Category: thiazole

57268-16-3, 5-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57268-16-3, A sol. of intermediate 7 (0.070 g, 0.14 mmol), 5-bromo-2-methylthiazole (0.051 g, 0.29 mmol), Cs2CO3 (0.047 g, 0.14 mmol), Pd(PPh3)4 (0.033 g, 0. 29 mmol) and a 3 N NaOH aq. sol. (0.024 ml, 0.07 mmol) in 1,4-dioxane (10 ml) was purged with N2 for 2 min. The r.m. was stirred at 80 0C overnight. After cooling, H2O was added and the product was extracted with DCM. The organic phase was washed with brine, dried (Na2SO4) filtered and concentrated under reduced pressure. The residue was purified by preparative HPLC [RP Shandon Hyperprep Cl 8 BDS (8 mum, 250 g, LD. 5 cm); mobile phase: (0.25 % NH4CO3 sol. in water, MeOH + CH3CN)]. The product fractions were collected and concentrated under reduced pressure. Yield: 0.013 g of compound 4 (19.7 %).

57268-16-3 5-Bromo-2-methylthiazole 13228663, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; VELTER, Adriana, Ingrid; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; WU, Tongfei; VAN BRANDT, Sven, Franciscus, Anna; SURKYN, Michel; ZAJA, Mirko; PIETERS, Serge, Maria, Aloysius; BERTHELOT, Didier, Jean-Claude; DE CLEYN, Michel, Anna, Jozef; OEHLRICH, Daniel; WO2010/89292; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

55690-60-3, 5-Methoxybenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55690-60-3, A mixture of 5-methoxy-1,3-benzothiazole-2-thiol (500 mg), thionyl chloride (2 mL) and DMF (1 drop) was stirred at 50 C. for 3 days. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the obtained mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (211 mg).1H NMR (300 MHz, DMSO-d6) delta 3.84 (3H, s), 7.15 (1H, dd, J=9.0, 2.5 Hz), 7.53 (1H, d, J=2.5 Hz), 7.97 (1H, d, J=9.0 Hz).

The synthetic route of 55690-60-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yamashita, Tohru; Kamata, Makoto; Hirose, Hideki; Murakami, Masataka; Fujimoto, Takuya; Ikeda, Zenichi; Yasuma, Tsuneo; Fujimori, Ikuo; Mizojiri, Ryo; Yukawa, Tomoya; US2011/263562; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169260-97-3,5-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: The carboxylic acid in question (0.55 mmol), the amine in question (0.50 mmol),1 -hydroxy-7-azabenzotriazole (HOAt, 0.75 mmol) and 1 -ethyl-3-(3-di methylaminopropyl)carbodiimide (EDO, 0.55 mmol) were dissolved in 6 mL of DMF. The resulting slurry was stirred for 24h at ambient temperature. Thereafter 3 mL of methanol and 0.2 g of silica gel 018 were added sequentially and the mixture was stirred for 2 h, thenfiltered and solid residue dissolved in 0.5-1 mL of DMSO for HPLC purification (H20:MeOH), gradient). Yield: 20- 80%., 169260-97-3

169260-97-3 5-(Trifluoromethyl)thiazol-2-amine 15388849, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (118 pag.)WO2018/229195; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72850-79-4, Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72850-79-4

A mixture of 2-bromothiazole 8 (152 mg, 0.50 mmol), Et3N (0.28 mL, 2.0 mmol, 4.0 equiv) and the appropriate isothiouronium salt (233 mg, 1.0 mmol, 2.0 equiv) were heated using MW irradiation at 130 C for 30 mins. The solvent was removed under reduced pressure and the orange residue was reconstituted in EtOH (5 mL) and treated with LiOH¡¤H2O (107 mg, 2.55 mmol, 5.1 equiv) for 5 h. The reaction mixture was concentrated under reduced pressure and partitioned between CH2Cl2 (10 mL) and H2O (10 mL). The isolated aqueous phase was made acidic (pH = 1) using 2 M HCl (ca. 3 mL) and extracted using CH2Cl2/EtOH (9:1, 4 ¡Á 10 mL). The combined organic extract was dried (MgSO4), filtered and concentrated to give the title compound (75 mg, 43%) as a white powder;

72850-79-4 Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate 13282759, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Hickey, Shane M.; White, Jonathan M.; Pfeffer, Frederick M.; Ashton, Trent D.; Synlett; vol. 26; 12; (2015); p. 1759 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-23-9, 2,6-Dichloro-1,3-benzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3622-23-9

A mixture of 2,6-dichlorobenzothiazole (1.0 g, 4.9 mmol) and 2-fluoro-4-iodoaniline (2.32 g, 9.8 mmol) in 20 mL BuOH was stirred at 90 C., and then HCl (4 M in dioxane, 1.0 mL) was added. The reaction mixture was stirred with heating at 90 C. overnight, under argon. NMR analysis then showed little 2,6-dichlorobenzothiazole remaining. After BuOH was removed by rotary evaporation, EtOAc (100 mL) and 1 N aqueous HCl (100 mL) were added. The organic layer was separated and washed with 1 N aqueous HCl (100 mL), saturated Na2O2S3 solution (50 mL), water (100 mL), and then dried over Na2SO4. Removal of solvent under reduced pressure afforded a residue, which was triturated with EtOAc (10 mL) and hexanes (40 mL). The solid was filtered and dried in vacuo to a constant weight, to afford the desired product as a light purple solid (0.75 g, 38%). 1H NMR (DMSO-d6) delta 10.45 (s, 1H), 8.35 (t, 1H), 7.95 (s, 1H), 7.70 (d, 1H), 7.58 (d, 2H), 7.30 (d, 1H).

As the paragraph descriping shows that 3622-23-9 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US2004/224997; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

i) To a solution of palladium (II) trifluoroacetate (66.0 mg, 0.20 mmol) and tri-t- butylphosphonium tetrafluoroborate (58.0 mg, 0.20 mmol) in anhydrous toluene (10 mL) under an argon atmosphere was added 2-bromo-l,3-thiazole-5-carbonitrile (756 mg, 4.00 mmol) followed by potassium phosphate tribasic (934 mg, 4.40 mmol) then tert-butyl piperazine-1-carboxylate (3.00 g, 16.00 mmol). The reaction mixture was heated at 8O0C for 16 hours. The reaction mixture was diluted with EtOAc (100 mL), water (100 mL) and the layers separated. The aqueous layer was extracted with EtOAc (100 mL), the combined organics washed with water (100 mL) and dried (MgSO4) to give a crude gum. The crude material was purified by flash column chromatography (isohexane to 50 % ethyl acetate then to ethyl acetate) to furnish the desired compound as a white solid (1.00 g, 85 % yield). MS (+ve ESI) (des Boc material) : 195 (M+H)+1R NMR (400.13 MHz, CDCl3) delta 1.48 (s, 9H), 3.57 (m, 8H), 7.69 (s, IH), 440100-94-7

As the paragraph descriping shows that 440100-94-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1127; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81449-93-6,Ethyl 2-chlorothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Dissolve ethyl 2-CHLOROTHIAZOLE-5-CARBOXYLATE (0.927 g, 4. 84 mmol) in methanol. Cool the solution to 0 C, then bubble NH3 into the reaction mixture for 10 minutes. Then seal the reaction vessel and stir for 3 hours. Concentrate the reaction mixture to give the title product : LH NMR (CDC13) : 8. 21 (s, 1H), 8.19 (s, 1H), 7.77 (s, 1H) ; HPLC [YMC-Pro pack C-18 (150 x 4.6 mm, S-5 microm), 0.05% TFA/acetonitrile in 0.05% TFA/WATER at 1.0 ML/MIN, 10-20% over 5 min, 20-95% over 18], tR = 6.9 min, 100% purity, 81449-93-6

Big data shows that 81449-93-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/80996; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.

106092-09-5, The synthetic route of 106092-09-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

16311-69-6, 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,5-dimethyl-4-(hydroxyethyl) thiazolium iodide (2.5 mmol, 700 mg), methylsulfonyl chloride (3 mmol, 0.25 ml) and triethylamine (5 mmol, 0.35 ml) in CH3CN(20 ml) was stirred at 0 C for 2 h, under argon. After rotary evaporation, the crude product was dissolved in ethanol (25 ml). Potassium thioacetate (3 mmol, 343 mg) was added dropwise and the mixture was allowed to reflux for 72 h. The product mixture was rotary evaporated to dryness, then the resultant crude solid was dissolved in formic acid (5 ml). Performic acid was generated by stirring hydrogen peroxide (14 mmol, 1.8 ml) and formic acid (30 mmol, 1.4 ml) at room temperature for 1 h. The performic acid solution was cooled to 0 C and added to the reaction mixture. The mixture was left stirring for 48 h. Excess solvent was removed by rotary evaporation and the final crude product was purified by HPLC. 1H NMR (300 MHz,DMSO-d6) delta 9.90 (s, H), 4.05 (s, 3 H), 3.14-3.19 (t, J = 7.1 Hz, 2 H),2.70-2.75 (t, J = 7.0 Hz, 2 H), 2.41 (s, 3 H).

16311-69-6, 16311-69-6 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide 9838770, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zeng, Hao; Wang, Kai; Tian, Yuan; Niu, Yijie; Greene, Landon; Hu, Zhichao; Lee, Jeehiun K.; International Journal of Mass Spectrometry; vol. 378; (2015); p. 169 – 174;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

344-72-9, Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 39 Preparation of Ethyl 2-Iodo-4-Trifluoromethyl-5-Thiazolecarboxylate To a cold (-5 C.) solution of 4.0 g (0.0166 mole) of ethyl 2-amino-4-trifluoromethyl-5-thiazolecarboxylate, prepared according to U.S. Pat. No. 2,726,237, in 30 ml. of 85% phosphoric acid and 30 ml. of 70% nitric acid was added a solution of 1.26 g (0.0166 mole) of sodium nitrite in 10 ml. of water in 10 minutes. The reaction mixture was stirred for 10 minutes and poured into a solution of 10 g of potassium iodide in 100 ml. of water. The reaction mixture was stirred overnight and extracted with ether. The ether solution was dried and concentrated and the residue was chromatographed on silica gel to give 1.5 g of the desired product, m.p. 75-76 C. Anal. Calc’d. for C7 H5 F3 INO3 S: C, 23.94; H, 1.44; N, 3.99; I, 36.15. Found: C, 23.93; H, 1.44; N, 3.95; I, 36.08.

344-72-9, The synthetic route of 344-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Monsanto Company; US4437875; (1984); A;; ; Patent; Monsanto Company; US4437876; (1984); A;,
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Thiazole | chemical compound | Britannica