Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

777-12-8, 102031 5 -chloro-2-methoxy-3 -ethylbenzoic acid (100mg, 0 .467mmo1) was dissolved in DMF (5m1). HBTU (2 13mg, 0.56 immol) was added followed by DIPEA (244u1, 1.4Ommol). The resulting mixture was stirred at rt for l5mins, then 6- (trifluoromethyl)benzo[d]thiazol-2-amine (102mg, 0 .467mmo1) was added. The resulting mixture was stirred at 120¡ãC for 24h. Saturated NH4C1 solution was added and extracted with EA for two times. The combined EA layer was dried over Na2504 and concentrated under reduced pressure. The residue was purified via silica gel column chromatography to give title compound as a yellow powder (115mg, 62percent). ?H NIVIR (300 IVIFIz, Acetone-d6) 8.40 (s, 1H), 8.10 (s, 1H), 7.90 (d, J = 8.7 Hz, 1H), 7.81 (d, J = 8.1 Hz, 1H), 7.39 (s, 1H), 2.72 (q, J=9.OHz, 2H), 1.24 (t, J = 9.0 Hz, 3H). MS (ESI) [M+H]requires m/z 401.03, found m/z400.6.

As the paragraph descriping shows that 777-12-8 is playing an increasingly important role.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 309 /V-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H- pyrazolo[3,4-/j]pyridin-5-yl]methyl}-2-methyl-1,3-thiazoIe-4-carboxamide2-Methyl-1 ,3-thiazole-4-carboxylic acid [e.g. available from Acros Organics] (125mg) was dried overnight under vacuum over phosphorus pentoxide and was then suspended in dry dichloromethane (2ml) and treated at 2O0C with oxalyl chloride (0.077ml) and DMF (1 drop). The mixture was stirred at room temperature for 25mins and was then added dropwise to a solution of Intermediate 16 (240mg) in anhydrous acetonitrile (5ml). DIPEA (0.155ml) was added and the solution stirred at room temperature for 3h. The solution was blown down to dryness and purified by mass directed autoprep HPLC to give a pale orange gum. The gum was further purified using an SPE cartridge (5g, aminopropyl) which had been pre-washed with methanol. Elution with methanol gave Example 309 as a pale orange gum (287mg). LCMS showed MH+ = 429; TRET = 2.37min., 35272-15-2

The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

101012-12-8, 2-Chloro-1,3-thiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of 2-chlorothiazole-5-carboxylic acid (compound of formula XIV) (25 g, 152.8 mmol) in thionyl chloride (54.54 g, 458 mmol, 3 eq) and a catalytic amount of DMF were heated at 1 10C for 16 hours. Then excess thionyl chloride was removed to give 28.3 g of crude 2-chlorothiazole-5- carbonyl chloride XV. In a sealed tube PCI5 (102 g, 489 mmol, 3.2 eq) was added to the acid chloride and the mixture was heated at 190C for 48 hours. The reaction mixture was slowly poured into ice water keeping the temperature below 10C. The flask was washed with dichloromethane and the aqueous phase was extracted with dichloromethane (3 X 200 ml). The combined organic phases were washed with water (1 x 100 ml) and brine (1 x 100 ml), dried over anhydrous Na2S04 and concentrated to give 42.5 g of crude material. The residue was dissolved in 100 ml dichloromethane, 100 ml 10% NaOH solution was added, and the mixture was stirred for 1 hour. The phases were separated and the aqueous phase was extracted with dichloromethane. The combined organic phases were washed with water and brine, dried over anhydrous Na2S04, and concentrated. The residue was purified through silica gel column using hexane as an eluent. 22.2 g (92.7 mmol) of product XIII were obtained (yield 61.3%).

101012-12-8, As the paragraph descriping shows that 101012-12-8 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; HUETER, Ottmar, Franz; HOPPE, Mark; SMEJKAL, Tomas; DUMEUNIER, Raphael; FEDOU, Nicolas; GODINEAU, Edouard; WEGE, Philip; MAIENFISCH, Peter; (61 pag.)WO2019/81575; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3364-80-5

General procedure: A solution of substituted o-phenyldiamine (1.0 equiv), thiazole-4-aldehyde or pyridine-2-aldehyde (1.0 equiv) with sodium pyrosulfite in DMF was stirred at 120¡ã C overnight. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product. If necessary, the crudeproduct could be recrystallized in DCM or dichloroethane to afford pure sample.

The synthetic route of 3364-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,615-21-4

14.5 g (87.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 200 ml ofDMF under a nitrogen stream in a four-necked reactor equipped with a thermometer. To this solution were added 36.3 g (263 mmol) of potassium carbonate and 25.0 g (105 mmol) of 1,1,1-trifluoro-4-iodobutane and the whole mass was stirred at 80 C. for 8 hours. After completion of the reaction, the reaction solution was cooled to 20 C. and added to 1,000 ml of water, and the mixture was extracted with 1,000 ml of ethyl acetate. After drying the ethyl acetate layer over anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate on a rotary evaporator to afford a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane/ethyl acetate=85:15) to afford 9.61 g of compound (3m) as a white solid (yield: 39.9%). The structure of the target product was identified by 1H-NMR .1H-NMR(500 MHz, CDC13 , TMS, oppm): 7.61(d, lH, 1=8.0 Hz), 7.54(d, lH, 1=7.8 Hz), 7.30(dd, lH, 1=7.8 Hz, 7.8 Hz), 7.09(dd, lH, 1=7.8 Hz, 8.0 Hz), 4.24(s, 2H), 3.81(t, 2H, 1=7.0 Hz), 2.16-2.26(m, 2H), 1.99-2.05(m, 2H)

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, Kei; OKUYAMA, Kumi; SANUKI, Kanako; (45 pag.)US2018/99921; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

777-12-8, To a stirred solution of methyl 5-chloro-3-cyano-2-methoxybenzoate (86mg, 0.382mmo1) in MeOH (3m1) was added 2.0 ml iN KOH solution. The resulting mixture was stirred at 60¡ãC overnight. The solvent was evaporated out and 4N HC1 in dioxane (lml) was added to the residue. The mixture was stirred for another 10mm before it was concentrated and dried under vacumn. To this residue was added HBTU (172mg, 0.456mmo1), DMF (3m1) and DIPEA (330u1, 1.9 mmol). The mixture was stirred for lOmins and then 6-(trifluoromethyl)benzo[d]thiazol-2-amine (83mg, 0.3 8mmol) was added. The resulting reaction was heated at 120 ¡ãC for 24hs. After cooled to rt, the mixture was separated between EA and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by column chromatography gave the 5-chloro-3-cyano-2- hydroxy-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)b enzamide as a yellow solid (62mg, 42percent). ?H NMR (300 IVIHz, Acetone-d6) 8.31 (dt, J = 1.6, 0.9 Hz, 1H), 7.85 (d, J = 3.0 Hz, 1H), 7.79 -7.65 (m, 2H), 7.14 (d, J = 3.0 Hz, 1H). MS (ESI) [M+H] requires m/z 398.00, found m/z 397.95.

The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

69812-29-9, General procedure: To a solution of 1 (0.5g, 2mmol) in CH2Cl2 (30mL), K2CO3 (1.8g, 6mmol) and the substituted benzoyl chloride (2mmol) were added and stirred at 0C untill the TLC analysis showed completion of the reaction, then filterd. The filtrate was washed with water, brine, dried, filtered and concentrated. Then the residue was purified by flash column chromatography on silica gel with CH2Cl2/CH3OH as the eluent to give the title compounds.

69812-29-9 2-Acetamido-4-methylthiazole-5-sulfonyl chloride 96951, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Xin; Lv, Xiao-Qin; Tang, Sheng; Mei, Lin; Li, Ying-Hong; Zhang, JingPu; Jiang, Jian-Dong; Peng, Zong-Gen; Song, Dan-Qing; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1053 – 1065;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7504-44-1,7504-44-1, 2-(4-Thiazolyl)acetic Acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

HATU (2.12 g, 5.58 mmol) was added to a mixture containing of 2-((lr, 4r)-4-((5 -amino-i -(phenyl sulfonyl)- 1H-pyrrolo[2,3 -b]pyridin-4- yl)amino)cyclohexyl)acetonitrile (Intermediate 2, 1.14 g, 2.78 mmol), 2-(thiazol-4-yl)acetic acid(400 mg, 2.79 mmol), DIPEA (722 mg, 5.59 mmol)and DMF (10 mL) at 0 C (ice / water) and was stirred at room-temperature for 2 hours. The reaction was partitioned between EtOAc (100 mL) and water (100 mL), the aqueous phase was extracted with ethyl acetate (50 mL x 3) and the combined organic extracts were dried over anhydrous Na2504, filtered, and concentrated to dryness. The residue was purified by flash column chromatography to provide the titlecompound (1.5 g, 95% yield) as a yellow solid. MS (ESI): mass calcd. for C26H26N60352,534.65; m/z found, 534.9 [M+H]t

7504-44-1 2-(4-Thiazolyl)acetic Acid 236262, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis M.; CHAI, Wenying; KOUDRIAKOVA, Tatiana; KRAWCZUK, Paul J.; KREUTTER, Kevin D.; LEONARD, Kristi; RIZZOLIO, Michele C.; SEIERSTAD, Mark; SMITH, Russel C.; TICHENOR, Mark S.; VENABLE, Jennifer D.; WANG, Aihua; (452 pag.)WO2018/112382; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of 1,2-benzisothiazol-3-one 1 (151 mg, 1 mmol), inTHF (10 ml), K2CO3 (276 mg, 2 mmol) was added at room temperaturefor 30 min, then t-butyl bromoacetate 10 (195 mg, 1 mmol)was added. After the reaction was stirred at room temperaturefor 3 h, the solvent was removed under vacuum. The residualwas isolated by column chromatography (ethyl acetate/petroleumether, 15:1) to yield 11. The intermediate 11 (265 mg, 1 mmol) indry CH2Cl2 (10 ml) was treated with trifluoroacetic acid (TFA,3.3 ml) for 5 h at room temperature and the solvent was removedunder vacuum. The residue washed with ethyl ether (2 25 ml) toyield the desired product 12 as white solid. A solution of compound 12 (209 mg, 1 mmol) in dry THF(10 ml) was added portion wise to a suspension of carbonyldiimidazole(162 mg, 1 mmol) in THF (5 ml) and the mixture was stirredat room temperature for 20 min and then refluxed for 10 min.A solution of primary amine (1 mmol) in THF (5 ml) was addedand the reaction mixture was stirred at room temperature overnight.A white precipitate formed, which was collected by suctionfiltration.

2634-33-5, The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2416 – 2426;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

383865-57-4, 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-urea Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and benzylamine the title compound was obtained as an off-white solid (99%), MS: m/e=399 (M+H+).

383865-57-4, 383865-57-4 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine 11402861, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica