Category: thiazole

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

556-90-1, General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.3 5-(4-Hydroxy-3-methoxybenzylidene)-2-iminothiazolidin-4-one (14c) Yellow solid; mp > 200 C; 215 mg, 43% yield; IR (neat) numax = 3364, 2955, 1735, 1680, 1584 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.76 (s, 1H), 9.29 (br s, 1H), 9.05 (s, 1H), 7.50 (s, 1H), 7.13 (s, 1H), 7.06 (d, J = 8.28, 1H), 6.9 (d, J = 7.92, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 175.91, 148.92, 148.35, 130.35, 125.94, 125.81, 123.69, 116.49, 113.88, 56.00; HRMS (ESI-TOF): m/z calculated for C11H10N2O3S [M+H]+, 251.0490; found 251.0491.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

78364-55-3, General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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Thiazole | chemical compound | Britannica

88982-82-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 4-bromothiazole-2-carboxylic acid 8 (5.5 g, 26.8 mmol) in anhydrous DMF (30 mL) was added carbonyl diimidazole (CDI) (5.2 g, 32.3 mmol), and the reaction mixture was stirred at room temperature for 1 h. (E)-4-[3-(3,4,5-Trimethoxyphenyl]-1,2,4-thiadiazol-5-ylamino)-N’-hydroxybenzamidine 7 (13 g, 32.3 mmol) was added to the reaction mixture and it was stirred at 110 C for 15 h. After completion of the process, the mixture was cooled down and poured into ice-cold water (35 mL), extracted by ethyl acetate (3¡Á15 mL), and the combined organic phases were washed with brine, dried over anhydrous sodium sulphate, filtered off, and concentrated under vacuum. The crude product was purified by column chromatography using ethyl acetate/hexane (1 : 1) to afford pure compound 9, yield 79 %.

The synthetic route of 88982-82-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sudhakar; Rao, A. Srinivasa; Reddy, Ch. Venkata Ramana; Russian Journal of General Chemistry; vol. 89; 8; (2019); p. 1696 – 1701;,
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Thiazole | chemical compound | Britannica

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Preparation of acetoacetamide derivatives (3a-e) was carried out as shown in Scheme 1. 2,2,6-Trimethyl-1,3- dioxine-4-one (1) (2eq) and appropriate arylamine (2a-e) (1eq) were mixed and refluxed for about 2-4h in toluene. The progress of the reactions was checked by TLC. Upon completion of the reaction, the product was filtered, washed with small portions of petroleum ether. Further purification was performed by crystallization of obtained product in hot ethanol. Characteristics data for prepared N-(aryl)-3- oxobutanamides are as follows:

29927-08-0, The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ebadi, Ahmad; Khoshneviszadeh, Mehdi; Javidnia, Katayoun; Ghahremani, Mohammad Hossein; Firuzi, Omidreza; Miri, Ramin; Letters in drug design and discovery; vol. 14; 8; (2017); p. 885 – 897;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

2- (3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) imidazo [1,2- a] pyridine(100 mg, 0.31 mmol),Palladium acetate (4 mg, 0.016 mmol),Triphenylphosphine (16 mg, 0.06 mmol),And sodium carbonate (66 mg, 0.62 mmol)After adding 1,4-dioxane and water at a ratio of 1: 1 in 2 mL portions4-Bromothiazole (51 mg, 0.31 mmol) was added thereto, and the mixture was stirred at 90 ¡ã C for 16 hours.After the reaction is completed, the reaction mixture is cooled to room temperature and the reaction product is separated into water and ethyl acetate. The combined organic layers were concentrated and the concentrate was purified by silica gel column chromatography (dichloromethane: ethyl acetate, 10: 1 v / v) to give 4- (3- (imidazo [1,2- a] pyridin- ) Phenyl) thiazole (45 mg, 52percent).

34259-99-9, As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Jeon Mun-guk; Kim Gwang-rok; Huh Yun-jeong; Lee Jun-mi; (27 pag.)KR2018/101671; (2018); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66947-92-0,Methyl 2-amino-1,3-benzothiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred mixture of VIII-2 (600 mg, 2.28 mmol) and CuBr2 (775 mg, 3.46 mmol) in MeCN (9 mL) was added tert-butyl nitrite (445 mg, 4.32 mmol). The reaction mixture was stirred at rt overnight. The mixture was diluted with EtOAc (40 mL), washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column (PE:EA=5:1) to give VIII-3 (140 mg, yield: 18%)., 66947-92-0

As the paragraph descriping shows that 66947-92-0 is playing an increasingly important role.

Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1826-11-5,2-Phenylthiazole,as a common compound, the synthetic route is as follows.

4.3.1.6 2-Phenylthiazole 11 Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1a (4.4 mg) gave [2′,6′-2H2]-11 (12.2 mg, 89%, 82%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1b (4.6 mg) gave [2′,6′-2H2]-11 (11.0 mg, 80%, 44%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 1c (3.8 mg) gave [2′,6′-2H2]-11 (13.6 mg, 98%, 72%D). Following general procedure A, exchange of 2-phenylthiazole 11 (13.8 mg) in the presence of catalyst 5 (3.4 mg) gave [2′,6′-2H2]-11 (10.8 mg, 78%, 59%D). deltaH (300 MHz, DMSO-d6) 7.97-7.93 (m, 3H), 7.78 (d, 1H, J=3.3 Hz), 7.54-7.48 (m, 3H).

1826-11-5, As the paragraph descriping shows that 1826-11-5 is playing an increasingly important role.

Reference£º
Article; Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc; Rojahn, Patrick; Weck, Remo; Tetrahedron; vol. 71; 13; (2015); p. 1924 – 1929;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Ethyl benzothiazole-2-carboxylate 4a (1 mmol) was taken in around bottom flask (10 mL). To it the aliphatic amine (4 equiv.) wasadded in excess along with (50 mg) of NH4Cl. The reaction mixturewas heated at 150 C for 2e3 h under magnetic stirring. Aftercompletion of reaction (TLC), the mixture was diluted using EtOAc,washed with1N HCl and brine, dried over anhydrous MgSO4 andconcentrated under reduced pressure to furnish the final productthat was then washed with cooled hexane.

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghonim, Aya E.; Ligresti, Alessia; Rabbito, Alessandro; Mahmoud, Ali Mokhtar; Di Marzo, Vincenzo; Osman, Noha A.; Abadi, Ashraf H.; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 154 – 170;,
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Thiazole | chemical compound | Britannica

6633-61-0,6633-61-0, Methyl 2-aminothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE I Preparation of Methyl 2-chlorothiazole-5-carboxylate To 5.0 g of methyl 2-aminothiazole-5-carboxylate [H. E. Faith, U.S. Pat. No. 2,405,820(1946)] suspended in 54 ml of 6 N hydrochloric acid stirred at-5-0 was added dropwise over 15 minutes 3.7 g of sodium nitrite dissolved in 10 ml of water. After stirring 5 minutes, the brown suspension was added in one portion to a rapidly stirred suspension of 10.6 g of cupric sulfate and 10.6 g of sodium chloride cooled at 5. The cooling bath was removed and stirring was continued for 30 minutes. The pH was adjusted to 7.3 with 6 N sodium hydroxide and the green suspension was filtered through Celite. The solid was washed with three portions of ethyl acetate and the extract was combined with the ethyl acetate extract of the original filtrate. After drying the combined extract over magnesium sulfate, concentration in vacuo gave a brown solid. Trituration with four portions of hot petroleum ether (35-60) served to separate the soluble product from some starting material. Concentration in vacuo of the petroleum ether solution gave 3.9 g. of pure methyl 2-chlorothiazole-5-carboxylate having a melting point of 41-46.

The synthetic route of 6633-61-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoffmann-La Roche Inc.; US4168380; (1979); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-60-7,2-Methylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of 2-methylthiazole-5-carbaldehyde (1 g, 7.86 mmol) and ethyl 2-azidoacetate (30% in DCM, 15.8 ml_, 31 .5 mmol) was added dropwise to a solution of NaOEt (21 % in EtOH, 1 1 .7 ml_, 31 .5 mmol) and EtOH (40 ml.) at 0. After stirring for 1 hour at 0C, the temperature was allowed to come to RT and the stirring was continued for another hour. The mixture was quenched with a saturated solution of NH4CI and extracted with Et20. The organic extract was dried over Na2S04, filtered and evaporated. Purification by column chromatography on silica gel using cyclohexane and EtOAc (from 0% to 30%) provided the title compound as brown solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 8.07 (d, 1 H), 7.27 (d, 1 H), 4.31 (q, 2H), 2.69 (s, 3H), 1 .32 (t, 3H). LC-MS: Rt = 1 .05 min; MS m/z [M+H]+ 239.1

1003-60-7, As the paragraph descriping shows that 1003-60-7 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
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Thiazole | chemical compound | Britannica