, Hyun-Ji; Sung, You Me; Lee, Taehee; Chung, Andrew; Hong, Sung-Ha; Cifelli, Jessica L.; Rubinshtein, Mark; Habib, Lila K.; Capule, Christina C.; Turner, R. Scott; Pak, Daniel T. S.; Yang, Jerry; Hoe, Hyang-Sook published an article.Product Details of 92-36-4 The title of the article was Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway. And the article contained the following:

The authors’ recent study demonstrated that an amyloid-β binding mol., BTA-EG4, increases dendritic spine number via Ras-mediated signaling. To potentially optimize the potency of the BTA compounds, the authors synthesized and evaluated an amyloid-β binding analog of BTA-EG4 with increased solubility in aqueous solution, BTA-EG6. The authors initially examined the effects of BTA-EG6 on dendritic spine formation and found that BTA-EG6-treated primary hippocampal neurons had significantly increased dendritic spine number compared to control treatment. In addition, BTA-EG6 significantly increased the surface level of AMPA receptors. Upon investigation into the mol. mechanism by which BTA-EG6 promotes dendritic spine formation, the authors found that BTA-EG6 may exert its effects on spinogenesis via RasGRF1-ERK signaling, with potential involvement of other spinogenesis-related proteins such as Cdc42 and CDK5. Taken together, the authors’ data suggest that BTA-EG6 boosts spine and synapse number, which may have a beneficial effect of enhancing neuronal and synaptic function in the normal healthy brain. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Product Details of 92-36-4

The Article related to bta eg6 preparation dendritic spine rasgrf1 erk signaling, hexaethylene glycol benzothiazole aniline derivative preparation dendritic spine, bta-eg6, dendritic spine, rap signaling, ras signaling and other aspects.Product Details of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Juhas, Martin; Bachtikova, Andrea; Nawrot, Daria Elzbieta; Hatokova, Paulina; Pallabothula, Vinod Sukanth Kumar; Diepoltova, Adela; Jandourek, Ondrej; Barta, Pavel; Konecna, Klara; Paterova, Pavla; Sestak, Vit; Zitko, Jan published an article in 2022, the title of the article was Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole.HPLC of Formula: 2010-06-2 And the article contains the following content:

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stages of the drug discovery pipeline due to their unspecific reactivity (PAINS), toxicity, insufficient stability, or low water solubility In this work, we investigated a series of substituted N-oxazolyl- and N-thiazolylcarboxamides of various pyridinecarboxylic acids. Final compounds were tested against several microbial species. In general, oxazole-containing compounds showed high activity against mycobacteria, especially Mycobacterium tuberculosis (best MICH37Ra = 3.13 μg/mL), including the multidrug-resistant strains. Promising activities against various bacterial and fungal strains were also observed None of the compounds was significantly cytotoxic against the HepG2 cell line. Exptl. measurement of lipophilicity parameter log k′w and water solubility (log S) confirmed significantly (typically two orders in logarithmic scale) increased hydrophilicity/water solubility of oxazole derivatives in comparison with their thiazole isosteres. Mycobacterial β-ketoacyl-acyl carrier protein synthase III (FabH) was suggested as a probable target by mol. docking and mol. dynamics simulations. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2

The Article related to aminothiazole aminooxazole antimicrobial mol docking, aminooxazole, aminothiazole, antimycobacterial activity, docking, isostere, molecular docking, molecular dynamics, pyridine, water solubility and other aspects.HPLC of Formula: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Johnson, Jino; Yardily, A. published an article in 2020, the title of the article was Synthesis, spectral investigation, thermal, molecular modeling and bio-molecular docking studies of a thiazole derived chalcone and its metal complexes.Application of 24295-03-2 And the article contains the following content:

A thiazole-based chalconoid ligand (E)-3-(2-hydroxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one (HPTP) and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. The synthesized compounds were characterized by elemental anal., molar conductance, UV-visible, FTIR, NMR, mass spectral techniques, magnetic susceptibility, powder XRD and SEM with EDAX. In addition, the structures were optimized with D. Functional Theory (DFT) computations. The Lewis base nature of HPTP, stability on coordination, charge transfer interactions, quantum chem. parameters and vibrational frequencies were analyzed. The mols. were docked with 5FX6 receptor as possible inhibitors of human rhinovirus (HRV) 3 C protease. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to transition metal hydroxyphenyl thiazolyl propenone schiff base complex preparation, optimized mol structure transition metal schiff base complex, nonlinear optical property transition metal schiff base complex, thermal stability magnetic property transition metal schiff base complex and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2021, El-Dash, Yara; Elzayat, Emad; Abdou, Amr M.; Hassan, Rasha A. published an article.Recommanded Product: 2010-06-2 The title of the article was Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition. And the article contained the following:

A series of novel hybrid compounds of hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine with aminothiazole scaffolds I (R = H, Br, O2N; R1 = H, Cl, Br; R2 = H, Me) were synthesized. The synthesized compounds were evaluated for their cytotoxic activity against the NCI-60 human tumor cell line panel. Compounds I (R = H; R1 = Cl; R2 = H) (II), I (R = Br; R1 = ; R2 = H) (III) and I (R = R1 = R2 = H) exhibited significant antiproliferative activities at 10-5 M dose. II exhibited excellent cytotoxic activity against CNS cancer cell lines including SNB-75 and SF-295 as well as renal cancer cell line CAKI-1 when compared with sorafenib as standard anticancer drug. In addition, III showed almost comparable anticancer activity to sorafenib against SNB-75 cell line and displayed moderate activity against SF-295 and CAKI-1 cell lines in comparison to sorafenib. II inhibited the vascular endothelial growth factor receptor 2 (VEGFR-2) with IC50 of 62.48 ± 3.7 nM and decreased both total VEGFR-2 and phosphorylated VEGFR-2 in treated SNB-75 cells suggesting its ability to down regulate cell proliferation, growth, and survival.. The flow cytometric anal. showed that II displayed its cytotoxic activity through the reduction of the cellular proliferation and induction of cell cycle arrest at the G2/M phase. II clearly boosted the level of the apoptotic caspase-3. All the synthesized compounds were also screened for their antibacterial and antifungal activity against four pathogenic strains of both Gram-pos. and Gram-neg. as well as Candida albicans. III exhibited antifungal activity against Candida albicans compared to nystatin as the standard antifungal compound The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to arylthiazolyl benzothienylpyrimidinylthioacetamide preparation antitumor activity vegfr2 inhibition, structure arylthiazolyl benzothienylpyrimidinylthioacetamide antitumor activity vegfr2 inhibition, lack antibacterial activity arylthiazolyl benzothienylpyrimidinylthioacetamide and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tomoshige, Shusuke; Nomura, Sayaka; Ohgane, Kenji; Hashimoto, Yuichi; Ishikawa, Minoru published an article in 2017, the title of the article was Discovery of Small Molecules that Induce the Degradation of Huntingtin.Computed Properties of 92-36-4 And the article contains the following content:

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. The authors designed two small hybrid mols. by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Computed Properties of 92-36-4

The Article related to huntington disease treatment huntingtin protein ciap1 hybrid mol preparation, bestatin hybrid preparation ciap1 mhtt interaction inhibitor huntington disease, huntington’s disease, drug design, medicinal chemistry, protein degradation, small-molecule protein degraders and other aspects.Computed Properties of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Butta, Ragavendra; Ummadi, Nagarjuna; Adivireddy, Padmaja; Venkatapuram, Padmavathi published an article in 2019, the title of the article was Synthesis and antimicrobial activity of pyrimidinylsulfamoyl azolylbenzamides.SDS of cas: 2010-06-2 And the article contains the following content:

A variety of sulfonamide linked azolyl pyrimidines I [R = H, Cl, Br, Me, NO2; X = O, S, NH] were prepared and studied for their antimicrobial activity. The chloro and nitro substituted thiazolyl pyrimidines I [R = Cl, NO2; X = S] displayed potential antibacterial activity against Bacillus subtilis. The chloro, bromo and nitro substituted imidazolyl pyrimidines I [R = Cl, Br, NO2; X = NH] showed potential antifungal activity against A. niger. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to diaryl pyrimidinylsulfamoyl aryloxazolyl benzamide preparation antibacterial antifungal, preparation diaryl pyrimidinylsulfamoyl arylthiazolyl benzamide antibacterial antifungal, antibacterial antifungal diaryl pyrimidinylsulfamoyl arylimidazolyl benzamide preparation and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2020, Han, Dong; Zhang, Chun-Hui; Fauconnier, Marie-Laure; Mi, Si published an article.Related Products of 24295-03-2 The title of the article was Characterization and differentiation of boiled pork from Tibetan, Sanmenxia and Duroc × (Landrac × Yorkshire) pigs by volatiles profiling and chemometrics analysis. And the article contained the following:

To characterize and differentiate boiled pork from three different pig breeds (Tibetan, Sanmenxia and Duroc × (Landrace × Yorkshire)), the volatile compounds in each were analyzed by gas chromatog.-olfactometry-mass spectrometry (GC-MS/O) and electronic nose (E-nose) combined with chemometrics anal. In total, 61 volatile compounds were identified, among which 25 compounds were selected as odor-active compounds in boiled pork. Moreover, seven odor-active compounds (hexanal, nonanal, 1-octen-3-ol, di-Me disulfide, heptanal, 2-pentylfuran and 2-ethylfuran) were the main contributors to the integral flavor of boiled pork due to their higher odor activity values (OAVs) ranging from 17.3 to 524.2. The odor-active compounds were examined by principal component anal. (PCA), agglomerative hierarchical clustering (AHC) and partial least squares-discriminant anal. (PLS-DA). The results showed that boiled pork from the three pig breeds could be clearly distinguished, and twelve odor-active compounds, including (E,E)-2,4-decadienal, Et hexanoate, di-Me disulfide, hexanal, 2-acetylthiazole, (E)-2-nonenal, 1-octen-3-ol, (E,E)-2,4-nonadienal, heptanal, (E)-2-octen-1-ol, styrene and (E)-2-octenal, were determined as potential flavor markers for discrimination. This study indicated that GC-MS/O and E-nose with chemometrics anal. are feasible methods to characterize and discriminate boiled pork from three pig breeds. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Related Products of 24295-03-2

The Article related to boiled pork volatiles profiling chemometrics analysis, (e,e)-2,4-decadienal, 1-octen-3-ol, 2-acetylthiazole, 2-ethylfuran, 2-pentylfuran, dimethyl disulphide, e-nose, gc–ms/o, heptanal, hexanal, nonanal, odour-active compounds, pork breeds, potential flavour markers and other aspects.Related Products of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kakati, Praachi; Singh, Preeti; Yadav, Priyanka; Awasthi, Satish Kumar published an article in 2021, the title of the article was Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives.Recommanded Product: 2010-06-2 And the article contains the following content:

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives resp. by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely, E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to tetrahydropyrimidine aminothiazole quinazolinone preparation green chem ionic liquid, thiourea urea ethyl acetoacetate benzaldehyde biginelli condensation, acetophenone thiourea hantzsch reaction, isatoic anhydride aniline triethylorthoformate niementowski reaction and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 11, 2013, Meltzer-Mats, Ella; Babai-Shani, Gali; Pasternak, Lily; Uritsky, Neta; Getter, Tamar; Viskind, Olga; Eckel, Jurgen; Cerasi, Erol; Senderowitz, Hanoch; Sasson, Shlomo; Gruzman, Arie published an article.Related Products of 92-36-4 The title of the article was Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives. And the article contained the following:

AMP activated protein kinase (AMPK) has emerged as a major potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-4-oxothiazolidin-2-ylidene)amino)benzoic acid (PT-1), which attenuates the autoinhibition of the enzyme AMPK, for the design and synthesis of different benzothiazoles with potential antidiabetic activity. We synthesized several structurally related benzothiazole derivatives that increased the rate of glucose uptake in L6 myotubes in an AMPK-dependent manner. One compound, 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole , augmented the rate of glucose uptake up to 2.5-fold compared with vehicle-treated cells and up to 1.1-fold compared to PT-1. Concomitantly, it elevated the abundance of GLUT4 in the plasma membrane of the myotubes and activated AMPK. S.c. administration of 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole to hyperglycemic Kuo Kondo rats carrying the Ay-yellow obese gene (KKAy) mice lowered blood glucose levels toward the normoglycemic range. In accord with its activity, compound 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole showed a high fit value to a pharmacophore model derived from the PT-1. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Related Products of 92-36-4

The Article related to denzothiazole derivative preparation hypoglycemic mechanism ampk antidiabetic target diabetes, plasma glut4 myotube ampk antidiabetic denzothiazole derivative preparation diabetes, mol modeling pharmacophore model food intake denzothiazole derivative preparation and other aspects.Related Products of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica