Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117724-63-7,2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.,117724-63-7

9-Dichloromethylidene-5-amino-benzonorbomene (175 mg, 0.73 mmol), 2- methyl-4-trifluoromethyl-thiazole-5-carboxylic acid (162 mg, 0.77 mmol, 1.05 eq.) and triethylamine (184 mg, 1.8 mmol, 2.5 eq.) were reacted with bis-(2-oxo-3-oxazolidinyl)- phosphinic acid chloride (278 mg, 1.09 mmol, 1.5 eq.) in dichloromethane (10 ml) at 25 0C for 20 hours. The reaction mixture in ethyl acetate was washed successively with water and saturated. Sodium chloride solution, dried over sodium sulphate, evaporated and purified on silica gel (ethyl acetate-hexane-(l:2) to give 250 mg colourless crystals (m.p. 136-139 0C).

The synthetic route of 117724-63-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/48556; (2007); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.911466-96-1,2-(Ethoxycarbonyl)thiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Isobutyl chloroformate (1.16 ml, 8.95 mmol) was added to an ice-cooled (0C) suspension of 2- (ethoxycarbonyl)-1 ,3-thiazole-4-carboxylic acid (216) (1.5 g, 7.46 mmol) and TEA (1 .25 ml, 8.95 mmol) in THF (60 ml). The reaction was stirred at 0C for 1 h. The reaction was filtered through a plug of Celite and NaBH4 (0.705 g, 18.64 mmol) was added to the filtrate and stirred for 2h. The reaction was diluted with sat. aq. Na2C03 solution and stirred for 10 mins, then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2S04), filtered and the solvent evaporated. Purification by flash column chromatography (eluting with a gradient of 40-50% EtOAc-Heptane) gave the titled compound (0.734 g, 52.6%) as a crystalline solid. 1 H-NMR (DMSO-d6, 500 MHz) d[ppm]= 7.85 (s, 1 H), 5.50 (t, J = 5.8 Hz, 1 H), 4.63 (dd, J = 5.8, 0.8 Hz, 2H), 4.37 (q, J = 7.1 Hz, 2H), 1.33 (d, J = 7.1 Hz, 3H) HPLCMS (ESI+): [m/z]: 187.90 [M+H], 911466-96-1

911466-96-1 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid 53487863, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VIFOR (INTERNATIONAL) AG; DUeRRENBERGER, Franz; BUHR, Wilm; BURCKHARDT, Susanna; BURGERT, Michael; KALOGERAKIS, Aris; REIM, Stefan; MANOLOVA, Vania; BOYCE, Susan; YARNOLD, Christopher John; PENA, Paula; SHEPHERD, Jon; LECCI, Cristina; JARJES-PIKE, Richard; SCOTT, John; (416 pag.)WO2017/68089; (2017); A2;,
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24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
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1123-99-5, 2-Iodobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under a nitrogen atmosphere, in 25 ml substrate is added into the test tube reactor 3dfm (0.2mmol, 52.0 mg), 1-chloro-butane (3.0mmol, 276.0 mg), PdCl2(dppf) (0.02mmol, 14.6 mg), DPPF (0.01mmol, 5.6 mg), Cs2CO3(0.3mmol, 195.0 mg), Na2S2O35H2O (0.5mmol, 248.0 mg), DMSO (4.0 ml) and glycol (0.1 ml). Heating the reaction system to 120 C for reaction. TLC detection after the reaction is ended, the system is cooled to room temperature. Hydrosolvent quenching reaction with saturated ammonium chloride, extracted with ethyl acetate (3*10 ml), column chromatography purification to obtain the product 3df (62%)., 1123-99-5

1123-99-5 2-Iodobenzo[d]thiazole 827981, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; East China Normal University; JIANG, XUE FENG; QIAO, ZONG JUN; (33 pag.)CN103848767; (2016); B;,
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556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-Oxo-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and piperidin-4-one the title compound was obtained as white solid (38%). MS: m/e=391 (M+H+).

383865-57-4, As the paragraph descriping shows that 383865-57-4 is playing an increasingly important role.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.

-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile Under an atmosphere of nitrogen, a mixture of 4-bromo-2-hydroxybenzonitrile (commercially available from for example Fluorochem) (15 g, 76 mmol), 4-methylthiazole (commercially available from for example Aldri

693-95-8, 693-95-8 4-Methylthiazole 12748, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; YALE UNIVERSITY; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMBRIDGE ENTERPRISE LIMITED UNIVERSITY OF CAMBRIDGE; CREWS, Craig, M.; BUCKLEY, Dennis; CIULLI, Alessio; JORGENSEN, William; GAREISS, Peter, C.; MOLLE, Inge, Van; GUSTAFSON, Jeffrey; TAE, Hyun-Seop; MICHEL, Julien; HOYER, Dentin, Wade; ROTH, Anke, G.; HARLING, John, David; SMITH, Ian Edward, David; MIAH, Afjal, Hussain; CAMPOS, Sebastian, Andre; LE, Joelle; WO2013/106646; (2013); A2;,
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14527-41-4, 5-Thiazolecarboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 3: Step a N-Methoxy-N-methylthiazole-5-carboxamide Triethylamine (2.77 mL, 19.9 mmol) was added slowly to a mixture of commercially available thiazole-5-carboxylic acid (1.03 g, 7.98 mmol), N,O-dimethylhydroxylamine hydrochloride (0.778 g, 7.98 mmol), and EDCI (1.83 g, 9.57 mmol) in CH2Cl2 (10 mL). The mixture was stirred at room temperature for 72 hours then quenched with saturated aqueous NaHCO3. Water (50 mL) was added followed by additional CH2Cl2. The mixture was stirred for 10 minutes and layers were separated. The CH2Cl2 layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure and the residual oil was chromatographed (CH2Cl2/EtOAc) to provide the title compound as a white solid., 14527-41-4

14527-41-4 5-Thiazolecarboxylic acid 84494, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; US2014/107096; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

0.15 mmol6-(2-chloropyrimidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole,0.30 mmol 4-cyclopropyl-2-aminothiazole,0.025 mmol of tris(dibenzylideneacetone) dipalladium,0.028 mmol 2-dicyclohexylphosphor-2′,6′-diisopropoxy-1,1′-biphenyl,Mix 0.5 mmol cesium carbonate and 80 mL 1,4-dioxane.Put it on a vacuum pump for 10 minutes.Remove the water in the reaction material,In an argon atmosphere,110 ¡ãC reaction overnight;After the reaction is completed, naturally cool to room temperature.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.Dry the resulting organic layer under reduced pressureThen column chromatography,N-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)pyrimidin-2-amine is obtained;0.5mmolN-(4-cyclopropylthiazol-2-yl)-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)Pyrimidin-2-amine,Mix 5 mL of ethanol with 0.5mL of hydrochloric acid 1,4-dioxane solution.70 ¡ã C reaction 2h;After the reaction is complete, the resulting material is adjusted to pH 8 with saturated sodium bicarbonate solution.Extracted with ethyl acetate,The resulting organic phase is washed with saturated sodium chloride solution.The resulting organic layer was spin-dryed under reduced pressure and then subjected to column chromatography.The target product N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine was obtained as a white solid.(N-(4-cyclopropylthiazol-2-yl)-4-(1H-indazol-6-yl)pyrimidin-2-amine.Compound No. 2n)., 324579-90-0

As the paragraph descriping shows that 324579-90-0 is playing an increasingly important role.

Reference£º
Patent; South Medical University Zhongxiyi Binding Hospital; Zhu Zhibo; Zhou Jin; Yang Zike; Wang Hao; Liao Bohong; (21 pag.)CN107721991; (2018); A;,
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Thiazole | chemical compound | Britannica