Category: thiazole

On July 1, 2019, Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T. published an article.Computed Properties of 2010-06-2 The title of the article was Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones. And the article contained the following:

A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, Mycobacterium tuberculosis and P. aeruginosa. Substituent effects on observed bioactivity have been explored; the para-fluorophenyl derivative I exhibited activity across the range of the bioassays employed, indicating the potential of the 2-chloro-3-[(4-arylthiazol-2-yl)amino]-1,4-naphthoquinone scaffold in the development of novel, broad spectrum therapeutics. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to chlorothiazolylaminonaphthoquinone preparation antimalaria antibacterial antituberculosis anticancer, 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones, anti-bacterial, anti-malarial, anti-tuberculosis, cytotoxicity, hela cells and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 20, 2021, Marcinkowska, Monika; Frank, Stephanie; Steinhaus, Martin; Jelen, Henryk H. published an article.HPLC of Formula: 24295-03-2 The title of the article was Key Odorants of Raw and Cooked Green Kohlrabi (Brassica oleracea var. gongylodes L.). And the article contained the following:

Volatile compounds of raw and cooked green kohlrabi were investigated using a sensomics approach. A total of 55 odor-active compounds were detected and identified in raw and cooked green kohlrabi using GC-O. Twenty-eight odor-active compounds with high flavor dilution (FD) factors ranging from 64 to 1024 were quantitated, and odor activity values (OAVs) were determined Eight compounds showed high OAVs in raw and cooked kohlrabi: five sulfur compounds (di-Me trisulfide, Me 2-methyl-3-furyl disulfide, and three isothiocyanates (1-isothiocyanato-3-(methylsulfanyl)propane, benzyl isothiocyanate, and 1-isothiocyanato-4-(methylsulfanyl)butane)), two lipid oxidation products (1-octen-3-one and trans-4,5-epoxy-(2E)-dec-2-enal), and 2-isopropyl-3-methoxypyrazine. Among these, the sulfur compounds contributed most to the overall smell of the raw and cooked vegetables. The quantitation anal. indicates that the eight odorants are the backbone compounds for raw and cooked kohlrabi. The OAVs for the backbone compounds and also for minor odorants are clearly higher in raw kohlrabi than in the cooked one. Differences can be explained by the influence of the cooking process. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).HPLC of Formula: 24295-03-2

The Article related to odorant raw cooked brassica kohlrabi, gc-o, aroma extract dilution analysis (aeda), isothiocyanate (itc), kohlrabi (brassica oleracea var. gongylodes l.), nitrile, odor activity value (oav), stable isotope dilution assay (sida) and other aspects.HPLC of Formula: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cernosek, Terezie; Eckert, Kevin E.; Carter, David O.; Perrault, Katelynn A. published an article in 2020, the title of the article was Volatile Organic Compound Profiling from Postmortem Microbes using Gas Chromatography-Mass Spectrometry.Recommanded Product: 24295-03-2 And the article contains the following content:

Volatile organic compounds (VOCs) are byproducts of cadaveric decomposition and are responsible for the odor associated with decomposing remains. The direct link between VOC production and individual postmortem microbes has not been well characterized exptl. The purpose of this study was to profile VOCs released from three postmortem bacterial isolates (Bacillus subtilis, Ignatzschineria indica, I. ureiclastica) using solid-phase microextraction arrow (SPME Arrow) and gas chromatog.-mass spectrometry (GC-MS). Species were inoculated in headspace vials on Standard Nutrient Agar and monitored over 5 days at 24°C. Each species exhibited a different VOC profile that included common decomposition VOCs. VOCs exhibited upward or downward temporal trends over time. Ignatzschineria indica produced a large amount of dimethyldisulfide. Other compounds of interest included alcs., aldehydes, aromatics, and ketones. This provides foundational data to link decomposition odor with specific postmortem microbes to improve understanding of underlying mechanisms for decomposition VOC production The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Recommanded Product: 24295-03-2

The Article related to forensic volatile organic compound gas chromatog mass spectrometry, cadaver decomposition, decomposition odor, forensic chemistry, forensic science, forensic taphonomy, postmortem microbiology, solid-phase microextraction arrow and other aspects.Recommanded Product: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2004, Moloney, Gerard P.; Garavelas, Agatha; Martin, Graeme R.; Maxwell, Miles; Glen, Robert C. published an article.Category: thiazole The title of the article was Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor. And the article contained the following:

The synthesis and vascular 5-HT1B receptor activity of a novel series of substituted 3-amido phenylpiperazine and 4-(4-methyl-1-piperazinyl)-1-benzo[b]thiophene derivatives is described. Modifications to the amido linked sidechains of the 3-amidophenyl piperazine derivatives and to the 2-side-chain of the 1-benzo[b]thiophene derivatives have been explored. Several compounds were identified which exhibited affinity at the vascular 5-HT1B receptor of pKB > 7.0. From the 3-amidophenyl-piperazine series, N-[5-(4-chlorophenyl)-2-thiazolyl]-3-(4-methyl-1-piperazinyl)benzamide (I) and from the benzo[b]thiophene-4-piperazine series N-(2-ethylphenyl)-4-(4-methyl-1-piperazinyl)benzo[b]thiophene-2-carboxamide (II) were identified as a highly potent, silent (as judged by the inability of angiotensin II to unmask 5-HT1B receptor mediated agonist activity in the rabbit femoral artery) and competitive vascular 5-HT1B receptor antagonist. The affinity of compounds from these two series of compounds for the vascular 5-HT1B receptor is discussed as well as a proposed mode of binding to the receptor pharmacophore. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Category: thiazole

The Article related to 5-ht antagonists (type 5-ht1b), 5-ht1b receptors role: bsu (biological study, unclassified), biol (biological study) (antagonists), molecular modeling, pharmacophores, structure-activity relationship, serotoninergic antagonist and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 16, 2013, Harriman, Geraldine C.; Masse, Craig E.; Harwood, James; Bhat, Sathesh; Greenwood, Jeremy Robert published a patent.Application of 64987-16-2 The title of the patent was Preparation of thienopyrimidinedione derivatives as ACC inhibitors. And the patent contained the following:

The present invention provides compounds, specifically thienopyrimidine derivatives I [X = O, S, or NR; R1 = H, (un)substituted alkyl; R2 = halo, R, OR, etc.; or R1 and R2 are taken together to form (un)substituted 4-7 membered partially unsaturated carbocyclo-, or heterocyclo-, benzo-, or 5-6 membered heteroaryl- fused ring; R = H, (un)substituted alkyl, Ph, etc.; L1, L2 = a bond, alkylene, cyclobutylenyl, etc.; R3 = H, halo, CN, etc.; R4 = H, (un)substituted 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, etc.; with the provisos], useful as inhibitors of Acetyl CoA Carboxylase (ACC), pharmaceutical compositions thereof, and methods of using the same for treating ACC-mediated disorders such as obesity, dyslipidemia, hyperlipidemia, fungal, parasitic or bacterial infections in a subject. The invention further provides a method of inhibiting ACC in a plant comprising contacting the plant with the inhibitor compound I. Over three-hundred compounds I were prepared E.g., a multi-step synthesis of (2S)-II, starting from Et 3-oxobutanoate and Et 2-cyanoacetate, was described. Exemplified compounds I were tested in in vitro ACC1 and ACC2 inhibition assays (data given). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to thienopyrimidinedione preparation acetyl coa carboxylase acc inhibitor metabolic disorder, antiobesity fungicide antiparasitic antibacterial thienopyrimidinedione preparation acc inhibitor, dyslipidemia hyperiipidemia treatment thienopyrimidinedione preparation acc inhibitor, thienopyrimidine preparation acetyl coa carboxylase acc inhibitor metabolic disorder and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 2, 2020, Zhang, KaiYue; Li, Jing; Wang, KaiXuan; An, Xiaoying; Wang, LanZhi published an article.Formula: C5H5NOS The title of the article was Atom-economical Approaches to 1,5-Benzodiazepines Containing Indole Ring via Fe3O4@SiO2-PTSA-catalyzed Multi-component Domino Reactions. And the article contained the following:

Four novel atom-economical approaches for synthesis of 1,5-dihydrospiro[benzo[b][1,4]diazepine-2,3′-indole] compounds, e.g., I via three-component or four-component domino reactions was developed in presence of a catalytic amount of magnetic nanoparticles (Fe3O4@SiO2-PTSA) in ethanol, which provided an efficient one-pot synthesis of 1,5-benzodiazepines with multi-ring system and functional groups containing indole, aryl, ester, acyl and alkyl groups in excellent yields. In a one-pot operation, two new nitrogen heterocycle (indole and diazepine) rings and four new chem. bonds (one C-C, two C-N and one C=C) were constructed by series of domino reactions. Furthermore, plausible catalytic synthesis reaction mechanisms had been proposed. The advantages of these methods were green reaction process, recyclable magnetic catalyst, mild reaction conditions, short reaction time and high yields of products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to iron oxide silica supported toluenesulfonic acid nanoparticle catalyst preparation, dihydrospiro benzodiazepine indole chemoselective regioselective green preparation atom economy, phenylenediamine ketone indole multicomponent domino magnetic nanoparticle catalyst, ketone phenylenediamine indole dmf dimethylacetal multicomponent domino magnetic nanocatalyst and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 16, 2001, Fotouhi, Nader; Gillespie, Paul; Guthrie, Robert William; Pietranico-Cole, Sherrie Lynn; Yun, Weiya published a patent.Synthetic Route of 19989-66-3 The title of the patent was Preparation of N-aroyldehydroamino acids as lymphocyte function associated antigen-1 antagonists.. And the patent contained the following:

Title compounds [I; R1 = H, OH, amino, halo; R2 = H, OH, halo; R3 = H; R2R3 = atoms to form Ph, pyrrole, pyrroline, pyrazole, triazole, imidazole, etc., rings; A = CH2CH2CH(OH), CH2CH2CO, CH2NHCO, etc.; R4, R5 = H, Me, Et; B = H, alkyl, (substituted) (bicyclic) (hetero)aryl, etc.; R6 = CO2H, CO2R7, CH2OH, etc.; R7 = alkyl, dimethylaminoalkyl, pyrrolidinylalkyl, etc.], were prepared Thus, Me (Z)-3-(1H-benzotriazol-5-yl)-2-[[2-chloro-4-[[(3-hydroxybenzyl)amino]carbonyl]-6-methylbenzoyl]amino]propenoate (preparation given) was stirred 125 h with LiOH in MeOH/THF/H2O to give 61% (Z)-3-(1H-benzotriazol-5-yl)-2-[[2-chloro-4-[[(3-hydroxybenzyl)amino]carbonyl]-6-methylbenzoyl]amino]propenoic acid. The latter inhibited LFA-1 binding to immobilized ICAM-1 with IC50 = 0.4 nM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Synthetic Route of 19989-66-3

The Article related to aroyldehydroamino acid preparation lymphocyte function associated antigen antagonist, propenoate aroylamino preparation lfa1 antagonist, amino acid dehydro aroyl lymphocyte function associated antigen antagonist, t cell activation inhibitor aroylaminopropenoate preparation, psoriasis graft rejection dermatitis asthma arthritis treatment aroylaminopropenoate and other aspects.Synthetic Route of 19989-66-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 4, 1997, Jeon, Yoon T.; Gluchowski, Charles published a patent.SDS of cas: 70202-00-5 The title of the patent was Preparation of novel indoles and benzothiazoles for cloned human alpha 2 receptors. And the patent contained the following:

The title compounds [I-IV; R1-R3 = H, C1-7 alkyl, C2-7 alkenyl, alkynyl; R4-R6 = H, halo, Oh, etc.; R7 = H, NH, C1-7 alkyl, etc.; R8 = H, C1-7 alkyl, C2-7 alkenyl, etc.; R9 = H, Ph, C1-7 alkyl, etc.; X = CH2, O, NH, S] which are selective for cloned human alpha 2 receptors and therefore useful for lowering intraocular pressure, for treating presbyopia, migraine, hypertension, alc. withdrawal, drug addiction, rheumatoid arthritis, ischemic pain, spasticity, diarrhea, nasal congestion, urinary incontinence as well as for use as analgesics, sedatives, anesthetics, cognition enhancers and ocular vasoconstriction agents, were prepared Thus, reaction of 7-bromo-5-aminoindole with 2-imidazoline-2-sulfonic acid (ISA) afforded 46% I [R1-R5 = H; R6 = Br; R7-R9 = H; X = N] which showed pEC50 of 9.36 at alpha 2 receptor. The experimental process involved the reaction of 7-chloro-benzothiazol-6-ylamine(cas: 70202-00-5).SDS of cas: 70202-00-5

The Article related to adrenoceptor agonist indole benzothiazole preparation, anesthetic indole benzothiazole preparation, sedative indole benzothiazole preparation, vasoconstriction ocular indole benzothiazole preparation, antiglaucoma agent indole benzothiazole preparation, migraine indole benzothiazole preparation, antihypertensive indole benzothiazole preparation and other aspects.SDS of cas: 70202-00-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Stevanovic, Nevena; Mazzeo, Paolo Pio; Bacchi, Alessia; Matic, Ivana Z.; Djordjic Crnogorac, Marija; Stanojkovic, Tatjana; Vujcic, Miroslava; Novakovic, Irena; Radanovic, Dusanka; Sumar-Ristovic, Maja; Sladic, Dusan; Cobeljic, Bofzidar; Andjelkovic, Katarina published an article.Name: 2-Acetylthiazole The title of the article was Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents. And the article contained the following:

In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4]x1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to quinolinylmethylene hydrazinylpyridinium zinc thiocyanide complex preparation crystal mol structure, thiazolylethylidene hydrazinylethylaminium bismuth complex preparation crystal mol structure antimicrobial, cytotoxic dna complexation metal hydrazone girard t p reagent, antimicrobial activity, cytotoxic activity, dna-binding experiments and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 15, 2007, Nunes, Joseph J.; Milne, Jill; Bemis, Jean; Xie, Roger; Vu, Chi B.; Ng, Pui Yee; Disch, Jeremy S. published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of benzimidazole derivatives as sirtuin modulators. And the patent contained the following:

The title compounds I [R1, R4, R6 = H or (un)substituted alkyl; R2 = (un)substituted NHCO, NHSO2, NHCONH, etc.; R3 = (un)substituted monocyclic or bicyclic (hetero)aryl; R5, R7 = H or solubilizing group; with provisos] and their analogs which are novel sirtuin-modulating compounds useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity, were prepared E.g., a 2-step synthesis of II, starting from 1,2-diaminobenzene and 6-aminopyridine-2-carboxylic acid, was given. Exemplified compounds I were tested for sirtuin modulating activity (data given). Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to benzimidazole preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor, thiazolopyridine preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor, oxazolopyridine preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica