Category: thiazole

Related Products of 152937-04-7On September 15, 2012 ,《Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Malmstroem, Jonas; Viklund, Jenny; Slivo, Can; Costa, Ana; Maudet, Mickael; Sandelin, Catrin; Hiller, Goesta; Olsson, Lise-Lotte; Aagaard, Anna; Geschwindner, Stefan; Xue, Yafeng; Vasaenge, Mervi. The article contains the following contents:

4-(1,3-Benzothiazol-2-yl)thiophene-2-sulfonamide (I) was found to be a moderately potent inhibitor of cyclin-dependent kinase 5 (cdk5) from a HTS screen. The synthesis and SAR around this hit is described. The X-ray coordinates of ligand I with cdk5 are also reported, showing an unusual binding mode to the hinge region via a water mol. The results came from multiple reactions, including the reaction of 2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7Related Products of 152937-04-7)

2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Related Products of 152937-04-7Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Phytochemical composition and biological activity of Neurada procumbens L. growing in southern Algeria》 was published in Journal of Food Processing and Preservation in 2020. These research results belong to Chelalba, Imane; Benchikha, Naima; Begaa, Samir; Messaoudi, Mohammed; Debbeche, Hanane; Rebiai, Abdelkrim; Youssef, Fadia S.. Quality Control of ABTS Diammonium The article mentions the following:

Neurada procumbens L. (Neuradaceae) is one of the most popular plants in the province of El-Oued in south-eastern Algeria. This study aimed to determine the antioxidant effectiveness of the 80% methanol extract of the aerial parts of the plant via the study of three-way antioxidant activity namely, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Catalase activity (CAT), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assays in addition to examining its inhibitory capacity on the proliferation of hepatic (HepG2) and colon cancer (HCT116) cells. Chem. profiling of the major constituents of its extract was tentatively done using LC-MS in addition to quant. determination of phenols, flavonoids, and chem. mineral elements by Inductively coupled plasma-optical emission spectrometry technique (ICP-OES). Practical applications : UHPLC/MS profiling resulted in the tentative identification of 14 compounds including fatty acids, flavones, flavonoids and sesquiterpenes. ICP-OES technique showed that Algerian N. procumben represents a potential source for essential macronutrient like Na, Fe, Ca, and K, it is also a rich source of phenolic compounds evidenced by its high total phenol content (56.23 mg GAE/g extract) and high total flavonoid content (30.10 mg RE/g extract). It also revealed a significant antioxidant potential in DPPH, CAT, and ABTS assays with EC50 equals to 75.84 mg TE/g extract, 136.55 mg eq. AG/g and 92.06 mg TE/g extract, resp., with no cytotoxic effect on hepatic and colon cancer cells revealing its relative safety. Thus, it can be concluded that N. procumbens L., acts as a promising source of antioxidants owing to its richness with phenolic compounds The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Quality Control of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Organocatalytic asymmetric [4+2] cyclization of 2-benzothiazolimines with azlactones: access to chiral benzothiazolopyrimidine derivatives》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Ni, Qijian; Wang, Xuyang; Xu, Fangfang; Chen, Xiaoyun; Song, Xiaoxiao. Application of 95-24-9 The article mentions the following:

An organocatalytic asym. domino Mannich/cyclization reaction between 2-benzothiazolimines I (R = H, 6-OMe, 5-Br, etc.; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.) with azlactones II (R2 = Me, Bn, 4-FC6H4CH2, etc.; R3 = Ph, 4-MeC6H4, 1-naphthyl, etc.) has been successfully developed. With the bifunctional squaramide catalyst, this formal [4+2] cyclization occurs with good to high yields and excellent stereoselectivities (up to 99% ee, >20 : 1 dr), providing an efficient and mild access to chiral benzothiazolopyrimidines III (R = H, 6-OMe, 5-Br, etc.; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.; R2 = Me, Bn, 4-FC6H4CH2, etc.; R3 = Ph, 4-MeC6H4, 1-naphthyl, etc.) bearing adjacent tertiary and quaternary stereogenic centers. The results came from multiple reactions, including the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Computed Properties of C18H24N6O6S4On May 15, 2021 ,《Excited state electronic structures and photochemistry of different oxidation states of 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Ji, Feixiang; Guo, Yurong; Wang, Mengqi; Wu, Zibo; Shi, Yanan; Zhao, Xiaoying; Wang, Haiyuan; Feng, Xia; Zhao, Guangjiu. The article conveys some information:

The mol. structures of 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), were calculated by using time-dependent d. functional theory (TDDFT) model with M062X method with 6-311G (d, p) basis set. In this work, the ABTS were theor. investigated from the geometric structure, the energy levels of the LUMO (LUMO) and the HOMO (HOMO), the energy level gap ΔEHOMO-LUMO of the mol. ground state, excited stated properties and the electronic absorption spectra of different oxidation states. We studied the energy levels of LUMO and HOMO of ABTS in different oxidation states. Frontier MO anal. can provide insight into the nature of excited states. ABTS was synthesized from N-ethylaniline by total synthesis. Then, we measured the UV-Vis spectra of ABTS before and after being oxidized by K2S2O8. The calculated electronic structures and photochem. properties of different oxidation state of ABTS were in accordance with the exptl. result. This work demonstrates the relationship between the electronic structures and photochem. of different oxidation states ABTS hence paves the way for the rationally synthesis and deepen understanding of the photophys. properties of ABTS materials. After reading the article, we found that the author used ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,Journal of Food and Nutrition Research (Bratislava, Slovakia) included an article by Godocikova, Lucia; Ivanisova, Eva; Noguera-Artiaga, Luis; Carbonell-Barrachina, Angel A.; Kacaniova, Miroslava. SDS of cas: 30931-67-0. The article was titled 《Biological activity, antioxidant capacity and volatile profile of enriched Slovak chocolates》. The information in the text is summarized as follows:

Different kinds and types of chocolates produced in Slovakia with various fruit and nut enrichments were analyzed regarding total polyphenols, flavonoids and phenolic acids contents using spectrophotometric methods and their volatile profile was analyzed using gas chromatog.-mass spectrometry. The method with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric reducing power method (FRAP) were used to measure antioxidant activity. Plain dark chocolate without any enrichment made by a traditional process contained the highest number of total polyphenols and phenolic acids and also had the highest antioxidant activity. Pos. correlation was observed between antioxidant activity and total contents of phenolic compounds, flavonoids and phenolic acids. The enrichment with different kinds of fruits did not increase the number of bioactive compounds or antioxidant capacity of chocolates but created more attractive sensory profiles due to the presence of new volatile compounds In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0SDS of cas: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of C18H24N6O6S4On October 15, 2019 ,《Development of antimicrobial and antioxidant electrospun soluble potato starch nanofibers loaded with carvacrol》 was published in International Journal of Biological Macromolecules. The article was written by Fonseca, Laura Martins; Cruxen, Claudio Eduardo dos Santos; Bruni, Graziella Pinheiro; Fiorentini, Angela Maria; Zavareze, Elessandra da Rosa; Lim, Loong-Tak; Dias, Alvaro Renato Guerra. The article contains the following contents:

In this study, a method was developed to encapsulated carvacrol in nanofibers from soluble potato starch. The carvacrol was added in starch solutions at various concentrations (0, 20, 30 and 40% volume/volume) and electrospun into fibers. The morphol., size distribution, thermal stability, FT-IR spectra, relative crystallinity (RC) and antioxidant of the electrospun fibers were analyzed. For mech. properties and antimicrobial activities evaluation electrospun nonwovens were obtain. The carvacrol-loaded nanofibers showed homogeneous morphol. and average diameters ranging from 73 to 95 nm. The carvacrol encapsulated in the nanofibers had greater thermal stability than the free carvacrol. FT-IR anal. showed interactions between starch and carvacrol. The RC of the nanofibers was approx. 40%. The electrospun nonwovens mech. properties did not present significant differences (p < 0.05). The 40% carvacrol-loaded nanofibers exhibited higher antioxidant activity with 83.1% of inhibition. The electrospun nonwoven loaded with 30% carvacrol resulted in 89.0% reduction of Listeria monocytogenes, 68.0% for Salmonella Typhimurium, 62.0% for Escherichia coli and 49.0% for Staphylococcus aureus. These electrospun nonwovens sustained antimicrobial activity for at least 30 days against S. aureus. The starch nanofibers are promising materials for application as a vehicle for carvacrol release in antimicrobial and antioxidant food packages. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2021,International Journal of Pharmaceutical Sciences and Research included an article by Vikram, V.; Kishore, P. Ram; Kalaiyarasan, A.; Hariram, N.. Computed Properties of C18H24N6O6S4. The article was titled 《Protein profiling and isolation of bioactive hydrolysates with antioxidant activity from stem callus tissue of tinospora cordifolia (willd.) miers exposed to cyclodextrin》. The information in the text is summarized as follows:

This study is aimed to evaluate the effects of different concentrations of cyclodextrin, an auxin stabilizing agent, on callus growth from the stem explants of Tinospora cordifolia and to assess the antioxidant properties of the bioactive hydrolyzates of callus tissue using chymotrypsin, trypsin, pepsin, and papain. Cyclodextrin exerted a dose- and time-dependent effect on the callus growth. α-Chymotrypsin hydrolyzate showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging, while trypsin hydrolyzate exhibited the highest 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) activity. Protein profiling of callus tissue revealed a few tissue-specific bands at 41, 30, 20, and 9 kDa with varying intensities. A growth medium containing sucrose has a specific impact on the expression of these polypeptides. Purification of 30 kDa polypeptide by Sephadex-G50 revealed distinct quant. differences to different concentrations of cyclodextrin. This study suggested that T.cordifolia callus tissue protein hydrolyzates exhibited antioxidant efficacy, leading to the development of a nutraceutical agent in promoting health. The experimental process involved the reaction of ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Synthesis and biological evaluation of some newly synthesized thiazolo-pyrimido-pyrimidobenzothiazoles》 were Pawde, A. V.; Kadam, D. B.; Vartale, S. P.. And the article was published in European Journal of Biomedical and Pharmaceutical Sciences in 2021. SDS of cas: 95-24-9 The author mentioned the following in the article:

Condensation of 2-amino-5-methylthiazole with bis(methylthio)methylene malononitrile give 6-cyano-5-imino-2-methyl-7-(methylthio)-5H-thiazolo[3,2-a]pyrimidine. Which on further condensation with various 2-amino-substituted benzothiazoles yield 12, 13-diimino-9-methyl- thiazolo[2,3-a]-4H-pyrimido[4,5-d]-4H-pyrimido[2,1-b]benzothiazoles I (R1 = H, Cl; R2 = H, Me, OMe, F, Cl, NO2; R3 = H, Me). Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

COA of Formula: C5H3ClN2SOn June 1, 2017, Spiliotopoulos, Dimitrios; Zhu, Jian; Wamhoff, Eike-Christian; Deerain, Nicholas; Marchand, Jean-Remy; Aretz, Jonas; Rademacher, Christoph; Caflisch, Amedeo published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain》. The article mentions the following:

Overexpression of the CREB-binding protein (CBP), a bromodomain-containing transcription coactivator involved in a variety of cellular processes, has been observed in several types of cancer with a correlation to aggressiveness. The authors have screened a library of nearly 1500 fragments by high-throughput docking into the CBP bromodomain followed by binding energy evaluation using a force field with electrostatic solvation. Twenty of the 39 fragments selected by virtual screening are pos. in one or more ligand-observed NMR experiments Four crystal structures of the CBP bromodomain in complex with in silico screening hits validate the pose predicted by docking. Thus, the success ratio of the high-throughput docking procedure is 50% or 10% if one considers the validation by ligand-observed NMR spectroscopy or x-ray crystallog., resp. Compounds 1 and 3 show favorable ligand efficiency in two different in vitro binding assays. The structure of the CBP bromodomain in the complex with the brominated pyrrole 1 suggests fragment growing by Suzuki coupling. In the experiment, the researchers used 2-(2-Chlorothiazol-5-yl)acetonitrile(cas: 865660-15-7COA of Formula: C5H3ClN2S)

2-(2-Chlorothiazol-5-yl)acetonitrile(cas: 865660-15-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.COA of Formula: C5H3ClN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Synthesis, characterization & pharmacological activity of 1,2,4-triazole derivatives (Z)-1(benzo[d]thiazole-2-yl)(1-subsituted phenylidene) hydrazine containing benzothiazole》 were Kmari, Sangeeta; Gupta, Sujeet Kumar; Kumar, Sandeep. And the article was published in World Journal of Pharmacy and Pharmaceutical Sciences in 2021. Application of 95-24-9 The author mentioned the following in the article:

The present study shows effort to synthesize new triazole products I (R = 3-nitrol, 2,5-dihydroxy, 2-bromo-4-chloro, etc.) and measure them for anti-convulsion action through Maximal electrode shock attack method. First step, aniline and potassium thiocynate were synthesized and reacted through using bromine solution and glacial acetic acid formaylation and gave complex 6-chlorobenzo[d] thiazole-2-amine. The above compound 6-chlorobenzo[d] thiazole-2-amine was once responded by way of 6-chlorobenzo[d] thiazole-2-amine in the occurrence of ethylene glycol, and hydrazine hydrate to present 1-(6-chlorobenzo[d] thiazole-2yl) hydrazine (II). Complex II used to be allowable to reply with numerous substituted potassium thiocynate offers conforming triazole products. Triazole products II had been replied through acetophenone and giacial acetic acid and ethanol at reflux for 5h to afford complexes I. Last triazole (Z)-1-(benzo[d] thiazole-2-yl)-2-(1-subsituted phenylthylidene) hydrazine I, was synthesized from substituted acetophenone through the response with ethanol. Pharmacol. screening through an ear electrode prompted cutting-edge 51mA for 0.3 2d in electro-convulsiometer for anti-conversant activity. The synthesized compound Is used to be I. The complicated I (R = 4-methoxy, 4-hydroxy) was once set up to be maximum powerful complicated with associate to general medications phenytoin sodium. The experimental part of the paper was very detailed, including the reaction process of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica