Category: thiazole

Berry, Craig R. published the artcileCycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1-b]thiazoles, Formula: C4H5NS2, the publication is Organic Letters (2007), 9(21), 4099-4102, database is CAplus and MEDLINE.

Thiazolium azomethine ylides, generated from 1,3-thiazoles equipped with a C-2 methanethiol group, participated in an efficient [3+2] cycloaddition reaction with acetylene derivatives to yield unique pyrrolo[2,1-b]thiazoles. The elimination of the methanethiol leaving group from the cycloadduct replaced the need for a sep. oxidation step and suppressed ring-opening side reactions. Products were obtained in short synthetic sequences to demonstrate their use as a scaffold for compound libraries.

Organic Letters published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Peng published the artcileStructure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5, COA of Formula: C14H18BNO2S, the publication is Bioorganic & Medicinal Chemistry (2010), 18(9), 3026-3035, database is CAplus and MEDLINE.

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogs and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC₅₀ range 60-100 nM) in the quinoline series.

Bioorganic & Medicinal Chemistry published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C65H82N2O18S2, COA of Formula: C14H18BNO2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Abdel Azzem, M. published the artcileElectroactive film of polyaniline substituted with the benzothiazole ring, Application In Synthesis of 92-36-4, the publication is Delta Journal of Science (1993), 17(3), 127-140, database is CAplus.

Voltammetric studies of ring-substituted aniline with a heterocyclic ring , i.e., 2-(4-aminophenyl)-6-methylbenzothiazole (ABT), were carried out in acetonitrile and acidic aqueous solutions Potential sweep electrolysis of 0.05M ABT at a glassy carbon electrode in CH₃CN containing 0.1M LiC10₄ and 0.05M pyridine produced a polymeric film. The film-coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of PABT prepared by constant current electrolysis was 3.8 × 10 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

Delta Journal of Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chen, Shanping published the artcileA Mild Two-Step Synthesis of Structurally Valuable Indole-Fused Derivatives, Computed Properties of 95-24-9, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A mild two-step synthetic approach for the preparation of structurally valuable indolo[3′,2′:4,5]pyrrolo[3,2,1-kl]phenothiazines, e.g., I, was developed. In this work, cyclohexanone was used as the key bridge to connect the indole and phenothiazine frameworks to construct a structurally valuable indole-fused derivative The present protocol achieved the cascade construction of multiple C-hetero bonds, affording a convenient approach access to hexacyclic-fused system that contained both indole and phenothiazine, two privileged skeletons.

Journal of Organic Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhou, Huaxi published the artcileRole of NOM in the Photolysis of Chlorine and the Formation of Reactive Species in the Solar/Chlorine System, COA of Formula: C18H24N6O6S4, the publication is ACS Omega (2022), 7(9), 7769-7776, database is CAplus and MEDLINE.

The solar/chlorine system has been proposed as a novel advanced oxidation process (AOP) for efficient pollutant degradation and water disinfection by producing a series of reactive species including hydroxyl radicals (HO^•), chlorine radicals (Cl^•), and so forth. In this study, the role of natural organic matter (NOM) in the photolysis of free available chlorine (FAC) and the formation of HO^• and Cl^• in the solar/chlorine system was investigated employing nitrobenzene and benzoic acid as selective chem. probes. The decay rate of FAC was significantly accelerated in the presence of NOM at pH 5.5 under simulated solar irradiation, likely due to the photoreaction between FAC and the photoexcited NOM. The decay rate of FAC increased upon increasing the electron-donating capacity of NOM, which indicated that phenolic components play a significant role in the photodegradation of FAC. This acceleration mechanism was further verified using 4-nitrophenol as a model phenolic compound NOM promoted Cl^• formation and quenched HO^• in the solar/chlorine system. The proposed reaction mechanism included the reaction of excited singlet phenolic compounds in NOM with FAC, which yielded Cl^•. This study provides a useful insight into future applications for using the solar/chlorine system as a novel AOP for wastewater treatment or disinfection.

ACS Omega published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C11H15NO2, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lin, Derong published the artcileComparison of apple polyphenol-gelatin binary complex and apple polyphenol-gelatin-pectin ternary complex: Antioxidant and structural characterization, HPLC of Formula: 30931-67-0, the publication is LWT–Food Science and Technology (2021), 111740, database is CAplus.

Polyphenol-gelatin binary complex and polyphenol-gelatin-pectin ternary complex were synthesized. The differences in antioxidant activity between the binary complex and ternary complex were evaluated by using ABTS, DPPH, and reducing power assays. The differences in structural characterization between the binary complex and ternary complex were investigated by SEM (SEM), NMR (¹H and ¹³C NMR), and Fourier transform IR (FT-IR) spectroscopy. The reducing power assays of the ternary complex was greater than that of the binary complex. The maximum of ABTS•+ scavenging activity of the binary complex and the ternary complex was 98.1% and 99.3%, resp., and the maximum DPPH• scavenging activity was 84.7% and 87.6%, resp. The results of structural characterization showed that they were very similar in structure. Both complexes are mainly composed of hydrogen bonds and hydrophobic interactions, but the ternary complex is more tightly bound. In addition, the surface is smoother, and the gap is smaller.

LWT–Food Science and Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Shang, Yuhao published the artcilePolyphenol Profiles and Antioxidant Activities of Non-centrifugal Sugars Derived from Different Varieties of Membrane-Clarified Sugarcane Juice, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Sugar Tech (2022), 24(2), 614-625, database is CAplus.

The objectives of this research were to determine the sugar compositions, polyphenol contents and antioxidant effects of non-centrifugal sugars (NCS) of different sugarcane varieties. The polyphenols contents and compounds of nine NCSs obtained from the juices of different sugarcane varieties clarified with a 50 nm ceramic membrane (M-NCSs) were measured via ultraperformance liquid chromatog.-mass spectrometry (UPLC-MS). Their antioxidant activities were investigated via 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2, 2′-azino-bis-(3-Et benzothia-zoline-6-sulfonic acid) (ABTS) assay, β-carotene-linoleate assays, and ferrous and cupric ion chelating assays. Results showed that the phenolic compound with the highest content was gallic acid, and all samples were abundant in phenolics, including flavonoids, with high antioxidative activities. The content of phenolics and flavonoids, ranged from 17.24 to 21.14 mg/mL and from 203.55 to 350.37μg/mL, resp. Among these M-NCSs, Funong 41 (G) genotype had the best DPPH free radical scavenging activity. The GUC 23-2 (A1) genotype showed the best ABTS free radical scavenging activity. β-Carotene-linoleate assays revealed that the 15-6013 (B2) genotype exhibited the best antioxidant activity. The Guitang 42 (E) genotype displayed the best ferrous ion chelating activity. The Zhongzhe 9 (F) genotype presented the best cupric ion chelating activity. In summary, sugarcane variety influenced the polyphenols contents and antioxidant effects of M-NCSs. This study lays a foundation for the further study of M-NCSs.

Sugar Tech published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C22H23ClN4, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ma, Dawei published the artcileEfficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Angewandte Chemie, International Edition (2009), 48(23), 4222-4225, S4222/1-S4222/18, database is CAplus and MEDLINE.

The first metal-catalyzed direct coupling of metal sulfides with aryl halides and subsequent intramol. condensation provided substituted benzothiazoles. A wide range of functional groups are tolerated under the reaction conditions.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sun, Mimi published the artcileA Bendable Biofuel Cell-Based Fully Integrated Biomedical Nanodevice for Point-of-Care Diagnosis of Scurvy, COA of Formula: C18H24N6O6S4, the publication is ACS Sensors (2021), 6(1), 275-284, database is CAplus and MEDLINE.

Fully integrated nanodevices that allow the complete functional implementation without an external accessory or equipment are deemed to be one of the most ideal and ultimate goals for modern nanodevice design and construction. In this work, we demonstrate the first example of a bendable biofuel cell (BFC)-based fully integrated biomedical nanodevice with simple, palm-sized, easy-to-carry, pump-free, cost-saving, and easy-to-use features for the point-of-care (POC) diagnosis of scurvy from a single drop of untreated human serum (down to 0.2μL) by integrating a bendable and disposable vitamin C/air microfluidic BFC (micro-BFC) (named iezCard) for self-powered vitamin C biosensing with a custom mini digital LED voltmeter (named iezBox) for signal processing and transmission, along with a ”built-in” biocomputing BUFFER gate for intelligent diagnosis. Under the simplicity- and practicability-oriented idea, a cost-effective strategy (e.g., biomass-derived hierarchical micro-mesoporous carbon aerogels, screen-printed technique, a single piece of Kimwipes paper, LED display, and universal components) was implemented for nanodevice design rather than any top-end or pricey method (e.g., photolithog./electron-beam evaporation, peristaltic pump, wireless system, and 3D printing technique), which enormously reduces the cost of feedstock down to ~USD 2.55 per integrated kit including a disposal iezCard (~USD 0.08 per test) and a reusable iezBox (~USD 2.47 for large-scale tests). These distinctive and attractive features allow such a fully integrated biomedical nanodevice to fully satisfy the basic requirements for POC diagnosis of scurvy from a single drop of raw human serum and make it particularly appropriate for resource-poor settings, where there is a lack of medical facilities, funds, and qualified personnel.

ACS Sensors published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C10H12F6N4O6PdS2, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ding, Hongyan published the artcileSKA3 promotes the proliferation, migration and invasion of endometrial carcinoma cells, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Chengdu Yixueyuan Xuebao (2021), 16(3), 293-298, database is CAplus.

Objective To investigate the effects of spindle and kinetochore associated complex subunit 3 (SKA3) on the proliferation, migration and invasion of endometrial carcinoma cells. Methods Real-time quant. polymerasechain reaction (RT-qPCR) and Western blotting were used to detect the levels of SKA3 mRNA and protein expression in endometrial epithelial cells HEECs and endometrial carcinoma cells KLE, JEC and Ishikawa cells. And the Ishikawa cells with the highest expression level were selected for subsequent research. Ishikawa cells were divided into three groups. In the control group, Ishikawa cells were cultured normally. In the si-SKA3 group, 50 nmol/L siRNA-SKA3 was transfected into Ishikawa cells according to liposome 2000 instructions. In the NC group, 50 nmol/L siRNA-NC was transfected into Ishikawa cells according to liposome 2000 instructions. Cell proliferation was detected by cell counting kit-8 (CCK8) and clonal formation assay. Cell invasion and migration were detected by Transwell and scratch assay. And protein expression of CyclinD1, MMP-2, AKT, and p-AKT were detected by Western blotting. Results Compared with the HEECs of endometrial epithelial cells, the expression levels of SKA3 mRNA and protein in each endometrial carcinoma cell line were significantly increased (P<0.05). After interference with SKA3 expression, the proliferation and invasion ability of Ishikawa cells were decreased, the width of scratches were enlarged, and the protein expression of CyclinD1 and MMP-2 were significantly decreased (P<0.05). Compared with the control group and the NC group, the expression of AKT protein in si-SKA3 group was not significantly changed (P>0.05), while the expression of p-AKT protein decreased (P<0.05). Conclusion Interference with SKA3 can inhibit the proliferation, migration and invasion of Ishikawa cells of endometrial carcinoma, of which the mechanism may be related to the inhibition of SKA3 on PI3K/AKT signaling pathway.

Chengdu Yixueyuan Xuebao published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica