Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63139-97-9,(2-Methylthiazol-5-yl)methanamine,as a common compound, the synthetic route is as follows.

63139-97-9, To the solution of 4-bromo-2-methyl-6-(((1S,2S)-2-(1-methyl-1H-pyrazol-3-yl)cyclopropyl)methoxy)pyridazin-3(2H)-one (made according to Example 1, by replacing ((1S,2S)-2-( 5-methylpyridin-2-yl)cyclopropyl)methanol with ((I S,2S)-2-(1-methyl-1H -pyrazol-3-yl)cyclopropyl)methanol, 27 mg, 0.08 mmol) in toluene (2 mL) under N2, (2-methylthiazol-5-yl)methanamine (13 mg, 0.096 mmol), Pd2(dba)3 (7 mg, 0.008 mmol), BINAP (7 mg, 0.012mmol) and Na01Bu (9 mg, 0.096 mmol) were added. After the reaction mixture was stirred at 85C for 4 h, 15 mL water was added. The mixture was extracted with EtOAc (3 x 10 mL). Thecombined organics were dried over MgS04, filtered and concentrated in vacuo. The residue was5 purified by reverse phase chromatography (X bridge Prep C180BD, 40-60% acetonitrile inwater with 10 mmol NH4HC03 modifier) to afford the title compound as an oil. 1H NMR (400MHz, MeOD) o 7.56 (s, 1H),7.42 (d, 1H), 5.96 (d, 1H), 5.89 (s, 1H), 4.59 (s, 2H), 4.15-5.11(m, 1H), 4.04-4.01 (m, 1H), 3.81 (s, 3H), 3.63 (s, 3H), 2.66 (s, 3H), 1.95- 1.89 (m, 1H), 1.61-1.53 (m, 1H), 1.01-0.95 (m, 2H); LRMS m/z (M+H) 387.1 found, 387.15 required.

The synthetic route of 63139-97-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; MCCOMAS, Casey C.; REGER, Thomas S.; QI, Changhe; WO2014/139150; (2014); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2786-51-8,5-Chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

2786-51-8, General procedure: 1 mL Xylene was added into the flask charged with 0.25 mmol 4-quinolinonyl triflate, 0.75 mmol benzothiazole, 5 mol% Pd(TFA)2 (4.1 mg), 20 mol% PCy (14 mg), 0.25 mmol K2CO3, 10 mol% CuI (4.7 mg). The mixture was stirred at 140oC under Ar for 12 hours, then cooled down to room temperature, diluted with 20 mL ethyl acetate and washed with 10 mL H2O. The aqueous layer was extracted twice with ethyl acetate (5 mL) and the combined organic phase was dried over Na2SO4. After evaporation of the solvents the residue was purified by flash column chromatography (silica gel, PE/EtOAc) to afford the desired products 3 and 5.

2786-51-8 5-Chlorobenzo[d]thiazole 14388566, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Tao; Tetrahedron Letters; vol. 57; 51; (2016); p. 5837 – 5840;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, Production Example 49; To a solution of ethyl 2-methyl-1,3-thiazole-4-carboxylate (14.53 g) in MeCN (150 mL) was added NBS (22.66 g), followed by heating under reflux for 3 hours. To the reaction mixture was added NBS (7.55 g), followed by heating under reflux for 2 hours. Under ice-cooling, to the reaction mixture was added a saturated aqueous NaHCO3 solution, followed by stirring for 5 minutes, and then extraction with EtOAc. The organic layer was dried over MgSO4 and then concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (hexane:EtOAc = from 100:0 to 60:40) to obtain ethyl 5-bromo-2-methyl-1,3-thiazole-4-carboxylate (8.52 g) as a yellow solid.

As the paragraph descriping shows that 6436-59-5 is playing an increasingly important role.

Reference£º
Patent; Astellas Pharma Inc.; EP2119716; (2009); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.,693-95-8

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

As the paragraph descriping shows that 693-95-8 is playing an increasingly important role.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
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399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 334: Methyl 2-(3-(4-(6-fluorobenzo[d]thiazol-2-yloxy)phenyl)isoxazole-5- carboxamido)-3-methylbutanoate; To methyl 2-(3-(4-hydroxyphenyl)isoxazole-5-carboxamido)-3-methylbutanoate (200 mg) in N,N’ -Dimethyl formamide (4 ml), cesium carbonate (245 mg) was added and stirred for 15 -20 minutes. To this 2-chloro-6-fluorobenzo[d]thiazole (141 mg) was added and the reaction mixture was stirred at RT for 18 hours. Solvent was evaporated to obtain pale brown solid, which was purified by column chromatography (silica gel, EtOAc – CHCI3) to obtain off white solid, which was crystallized using DCM- Petroleum ether to obtain the title compound as white solid. Yield: 240 mg (81 %); MS (ES+): m/z 470 (M+l); 1HNMR (DMSOd6,300MHz): delta 9.27 (d, IH), 8.08 (d, 2H), 7.93 (dd, IH), 7.8 (s, IH), 7.74 (dd, IH), 7.67 (d, 2H),7.31 (m, IH), 4.33 (m, IH), 3.69 (s, 3H), 2.23 (m, IH), 0.98 (d, 6H)., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIRAMAL LIFE SCIENCES LIMITED; GANGOPADHYAY, Ashok Kumar; KADAM, Kishorkumar, Shivajirao; JADHAV, Ravindra, Dnyandev; MISTRY, Hitesh; SHARMA, Rajiv; WO2010/23609; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.

N- (5-Nitro-1, 3-thiazol-2-yl) pentanamide To a solution of 2-amino-5-nitrothiazole (205 mg, 1.41 mmol) and triethylamine (271 muL, 2.11 mmol) in methylene chloride (25 mL) was added dropwise n-valeroylchloride (180 pL, 1.48 mmol). The reaction solution was stirred over night and washed with a saturated sodium bicarbonate solution. The layers were separated and the organic layer was dried with sodium sulfate, filtered and concentrated. The crude product was purified on a silica gel column using hexane/ethyl acetate (4: 1) as the eluent to give 130 mg (40% yield) of the title compound as a light yellow solid: mp 155-156 C ; IH NMR (CDC13, 300 MHz) 8 11.2 (br s, 1 H), 8.29 (s, 1 H), 2. 59 (t, J= 7 Hz, 2 H), 1.84-1. 74 (m, 2 H), 1. 51-1. 39 (m, 2 H), 0. 98 (t, J= 7 Hz, 3 H) ; 13C NMR (CDC13, 75 MHz) 8 171. 67,162. 02,143. 46, 139. 46, 35.98, 26.38, 22.24, 13.67 ; EIMS (70 eV) m/z (relative intensity) 229 (M+, 34), 85 (100), 57 (24)., 121-66-4

121-66-4 5-Nitrothiazol-2-amine 8486, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WO2003/89419; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-77-3,2,4-Dibromothiazole,as a common compound, the synthetic route is as follows.

Frame-dried 200 mL four-necked flask was purged with nitrogen and Xantphos (Xantphos, 220 mg, 0.38 mmol),Tris (dibenzylideneacetone) dipalladium (0) (Pd 2 (dba) 3,840 mg, 0.38 mmol) and dry tetrahydrofuran (dry THF, 75 mL) were added and stirred for 5 minutes, Thereby preparing a THF solution.Another flame-dried 200 mL four-necked flask was purged with nitrogen, 2,4-dibromothiazole (Compound 101 in the following formula (A), 3.6 g, 15 mmol),Phenylboronic acid (1.9 g, 16 mmol),Triopotassium phosphate (9.6 g, 45 mmol),The above THF solution was added, And the mixture was heated under reflux at 60 C. for 18 hours.After returning to room temperature,Celite filtration was carried out using dichloromethane. Removal of the solvent and purification by column chromatography gave the compound of the following formula (A), And 2.4 g of a white solid compound represented by “102” (yield: 66%).

4175-77-3, As the paragraph descriping shows that 4175-77-3 is playing an increasingly important role.

Reference£º
Patent; Nara Institute of Science and Technology; Kawai, Tsuyoshi; Asato, Ryousuke; Yanagida, Takayuki; Okada, Go; Nakajima, Takuya; (35 pag.)JP2018/140974; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.21 2-(3-(4-Methoxyphenyl)propanoyl)benzo[d]isothiazol-3(2H)-one (25) Compound 25 was prepared through 3-(4-methoxyphenyl)propionic acid, obtained a white solid in 94% yield. Mp 110.8-112.1 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 8.0 Hz, 1H), 7.20 (d, J = 8.4 Hz, 2H), 6.86 (d, J = 8.4 Hz, 2H), 3.72 (s, 3H), 3.36 (t, J = 7.6 Hz, 2H), 2.90 (t, J = 7.6 Hz, 2H). 13C NMR (101 MHz, DMSO-d6) delta 172.7, 163.5, 158.1, 141.3, 135.0, 132.9, 129.8, 127.4, 126.6, 125.7, 122.5, 114.2, 55.4, 39.4, 29.2. IR (KBr, cm-1): 1690, 1671. HRMS-ESI (m/z) calcd for C17H15NO3S [M+H+] 314.0851, found 314.0836.

2634-33-5, As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
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668484-45-5, 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

668484-45-5, 2-(4-(tert-butoxycarbonyl)piperazin- 1 -yl)thiazole4-carboxylic acid (156 mg, 0.5 mmol), tert-butyl 2-amino-4-(thiophen-2-yl) phenylcarbamate (130 mg, 0.45 mmol) and EDCI (191 mg, 1 mmol) were added into Py (5 ml). The mixture was stirred at room temperature for overnight. When the reaction finished, it was concentrated and water was added. The yellow solid was collected as product (210 mg, 80% yield).

As the paragraph descriping shows that 668484-45-5 is playing an increasingly important role.

Reference£º
Patent; Regenacy Pharmaceuticals, LLC; van Duzer, John H.; Mazitschek, Ralph; (123 pag.)US2018/141923; (2018); A1;,
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Thiazole | chemical compound | Britannica