Category: thiazole

848841-68-9, 4-(4-Chlorothiazol-2-yl)morpholine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,848841-68-9

Method B; N- { 4-Chloro-5-[8-( 1 -ethyl-propyl)-2,6-dimethyl-imidazo [1,2- b]pyridazin-3-yl]-thiazol-2-yl } -morpholine.; A 20L reactor flask under nitrogen is charged with 2900 ml of dry and degassed DMF then with 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (287 g, 0.836 mol), 2-morpholino-4-chlorothiazole (205.4 g, 1.01 mol, 1.2 equv.), Pd(OAc)2 (3.74 g, 7.91 mmol, 0.01 equiv.), triphenylphosphine (8.77g, 33.1 mmol, 0.04 equiv.), Copper iodide (8 g, 41.59 mmol, 0.05 equiv.) and cesium carbonate (544.9 g, 1.65 mol). The reaction mixture is heated at 120C. After 16 h at 120C, 1.87 g of Pd(OAc)2 and 4.38 g of triphenylphosphine more is added. After 1 h, the mixture is cooled, quenched with NH4CI solution (4300 mL) and extracted with MTBE (2900 mL), the aqueous phase is extracted twice more with 2000 ml of MTBE. The organic phases are washed with sat NaCl aq (2000 mL), then treated with charcoal 72 g in flask bottle and filtered on Celite. The filtrate is concentrated under vacuum to afford 373.8 g (79.3%) of the title compound which is 81.4%-area HPLC analysis the rest being solvent and with no detectable Example 200 by-product.

The synthetic route of 848841-68-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/102194; (2006); A1;,
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78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.,14542-12-2

This material (3.4 g, 29.6 mmol, 1 eq) was treated with TBDPSCI (8.94 g, 1.1 eq),imidazole (4.0 g, 2 eq) in 20 mL DCM. The mixture was stirred for 14 h. After removalof solvent, extraction with EtOAc and drying the organic layer with Na2C03,evaporation of the solvent afforded 10.5 g of the desired product quantitavely.1HNMR(CDCI35): 1.1 (s, 9 H) 4.90.(s, 2H) 7.30-7.40 (m, 7 H) 7.60-7.70 Patent; SCHERING CORPORATION; WO2006/19957; (2006); A2;,
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18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Amino-thiazole-4-carboxylic acid ethyl ester (460 mg) obtained in the same manner as in Chem. Pharm. Bull, 19(1) 119-123 (1971) was dissolved in ethanol (7 ml). Hydrazine monohydrate (1.3 ml) was added to this solution and the mixture was refluxed at 100C for 22 hr. The reaction mixture was cooled to room temperature and the obtained solid was collected by filtration and washed with ethanol. This solid was dried in vacuo to give the title compound (280 mg).1H-NMR(?, 300MHz, DMSO-d6) 4.26(2H,s),7.07(2H,s),8.00(1H,s),8.83(1H,s)., 18903-18-9

The synthetic route of 18903-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

[00217] A solution of 3-(10,l l-dihydro-5H-dibenzo[?/]azepin-5-yl)propan-l-amine hydrochloride (0.075 g, 0.259 mmol) in DMF (0.85 mL) was cooled to 0 C, treated with Et3N (0.144 mL, 1.03 mmol), and 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.073 g, 0.285 mmol). The mixture was warmed to 25 C and stirred for 2 h. The mixture was partitioned between water (50 mL) and CH2CI2 (50 mL). The organic layer was washed with saturated aqueous NaCl (5 x 30 mL), dried (Na2S04), and concentrated in vacuo. The residue was dissolved in a minimal amount of CH2CI2 and purified by flash chromatography (S1O2, 2-5% ethyl acetate -hexanes) to afford the title compound (0.032 g, 26%) as a white solid. 1H NMR (600 MHz, CD3OD) delta 7.10- 7.01 (6H, m), 6.88-6.85 (2H, m), 3.71 (2H, t, J= 6.6 Hz), 3.02 (3H, br s), 2.99 (2H, J = 6.6 Hz), 2.36 (3H, s), 2.23 (3H, s), 1.71 (2H, quintet, J= 6.6 Hz); 13C NMR (150 MHz, CD3OD) delta 169.8, 159.2, 151.7, 148.2, 134.2, 129.5, 126.1, 12.4, 119.6, 119.5, 46.9, 40.5, 31.9, 27.2, 21.2, 15.0; LCMS m/z 471.2135 ([M + H+], C23H27N4O3S2 requires 471.1519).

69812-29-9, As the paragraph descriping shows that 69812-29-9 is playing an increasingly important role.

Reference£º
Patent; MT. SINAI SCHOOL OF MEDICINE; OHLMEYER, Michael; NARLA, Goutham; DHAWAN, Neil; KASTRINSKY, David; WO2013/25882; (2013); A2;,
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2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The corresponding halide reagent (1mmol) was added to a mixture of thiourea (1.1mmol) (compounds a) or selenourea (compounds b) in absolute ethanol or dry methanol (20mL) for compound 1b. The mixture was stirred at reflux for 0.5?15h. The product was isolated by filtration or by rotatory evaporation of the solvent under vacuum and purified by recrystallization, washing or column chromatography., 2516-40-7

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

Reference£º
Article; Alcolea, Veronica; Plano, Daniel; Encio, Ignacio; Palop, Juan Antonio; Sharma, Arun K.; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 407 – 418;,
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62266-82-4, 6-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62266-82-4, Example 12A 2-amino-5-bromothiophenol and its disulfide A mixture of 6-bromobenzothiazolone (CAS number 62266-82-4, Aldrich Chemical Company (12.9 g, 56.1 mmol), NaOH (33 g, 0.825 mol) and water (90 mL) was heated to 100 C. for 15 hours under nitrogen. The mixture was cooled to 0 C. and pH was adjusted to pH 5 using 5N acetic acid at 0-10 C. under nitrogen. The precipitate was filtered, washed with water and vac. dried at 45 C. to give the product as a mixture of 2-amino-5-bromothiophenol and its disulfide (11.47 g, 100%).

62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Cowart, Marlon D.; Ku, Yi-Yin; Chang, Sou-Jen; Fernando, Dilinie P.; Grieme, Timothy A.; Altenbach, Robert J.; US2004/224953; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

30 mg (0.19 mmol) of 4,5,6,7-tetrahydrobenzo [d] thiazol-2-amine 53 mg (0.19 mmol) of 2, 4′-dibromoacetophenone was dissolved in 3 ml of ethanol and stirred in a microwave reactor at 150 C for 20 minutes. The residue was concentrated under reduced pressure and subjected to column chromatography (EtOAc: Hex = 1: 5) to obtain Compound 2c (14 mg, 22%)., 2933-29-1

2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Chung-Ang University Industry-Academic Cooperation Foundation; Min, Kyung Hoon; Kwon, Ahra; Song, Ji Ho; (22 pag.)KR2017/23387; (2017); A;,
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19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.88g (0.005 mol) 2-amino-6-cyanobenzothiazole was dissolved in 10 mL of N,N-dimethylformamide, 0.4 g (0.01 mol) of sodium hydroxide was added with stirring, After 10 minutes, 1.26 g (0.005 mol) of 2,6-dichloro-3,5-dinitrotoluene was added thereto, The reaction was continued at room temperature for 5 hours. After completion of the TLC monitoring reaction, the reaction solution was poured into 50 mL of saturated brine and extracted with ethyl acetate. The organic phase was extracted with anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography (eluent ethyl acetate and petroleum ether (Boiling range 60-90 C) in a volume ratio of 1:10) to give 0.40 g of compound 4405, Yellow solid. Melting point 229-231 C., 19759-66-1

The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SINOCHEM CORP; Shenyang Research Institute Of Chemical Industry Co., Ltd .; GUAN, AIYING; LI, HUICHAO; SUN, QIN; LIU, CHANGLING; WANG, JUNFENG; SUN, XUFENG; YANG, FAN; (21 pag.)CN104177310; (2016); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

Manufacturing Example 88-1-1 Thiazole-2-yl-methanol; To a mixture of 2-formylthiazole (300 mg, 2.65 mmol) and methanol (30 mL) was added sodium borohydride (201.0 mg, 5.30 mmol) at 0 C., which was stirred for 1 hour at room temperature. Water was added to this reaction mixture, which was then extracted with ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure, and the residue was purified by NH silica gel column chromatography (diethyl ether) to obtain the title compound (251.2 mg, 82%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.74 (2H, d, J=6.0 Hz), 6.04 (1H, t, J=6.0 Hz), 7.63-7.65 (1H, m), 7.73-7.75 (1H, m)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
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Thiazole | chemical compound | Britannica