Category: thiazole

53332-78-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53332-78-8,Thiazol-2-ylmethanamine dihydrochloride,as a common compound, the synthetic route is as follows.

General procedure: A mixture of the intermediate obtained from step 2 (1.00 g; 2.96 mmol), HATU (1.24 g; 3.25 mmol), DMF (2.50 mL) and DIPEA (0.56 mL; 3.25 mmol) is stirred at r.t. for 20 min. The amine 4-cyanobenzylamine (0.36 mL, 2.96 mmol) is added and the resulting mixture is stirred at r.t. for 2 h. A molar surplus of aq. NaHCOs solution is added with stirring and the precipitate is filtered off and dried at 50 C to yield the title compound. C20H19CI2N3O3S ESI pos.+neg. (Loop-Inj.): [M+H]+ 452 m/z (0129) HPLC (RT): 0.70 min (HPLC method A)

53332-78-8 Thiazol-2-ylmethanamine dihydrochloride 44890709, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; KAUSCHKE, Stefan; PAUTSCH, Alexander; WIEDENMAYER, Dieter; (41 pag.)WO2018/104220; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1; a) 2-(Tert-butoxycarbonylamino)-5-fluorothiazole; 2-(Tert-butoxycarbonylamino)thiazole (lOg, 0.050mol) in THF (0.2L) was cooled to -50C under argon. tBuLi solution in pentane (60mL of a 1.7M solution, 0.102mol, 2.05eq) was added over a period of 30min and the temperature kept below -40C. The suspension thus obtained was stirred at -50C for 30min. A solution of N-fluorobenzenesulfonimide (NFSi) was prepared (22. Og, 0.07mol in 70mL THF, 1.4eq) and 50mL of this solution (leq) was added over a 5min period and the temperature kept under -40C. The reaction was stirred for 20min at -50C. Then tBuLi (lOmL, 0.017mol, 0.35eq) and the NFSi solution (lOmL, 0.4eq) added. The solution thus obtained was stirred at -50C for 45min and then added to saturated NH4CI solution (300mL). The organic phase was separated and the aqueous phase further washed with diethylether (lOOmL). The combined organic fractions were washed with brine (20mL) solution and dried (Na2SO?}). The solvent was removed and the solid further dried to afford a brown solid. To this crude product was added trifluoroethanol (60mL) and formic acid (0.6mL). The suspension was heated to 85C until it gave a solution. The flask was then cooled to RT and the precipitate thus formed filtered off to afford, after drying under high vacuum, the title compound (6.4g, contains 2.3% of starting material according to HPLC at275nm). After a second crystallisation (trifluoroethanol (22mL) and formic acid (0.22mL),for 20min at 85C), the title compound was obtained as an off white solid (4.6g, contains 1% of starting material, 97.5% pure by HPLC). ‘HNMR (CDC13) 8: 6.90 (1H, d, CHCF), 1.60 (9H, s, Boc-H)., 170961-15-6

As the paragraph descriping shows that 170961-15-6 is playing an increasingly important role.

Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,78364-55-3

General procedure: The mixture of 6-fluoro-2-hydrazinylbenzo[d]thiazole (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 ¡ãC for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1603-91-4,4-Methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

Mix 3-bromoacetophenone (0.6 mmol, 119 mg) and p-toluenesulfonyl hydrazide (0.6 mmol, 112 mg) in toluene (10 mL), and react at 40 oC for 2 hours.Then add 2-amino-4-methylthiazole (0.4 mmol, 46 mg), Cu (NO3) 2 ¡¤ 3H2O (16 mg), and lithium t-butoxide (96 mg) to the above reaction system at 100 oC The reaction was continued for 3 hours. After the TLC detection reaction was completed, dichloromethane was added to the system, successively washed with brine and water, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and separated by column chromatography to obtain the final pure compound 3t (80%, 95.1 mg)., 1603-91-4

As the paragraph descriping shows that 1603-91-4 is playing an increasingly important role.

Reference£º
Patent; Jining Medical University; Xie Zengyang; Liu Jun; Yang Qianqian; Zhang Bo; (15 pag.)CN110229121; (2019); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.405939-39-1,tert-Butyl (5-bromothiazol-2-yl)carbamate,as a common compound, the synthetic route is as follows.

Example 15, Step F[00158] To LDA (177.21 mmol) in THF (100 mL) was added compound 15_2 (15 g, 53.7 mmol) in THF dropwise at 0C under N2 and the mixture stirred at 0C for 15 mins. Diethyl pyrocarbonate (28.73 g, 177.21 mmol) was then added dropwise at 0C and the reaction mixture stirred at room temperature overnight. The mixture was diluted with EtOAc and washed with water, brine, dried over MgS04 and concentrated in vacuo. The residue was purified by silica column chromatography (PE: EtOAc=10:1) to afford product 15_3 (6 g, 32% yield).[00159] This compound was characterized by proton NMR (1HNMR) in accordance with the procedures described herein. Proton NMR yielded the following results: 1H NMR (CDCI3, 400 MHz): delta 9.409 (brs, 1 H), 4.367 (q, 2H, J=7.2 Hz), 1.577 (s, 9H), 1.380 (t, 3H, J=7.2 Hz).

405939-39-1, As the paragraph descriping shows that 405939-39-1 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADDEX PHARMA S.A.; LIVERTON, Nigel, J.; BOLEA, Christelle; CELANIRE, Sylvain; YUNFU, Luo; WO2012/8999; (2012); A2;,
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Thiazole | chemical compound | Britannica

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19952-47-7, General procedure: All microwave irradiation experiments were carried out in CEM-Discover monomode microwavedevice, operating at a frequency of 2.45 GHz. Substituted aminobenzothiazole, equimolar amount ofsubstituted benzaldehyde (1.5 mmol) and mercaptoacetic acid in absolut ethanol (3 mL) were placed ina 10 mL reaction vial containing a stirring bar. The vial was sealed with a Teflon septum and placedinto the microwave cavity. It was irradiated at 100 C using 100 W as maximum power for 30 min.at the end of the reaction the mixture was rapidly cooled with gas jet cooling to room temperature.The clean product was obtained after filter under reduced pressure.

The synthetic route of 19952-47-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Petrou, Anthi; Eleftheriou, Phaedra; Geronikaki, Athina; Akrivou, Melpomeni G.; Vizirianakis, Ioannis; Molecules; vol. 24; 21; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a 250 mL round bottom flask was added ethyl benzothiazole-2-carboxylate (1.0363 g, 5.0 mmol). 20 mL ethanol and 2 mL hydrazine hydrate were added followed by heating the solution to reflux for 6 hours. The reaction mixture was cooled to room temperature and solid precipitate was filtered, collected, and recrystallized in ethanol to yield benzo[d]thiazole-2-carbohydrazide (943.4 mg, 89.1% yield).

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY; Hagen, Timothy J.; Thompson, Michael; Troxell, Jeremy R.; Hartnett, Brian E.; (69 pag.)US2018/271098; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6633-61-0,Methyl 2-aminothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

6633-61-0, To a preheated (50 C.) slurry of copper (II) chloride (932 mg), 10 mL of acetonitrile was added, along with the thiazole aminoester (1 g) and amyl nitrite (737 mg). The mixture was heated at 50 C. for 2 h. The resulting mixture was concentrated and purified by Biotage (5-10% ethyl acetate in hexane) to give the chloride as a brown solid.

As the paragraph descriping shows that 6633-61-0 is playing an increasingly important role.

Reference£º
Patent; Raghavan, Subharekha; Colletti, Steven L.; Ding, Fa-Xiang; Shen, Hong; Tata, James R.; Lins, Ashley Rouse; Smenton, Abigail Lee; Chen, Weichun; Schmidt, Darby Rye; Tria, George Scott; US2006/293364; (2006); A1;,
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Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 Preparation of ethyl 2-chlorothiazol-4-carboxylate 17 g (100 mmol) ethyl 2-aminothiazol-4-carboxylate (Example 30, step 1) was added to 150 ml acetonitrile, and 18.5 g (110 mmol) dihydrated cupric chloride was added, and then, with mechanical stirring, 18.5 ml (130 mmol) isoamyl nitrite was slowly added dropwise, followed by continuing the reaction for 4 hr after complete of addition. To the resulting mixture, ethyl acetate and water were added, filtered to remove insoluble solids, and the layers were separated. The aqueous phase was further extracted with ethyl acetate, the resultant organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain 16 g of an oily liquid 1H NMR (CDCl3) 1.39-1.43(3H,t, J=7.0Hz); 4.40-4.44(2H,m, J=7.0Hz); 8.08(1H, s).

5398-36-7, 5398-36-7 Ethyl 2-aminothiazole-4-carboxylate 73216, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
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Thiazole | chemical compound | Britannica

16582-58-4,16582-58-4, 6-Iodobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Chloroacetyl chloride (0.06 mol) was added dropwise to a mixture of the appropriate 2-amino-6-Substituted benzothiazole, 3a-k (0.05 mol) and K2CO3 (0.06 mol) in benzene (50 mL) at room temperature. The reaction mixture was refluxed for 6-12 h, then, after cooling to room temperature, it was slowly poured into 100 mL of ice water. A solid was formed thereafter. The precipitate was separated by filtration and washed successively with water. The product was dried under vacuum to obtain 4a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system.

The synthetic route of 16582-58-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Patel, Rahul V.; Patel, Paresh K.; Kumari, Premlata; Rajani, Dhanji P.; Chikhalia, Kishor H.; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 41 – 51;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica