Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.247037-82-7,Thiazole-2-carboximidamide hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of ethyl 3-oxobutanoate (0.4 g, 3 mmol), cyclohexanecarbaldehyde (0.34 g, 3 mmol), 1,3-thiazole-2-carboximidamide HCl salt (0.49 g, 3 mmol) and KOAc (0.59 g, 6 mmol) in CF3CH2OH (10 mL) was stirred for 24 hours at 90 C. After being cooled, it was partitioned (EtO Ac-brine). The organic was dried (Na2SO4), filtered and concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (0.35 g, 34%). ESIMS m/z = 334.1 [M+H]+.

247037-82-7, The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; CAO, Hui; LI, Wei; PENG, Xiaowen; JIN, Meizhong; KASS, Jorden; GAO, Xuri; OR, Yat, Sun; (99 pag.)WO2017/11552; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of 6 (500mg, 3.20mmol) in tetrahydrofuran (20mL) were added pyridine (1.30mL, 16.0mmol) and acetyl chloride (0.60ml, 7.90mmol) at 0C, and the reaction mixture was stirred for 21h at room temperature. After the volatiles of the mixture were removed in vacuo, water was poured into the residue, and the suspension was stirred for 1h. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to yield 7 (585mg, 91%) as a colorless powder. 1H NMR (200MHz, DMSO-d6) delta 2.15 (s, 3H), 2.52 (s, 3H), 12.35 (br s, 1H); MS (ESI): m/z 201 [M+H]+, 223 [M+Na]+, 199 [M-H]-., 67899-00-7

As the paragraph descriping shows that 67899-00-7 is playing an increasingly important role.

Reference£º
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13623-11-5,2,4,5-Trimethylthiazole,as a common compound, the synthetic route is as follows.

2,4,5-trismethyl thiazole (2.5 g, 19.65 mmol), N-bromosuccinimide(10.49 g, 58.96 mmol) and benzoyl peroxide (30 mg) were dissolved in 150 ml of CCl4. Resulting mixture was stirred at 70 C for 5 h. After cooling, succinimide salt was removed by water washing and product was extracted by DCM (50 ml ¡Á 2).To this organic layer washed with brine solution and dried over Na2SO4. This product was also not stable at room temperature for long time and it was stable only at below 15 C in DCMsolvent. This crude product was also used for further synthesiswithout purification.

13623-11-5, The synthetic route of 13623-11-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mahesh; Karpagam; Journal of Fluorescence; vol. 26; 4; (2016); p. 1457 – 1466;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

79836-78-5, Ethyl 2-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Intermediate 15-a To a solution of ethyl 2-methylthiazole-5-carboxylate (5.82 g, 34.0 mmol) in THF (170 ml), cooled to 0 C, was added a 1.0M solution of LiAIH4 in THF (34.0 ml, 34.0 mmol) and the reaction was slowly warmed to room temperature and stirred overnight. Water (1.3 ml) was slowly added, followed by 15% NaOH (1.3 ml_). The solution was stirred for 2 hours at room temperature then filtered over celite. The filtrate was concentrated under reduced pressure to provide intermediate 15-a as a yellow oil., 79836-78-5

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; JAQUITH, James B.; WO2013/177668; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 63 (3-Chloro-5-thiazol-4-yl-phenyl)-(1 H-imidazol-2-yl)-methanoneA solution of Example 53 (50 mg, 0.15 mmol) in 1 ,4-dioxane (3 ml_) was stirred in a microwave reaction tube. 4-Tributylstannanyl-thiazole (62 mg, 0.165 mmol) followed by Pd(PPh3)4 (10 mg, 8.6 mumol) was added to the stirred mixture. The tube was sealed and the reaction was heated at 1200C for 30 mins. The mixture was then diluted with EtOAc (20 ml.) and washed with brine. The organic phase was then dried over Na2SO4, filtered and the solvent evaporated. The crude was triturated in dichloromethane and the collected precipitate was purified further by SiO2 chromatography (Hexanes/ EtOAc; 9:1 to 2:1 ) to give the title compound as a beige solid (10 mg, 23%). MS(ESI) m/z 289.9 (M+H)+. 1H NMR (400 MHz, DMSO-d6): 13.62 (1 H, s), 9.28 (1 H, d), 8.97 (1 H, t), 8.58 (1 H, t), 8.46 (1 H, d), 8.34 (1 H, t), 7.58 (1 H, s), 7.39 (1 H, s).

173979-01-6, The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5304-21-2,6-Bromo-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,5304-21-2

Compound 11 (114 mg, 0.500 mmol)Was dissolved in methanol (5.00 mL), And benzaldehyde (51.0 muL, 0.500 mmol),Sodium hydroxide (60.0 mg, 1.50 mmol) was added,And heated under reflux for 14 hours under stirring.Precipitated crystals were collected by filtration,And washed with methanol and purified water to obtain Compound 12 in a yield of 50.0 mg (31.8percent).

As the paragraph descriping shows that 5304-21-2 is playing an increasingly important role.

Reference£º
Patent; Kyoto University; Nihon Medi-Physics Co.,Ltd.; Saji, Hideo; Ono, Masahiro; Inohara, Tadashi; Seki, Ikuya; (24 pag.)JP2016/79108; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23056-10-2,5-Thiocyanatothiazol-2-amine,as a common compound, the synthetic route is as follows.

To a solution of Part A thiocyanate (800 mg, 5.09 mmol) and Example 1D (1.51 g, 5.09 mmol) in THF (20 mL) was added DEPBT (3.05 g, 10.18 mmol) and iPr2NEt (1.8 mL, 10.18 mmol). The reaction mixture was stirred at RT for 18 h, then was concentrated in vacuo. The residue was taken up in EtOAc and brine, and extracted with EtOAc (3¡Á). The combined organic extracts were washed with 1N aqueous HCl, H2O, 5% aqueous NaHCO3, H2O, and brine, dried (MgSO4), and concentrated in vacuo. The residue was chromatographed (SiO2; continuous gradient 10% EtOAc/Hex to 100% EtOAc/Hexane) to give Part B compound (927 mg, 42%) as an orange solid.

23056-10-2, As the paragraph descriping shows that 23056-10-2 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7709-58-2, 4-(Chloromethyl)thiazole hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20 ml (0.29 mol) of cyclopropylamine was added to a solution of 4.9 g (29.0 mmol) of 4- (chloromethyl)-thiazole hydrochloride in 45 ml ethanol and 45 ml of saturated aqueous sodium hydrogen carbonate. The reaction mixture was stirred for 20 hrs at ambient temperature and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were dried over magnesium sulphate and concentrated in vacuum. Column chromatography (gradient n- pentane/ethyl acetate) yielded 1.5 g (32% yield) of N-(1 ,3-thiazol-4-ylmethyl)cyclopropylamine. At ambient temperature a solution of 0.28g (1.4 mmol) of 3-(difluoromethyl)-1-methyl-pyrazole- 4-carbonyl chloride in 2 ml of tetrahydrofurane was added drop wise to a solution of 0.20 g (1.3 mmol) of N-(1 ,3-thiazol-4-ylmethyl)-cyclopropylamine and 0.6 ml triethylamine in 4 ml tetrahydrofurane. The reaction mixture was stirred for 16 hrs at ambient temperature and quenched with water. The watery layer was extracted three times with ethyl acetate (3 x 20 ml), the combined organic layers were dried over magnesium sulphate and concentrated in vacuum. Column chromatography (gradient n-pentane/ethyl acetate) yielded 0.13 mg (51 % yield) of N- cyclopropyl-N-(1 ,3-thiazol-4-yl-methyl)-1-methyl-3-difluoromethyl-pyrazole-4-carboxamide (M+1 = 313)., 7709-58-2

7709-58-2 4-(Chloromethyl)thiazole hydrochloride 2763289, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER CROPSCIENCE SA; WO2008/15189; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42182-65-0,Benzo[d]thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,42182-65-0

A solution of 4-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol (60 mg, 0.27 mmol), benzothiazol-2-yl-methylamine (89 mg, 0.54 mmol), pyridine (28 muL, 0.32 mmol) in anhydrous acetonitrile (0.4 mL) was stirred at 85C overnight. The solution was then concentrated and the residue was purified by preparative TLC (silica gel, dichloromethane/methanol 92/8) to give 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol (33.8 mg, 36%) as a yellow oil. ESI-MS m/z 350 (M+H)+. 1H NMR (CDCl3), delta (ppm): 8.78 (s, 1H), 7.97 (d, J = 8.1 Hz, 1H), 7.83 (d, J = 8.1 Hz, 1H), 7.48 (t, J = 7.5 Hz, 1H), 7.39-7.31 (m, 2H), 6.77-6.75 (m, 2H), 6.56 (br s, 1H), 5.16 (s, 2H), 2.30 (s, 3H).

42182-65-0 Benzo[d]thiazol-2-ylmethanamine 350414, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

Step 1 : Na (0.69 g, 30 mmol) was added to a solution of ^-butylthiol(3.38 mL, 30 mmol) at room temperature portionwise and stirred for 0.5 h. Then, 4- bromothiazole 1 (0.49 g, 3.0 mmol) was added and the mixture was heated to reflux overnight. LC-MS indicate desired product formed and the reaction was concentrated. The residue was dissolved in EA, filtered through silica gel and the filtrate was concentrated again. The residue was used for the next step directly., 34259-99-9

34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ACHAOGEN, INC.; WO2009/55696; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica