Category: thiazole

7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Comparative Example 1 Synthesis of 2-chloro-5-methylthiazole In a 300 ml volume three necked flask equipped with a stirrer, a dropping funnel and a thermometer, 20 g of 2-amino5-methylthiazole (0.175 mol), 35 ml of 36% hydrochloric acid (0.407 mol) and 30 ml of water were placed and cooled to -5 C. To the mixture, 14 g of sodium nitrite (0.203 mol) dissolved in 30 ml of water was gradually added dropwise at 0 C. or lower. The reaction mixture was further caused to react for three hours at 0 C. or lower to give the diazonium base. The reaction mixture was heated to 80 C. for three hours and extracted with three 40 ml portions of chloroform to give a chloroform solution containing 2-chloro-5-methylthiazole. The chloroform was removed by atmospheric distillation and remained fraction was distilled under reduced pressure to isolate 10.3 g of 2-chloro-5-methylthiazole (0.077 mol) with a yield of 44%., 7305-71-7

Big data shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Patent; Kureha Chemical Industry Co., Ltd.; US5811555; (1998); A;,
Thiazole | C3H3NS – PubChem
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19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: A mixture of 2-aminobenzothiazole (0.150g, 1mmol), phenyl isothiocyanate (0.135g, 1 mmol) and Dimethyl amino pyridine (5 mol%) in DMF (1 mL) was stirred at room temperature for 2.0 h and the progress of the reaction was followed by TLC. After completion of the reaction, water (5 mL) was added to reaction mixture and extracted with ethyl acetate (2×5 mL). The organic layer was separated and dried over anhy. Na2SO4, and solvent was removed under reduced pressure. The crude product was purified by column chromatography (60-120 mesh) using (ethyl acetate: n-hexane, 10:90) to obtain 3a (0.256g, 90%) as a white powder.

19952-47-7, As the paragraph descriping shows that 19952-47-7 is playing an increasingly important role.

Reference£º
Article; Kumbhare, Ravindra M.; Dadmal, Tulshiram; Kosurkar, Umesh; Sridhar; Rao, J. Venkateswara; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 453 – 455;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a stirred solution of compound 64 (5 g, 38.75 mmol) in CH2C12 (150 mL) under inert atmosphere were added triethyl amine (8.3 mL, 58.13 mmol), methanesulfonyl chloride (4.6 mL, 46.51 mmol) at 0 C; warmed to RT and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (50 mL) andextracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 65 (5 g, 87%) as a pale-yellow syrup. TLC: 30% EtOAc/ hexanes (Rf: 0.8); LC-MS: 77.92%; 147.7 (M+1) (column; Ascentis Express C18, (50 x 3.0 mm, 2.7 jim); RT 1.71 mm. 0.025% Aq. TFA + 5% ACN: ACN + 5% 0.025% Aq. TFA, 1.2 mL/min).

56012-38-5, 56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William; ARNOLD, Lee, Daniel; LI, Leping; BURES, Mark; HAYDAR, Simon; MAAG, Hans; BANNEN, Lynne; (176 pag.)WO2018/53157; (2018); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

5464-79-9, Step A. A solution of AICl3 (5 mmole) in ETSH (10 ML) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole).. The mixture was stirred at 0-5 C. for 2 h.. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Metabasis Therapeutics, Inc.; US6756360; (2004); B1;,
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556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.4 5-(4-Hydroxy-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14d) Orange solid; mp > 200 C; 330 mg, 61% yield; IR (neat) numax = 3164, 2772, 1679, 1604 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.46 (br s, 1H), 9.18 (s, 1H), 8.05 (s, 1H), 7.75 (d, J = 8.74, 1H), 7.55 (s, 1H), 7.24 (d, J = 8.72, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.71, 175.57, 153.52, 137.52, 136.46, 129.04, 127.52, 126.27, 125.66, 120.53 HRMS (ESI-TOF): m/z calculated for C10H7N3O4S [M+Na]+, 288.0055; found 288.0046.

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19654-14-9, 2-(3-Bromophenyl)benzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,3,5-tris(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (4) (500 mg, 1.14 mmol), 2-(3-bromophenyl)benzo[d]thiazole (7) (1.15 g, 3.98 mmol), tetrakis(triphenylphosphine)palladium (140 mg, 0.12 mmol), sodium carbonate (1.51 g, 14.2 mmol), THF (25 mL), and water (14 mL) was degassed for 25 minutes. The mixture was heated at reflux (80 C.) overnight under argon. After cooling, the mixture was poured into ethyl acetate (125 mL) then washed with saturated sodium bicarbonate solution (100 mL), water (100 mL), and brine (100 mL). A flash column (gradient of 5 to 10% acetone in hexanes) and precipitation from methylene chloride/methanol gave 611 mg of material (ET-3) in 76% yield., 19654-14-9

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zheng, Shijun; US2011/196158; (2011); A1;,
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Thiazole | chemical compound | Britannica

348-40-3, 6-Fluorobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,348-40-3

Concentrated hydrochloric acid (0.067 mol) was added dropwise with stirring tohydrazine hydrate (0.12 mol) at 5-6 C followed by ethylene glycol (30 mL);thereafter, 6-uorobenzo[d]thiazol-2-amine (1) (20 mmol) was added in portionsand the resultant mixture was reuxed for 2-3 h and cooled at room temperature.The reaction progress was monitored by TLC using toluene:ethylacetate (75:25) asmobile phase. The reaction mixture was ltered and the resulting precipitates werewashed with distilled water. The resulting crude was recrystallized from ethanol. IR(KBr) mmax: 3010 (=C-H str), 1645 (C=C str), 1398 (C=N str). The 1HNMR(DMSO-d6) spectrum of this product showed signals: d 7.2-7.4 (3H, m, Ar C-H), at4.0 (1H, br, NH) and 4.75 (2H, br, NH2) ppm. The peaks in its 13CNMR (DMSO-d6)d: 106.1, 112.4, 115.5, 129.7, 145.5, 157.5, 171.2 ppm.

The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2103-99-3,4-(4-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

3,4-Dibutyryloxybenzoic acid (216 mg, 0.73 mmol) was dissolved in dichloromethane (5 mL). DMF (50 muL) and 2 M oxalyl chloride in CH2Cl2 (0.6 mL) were added to it at RT The mixture became a yellowish solution. After 0.5 hour stirring, the solvent was removed in vacuo. The residue was dissolved in dioxane (10 mL). 2-Amino-4-(4-chlorophenyl)thiazole (210 mg, 1.0 mmol) was added to it, followed by addition of pyridine (150 uL). The mixture was heated at 100¡ã C. for 1 hour. After cooling down to RT, the solvent was removed in vacuo. The residue was dissolved in EtOAc (50 mL) and washed with water (50 mL). The EtOAc solution was dried over sodium sulfate. After filtration and concentration, the residue was purified by chromatography eluted with CHCl3. The collected fractions were concentrated and purified again by chromatotron (silica) eluted with CHCl3 to afford the product (120 mg, Y=34percent). 1H NMR (CDCl3) delta 10.01 (bs, 1 H), 7.70-7.80 (m, 4 H), 7.35 (d, J=8.7 Hz, 2 H), 7.30 (dd, J=8.44 Hz, J=1.8 Hz, 1 H), 7.18 (s, 1 H), 2.55 (t, d=7.5 Hz, 2 H), 2.54 (t, d=7.5 Hz, 2 H), 1.70-1.86 (m, 4 H), 1.06 (t, d=7.5 Hz, 3 H), 1.05 (t, d=75 Hz, 3 H); 13C NMR (CDCl3) delta 170.5, 170.2, 163.0, 158.2, 148.9, 145.7, 142.3, 133.7, 132.5, 130.0, 128.7 (2 C), 127.2 (2 C), 125.4, 123.9, 123.1, 108.5, 35.9, 35.8, 18.5, 18.4, 13.7 (2 C); MS (MALDI-TOF) m/z calcd for C24H24ClN2O5S (M+H+) 487, found 487., 2103-99-3

The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Apogee Biotechnology Corporation; US2007/32531; (2007); A1;,
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Thiazole | chemical compound | Britannica

51640-36-9,51640-36-9, 2-Chlorothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-{[2-(4-acetylpiperazin-1-yl)pyrimidin-4-yl]amino}-1,3-thiazole-5-carbonitrile (4-5) 2-(4-acetylpiperazin-1-yl)pyrimidin-4-amine 4-4 (0.1 g, 0.45 mmol) was dissolved in dry TBF and then 1 equivalent of sodium hydride (0.036 g, 0.45 mmol) was added and this was stirred for 20 minutes at 25 C. then 2-chloro-1,3-thiazole-5-carbonitrile 2-2 (0.065 g, 0.45 mmol) was added followed immediately by 1 more equivalent of sodium hydride. The reaction was then stirred at 100 C. for 3 hours. The reaction was cooled to 25 C. and methanol was added. This solution was loaded directly onto a silica column and eluted with DCM:MeOH:NH4OH (95:5:0.5). Fractions were combined and evaporated to yield the product, 4-5. Hi-Res MS: calc: 330.1132 found: 330.1137. 1H-NMR (DMSO): 8.33 ppm (s, 1H); 8.19 ppm (d, 1H); 6.34 ppm (d, 1H); 3.88 ppm (m, 2H); 3.80 ppm (m, 2H); 3.57 ppm (m, 4H); 2.07 ppm (s, 3H).

The synthetic route of 51640-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-06-9,4-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: Compound 9 (0.1mmol) added to dry CH2Cl2 (15mL) was stirred at 0C and oxalyl chloride (2.0mmol) was dripped into the mixture and stirred at the same temperature for 12h. After the reaction, the solvent and excess oxalyl chloride was evaporated under the reduced pressure, then add CHCl3. Compounds 2 (0.1mmol) and triethylamine (0.15mmol) were added to the mixture and reflux at 65C for 5h. After the reaction, the solvent was evaporated under reduced pressure, and the crude product was purified by chromatography on silica gel eluted with petroleum CH2Cl2/CH3OH (V: V=60:1) to offer the target compounds 11a-11k in good yields., 20358-06-9

As the paragraph descriping shows that 20358-06-9 is playing an increasingly important role.

Reference£º
Article; Jin, Le; Huang, Rizhen; Huang, Xiaochao; Zhang, Bin; Ji, Min; Wang, Hengshan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1759 – 1775;,
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Thiazole | chemical compound | Britannica