Category: thiazole

74370-93-7, 4-(tert-Butyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-(iert-butyl)thiazol-2-amine (200 mg, 1.28 mmol), and DIEA (438 muIota_, 2.56 mmol) in THF (1.5 mL) was added cyclopentanecarbonyl chloride (172 muL, 1.41 mmol). After allowing to stand at ambient temperature for 1 h, the mixture was washed with 1 N NaOH (2X2 mL), brine (2X2 mL), dried with sodium sulfate, filtered, and concentrated. Flash chromatography (0-20% hexanes/ethyl acetate) provided N-(4-tert-butyl-1 ,3-thiazol-2- yl)cyclopentanecarboxamide (286 mg, 89% yield) (A127) as a colorless solid. LCMS for C13H2oN2OS, found 253 [M+H]+., 74370-93-7

74370-93-7 4-(tert-Butyl)thiazol-2-amine 2734202, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; KEZAR LIFE SCIENCES; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MCMINN, Dustin; JOHNSON, Henry; TAUNTON, John, William; CARRASCO, Yazmin, Paulina; SHARP, Phillip, Patrick; (156 pag.)WO2019/46668; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

6436-59-5, Ethyl 2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 46 Ethyl 2-methyl-1 ,3-thiazole-4-carboxylate [6436-59-5] (5.0g, 29.2mmol) was dissolved in acetonitrile (50ml_). To this, NBS (5.7g, 32.03mmol) was added at room temperature and the mixture heated at reflux for 2 hours. To this, NBS (2.5g, 14.05mmol) was added and the mixture heated at reflux for 2 hours. To this, NBS (2.5g, 14.05mmol) was added and the mixture heated at reflux for 18 hours. The mixture was diluted with saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layer was dried with MgS04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-50% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 46 (1.58g) as a cream solid. LCMS (Method 2) Rt 2.88 min; m/z(M+H)+ 250/252, 6436-59-5

As the paragraph descriping shows that 6436-59-5 is playing an increasingly important role.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
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Thiazole | chemical compound | Britannica

20949-81-9, 2-Phenylthiazole-4-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20949-81-9, COMPOUND 12.1. 38: 4-{6,7-DIMETHOXY-2-[(2-PHENYL-1,3-THIAZOL-5- YL) METHYLl-1, 2, 3, 4-TETRAHYDROISOOUINOLIN-1-YL- N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 7 (50 mg, 0.14 mmol) and 2-phenyl-4-thiazolecarbaldehyde (51 mg, 0.27 mmol) were dissolved in 1,2-dichloroethane (2 mL) and sodium triacetoxyborohydride (115 mg, 0.54 mmol) was added. The reaction mixture was stirred at room temperature for 18 h. Resin-bound tosylhydrazine (0.27 g, 1.5 mmol/g) was added and the mixture was agitated for another 2 h. Dichloromethane and 2 M aqueous sodium hydroxide solution were added, the mixture was shaken and passed through a Whatman 1PS filter paper. The organic phase was evaporated to dryness and purified by flash chromatography to yield the product (74 mg, 0.136 mmol, quant.). 1H NMR (500 MHz, CDC13) : 1.09, 1.23 (2 brs, 6H), 2.80, 3.04, 3.28 (3 m, 6H), 3.52 (brs, 2H), 3.82, 3.90 (2 d, J 14 Hz, 2H), 3.61, 3.85 (2 s, 6H), 4.78 (s, 1H), 6.20, 6.63 (2 s, 2H), 7.35-7. 43 (m, 7H), 7.94 (d, J 7.5 Hz, 2H). (+) LRESIMS m/z 542 (100) [M+H] +.

The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-16-0,2-Cyanothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5 mg iron trichloride (FeCI3), 2 g of sodium and 40 ml of t-amylalcohol is heated to 110 0C for 20 minutes before a mixture of 3.9 g of the thiazole-2-nitrile of the formula 1 and 7.82 g of 8 is added portion-wise. The reaction mixture is stirred at 1 10 0C for 3 hours before it is poured onto 6.3 g acetic acid in a water-methanol mixture (100ml/100ml). Bchner filtration and exhaustive washing with methanol affords 4.5 g of the desired 1 ,4- diketopyrrolo[3,4-c]pyrrole (DPP) derivative of the formula A-42 as dark blue powder; ESI- MS m/z (% int.): 302.15 ([M+H]+, 100%)., 1452-16-0

1452-16-0 2-Cyanothiazole 15111480, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BASF SE; HAYOZ, Pascal; AEBISCHER, Olivier Frederic; DUeGGELI, Mathias; TURBIEZ, Mathieu G. R.; FONRODONA TURON, Marta; CHEBOTAREVA, Natalia; WO2010/115767; (2010); A1;,
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Thiazole | chemical compound | Britannica

61296-22-8,61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Key Intermediate 1 Clnt-l A”) : 2-bromo-5-(3-ethoxy-benzesulfonylVthiazole [0103] Part A: A mixture of 3-ethoxythiophenol (10.0 g, 0.065 mol), 2-amino-5- bromothiazole monohydrobromide (17.7 g, 0.068 mol), 1 M aqueous NaOH (200 mL), and THF (200 mL) was stirred at RT for 15 min. The reaction mixture was warmed to 55 0C over Ih, cooled to RT and concentrated under reduced pressure to remove THF. The residue was partitioned between EtOAc (ca. 500 mL) and water (ca 100 mL), and the layers were separated. The organic phase was washed with saturated aqueous NaCl (1 x 200 mL), dried (Na2SO4), and concentrated under reduced pressure to give a solid. The solid was triturated with CH2Cl2.”hexanes (ca. 10:1) to provide 5-(3-ethoxy-phenylsulfanyl)-thiazol-2-ylamine (13.2 g, 80%) as a light brown solid. LCMS (m/z): 253 (M+H)+

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; ICAGEN, INC.; WO2007/75852; (2007); A2;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-34-9,Benzothiazolone,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 9.2 g, 66.6 mmol) and 1,4-dibromobutane (21.0 mL, 177.6 mmol) were added, under stirring, to a solution of benzo[d]oxazol-2(3H)-one (3.0 g, 22.2 mmol) in anhydrous DMF (30 mL). The reaction mixture was heated at 60 C for 3 h. After cooling, the reaction mixture was poured into 100 mL water and extracted with ethyl acetate (3 x 70 mL). The combined organic layers were washed with saturated aqueous NaCl and dried over sodium sulfate. The solvent was removed in vacuo, and the residue was purified by flash column chromatography (SiO2) using hexane/ethyl acetate (8:2) as eluent to give 3.6 g (62%) of 2e as a white solid. 4.2.1.3 3-(2-Bromoethyl)benzo[d]thaizol-2(3H)-one (2b) General procedure A, yield 57%, white solid. 1H NMR (400 MHz, CDCl3) delta 7.64-6.99 (m, 4H), 4.37 (t, J = 6.2, 2H), 3.82 (t, J = 6.1, 2H). 13C NMR (101 MHz, CDCl3) delta 166.07, 154.40, 142.70, 135.83, 134.62, 122.03, 120.40, 55.74, 39.59. MS (EI) m/z 258 (M++1).

934-34-9, The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abdelazeem, Ahmed H.; Khan, Shabana I.; White, Stephen W.; Sufka, Kenneth J.; McCurdy, Christopher R.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3248 – 3259;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.394223-37-1,Benzo[d]thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

To a mixture of compound B-188 (2.8 g, 17 mmol) in anhydrous dichloromethane (20 mL) was added manganese dioxide (14 g, 0.16 mol) at room temperature. The mixture was stirred at room temperature for 16 hours. On completion, the reaction was filtered, and the filtrate was concentrated in vacuo to give compound B-189 (2.5 g, 93% yield) as a yellow solid.

394223-37-1, As the paragraph descriping shows that 394223-37-1 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Hydrazone of 5-thiazolecarboxaldehyde and t-butylcarbazate Using the procedure of Example 1D, but replacing benzaldehyde with 5-thiazolecarboxaldehyde (Dondoni, et. al., Synthesis, 998(1987)), provided the desired compound., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbott Laboratories; US5461067; (1995); A;,
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Thiazole | chemical compound | Britannica

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61830-21-5

General procedure: A mixture of 2-aminothiazole derivatives 2a-h and 3a-e (1.0 mmol) and K2CO3 (4.0 mmol) was stirred at room temperature with drop-wise addition of 4-chlorobutyryl chloride (4.0 mmol) in chloroform for 48 h. The reaction mixture was monitored by TLC (using chloroform/ethyl acetate 9:1). Ammoniated water was added, and the organic layer was separated and dried over anhydrous Na2SO4, and the solvent was removed in vacuum. The resulting precipitate was crystallized from ethanol to give crystals of pure N-(thiazole-2-yl)-4-chlorobutanamide derivatives.

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghabbour, Hazem A.; Kadi, Adnan A.; Eltahir, Kamal E. H.; Angawi, Rihab F.; El-Subbagh, Hussein I.; Medicinal Chemistry Research; vol. 24; 8; (2015); p. 3194 – 3211;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-81-9,2-Phenylthiazole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of aldehyde 5 (10 mmol), benzoylacetone 6(10 mmol), concentrated H2SO4 (0.1 mL), thiourea andmethanol (50 mL) was refluxed for 24 h. The mixture wascooled and the precipitates were collected and crystallizedfrom methanol to produce compound 7.Yield: 74%. mp:148-151C , 1HNMR (DMSO-d6) : 1.69(s,3H,CH3), 5.45 (s,1H,H4), 7.35 (s, 1H,H-thiazol), 7.45-7.82 (m, 10H, phenyl), 7.89 (bs,1H, NH), 9.20 (bs,1H, NH),13CNMR (DMSO-d6) : 16.3 (CH3-C6), 55.2 (C4-tetrahydropyrimidine), 110.3, 113.4, 127.1, 127.3, 128.1,128.2, 129.3, 129.5, 130.1, 130.3, 131.4, 133.4, 133.7, 137.8,155.2, 162.3, 170.1, 175.3, 188.4, IR (KBr) cm-1: 3317,3114, 2924, 1713, 1674, 1180. Anal. Calcd. for C21H17N3OS2: C, 64.42; H, 4.38; N, 10.73. Found: C, 64.39; H, 4.46;N,10.56.

20949-81-9, The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sharifzadeh, Mohammad; Khademi, Hamid Reza; Almasirad, Ali; Rezayan, Zahra; Ghayahbashi, Mohsen Rezayan; Amini, Mohsen; Letters in drug design and discovery; vol. 10; 9; (2013); p. 900 – 905;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica