Category: thiazole

913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

913836-22-3, In an oven-dried vial, methyl 5-bromothiazole-4-carboxylate (200 mg, 0.90 mmol) was dissolved in MeCN (2.4 mL). Morpholine (87 uL, 0.99 mmol) and DBU (0.2 mL, 1.35 mmol) were added to the vial sequentially. The vial was sealed and heated to 80 C for 5 hours. Cool the vial to room temperature and quench with water. Extract aqueous layer (3x) with EtOAc. The organic layer was dried with Na2SO4, filtered and concentrated. The crude product was purified on silica gel (hexane/EtOAc: 0% to 80%), affording methyl 5- morpholinothiazole-4-carboxylate (120 mg, 58%) as a white solid. ESI MS m/z = 229.1 [M+H]+.

As the paragraph descriping shows that 913836-22-3 is playing an increasingly important role.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; SHOOK, Brian, C.; KIM, In, Jong; BLAISDELL, Thomas, P.; YU, Jianming; PANARESE, Joseph; LIN, Kai; RHODIN, Michael, H.J.; McALLISTER, Nicole, V.; OR, Yat, Sun; (447 pag.)WO2019/67864; (2019); A1;,
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Thiazole | chemical compound | Britannica

4175-77-3, 2,4-Dibromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) Synthesis of 4-bromothiazol A solution of 10.0 g (41.2 mmol) 2,4-dibromothiazol in ether (210 ml) was cooled to -78 C. and 28.3 ml (45.3 mmol, 15% in hexane) n-butyllithium was added in drops at this temperature. After 30 min of stirring, 3.3 ml (82.3 mmol) methanol was added at -78 C. to the reaction mixture. Heating was subsequently performed to RT over a period of 16 h. The reaction mixture was filtered over silica gel and washed with a n-hexane/AE mixture (2:1). The filtrate was concentrated in a vacuum, whereby 6.7 g (40.9 mmol, 99%) 4-bromothiazol was obtained.

4175-77-3, The synthetic route of 4175-77-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Grunenthal GmbH; US2008/261996; (2008); A1;,
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Thiazole | chemical compound | Britannica

20949-84-2, 4-Formyl-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 51 6-FLUORO-2-[2-(2-METHYL-THIAZOL-4-YL)-VINYL]-3-(2-METHYL-PHENYL)-3H-QUINAZOLIN-4-ONE Anhydrous zinc chloride (0.136 g, 1.0 mmol) was fused with a nitrogen purge in a round bottom flask with an open flame. The reaction vessel was allowed to return to ambient temperature, then dioxane (10 mL) was added. To this mixture was added 6-fluoro-2-methyl-3-(2-methyl-phenyl)-3H-quinazolin-4-one (0.1 34 g, 0.5 mmol), acetic anhydride (0.141 mL, 1.5 mmol), and 2-methylthiazole-4-carboxaldehyde (0.191 g, 1.5 mmol). The reaction was refluxed 3.5 hours, at which time the reaction was allowed to cool to ambient temperature. Once the reaction had cooled to ambient temperature it was diluted with water. The resulting mixture was repeatedly extracted with chloroform. The chloroform extracts were combined and the resulting chloroform layer was washed with water and brine, dried over sodium sulfate and concentrated to leave a dark residue. This residue was triturated with ether, filtered and dried to afford 0.04 g (21%) of 6-fluoro-2-[2-(2-methyl-thiazol-4-yl)-vinyl]-3-(2-methyl-phenyl)-3H-quinazolin-4-one as a tan solid. Melting point: 211-212 C.; NMR delta 7.91 (dd, J=3, 8.3 Hz, 1 H), 7.87 (d, J=15 Hz, 1 H), 7.75 (dd, J=5, 9 Hz, 1 H), 7.49 (dt, J=3, 9 Hz, 1 H), 7.42 (sym m, 3 H), 6.61 (d, J=15 Hz, 1 H), 2.60 (s, 3 H), 2.09 (s, 3 H)., 20949-84-2

20949-84-2 4-Formyl-2-methylthiazole 2763191, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US6306864; (2001); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117043-86-4,4-(Aminomethyl)thiazole Hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of thiazol-4-ylmethanamine hydrochloride (100 mg, 0.664 mmol) in acetonitrile (3 mL), potassium carbonate (229 mg, 1.66 mmol) and DMF (2 mL) were added. After the mixture was cooled to a temperature between -10 C. and -15 C., ethyl 2-bromoacetate (73 muL, 0.66 mmol) diluted with acetonitrile (1 mL) was added dropwise thereto. The temperature was gradually raised to room temperature, and the mixture was stirred overnight. Insoluble matters were separated by filtration, and the filtrate was concentrated under reduced pressure., 117043-86-4

As the paragraph descriping shows that 117043-86-4 is playing an increasingly important role.

Reference£º
Patent; Ajinomoto Co., Inc.; MATSUMOTO, Kayo; MIYANAGA, Wataru; DOHI, Mizuki; NAKAGAWA, Tadakiyo; KOBAYASHI, Kaori; TAKESHITA, Sen; (67 pag.)US2016/46592; (2016); A1;,
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Thiazole | chemical compound | Britannica

14542-12-2, Thiazol-2-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Manufacturing Example 88-1-2 2-Chloromethyl-thiazole; To a mixture of thiazole-2-yl-methanol (251 mg, 2.18 mmol) described in Manufacturing Example 88-1-1 and dichloromethane (10 mL) was added thionyl chloride (191 muL, 2.62 mmol) at room temperature, which was stirred for 30 minutes. Saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, which was then extracted with dichloromethane. The organic layer was separated, washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (220.5 mg, 76%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 5.11 (2H, s), 7.81-7.83 (2H, m).

14542-12-2, 14542-12-2 Thiazol-2-ylmethanol 2795213, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
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137-00-8, 4-Methyl-5-thiazoleethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-(2-hydroxyethyl)-4-methylthiazole 7 (3.0 g, 21.0 mmol) and methyl iodide (2.64 mL, 42.0 mmol) were mixed and refluxed for 2 h. After evaporation of excess methyl iodide, to the residual brown syrup was added ether (50 mL) and stirred for 30 min, the precipitate was filtered to get 17 as a pale-yellow solid (5.76 g, 96.3%). Mp: 82-84 C; 1H NMR (D2O, ppm): 4.14 (s, 3 H, CH3N), 3.90 (t, 2 H, CH2CH2O, J = 5.6 Hz), 3.19 (t, 2 H, CH2CH2O, J = 6.0 Hz), 2.53 (s, 3 H, CCH3).

137-00-8, The synthetic route of 137-00-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fan, Wei; Wu, Yong; Li, Xian-Kun; Yao, Nian; Li, Xun; Yu, Yong-Guo; Hai, Li; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3651 – 3661;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7336-54-1,N-(5-bromothiazol-2-yl)acetamide,as a common compound, the synthetic route is as follows.,7336-54-1

EXAMPLE 79 A mixture of 2-acetylamino-5-bromothiazole (2.2 g), 4-amino-2-mercaptopyrimidine (1.3 g) and potassium carbonate (2.0 g) in N,N-dimethylformamide (50 ml) was heated at 90 C. for 2 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The precipitation was collected by filtration, washed with water and dried in vacuo to give solid. The solid was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 200 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give 2-acetylamino-5-(4-aminopyrimidin-2-ylthio)thiazole (1.3 g, yield: 48.7%). mp: 255-258 C. (dec.) IR (Nujol): 3400, 3350, 3200, 1692, 1650, 1585, 1325, 1300 cm-1 NMR (DMSO-d6, 200 MHZ, ppm): 2.16 (3H, s), 6.17 (1H, d, J=6Hz), 7.02 (2H, s), 7.59 (1H, s), 7.85 (1H, d, J=6Hz), 12.31 (1H, s) Mass: M+1 268, M 267, m/e 225, 205, 183

As the paragraph descriping shows that 7336-54-1 is playing an increasingly important role.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5256675; (1993); A;,
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Thiazole | chemical compound | Britannica

3704-41-4, 2-(4-Nitrophenyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(4-nitrophenyl)thiazole (6 g, 29.10 mmol, 1 eq.) in DMF (50 mL), was added NBS (15.54 g, 87.29 mmol, 3 eq.). The mixture was stirred at 80C for 15 mins and LCMS showed the reaction was complete. The mixture was poured into water (1L) and filtered. The filter cake was washed with MeOH (50 mL) and dried to give 5-bromo-2- (4- nitrophenyl)thiazole (7.3 g, crude) as a yellow solid. 1H NMR (400MHz, METHANOL-d4) delta = 8.35 (br s, 2H), 8.18 (br s, 2H), 8.07 – 7.88 (m, 1H).

3704-41-4, 3704-41-4 2-(4-Nitrophenyl)thiazole 13546655, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CYTEIR THERAPEUTICS, INC.; CASTRO, Alfredo, C.; MCCOMAS, Casey, Cameron; VACCA, Joseph; (214 pag.)WO2019/14315; (2019); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61830-21-5,Ethyl 2-amino-5-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,61830-21-5

General procedure: A mixture of 2-amino-5-bromothiazole-4-carboxylate (34, 2.22g,0.01 mol), the appropriate 2-thioxo-quinazoline analogs (14-17,0.01 mol), anhydrous potassium carbonate (1.5 g, 0.01 mol) in DMF(10 ml) was heated under reflux for 14-16 h. Solvent was then removed under reduced pressure and continued as mentioned under compounds 21-24 (Table 1).

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 33 – 45;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of A (10 g, 48 mmol) in THF (50 mL) at 0C under nitrogen was added aq.NaOH (72ml, 2M, 145 mmol). Reaction mixture was stirred at room temperature for 30-120min, monitored by TLC. Mixture was acidified with aq.HCl (6M) to pH=3-4, and precipitate filtered to give 1 (7 g, 81%) as a white solid., 32137-76-1

32137-76-1 Ethyl 1,3-benzothiazole-2-carboxylate 640708, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
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Thiazole | chemical compound | Britannica