Category: thiazole

Barni, Ermanno published the artcileMonoazo dyes for polyamide derived from 4-alkylamido-2-hydroxybenzoic acids, Quality Control of 92-36-4, the publication is Dyes and Pigments (1984), 5(1), 15-36, database is CAplus.

Data on a series of 65 azo disperse dyes I (R = C₁-C₁₅ alkyl; A mono- or disubstituted or unsubstituted) are reported. The dyes are suitable for application to polyamide fibers and produce yellow to red-orange shades. Many correlations between the nature of substituents and the phys., spectroscopic or tinctorial properties of the dyes were established. Correlations between structure and color of dyed fabrics were also found.

Dyes and Pigments published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Quality Control of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Henglein, A. published the artcileDependence of the intensity of fluorescence on the quencher concentration in micellar systems, COA of Formula: C14H12N2S, the publication is Berichte der Bunsen-Gesellschaft (1978), 82(10), 1107-12, database is CAplus.

The quenching of the fluorescence of 2-(4-aminophenyl)-3-methylbenzothiazol solubilized in micelles of sodium dodecylsulfate by duroquinone was investigated. The decay constant k₀ in the absence of quencher is 6.9 × 10⁸ s^-1. At constant concentrations of the fluorescing and the quenching compounds the fluorescence intensity decreases with decreasing surfactant concentration This effect is explained by the changes in the distribution of the emitting and quenching mols. among the micelles. A relationship is given which takes into account the statistical distribution of solubilized mols. The 1st order rate constant is k_m = m·k₁ for quenching in a micelle carrying m mols. of the quencher, k₁, the rate constant for quenching in a micelle containing 1 mol. of the quencher, was 3.5 × 10⁸ s^-1. The ion pair formation in micelles containing 2-(4-aminophenyl)-3-methylbenzothiazol and duroquinone, the biphotonic ionization of 2-(4-aminophenyl)-3-methylbenzothiazol in anionic micelles and in MeOH solution, and the formation of the triplet state of this compound in toluene and in acid aqueous solutions were studied by laser flash photolysis.

Berichte der Bunsen-Gesellschaft published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Nazare, Marc published the artcileA flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones, Name: 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, the publication is Angewandte Chemie, International Edition (2004), 43(34), 4526-4528, database is CAplus and MEDLINE.

The “ringmaster” [Pd(tBu₃P)₂] served as the catalyst in the direct synthesis of indoles, e.g., I, by annulation of ortho-chloroanilines with ketones. This versatile method can be used to synthesize a variety of functionalized indoles and azaindoles, e.g., II.

Angewandte Chemie, International Edition published new progress about 30536-19-7. 30536-19-7 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, and the molecular formula is C6H4ClN3S, Name: 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Stanetty, Peter published the artcileHalogenated 2′-Chlorobithiazoles via Pd-Catalyzed Cross-Coupling Reactions, Synthetic Route of 329794-40-3, the publication is Journal of Organic Chemistry (2006), 71(10), 3754-3761, database is CAplus and MEDLINE.

Halogenated bithiazoles allow facile further functionalization and are, therefore, suitable intermediates for the synthesis of compounds with interesting biol. activity or material science properties. The applicability of three coupling methods (Negishi, Suzuki, and Stille) for the synthesis of the title compounds was compared. The Negishi method proved to be troublesome, and side reactions were predominant. The synthesis of the first thiazoleboronic acid ester offered a new method for the formation of bithiazoles, not generally applicable so far. The lower toxicity compared to that of tin organyls make this method an approach with interesting perspectives. The Stille coupling proved to be superior to the other methods and enabled the synthesis of the title compounds with diverse connectivity.

Journal of Organic Chemistry published new progress about 329794-40-3. 329794-40-3 belongs to thiazole, auxiliary class Thiazole,Chloride,Benzene, name is 2-Chloro-5-phenylthiazole, and the molecular formula is C20H19NO4, Synthetic Route of 329794-40-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Campaigne, E. published the artcileReactions of 4-chloroacetoacetic esters with thioureas, Quality Control of 64987-16-2, the publication is Journal of Heterocyclic Chemistry (1980), 17(6), 1255-7, database is CAplus.

Thiazoles I (R = Me, Et) were prepared in 61 and 83% yields, resp., by cyclizing ClCH₂COCH₂CO₂R (II) with H₂NCSNH₂. Cyclizing II with III (n = 1, 2) gave 50-88% IV. Hydrolysis of IV (R = Et) gave IV (R = H).

Journal of Heterocyclic Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Quality Control of 64987-16-2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Takahashi, Torizo published the artcilePyridine derivatives containing sulfur. XVII. Synthesis of pyridothiazoles and pyrimidazoles, Application In Synthesis of 31784-71-1, the publication is Yakugaku Zasshi (1946), 66(No. 7/8A), 26, database is CAplus.

By the use of Cu(SCN)₂ in glacial AcOH solution the following 2-aminopyrido[2,3-d]thiazoles were obtained: 6-nitro, yellow plates, m. 183°, from 2-amino-5-nitropyridine; 6-bromo, yellow plates, m. 135°, from 5-bromo-2-amino-pyridine; and 5-chloro, pale yellow needles, m. 69-71°, from 2-chloro-5-aminopyridine. BrCH₂COMe with 5-bromo- or 5-nitro-2-aminopyridine gave 6-bromo-2-methyl-imidazo[1,2-a]pyridine HCl salt, colorless, efflorescent rhomboprisms, and the 6-nitro analog (I), bright yellow needles, m. 161°. Reduction of I gave the corresponding amino compound, colorless needles, m. 77° (N-Ac derivative), colorless needles, m. 181°.

Yakugaku Zasshi published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C5H6N2O2, Application In Synthesis of 31784-71-1.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chen, Yen Ting published the artcileParallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Bioorganic & Medicinal Chemistry (2004), 12(12), 3289-3298, database is CAplus and MEDLINE.

Protein tyrosine phosphatases (PTPases) regulate intracellular signal transduction pathways by controlling the level of tyrosine phosphorylation in cells. These enzymes play an important role in a variety of diseases including type II diabetes and infection by the bacterium Yersinia pestis, which is the causative agent of bubonic plague. This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases. The library members are based on the bis(aryl α-ketocarboxylic acid) motif that incorporates a carboxylic acid on the central benzene linker. This carboxylic acid was coupled with a variety of different aromatic amines through an amide linkage. The aromatic component of the resulting amides is designed to make contacts with residues that surround the active site of the PTPase. The library was screened against the Yersinia PTPase and PTP1B. Based upon the screening results, four members of the library were selected for further study. These four compounds were evaluated against the Yersinia PTPase, PTP1B, TCPTP, CD45, and LAR. Compound 14 has an IC₅₀ value of 590 nM against PTP1B and is a reversible competitive inhibitor. This affinity represents a greater than 120-fold increase in potency over compound 2, the parent structure upon which the library was based. A second inhibitor, compound 12, has an IC₅₀ value of 240 nM against the Yersinia PTPase. In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45.

Bioorganic & Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ikhtiarini, Asefin Nurul published the artcileOptimization of ultrasound-assisted extraction and the antioxidant activities of Sidaguri (Sida rhombifolia), Synthetic Route of 30931-67-0, the publication is Journal of Applied Pharmaceutical Science (2021), 11(8), 070-076, database is CAplus.

Sidaguri (Sida rhombifolia) is widely distributed in tropical and subtropical regions and has been reported to possess many bioactive compounds that are beneficial for human health, including polyphenolics having antioxidant activities. The objective of this study was (1) to optimize ultrasound-assisted extraction (UAE) of Sidaguri and (2) to evaluate antioxidant activities of extracts resulting from the optimized condition using radical scavenging assay of 2,2′-diphenil-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid. The optimum UAE conditions obtained were solvent to solid ratio of 26:1, temperature of extraction of 45.45°C, methanol concentration of 42%, power of sonication of 86%, and time of extraction of 5 min. Sidaguri obtained from locations of Kretek and Ngemplak had the highest radical scavenging activity accounting for 83.69% ± 0.30% and 82.95% ± 0.49%, resp.

Journal of Applied Pharmaceutical Science published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Synthetic Route of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Akerfeldt, Stig published the artcileIn vivo antiviral effects of benzothiazole derivatives against various influenza A2 strains, Application In Synthesis of 92-36-4, the publication is Journal of Medicinal Chemistry (1970), 13(5), 1012-13, database is CAplus and MEDLINE.

Seventeen derivatives of benzothiazole were investigated for antiviral activity against various influenza A2 strains in mice. Aminoadamantane was used as an internal standard in the experiments 2-Aminobenzothiazole and 2-amino-4-chlorobenzothiazole gave a protective effect comparable to, or better than, that found for aminoadamantane. Small variations in the structure of these 2 compounds caused a complete disappearance of the antiviral effect. To be effective the active compounds had to be administered in near-toxic doses. All 17 compounds were also tested for antiviral effect against rhino virus 33342, adeno virus 3, and herpes simplex virus. Significant antiviral effect could not be demonstrated for any compound in vitro.

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Anonymous published the artcilePreparation of amino substituted hydroxyphenyl benzophenone derivatives and their uses as UV filters in sunscreen formulations, Category: thiazole, the publication is IP.com Journal (2003), 3(8), 40, database is CAplus.

Described are synthesis of amino substituted hydroxyphenyl benzophenone derivatives The compounds are useful as UV filters in sunscreen applications. For example, comound I synthesized by reacting anhydrous 4-diethylamino 2-hydroxy benzophenone carboxylic acid with 2,2-dimethyl-1,3-propanediol was found to be a good UV absorber and was incorporated into sunscreen formulations.

IP.com Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica