Category: thiazole

Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization was written by Matter, Hans;Zoller, Gerhard;Herling, Andreas W.;Sanchez-Arias, Juan-Antonio;Philippo, Christophe;Namane, Claudie;Kohlmann, Markus;Pfenninger, Anja;Voss, Marc D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.SDS of cas: 55661-33-1 This article mentions the following:

The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chem. motif that was subsequently optimized to arrive at a chem. series of potent and promising SCD1 inhibitors. In particular, compound SAR224 was selected for further pharmacol. profiling based on favorable in vitro data. After oral administration to male ZDF rats, this compound significantly decreased the serum fatty acid desaturation index, thus providing conclusive evidence for SCD1 inhibition in vivo by SAR224. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1SDS of cas: 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.SDS of cas: 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors was written by Orjales, Aurelio;Mosquera, Ramon;Lopez, Beatriz;Olivera, Roberto;Labeaga, Luis;Nunez, M. Teresa. And the article was included in Bioorganic & Medicinal Chemistry in 2008.COA of Formula: C4H6N2S This article mentions the following:

New series of 2-(4-methylsulfonylphenyl) and 2-(4-sulfamoylphenyl)pyrimidines were synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). COX-1 and COX-2 inhibitory activity of these compounds was determined using purified enzyme (PE) and human whole blood (HWB) assays. Extensive structure-activity relationship (SAR) work was carried out within these series, and a wide number of potent and specific COX-2 inhibitors were identified (HWB COX-2 IC₅₀ = 2.4-0.3 nM and 80- to 780-fold more selective than rofecoxib). In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1COA of Formula: C4H6N2S).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.COA of Formula: C4H6N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

CNDO/S method interpretation of ultraviolet spectra of phenylthiazoles was written by Bouscasse, L.;Lebreton, M.;Aune, J. P.. And the article was included in Spectroscopy Letters in 1994.Application of 1826-13-7 This article mentions the following:

The UV spectra of three phenylthiazoles are reported. These exptl. results are interpreted using CNDO/S method (CNDO for Spectroscopy). Calculations show that the observed transitions, except two, are pseudo π → π^* type transitions. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Application of 1826-13-7).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Application of 1826-13-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate was written by Judge, Russell A.;Scott, Victoria E.;Simler, Gricelda H.;Pratt, Steve D.;Namovic, Marian T.;Putman, C. Brent;Aguirre, Ana;Stoll, Vincent S.;Mamo, Mulugeta;Swann, Steven I.;Hobson, Adrian D.. And the article was included in ChemBioChem in 2018.Category: thiazole This article mentions the following:

We describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a structure surrogate to guide compound design. A subset of these mols. also showed robust activity in a cell-based myosin phosphatase assay and in a mech. hyperalgesia in vivo pain model. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4Category: thiazole).

6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A grand product design model for crystallization solvent design was written by Chai, Shiyang;Liu, Qilei;Liang, Xinyuan;Guo, Yansuo;Zhang, Song;Xu, Chengqiu;Du, Jian;Yuan, Zhihong;Zhang, Lei;Gani, Rafiqul. And the article was included in Computers & Chemical Engineering in 2020.Application of 1843-21-6 This article mentions the following:

Solvents play an important role in crystallization processes. The screening/design of solvents for crystallization (crystallization solvents) is still of great concern in research and development. At present, most of the design/screening methods of crystallization solvents are still based on the trial-and-error approach. In this paper, the Grand Product Design (GPD) model is applied for the screening/design of crystallization solvents. The GPD-model includes process sub-model, property sub-model, quality sub-model, cost sub-model, pricing sub-model, economic sub-model and environmental sub-model as well as other factors such as company strategy, government policies and regulations. Solution strategies are given for three cases: solvent design for a fixed process, process design for a fixed solvent and simultaneous design of solvent and process. Taking 2-Mercapotobenzothiazole (MBT) as an example, the solvent design for a fixed (existing) process design is carried out by using the problem specific GPD-model, in which the GPD-model is formulated as Mixed-Integer Non-Linear Programming (MINLP) model with objective function, process sub-model, property sub-model, quality sub-model, pricing sub-model, cost sub-model, economic sub-model and environmental sub-model. The established MINLP model is then solved by the decomposition-based approach. Experiments are carried out to verify the candidate solvents, which is found to perform better in terms of product purity and recovery than the best-known solvents in use. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application of 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel acyl coenzyme A: diacylglycerol acyltransferase 1 inhibitors-synthesis and biological activities of N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides was written by Nakada, Yoshihisa;Ogino, Masaki;Asano, Kouhei;Aoki, Kazuko;Miki, Hiroshi;Yamamoto, Toshihiro;Kato, Koki;Masago, Minori;Tamura, Norikazu;Shimada, Mitsuyuki. And the article was included in Chemical & Pharmaceutical Bulletin in 2010.Category: thiazole This article mentions the following:

In a program to discover new small mol. diacylglycerol acyltransferase (DGAT)-1 inhibitors, screening of our inhouse chem. library was carried out using recombinant human DGAT-1 enzyme. From this library, the lead compound 1a (I) was identified as a new class of DGAT-1 inhibitor. A series of novel N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides 2 was designed from 1a, synthesized and evaluated for inhibitory activity against DGAT-1 enzyme. Among these compounds, N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(4,5-diethoxy-2-methylphenyl)-4-oxobutanamide 9 was found to exhibit potent inhibitory activity and good enzyme selectivities. Following administration in KKA^y mice with 3 mg/kg high fat diet admixture for four weeks, 9 reduced body weight gain and white adipose tissue weight without affecting total food intake. These results suggested that the small mol. DGAT-1 inhibitor might have potential in the treatment of obesity and metabolic syndrome. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Category: thiazole).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA was written by Roman, Raquel;Navarro, Antonio;Wodka, Dariusz;Alvim-Gaston, Maria;Husain, Saba;Franklin, Natalie;Simon-Fuentes, Antonio;Fustero, Santos. And the article was included in Organic Process Research & Development in 2014.Related Products of 55661-33-1 This article mentions the following:

In this contribution we report the synthesis of fluorinated and nonfluorinated tebufenpyrad analogs to explore potential druglike properties through the phenotypic screening as part of the Lilly Open Innovation Drug Discovery (OIDD) program. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Related Products of 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Related Products of 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reactions of 2-aminobenzothiazoles with phenyl glycidyl ether was written by Ambartsumova, R. F.;Kosmacheva, L. P.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1991.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

Aminobenzothiazoles I (R = H, Me, Et, Ph, CH₂Ph, COMe, cyclohexyl; R¹ = H) react with Ph glycidyl ether at the ring N atom to form II, while in base the reaction takes place at the amino group to give phenoxypropylamino derivatives, e.g., I [R = CH₂CH(OH)CH₂OPh]. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A Novel Route to Substituted 2-(N-Arylamino)benzothiazoles via Iron-Promoted C-S Bond Formation was written by Pinapati, Srinivasa Rao;Mandapati, Usha Rani;Tamminana, Ramana;Rudraraju, Ramesh Raju. And the article was included in ChemistrySelect in 2019.Computed Properties of C13H10N2S This article mentions the following:

The synthesis of 2-(N-arylamino)benzothiazoles I (R = Bu, cyclohexyl, 2-nitrophenyl, etc.; R¹ = H, 5-Me, 7-NO₂, etc.) has been demonstrated in the presence of transition metal under mild reaction conditions. In this paper, disubstituted thioureas R²NHC(S)NHR (R² = 2-iodo-4-methylphenyl, 2-iodo-6-nitrophenyl, 4,5-dimethyl-2-iodophenyl, etc.) have also been reported from isothiocyanates R²NCS at room temperature Subsequently, C-S cross-coupling reaction was described for the construction of benzothiazoles I using cheap, readily available and air stable iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed for reveal the mechanism. In addition, a broad range of substrate scope has been explored. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Computed Properties of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Computed Properties of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Direct transition metal-free C-S bond formation: synthesis of 2-aminobenzothiazole derivatives via base-mediated approach was written by Wang, Rui;Chen, Zhi;Yue, Liang;Pan, Wei;Zhao, Jun-Jie. And the article was included in Tetrahedron Letters in 2012.Name: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

A general, efficient, and more practical protocol for the base-mediated intermol. or intramol. S-arylation leading to the 2-aminobenzothiazole derivatives, e.g., I (R¹ = H, Me, Meo, F, Cl; R² = H, Me, Cl, Br, NO₂), is reported. Remarkably, all reactions were carried out under transition-metal-free conditions with good to excellent yields, rendering the methodol. presented herein highly valuable from both environmental and economic points of view. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Name: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica