Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194374-25-8,2-Bromo-5-methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Bromo-5-methylthiazole-4-carboxylic acid (118 mg, 0.5 32 mmol) was suspended in anhydrous DCM (5 mL), and a drop a DMF was added. Then, oxalyl chloride (2 M in DCM) (0.725 mL, 1.45 mmol) was added dropwise, and the reactionmixture was stirred for 1 h at rt (bubbling observed; the mixture became homogeneous). Then, DCM was removed under reduced pressure, and the obtained acid chloride (brown syrup) was used in the subsequent step. In a separate flask, to a suspension of Intermediate 2, HC1 (141 mg, 0.483 mmol) in THF (5 mL), was added DIEA (0.084 mL, 0.483 mmol) and trimethylsilyl cyanide (0.644 mL, 4.83 mmol). The resultant solutionwas stirred at rt for 10 mm, and then was treated with a solution of acid chloride obtained as described above in THF (5 mL). The mixture was stirred at 50 C for 1.5 h. The reaction mixture was concentrated, then trifluoroethanol (10 mL) was added. The residue was purified by flash chromatography (solid loading on CELITE, 0-100% EtOAc/Hex) affording Intermediate 24 (86 mg, 39% yield) as a off-white solid. MS(ESI) m/z: 459.0(M+H) ?H NMR: (400 MHz, CDC13) oe ppm 9.91 (s, 1H), 8.46 (dd, J7.8, 1.0 Hz, 1H),7.86 – 7.80 (m, 1H), 7.80 – 7.74 (m, 1H), 7.70 (d, J8.1 Hz, 1H), 7.37 (br d, J=7.9 Hz,1H), 4.47 (sxt, J=8.2 Hz, 1H), 3.83 (quin, J8.5 Hz, 1H), 2.77 – 2.69 (m, 1H), 2.63 – 2.34(m, 5H), 2.17 (dd,J=10.8, 8.8 Hz, 1H), 2.04- 1.97 (m, 1H), 1.60 (s, 3H)., 1194374-25-8

As the paragraph descriping shows that 1194374-25-8 is playing an increasingly important role.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 2-araino-l-(4-methoxyphenyl)ethanone hydrochloride (8 mg, 0.04 mmol), benzothiazole-6-carboxylic acid (7 mg, 0.04 mmol), tris(dimethylamino)chloro phosphonium hexafluorophosphate (48 mg, 0.14 mmol), and N,N-diisopropylethylamine (24 muL, 0.14 mmol) in NMP (600 muL) was stirred at room temperature overnight, then the solvents were evaporated in vacuo. The resulting residue was dissolved in acetic anhydride (400 muL) followed by the addition of TFA (100 muL). The reaction mixture was heated at 90 0C for 1 h, cooled to the room temperature, and concentrated in vacuo. The resulting residue was dissolved in DMSO (200 mul) and subjected to HPLC purification (Method T) to provide 6-(5- (4-methoxyphenyl)oxazol-2-yl)benzo[dJthiazole (2 mg). LC/MS (ESI) m/z 309.1 [M+H]. HPLC retention time (Method A) = 3.53 min., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; AMPHORA DISCOVERY CORPORATION; WO2007/149395; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

[00181] A solution of 6-(trifluoromethyl)benzo[d]thiazole (3) (830 mg, 4.08 mmol) and hydrazine monohydrate (1.52 g, 30.6 mmol) in ethanol (20 mL) was heated to reflux for 1.5 h. The mixture was added to a solution of acetic acid (3 mL) in water (100 mL) and extracted with DCM. The organic extract was dried over Na2S04and concentrated under reduced pressure. The crude material was purified by silica gel chromatography to afford 670 mg (84%) of the title compound as a yellow oil. NMR (400 MHz, CDCI3) delta 7.62 (d, J= 1.2 Hz, 1H), 7.39 (dd, J = 8.4, 2.0 Hz, 1H), 6.75 (d, J= 8.4 Hz, 1H), 4.49 (s, 2H), 2.95 (s, 1H).

131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOGRA PHARMA LIMITED; VITI, Francesca; BELLINVIA, Salvatore; DEMARTIS, Salvatore; (104 pag.)WO2015/197861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15864-32-1, Under a nitrogen atmosphere a solution of 2-amino-6-brombromobenzothiazole (2, 0.00213 mol),acetonitrile (5 mL), and acetic anhydride (0.003 mol) was stirred at 60 C for 40 min with the additionof few drops of conc. H2SO4, After 40 min distilled water (15-20 mL) was added to form a precipitateand stirring was continued for one hour at room temperature. The solution was filtered and washedwith water and the product further analyzed by spectroscopic techniques [25].

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Gull, Yasmeen; Rasool, Nasir; Noreen, Mnaza; Nasim, Faiz-Ul-Hassan; Yaqoob, Asma; Kousar, Shazia; Rashid, Umer; Bukhari, Iftikhar Hussain; Zubair, Muhammad; Islam, Md. Saiful; Molecules; vol. 18; 8; (2013); p. 8845 – 8857;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-55-3, Benzo[d]thiazol-7-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1123-55-3, A mixture of 1, 3-BENZOTHIAZOL-7-AMINE (Description 43,30 mg, 0.2 mmol) and [4- (trifluoromethyl) benzyl] isocyanate (Description 3,40 mg, 0.2 mmol) in DCM (2 ml) was stirred at room temperature for 18 h. TLC analysis showed minimal reaction therefore 1,2-dichloroethane (1 ml) was added and the mixture was heated at 80C for 4 h. N, N-DIMETHYLFOM-LAMIDE (0.25 ml) was then added and the mixture was heated at 80C for 18 h. The mixture was then cooled to room temperature and stirred at this temperature for 2 h. The mixture was filtered to give the title compound as a white solid (28 mg, 40%). 1H NMR (d6 DMSO, 400 MHz) 8 9.33 (1H, s), 8.74 (1H, s), 7.82 (1H, d, J7. 9), 7.73 (3H, m), 7.55 (2H, d, J 8. 0), 7.45 (1H, t, J 8. 0), 7.10 (1H, br. t, J 5.9), 4.44 (2H, br. d, J 5. 9). M/Z (ES+) 352 (M+H+).

As the paragraph descriping shows that 1123-55-3 is playing an increasingly important role.

Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/28445; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Example 10; Preparation of 7V-(6-Phenylbenzo[15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng; WO2010/8847; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1) Formation of tert-butyl (6-bromo-1 ,3-benzothiazol-2-yl) carbamate2-Amino-6-bromobenzothiazole (2.0 g; 8.7 mmol) was suspended in DCM (40 ml.) to which were added di-te/f-butyl dicarbonate (2.86 g; 13.1 mmol) and DMAP (4 mg; 0.03 mmol). The resulting mixture was stirred at RT for 16 h then concentrated in vacuo. The residue was suspended in 2M NH3 in MeOH and stirred at RT for 2 h then concentrated in vacuo. The residue was triturated in water and filtered to afford the title compound (2.64 g, 92%) as a white solid. 1H NMR (DMSOd6, 300 MHz) delta 1 1.86 (s, 1 H), 8.19 (d, J = 2.0 Hz, 1 H), 7.60 (d, J = 8.5 Hz, 1 H), 7.52 (dd, J = 2.0, 8.5 Hz, 1 H), 1.51 (s, 9H).

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14527-44-7,Methyl thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 2-bromo-5-(4-methoxybenzyloxy)pyridine (1 .10 g), methyl thiazole-5- carboxylate (644 mg), Pd(P(f-Bu)3)2 (153 mg), Cs2CO3 (1 .20 g) and DMF (10 mL) was evacuated and refilled with nitrogen three times. The mixture was stirred at 150C under N2 atmosphere for 3 hours. Insoluble material was removed by filtration through Celite. The filtrate was diluted with H2O (100 mL). The solid obtained was collected by filtration and washed with MeOH to provide the subtitle compound. MS ESI+: m/z = 357 [M+H]+.

14527-44-7, 14527-44-7 Methyl thiazole-5-carboxylate 331117, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 4-nitrophenyl)boronic acid (23.00 g, 137.78 mmol, 1.00 eq.), 2-bromothiazole (25.54 g, 155.69 mmol, 14.03 mL, 1.13 eq.), Na2C03 (36.51 g, 344.45 mmol, 2.50 eq.) and Pd(dppf)Cl2.CH2Cl2 (6.75 g, 8.27 mmol, 0.06 eq.) in Tol. (250.00 mL)/H20 (100.00 mL)/dioxane (250.00 mL) was degassed and purged with N2 for 3 times. The mixture was stirred at 80C for 12 hrs under N2 atmosphere and LCMS showed the reaction was complete. The mixture was concentrated and the residue was purified by column chromatography (Petroleum ethenEthyl acetate=50: l to 5: 1) to give 2-(4-nitrophenyl)thiazole (14.00 g, 67.89 mmol, 56.00% yield) as a yellow solid. 1H NMR (400MHz, CHLOROFORM-d) delta = 8.35 – 8.29 (m, 2H), 8.21 – 8.12 (m, 2H), 7.99 (d, J = 3.2 Hz, 1H), 7.50 (d, J = 3.2 Hz, 1H).

3034-53-5, The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CYTEIR THERAPEUTICS, INC.; CASTRO, Alfredo, C.; MCCOMAS, Casey, Cameron; VACCA, Joseph; (214 pag.)WO2019/14315; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

31785-05-4, Ethyl 5-amino-2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 22: Compound 52 5-Amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (150mg, 0.806mmol) was dissolved in dichloromethane (3ml_). To this, pyridine (0.195ml_, 2.42mmol) was added at room temperature. To this, benzenesulfonyl chloride (171 mg, 0.967mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo, diluted with water and extracted with ethyl acetate. The organic layer was dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was dissolved in tetrahydrofuran (3ml_) and water (1 ml_). To this, lithium hydroxide monohydrate (101 mg, 2.41 mmol) was added at room temperature and stirred for 12 hours. The mixture was concentrated in vacuo and diluted with water. The mixture was acidified with 1 N hydrochloric acid solution. The product was collected by filtration, washed with diethyl ether and dried under vacuum to give Compound 52 (28mg). 1 H NMR (DMSO-de) delta: 7.85-7.75 (2H, m), 7.70-7.62 (1 H, m), 7.62-7.54 (2H, m), 2.75 (3H, obs) LCMS (Method 30) Rt 4.63 min; m/z(M-H)” 297

31785-05-4, As the paragraph descriping shows that 31785-05-4 is playing an increasingly important role.

Reference：
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica