Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94284-66-9,1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone (1 mol) in methanol (4.0-4.1 l), was added dropwise to a cooled solution of corresponding aromatic aldehydes (1 mol) in 10% NaOH (600-650 ml). The solution was maintained at 0 C for 1.5 h and then was allowed to stir at room temperature. After some time (5-12 h) solid started separating out. The solid was filtered under vacuum and recrystallized from dioxane or ethanol to give the title chalcones. The yield range after recrystallization of chalcones was 32-84%., 94284-66-9

As the paragraph descriping shows that 94284-66-9 is playing an increasingly important role.

Reference£º
Article; Liaras; Geronikaki; Glamo?lija; ?iri?; Sokovi?; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3135 – 3140;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

405939-39-1,405939-39-1, tert-Butyl (5-bromothiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of diisopropylamine (64 ml, 446 mmol) in 200 mL of tetrahydrofuran was added to a dry three-neck bottle, which was protected under nitrogen, and cooled to 0 C, and then n-butyllithium (2.5M, 173ml, 431.7mmol) was added. The reaction was conducted for 1 hour after addition was completed. A solution of tert-butyl 5-bromothiazol-2-ylcarbamate in 400 mL of tetrahydrofuran was added dropwise at 0 C, and the reaction was conducted for 2 hours after addition was completed. TLC showed the reaction was completed. At 0 C, the reaction was quenched by slow addition of ice water (5 mL), stirred for 30 min, then saturated ammonium chloride (500mL) aqueous solution was added, and separated. The aqueous layer was extracted with dichloromethane (2 ¡Á 300 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was recrystallized with petroleum ether : ethyl acetate = 30:1 to give 31g of tert-butyl 4-bromothiazol-2-ylcarbamate as a white solid, yield 77.5%, MS(ESI): m/z 278.98 (M + H)+.

As the paragraph descriping shows that 405939-39-1 is playing an increasingly important role.

Reference£º
Patent; Genfleet Therapeutics (Shanghai) Inc.; ZHOU, Gang; (44 pag.)EP3613737; (2020); A1;,
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Thiazole | chemical compound | Britannica

7238-61-1,7238-61-1, 2-Bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A dioxane (10.00 mL) mixture of a compound WX022-1 (206.90 mg, 1.50 mmol), a compound WX022-2 (222.56mg, 1.25 mmol), [1,1?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (94.16 mg, 0.125 mmol) and sodium carbonate(264.98 mg, 2.50 mmol) was reacted at 85 C for 3 hours under the protection of nitrogen. After the reaction wascompleted, the mixture was cooled down and 1M hydrochloric acid was added to adjust the pH to 6. The mixture wasdiluted with 10 mL of water, and extracted with 20mL of ethyl acetate twice, and the water phase was adjusted withNaHCO3 (aq) to a pH of 8. Then the mixture was extracted with 20mL of ethyl acetate twice, dried with anhydrous sodiumsulfate and spin-dried to obtain the compound WX022-3. 1H NMR (400MHz, CHLOROFORM-d) delta = 7.81 (br d, J=7.8Hz, 2H), 6.90 (br d, J=8.3 Hz, 1H), 6.94-6.87 (m, 1H), 6.80 (s, 1H), 2.49 (s, 3H).

7238-61-1 2-Bromo-4-methylthiazole 551541, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-76-6,Ethyl 2-amino-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

7210-76-6, A mixture of 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester (1.0 g, 5.4 mmol) inN,N-dimethylformamide at [25 oC] was treated with triethylamine (1.89 mL, 13.5 mmol) and triphenylmethylchloride (1.66 g, 5.94 mmol). The reaction was stirred at [2 oC] for 2 days. At this time, the reaction was concentrated in vauco. The residue was dissolved in dichloromethane (100 mL) and was washed with a IN aqueous hydrochloric acid solution (1 x 20 mL), a saturated aqueous sodium bicarbonate solution [(1] x 20 mL), and a saturated aqueous sodium chloride solution [(1] x 20 mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo to afford 4-methyl-2- (trityl-amino)-thiazole-5-carboxylic acid ethyl ester (2.3 g, quant.). The product was used without further purification: LR-MS for [C26H24N202S] [(M-H) +] at [RN/Z = 427.]

7210-76-6 Ethyl 2-amino-4-methylthiazole-5-carboxylate 343747, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
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Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 3-[(5-nitrothiazol-2-yl)mercapto]-5-phenyl-1,2,4-triazole (SU4390) (Compound 7) The key starting material 2-bromo-5-nitrothiazole was prepared by treating 2-amino-5-nitrothiazole (Aldrich) with sodium nitrite and hydrogen bromide (Fr. Demande 2,015,434, 1970)., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Sugen, Inc.; US5883110; (1999); A;,
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Thiazole | chemical compound | Britannica

170235-26-4, Methyl 2-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of methyl 2-bromothiazole-4-carboxylate (0.20 g, 0.901 mmol) in THF (10 mL) was treated with morpholine (0.17 mL, 1.94 mmol) and re fluxed for 18 h. The reaction was then diluted with ethyl acetate and washed with sat. NaHC03 (lx), brine (lx) and dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by silica gel chromatography (2.5 x 10 cm, 50% AcOEt/CH2Cl2) to give the title material (0.192 g, 92%) as a yellow solid. 1H NMR (CDCl3, 400 MHz) delta ppm: 7.44 (s, 1H) 3.82 (s, 3H) 3.75 (m, 4H) 3.45 (m, 4H)., 170235-26-4

As the paragraph descriping shows that 170235-26-4 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITE DE MONTREAL; BANVILLE, Jacques; REMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBE, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.; WO2013/163279; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55707-55-6,Di(2-thiazolyl)methanone,as a common compound, the synthetic route is as follows.

55707-55-6, General procedure: In a flame-dried apparatus and under argon atmosphere, a solution of cis-propenylbromide(0.425 mL, 0.005 mol) in anhydrous THF (30 mL) was added dropwise to magnesium turnings(0.005 mol) in THF (5.0 mL). After a gentle warming the Grignard formation was observed and thereaction was allowed until the magnesium was consumed. The resulting solution was withdrawn witha graduate syringe and a half amount was inserted in a dropping funnel and the other half in anotherone. Each funnel was connected with a flame-dried round-bottomed flask in which 0.00025 mol ofketone were dissolved in 5.0 mL of anhydrous THF and kept at -70 C. After about 15 min fromthe addition of the Grignard solution, the reaction was quenched with aqueous (NH4)2SO4 andextracted with diethyl ether. The organic layer was dried over anhydrous Na2SO4, and the solventwas removed after filtration. The reaction mixture was analyzed through 1H-NMR spectroscopy.The reaction products were recognized by comparison with literature data in case of reaction withbenzophenone [25] and with data obtained in experiments reported in Table 1, entries 5 and 6.

55707-55-6 Di(2-thiazolyl)methanone 13331906, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Boga, Carla; Bordoni, Silvia; Casarin, Lucia; Micheletti, Gabriele; Monari, Magda; Molecules; vol. 23; 1; (2018);,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.100367-77-9,Ethyl 2-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Step 3 : (2-bromothiazol-4-yl)methanolA solution of ethyl 2-bromothiazole-4-carboxylate (7.821 g, 33.13 mmol) in THF (100 mL) was cooled in an ice-bath and treated portionwise with lithium borohydride (1.083 g, 49.70 mmol). After 1 hour MeOH (1.614 g, 2.040 mL, 50.36 mmol) was added over a period of half an hour. The reaction was allowed to stir for 3 hours and then the solvent was concentrated in vacuo and the resultant residue was dissolved in EtOAc, washed with HCl (2x), saturated sodium bicarbonate, followed by brine, dried (Na2SO4), concentrated and purified by column chromatography (EtOAc/Petroleum ether 1: 1) to give the required product as a colorless oil (4.3Og, 67percent Yield). 1H NMR (CDCl3, 400 MHz) delta 2.51 (IH, m), 4.75 (2H, m), 7.19 (IH, s); MS (ES+) 195.96, 100367-77-9

100367-77-9 Ethyl 2-bromothiazole-4-carboxylate 353965, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; COLLIER, Philip, N.; WO2010/129668; (2010); A1;,
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Thiazole | chemical compound | Britannica

405939-39-1, tert-Butyl (5-bromothiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 158 diisopropylamine (64mL, 446mmol) in 154 THF (100mL) was added dropwise 159 n-BuLi (2.5M, 173mL) under N2 atmosphere at 0C. After that a solution of 156 47 (40g, 143.9mmol) in THF (400mL) was added dropwise at 0C. The reaction mixture was stirred at the same temperature for 2h, and then quenched with sat. 160 NH4Cl (500mL) and extracted with ethyl acetate (3¡Á300mL). The combined organic layers were washed with brine (100mL) and dried over anhydrous Na2SO4. The organic layers were evaporated to dryness and the crude product was purified by silica gel flash chromatography (eluting with ethyl acetate in 74 petroleum ether 1-30%) to give the 20 title compound 48 as a white solid (31.2g, yield=78%). 1H NMR (400MHz, CDCl3) delta 8.05 (br, 1H), 6.78 (s, 1H), 1.56 (s, 9H); LC/MS (ESI, m/z) 222.98 [M+H-56]+.

405939-39-1, The synthetic route of 405939-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
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Thiazole | chemical compound | Britannica

4175-76-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-76-2,2,4-Dichlorothiazole,as a common compound, the synthetic route is as follows.

Example 74 Preparation of 3-(4-Chloro-thiazole-2-yl)pyridine To a suspension of pyridin-3-ylboronic acid (3.87 g, 31.5 mmol) in toluene (120 mL) was added 2,4-dichlorothiazole (4.62 g, 30 mmol) followed by ethanol (60 mL) and a 2.0 M solution of K2CO3 (30.0 mL, 60.0 mmol). The solution was degassed by applying vacuum and then purging with nitrogen (3 times). To the reaction mixture was added tetrakis(triphenylphosphine)palladium (0) (1.733 g, 1.500 mmol) and the flask was heated at 95 C under nitrogen for 16 hours. The aqueous layer was removed and the organic layer was concentrated. The crude product was purified via silica gel chromatography (0-100% ethyl acetate/hexanes) to afford the title compound as a brown solid (4.6 g, 74%): mp 84-86 C; IR (KBr) 3092 cm-1; 1H NMR (400 MHz, CDCl3) delta 9.16 – 9.13 (m, 1H), 8.69 (dd, J = 4.8, 1.6 Hz, 1H), 8.23 (ddd, J = 8.0, 2.2, 1.7 Hz, 1H), 7.40 (ddd, J = 8.0, 4.8, 0.8 Hz, 1H), 7.16 (s, 1H).

The synthetic route of 4175-76-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dow AgroSciences, LLC; Trullinger, Tony; Hunter, Ricky; Garizi, Negar; Yap, Maurice; Buysse, Ann; Pernich, Dan; Johnson, Timothy; Bryan, Kristy; Deamicis, Carl; Zhang, Yu; Niyaz, Noormohamed; McLeod, CaSandra; Ross, Ronald; Zhu, Yuanming; Johnson, Peter; Eckelbarger, Joseph; Parker, Marshall; EP2604268; (2015); B1;,
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Thiazole | chemical compound | Britannica