Category: thiazole

64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 250 mL three-neck flask, copper cyanide (7.28 g, 80 mmol) was successively added.Anhydrous acetonitrile (30mL),Tert-butyl nitrite(10 mL, 80 mmol),Raise the temperature to 50CA solution of 2-(2-aminothiazol-4-yl)acetic acid ethyl ester (7.5 g, 40 mmol) in anhydrous acetonitrile (20 mL) was added dropwise, and the addition was completed within 1 h and the reaction was continued for 2.5 h. The solvent is distilled off under reduced pressureThe crude product was purified by column chromatography (petroleum ether/ethyl acetate (V/V) = 25/1) to give a slightly yellow liquid (2 g, 25%)., 64987-16-2

As the paragraph descriping shows that 64987-16-2 is playing an increasingly important role.

Reference：
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Yingjun; Ren Qingyun; Liu Xinchang; Wang Chaolei; S ·geerdeman; (80 pag.)CN103664897; (2018); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A compound of Formula P-1 is treated with, for example, potassium thiocyanate and bromine in acetic acid to produce a compound of Formula P-2. The compound of Formula P-2 is treated with an acetylating reagent such as acetyl chloride to produce a compound of Formula P-3. The compound of P-3 is reacted with, for example, bis(pinacolato)diboron (compound P-4) in the presence of a catalyst such as palladium chloride to produce a compound of Formula P-5.

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INTELLIKINE, LLC; LIU, Yi; REN, Pingda; JESSEN, Katayoun; GUO, Xin; ROMMEL, Christian; WILSON, Troy, Edward; WO2014/151147; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

0.56 g of ethyl mercaptan sodium salt (80%) was added to a mixture of 0.86 g of 5-chlorothiazole-4-carboxylic acid ethyl ester, 3 ml of DMF and 1 ml of THF, under ice cooling, and then the mixture was stirred at room temperature for 1 hour. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.71 g of 5-ethylsulfanylthiazole-4-carboxylic acid ethyl ester., 425392-45-6

425392-45-6 Ethyl 5-chlorothiazole-4-carboxylate 58758599, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Nokura, Yoshihiko; Ito, Mai; Shimizu, Chie; Mizuno, Hajime; US2015/94329; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

B) A-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.15 g, 0.806 mmol), cyclopropancarboxaldehyde (0.23 g, 3.29 mmol) was treated with cyclopropanecarboxaldehyde (0.230 g, 3.22 mmol) and tetraisopropyl-orthotitanate (0.916 g, 3.22 mmol) and stirred at room temperature overnight. Ethanol (5 mL) and sodium cyanoborohydride (0.213 g, 3.22 mmol) were added and the reaction mixture was stirred for 5 h. Water (0.5 mL) was added to the reaction mixture and the solvent was evaporated. The residue was purified by flash chromatography on silica gel with ethyl acetate/methanol 100:0?90:10 gradient to yield 5-((cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid isopropyl ester (0.170 g, 83%) as a yellow oil

31785-05-4, The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a stined solution of 2-bromo-6-methoxybenzo[d]thiazole (8.00 g, 32.8 mmol) in dichloromethane (20 mL) at 15 C was added tribromoborane (9.1 mL, 98 mmol) dropwise. The resulting mixture was heated at 40 C for 6 h then poured into ice water. The precipitate was filtered and the filtrate was extracted with dichloromethane (40 mL x 3). The precipitate and the organic layers were combined, dried over Na2504,and concentratedto give the title compound.MS: m/z = 229.9, 231.9 (M + 1). ?H NMR (400 MHz, CD3OD): oe7.74 (d, J= 8.8 Hz, 1H), 7.28 (d,J=2.4Hz, 1H),7.00(dd,J,=8.8Hz, J2=2.4Hz, 1H)., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an 8 mL screw cap vial was added a solution of 3-benzyl-6-mercapto-5- [METHYL-LH-PYRIMIDINE-2,] 4-dione, (0.025 g, 0.1 mmol) in dimethylformamide (1 [ML),] a solution of 2-bromo-6-methoxybenzothiazole (0.15 mmol) in dimethylformamide (0.3 mL) and diisopropylethylamine (0.05 mL, 0.3 mmol). The vial was capped and the reaction mixture was shaken for 24 hours at [100C.] The solvent was removed under vacuum. Purification was carried out via reverse- phase HPLC (ODS AC-18, [5] [T,] 30 mm [X100] mm, 3% n-propanol in acetonitrile and [3%] n-propanol in water 10 % to [90%] over 10 minutes) to give 3-benzyl-6- (6- [METHOXY-BENZOTHIAZOL-2-YLAMINO)-5-METHYL-1H-PYRIMIDINE-2,] 4-dione. MS [(APCI),] m/z [( [M+H] +)] 395.1.

2941-58-4, The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/14868; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 114 – preparation of N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-6-carboxamide[00151] HATU (695 mg, 1 .83 mmol) was added to Compound 2 (400 mg, 1 .41 mmol), benzo[d]thiazole-6-carboxylic acid (290 mg, 1 .62 mmol) and DIPEA (0.737 mL, 4.22 mmol) in DMA (15 mL) and the resultant mixture stirred at ambient temperature for 16 hours under an inert atmosphere. The reaction mixture was diluted with EtOAc (300 mL), and washed with water (2 x 200 mL). The organic layer was dried over Na2S04, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 20 to 100% EtOAc in isohexane. The pure fractions were evaporated to a yellow solid which was triturated with DCM and filtered to afford the desired material as a white solid (287 mg, 46 %). 1H NMR (400 MHz, DMSO) delta 10.05 (s, 2H), 9.57 (s, 1 H), 8.82 (d, J= 1 .5 Hz, 1 H), 8.23 (d, J= 8.5 Hz, 1 H), 8.15 (dd, J = 1 .74, 8.6 Hz, 1 H), 7.87 (d, J = 2.1 Hz, 1 H), 7.58 – 7.65 (m, 1 H), 7.47 – 7.57 (m, 2H), 7.24 (d, J= 8.42 Hz, 1 H), 6.98 (d, J= 8.37 Hz, 1 H), 4.32 (m, 4H), 2.24 (s, 3H). m/z (ES+), (M+H)+ = 446.

3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

939-69-5, 6-Hydroxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

939-69-5, Example 4 Synthesis of Compounds 4 and 13 2-Cyano-6-t-butyldiphenylsiloxy-benzothiazole. A solution of 2-cyano-6-hydroxybenzothiazole (5.0 g, 28 mmol) in 100 ml of anhydrous DMF under inert atmosphere was treated with 2.9 g of imidazole (4.2 mmol) followed by t-butyldiphenylchlorosilane (9.34 g, 34 mmol). The reaction was stirred at room temperature for 3 h and then diluted with 200 ml of ethyl acetate and washed with water (4*400 ml). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography, eluding with 5-10percent ethyl acetate/hexanes to afford 13.0 g of the desired product containing ~10percent silyl impurity in quantitative yield. The product was taken on without further purification. 1 H NMR (CDCl3): delta 1.12 (s, 9H); 7.13-7.46 (m, 8H); 7.70-7.72 (m, 4H); 7.92-7.95 (d, 1H).

The synthetic route of 939-69-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Lumigen, Inc.; US6045991; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

59418-09-6, Methyl 4-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,3-bis(dicyclohexylphosphino)propane (dcypp: 20.0 mol%, 21.9mg) was dissolved in o-dichlorobenzene (1.0 mL) in a two-necked flask equipped under argon atmosphere. Then, RhH(CO)(PPh3)3 (10.0 mol%, 23.0 mg), 4-phenylthiazole 1a (0.25 mmol, 40.3 mg)and 2-methylthiothiazole 5 (0.75 mmol, 78 L) were added to the solution, and the mixture was heated at reflux for 3 h. Then, the solvent was removed under reduced pressure, and the residue was purified byflash columm chromatography on silica gel giving 2-(methylthio)-4-phenylthiazole 3a (38.5 mg, 74%). 3a11, 59418-09-6

As the paragraph descriping shows that 59418-09-6 is playing an increasingly important role.

Reference：
Article; Arisawa, Mieko; Nihei, Yuri; Yamaguchi, Masahiko; Heterocycles; vol. 90; 2; (2015); p. 939 – 949;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

2-[(1-Benzothiazol-6-yl-methanoyl)-amino]-3-phenyl-propionic acid Benzothiazole-6-carboxylic acid (2h, 258 mg) is dissolved in dichloromethane (10 ml), and treated with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (345 mg). The reaction is stirred for 10 minutes. 1-Hydroxybenzotriazole (244 mg) is added and the mixture is stirred for a further 10 minutes. L-Phenylalanine t-butyl ester hydrochloride (200 mg) is added and the reaction maintained at room temperature for 72 hours. The mixture is concentrated, the residue taken up in ethyl acetate and washed with water, sodium bicarbonate, and brine. The organic phase is dried (MgSO4), concentrated, and then purified by chromatography on silica (10% diethyl ether/DCM). This afforded the ester intermediate as a solid (60 mg).

3622-35-3, 3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; The Procter & Gamble Company; US2004/6104; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica