Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

161798-03-4, Example 3Preparation of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC)To a 500 ml three-necked bottle was added 28.0 g of ethyl 2-[3-formyl-4-(2-methyl propoxy)phenyl]-4-methyl-5-thiazolcarboxylate, 280 ml of 10% sodium hydroxide solution and 90 ml of ethanol, the reaction was performed under stirring at about 80 C. for about 4 h, then the reaction stopped, cooled, adjusted by adding dropwise slowly a concentrated hydrochloride to about pH 3. A white solid was precipitated and filtered. The filter cake was washed with water, and dried by vacuum sucking. The filter cake was recrystallized with ethyl acetate, filtered, then dried at 70-75 C. in a reduced pressure (-0.080 to -0.085 MPa) to obtain 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC) (11.2 g) as a white crystalline. Purity (by HPLC): 99%. IR (KBr): 3432, 2966, 2871, 1679, 1652, 1605, 1513, 1447, 1427, 1371, 1179, 1111, 1014 cm-1. 1H-NMR (500 MHz, DMSO-d6) delta (ppm): 13.360 (1H, s), 10.397 (1H, s), 8.191-8.153 (2H, m), 7.337-7.319 (1H, d), 3.990-3.977 (2H, d), 2.659 (3H, s), 2.163-2.084 (1H, s), 1.045-1.031 (6H, d).

161798-03-4 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 10904158, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.; US2011/282069; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64485-82-1,(Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate,as a common compound, the synthetic route is as follows.

Example 33; (Z)-5-benzo[d]thiazol-2-yl-2-(5-(trifluoromethyl)-2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)ethanethioate; Step 1 : To a solution of 1 (43 g, 0.2 moL) in 300 mL DMF was added 63 mL TEA. The mixture was stirred for 10 min, then 123 g of trityl chloride was added and the mixture was kept at 50 0C for 72 hrs. The mixture was concentrated and extracted with acetic ether. The acetic ether was washed with 1% NaOH solution three times, the organic layer was dried over Na2SO4, filtered and the filtrate was concentrated under reduced pressure. The residue was dried in vacuum overnight to provide (Z)-ethyl-2-(2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)acetate 2 (120 g, yield 85%).

64485-82-1, The synthetic route of 64485-82-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACHAOGEN, INC.; WAGMAN, Allan, Scott; MOSER, Heinz, Ernst; WO2010/30811; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

38585-74-9, Thiazol-5-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

REFERENCE EXAMPLE 50 2-Fluoro-4-(thiazol-5-ylmethoxy)benzonitrile Diisopropylazodicarboxylate (4.0 g) was dissolved in a little anhydrous tetrahydrofuran (about 10 ml) and added dropwise to a stirred solution of triphenylphosphine (5.2 g) in anhydrous tetrahydrofuran (150 ml) at 0 C. under nitrogen. After stirring at 0 C. for 15 minutes, during which time a white precipitate formed, a mixture of 2-fluoro-4-hydroxybenzonitrile (S. M. Kelly, Helv.Chim.Acta. 1984, Volume 67, P.1572-1579) (2.0 g) and thiazole-5-methanol (2.3 g) in anhydrous tetrahydrofuran (20 ml) was added dropwise whilst maintaining the temperature at or below 5 C. The reaction mixture was stirred in the cooling bath for a further 2 hours then allowed to warm slowly to room temperature. After standing at room temperature overnight the reaction mixture was partitioned between ethyl acetate (200 ml) and saturated aqueous ammonium chloride solution (200 ml). The layers were separated and the organic phase washed with water (100 ml), dried over magnesium sulphate and evaporated. The residue was purified by flash chromatography on silica eluding with a mixture of ethyl acetate and cyclohexane (1:1, v/v). Fractions homogenous in the required product were combined and evaporated affording the title compound as a pale yellow solid (2.0 g).

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Rorer Limited; US6124343; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

Hydroxylamine hydrochloride (9.03 g, 130 mmol) was added to a solution of 1 ,3-thiazole-2-carbaldehyde (14.71 g, 130 mmol) and pyridine (10.5 mL, 130 mmol) in DCM (100 mL). The reaction mixture was stirred overnight at room temperature and then washed twice with water. The organic layer was dried over MgS04 and then evaporated under reduced pressure to give 15.26 g of 1 ,3-thiazole-2-carbaldehyde oxime (yield 92percent)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE – CNRS -; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); INSTITUT PASTEUR DE LILLE; DEPREZ, Benoit; WILLAND, Nicolas; FLIPO, Marion; DESROSES, Matthieu; BAULARD, Alain; LEROUX, Florence; WO2013/60744; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

777-12-8, To a stirred solution of methyl 5-chloro-2-methoxy-3-((methoxymethoxy)methyl)benzoate (122mg, 0.445mmo1) in MeOH (5m1) was added 2.2 ml iN KOH solution. The resulting mixture was stirred at 60¡ãC overnight. After cooled to rt, the reaction was partitioned between EA and 2percent citric acid. The EA layer was washed with brine, dried over Na2504 and concentrated in vacuo. To this residue was added HBTU (98mg, 0.258mmo1), DMF (3m) and DIPEA (187u, 1.075 mmo). The mixture was stirred for lOmins and then 6-(trifluoromethy)benzo[d]thiazo-2-amine (47mg, 0.2l5mmo) was added. The resuting reaction was heated at 120 ¡ãC for 24hs. After cooed to rt, the mixture was separated between EA and water. The organic ayer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by coumn chromatography gave the 5- choro-2-hydroxy-3 -((methoxymethoxy)methy)-N-(6-(trifluoromethy)benzo[d]thiazo -2y)benzamide as a yeow soid (37mg, 39percent). ?H NMR (400 MHz, Choroform-d) 8.16 (s, 1H), 7.99 (d, J = 2.5 Hz, 1H), 7.91 (d, J = 6.1 Hz, 1H), 7.72 (d, J = 6.1 Hz, 1H), 7.48 (d, J =2.5 Hz, 1H), 4.80 (s, 2H), 4.78 (s, 2H), 3.47 (s, 3H). MS (ESI) [M+Na] requires m/z 469.02, found m/z 468.55.

777-12-8 6-(Trifluoromethyl)benzo[d]thiazol-2-amine 2735955, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-01-2,Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

b) Preparation of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula IV1.350.0gm of Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula III] 332. Ogm of potassium carbonate and 330.0gm of isobutyl bromide were added to 1.751tr of DMF. Reaction mixture was heated to 90 +/- 3C and stirred for 4 hr. Reaction mixture was cooled to 25C and slowly added 10.50 ltr of water. Slurry of the product formed was stirred for 2.0hr, filtered, washed and dried under vacuum to give 389 gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.079-1.101 (doublet, 6H); delta 1.366-1.413 (triplet,3H); delta 2.185-2.230 (multiplet, 1H); delta 2.769 (singlet, 3H); delta 3.914-3.935 (doublet, 2H); delta 4.316-4.387 (quartet, 2H); delta 7.045-7.074 (doublet, 1H); delta 8.188-8.225 (doublet of doublet, 1H); delta 8.353-8.361 (doublet, 1H).? Mass (m/e): 348.3

161798-01-2, The synthetic route of 161798-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of Compound J (5.6 g, 40 mmol) and CuBr (8.5 g, 60 mmol) in CH3CN (100 mL) was added dropwise t-BuONO (6.2 g, 7.2 mL, 60 mmol) at 0 ¡ãC. Then the reaction mixture was warmed to room temperature and further stirred for additional 30 mins. After that, the precipitate was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: 100percent petroleum ether) to afford the desired product K (3.5 g, 43 percent) as a light yellow oil containing small amount of petroleum ether. 1H NMR (400 MHz, CDC13): delta 6.77 (s, 1H), 2.00-1.95 (m, 1H), 0.94-0.85 (m, 4H)., 324579-90-0

The synthetic route of 324579-90-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei; WO2014/37480; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

Add 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide A (4mmol, 1071mg), compound N1 (4mmol, 601mg) to the flask, add no 150ml of water toluene was installed on the water separator device, and the reaction was heated and refluxed for 24h. After the reaction was completed, toluene was distilled off under reduced pressure to obtain crude intermediate O1., 302964-24-5

302964-24-5 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 21911644, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Medical University; Zhao Jinwu; Xu Jingxiu; Zuo Changqing; (12 pag.)CN111039890; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H).

4175-66-0, As the paragraph descriping shows that 4175-66-0 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-formaldehyde thiazole (113 mg, 1mmol) dissolved in 2 ml methanol, by adding 2-hydroxypropanedinitrile acetic acid solution (0.4 ml, 5mol/L), then rapidly added to 4-dimethyl aminopyridine (12 mg), 50 ¡ãC stirring under 40 minutes. After concentrating the reaction solution through the column chromatography separation to obtain 4 – (hydroxy-a)-thiazole acetic acid methyl ester (144 mg, 83percent)., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Patent; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; Zhang, ZhiLiu; Lin, XiaoJuan; Yu, Haiyu; Wu, Chengde; Ma, RuJian; Chen, ShuHui; (8 pag.)CN103086881; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica