Category: thiazole

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: Dry sodium nitrite (1.04 g, 15 mmol) was slowly added with stirring to cold concentrated sulphuric acid (10 ml) and warmed to 50 C on water bath. The solution was then cooled to 0 C and a mixture of glacial acetic acid/propionic acid (30 ml, 5:1) was added dropwise with stirring so as to maintain the temperature below 15 C. The resulting solution was then cooled below 0 C and to this, 2-amino-5-nitrothiazole (2.17 g, 15 mmol) was added in small portions while stirring. The stirring was further continued at this temperature for 2 h. The resulting diazonium salt solution was slowly added to resorcinol (1.65 g, 15 mmol) dissolved in 50 ml of 10% sodium hydroxide solution with the reaction temperature was maintained below 0 C. The solution was stirred for 2 h and stood for 30 min to allow the precipitate to settle. The precipitate was filtered and washed several times with water until the filtrate was neutral. The product was finally purified by column chromatography over SiO2 with benzene and ethyl acetate (1:1) as an eluate to give 1.75 g (45% yield) of a., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Article; Kariduraganavar; Tambe; Tasaganva; Kittur; Kulkarni; Inamdar; Journal of Molecular Structure; vol. 987; 1-3; (2011); p. 158 – 165;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Method A [31]: To a solution of the starting aldehyde (1.5 mmol) and ketone (0.75 mmol) in methanol (10 mL) was added the solution of sodium methoxide in methanol (5.4 M, 0.14 mL,0.75 mmol), and the mixture was stirred for 4-18 h and monitored with TLC. When the reaction was completed, the following two work-up procedures were applied. Procedure 1: if precipitate was observed, the precipitate was filtered and rinsed with cold methanol. Procedure 2: if no precipitate was observed, then saturated solution of ammonium chloride was added, and the subsequent mixture was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated under vacuum to give a crude product, which was purified by preparative TLC (3e5percent methanol in dichloromethane) or column chromatography (2percent methanol in dichloromethane)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Article; Samaan, Nawras; Zhong, Qiu; Fernandez, Jayjoel; Chen, Guanglin; Hussain, Ali M.; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 123 – 131;,
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39136-63-5, 5-Phenylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate To 5-phenylthiazol-2-amine (0.52 g, 2.9 mmol) in acetonitrile (6 mL) was added Iota, Gamma-thiocarbonyldiimidazole (0.68 g, 3.8 mmol). The reaction mixture was stirred at 65 C for 2 hours. The precipitate was filtered and washed with acetonitrile (2 x 20 mL) to yield intermediate N-(5-phenylthiazol-2-yl)- ^-imidazole-l- carbothioamide. The intermediate was taken up in N,N-dimethylformamide (30 mL) and treated with (3-(aminomethyl)-3-hydroxy-l-ammoniobicyclo[2.2.2]octan-l- yl)trihydroborate (0.5 g, 2.9 mmol). The reaction mixture was stirred for 5 hours at 65 C. The reaction was concentrated in vacuo and purified via silica gel chromatography (30-100% ethyl acetate/hexane). The product fractions were combined and concentrated in vacuo to yield (3-hydroxy-3-((3-(5-phenylthiazol-2- yl)thioureido)methyl)-l-ammoniobicyclo[2.2.2]octan-l-yl)trihydroborate (.85 g, 2.19 mmol, 74.4 % yield) as a white powder. LC/MS confirmed product with loss of BH3 in the LC/MS conditions: retention time 3.26 (M+1-BH3= 375.33)., 39136-63-5

39136-63-5 5-Phenylthiazol-2-amine 873119, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.; WO2011/53292; (2011); A1;,
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5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 1 (7.8 g, 45.3mmol), Boc2O (9.9 g, 45.3 mmol), DMAP (0.1 g, 0.82mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 4 h. After completion of the reaction, the mixture was washed with H2O (30mL), brine (30 mL), the organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatograph on silica gel (200-300 mesh) by ethyl acetate and petroleum ether (v/v = 1:2) as eluent to afford 2 as a light yellow solid (11.5 g, yield 93.5%).

5398-36-7, The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Feng-Yun; Guo, Xiao-Feng; Fan, Zhi-Jin; Zhang, Yu-Qing; Zong, Guang-Ning; Qian, Xiao-Lin; Ma, Liu-Yong; Chen, Lai; Zhu, Yu-Jie; Tatiana, Kalinina; Morzherin, Yury Yu.; Belskaya, Nataliya P.; Chinese Chemical Letters; vol. 26; 10; (2015); p. 1315 – 1318;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90533-23-6,4-(3-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,90533-23-6

Step 3:; To a solution of 4-(3-chlorophenyl)thiazol-2-amine (1 g) in tetrahydrofuran (20 mL) was added NBS (0.88 g). After stirring at room temperature overnight, the mixture was partitioned between ethyl acetate (30 mL) and water (20 mL). The organic phase was washed with water (20 mL x 2), dried and concentrated to give 5-bromo-4-(3-chlorophenyl)thiazol-2-amine (1.05 g) as a red liquid. MS(ES ) m/z 289 (MH ).

90533-23-6 4-(3-Chlorophenyl)thiazol-2-amine 675261, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting; WO2012/100734; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

e. N-(4,5-Dimethyl-2-thiazolyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m.p. 264-265 C (decomp., from ethylene chloride), from 2-methyl-4-(1-pyrrolidyl)-2-H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid chloride-1,1-dioxide and 2-amino-4,5-dimethyl-thiazole.

2289-75-0, As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim GmbH; US3992535; (1976); A;,
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Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61296-22-8, [00156] Di-tert-butyl dicarbonate (28.90 g, 132.4 mmol) was added portionwise to a suspension of 2-amino-5-bromothiazole monohydrobromide (28.64 g, 110.3 mmol) in pyridine (100 mL) over 20 minutes at room temperature. The mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was extracted between 0.5 N HCl (200 mL) and ethyl acetate (200 mL). The organic layer was separated and concentrated. The residue was filtered through a pad of silica gel using 10% ethyl acetate/hexane as a solvent. The filtrate was concentrated to give tert-butyl-5-bromothiazol-2-ylcarbamate (19.5 g, 63% yield) as a white solid. LCMS (Conditions A): 3.40 min (RT); (M+H)+ = 225.12 (100%), 223.12 (95%). 1H NMR, 400 MHz, CDCl3: delta 7.27 (s, 1 H), 1.60 (s, 9 H).

61296-22-8 2-Amino-5-bromothiazole monohydrobromide 2723848, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/155389; (2009); A1;,
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Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 51 (0.5g, 1.8mmol), 48 (0.381g, 2.7mmol) and triphenylphosphine (0.707g, 2.7mmol) in anhydrous THF (20mL) at 0C was added diisopropyl azodicarboxylate (DIAD) (0.545g, 2.7mmol) dropwise. The reaction mixture was allowed to stir at room temperature for 10min and then stirred at 40C overnight. The resulting mixture was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in 74 petroleum ether 2-5%) to give the 172 product 52a as a white solid (0.365g, yield=50%)., 944804-88-0

As the paragraph descriping shows that 944804-88-0 is playing an increasingly important role.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

A solution of ethyl 2-methylthiazole-4-carboxylate (1.00 g, 5.8 mmol) in toluene (18 mL) at -78 C. was treated dropwise with a diisobutyl aluminum hydride solution in dichloromethane (11.1 mL, 1 M) over 30 minutes, stirred at -78 C. for 4 hours, quenched with acetic acid (0.46 mL), warmed to 25 C. and concentrated. The concentrate was treated with dichloromethane and Rochelle’s salt, stirred vigorously until a clear, two-phase solution formed (approximately 10 minutes). The layers were separated and organic layer was washed with 10% NaHCO3, brine, dried over Na2SO4, filtered and concentrated. The residue was chromatographed on silica gel, eluting with 14% ethyl acetate in hexanes to give the title compound (0.28 g, 38% yield)., 6436-59-5

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.; US2005/131017; (2005); A1;,
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615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,615-21-4

Into a four-necked reactor equipped with a thermometer,In a nitrogen stream,5.0 g (30.3 mmol) of 2-hydrazinobenzothiazole was added,Was dissolved in 100 ml of DMF.To this solution were added 20.9 g (152 mmol) of potassium carbonate,5.17 g (30.3 mmol) of 5-bromovaleronitrile was added,And the mixture was stirred at 60 C. for 8 hours.After completion of the reaction,The reaction solution was cooled to 20 C.,The reaction solution was poured into 500 mL of water,And extracted with 500 ml of ethyl acetate.The ethyl acetate layer was dried over anhydrous sodium sulfate.After filtering off sodium sulfate,Ethyl acetate was distilled off under reduced pressure on a rotary evaporator to obtain a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40) to obtain 3.41 g of Intermediate J (yield: 45.7 mol%) as a white solid

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; KIRIKI, SATOSHI; (84 pag.)JP2017/206504; (2017); A;,
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