Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139670-03-4,2-Bromo-4-chlorothiazole,as a common compound, the synthetic route is as follows.

Isopropylmagnesium chloride lithium chloride complex solution (4.58 mL, 5.95 mmol) was added slowly to a suspension of 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (784 mg, 1.983 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q, step 2) (394 mg, 1.983 mmol) in THF (30 mL). The mixture was stirred at room temperature for 40 mins. The reaction mixture was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulphate and evaporated under vacuum. Purification by chromatography on silica, eluting with 10-60% EtOAc/hexane afforded the title compound. [1181] 1H NMR (400 MHz, CDCl3) delta 7.79-7.59 (4H, mult), 7.51 (1H, s), 6.51 (1H, s), 4.41 (2H, t), 3.50 (2H, t), 3.41 (3H, s), 3.35 (3H, s) [1182] LC-MS Rt 1.20 mins [M+H]+ 454.0 (Method 2minLowpHv03)

139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
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89281-44-7, 2-Methylthiazol-5-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

89281-44-7, Compound 3 was dissolved in methanol (10 mL), and then a solution of the corresponding thiazole amine in methanol (5 mL) was added to the solution. The reaction mixture was stirred at 45 C for 12 h. After the reaction was completed, which was monitored with TLC, the mixture was concentrated and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. Crude product was purified by column chromatography (ethyl acetate/petroleum ether = 8:1) to give compound 7a and 7b.

As the paragraph descriping shows that 89281-44-7 is playing an increasingly important role.

Reference£º
Article; Zheng, Min; Yao, Ting-Ting; Xu, Xiao-Jun; Cheng, Jing-Li; Zhao, Jin-Hao; Zhu, Guo-Nian; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3565 – 3568;,
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72605-86-8, Methyl 2-chlorothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72605-86-8, General procedure: A mixture of compounds 12a-c (6.5 mmol, 1.0 eq), methyl2-chlorothiazole-5-carboxylate (1.2 g, 6.5 mmol, 1.0 eq),and K2CO3 (904.0 mg, 6.5 mmol, 1.0 eq) in CH3CN(10.0 mL) was stirred at 82 C for 16 h. The mixture wasconcentrated to give the crude compounds 13-15, whichwas put into next step without further purification.

As the paragraph descriping shows that 72605-86-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jiankang; Xi, Jianjun; He, Ruoyu; Zhuang, Rangxiao; Kong, Limin; Fu, Liping; Zhao, Yanmei; Zhang, Chong; Zeng, Linghui; Lu, Jingyi; Tao, Rujia; Liu, Zhengmengtong; Zhu, Huajian; Liu, Shourong; Medicinal Chemistry Research; vol. 28; 10; (2019); p. 1633 – 1647;,
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911466-96-1,911466-96-1, 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Compound 3A (0.300 g, 1.49 mmol) was dissolved in N,N- dimethylformamide (2.98 mL), and then treated successively with PYBOP (0.854 g, 1.64 mmol), 4-methylmorpholine (0.492 mL, 4.47 mmol) and 1,2,3,4- tetrahydroquinoline (0.218 mL, 1.64 mmol). The reaction was stirred overnight at room temperature and was then slowly added to 15 mL of water, The aqueous layer was extracted with CH2CI2 (3 x 15 mL). The combined organic layer was washed with saturated aqueous NaHCO3 solution (25 mL) and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated. The product was purified by flash chromatography using a gradient of 0-40% ethyl acetate-hexanes to provide compound 4A (0.121 g, 26% yield).

The synthetic route of 911466-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2009/58730; (2009); A1;,
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1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(5-thiazolyl)-3-cyclohexylpropan-1-ol A solution of thiazole-5-carboxaldehyde (2.31 g, 20.4 mmol) in 20 mL of in THF was added to a cold (0 C.) solution of 2-cyclohexylethylmagnesium bromide (prepared from 2-bromoethylcyclohexane (7.88 g) and magnesium turnings (1.22 g)) in 30 mL of ethyl ether and the mixture stirred 30 minutes. The cold bath was removed and the mixture stirred for 2 hours more and then quenched by the addition of 3N aqueous HCl. The solution was stirred until 2 clear phases resulted and then the layers were separated. The pH of the aqueous phase was adjusted to 4 with 2M aqueous sodium carbonate and then extracted with 3 portions of ethyl acetate. All the organic phases were combined and washed with brine, dried, filtered and concentrated. The residue was purified by column chromatography on silica gel (125 g, 50% ethyl acetate/hexanes) to provide 2.69 g (58%) of the title compound. MS (DCI, NH3): 226 (MH+); 243 (M+NH4)+.

1003-32-3, As the paragraph descriping shows that 1003-32-3 is playing an increasingly important role.

Reference£º
Patent; University of Pittsburgh; US6204293; (2001); B1;,
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1003-61-8, 2-Aminothiazole-5-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Amino-5-formylthiazole (11.5 g, 90 mmol) was dissolved in methanol (120 mL), and sodium borohydride (5.11 g, 135 mmol) was added thereto while cooling with ice, followed by stirring at the same temperature for 1 hour. Acetone (6 mL) and water (10 mL) were added to the reaction mixture, followed by stirring. The residue obtained by evaporating the reaction mixture under reduced pressure was purified using medium pressure silica gel flash column chromatography (methanol:chloroform=1:15), thereby giving the title compound (5.09 g, 43%) as a white solid.

1003-61-8, 1003-61-8 2-Aminothiazole-5-carbaldehyde 2737798, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; Urade, Yoshihiro; Kitade, Makoto; Yamane, Keiko; Aoki, Shinichi; Yamanaka, Hiroyoshi; US2013/165438; (2013); A1;,
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2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.33 2-(4-(Thiophen-2-yl)butanoyl)benzo[d]isothiazol-3(2H)-one (37) Compound 37 was prepared through 4-(2-thienyl)butyric acid, obtained a white solid in 81% yield. Mp 117.4-118.3 C. 1H NMR (400 MHz, DMSO-d6) delta 7.95 (t, J = 8.0 Hz, 2H), 7.79 (t, J = 8.0 Hz, 1H), 7.47 (t, J = 7.6 Hz, 1H), 7.33 (dd, J = 4.8, 0.8 Hz, 1H), 6.95 (dd, J = 4.8, 3.6 Hz, 1H), 6.89 (d, J = 2.8 Hz, 1H), 3.16 (t, J = 7.6 Hz, 2H), 2.91 (t, J = 7.6 Hz, 2H), 2.04-1.96 (m, 2H); 13C NMR (101 MHz, DMSO-d6) delta 173.1, 163.5, 144.5, 141.4, 135.0, 127.4, 126.5, 125.7, 125.1, 124.1, 122.5, 36.5, 28.9, 26.2. IR (KBr, cm-1): 1699, 1687. HRMS-ESI (m/z) calcd for C15H13NO3S2 [M+H+] 304.0466, found 304.0478., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
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78502-81-5, 5-Bromo-2-methyl-4-phenylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 27A (40 mg, 0.116 mmol), 5-bromo-2-methyl-4-phenylthiazole (59 mg, 0.232 mmol), Pd(PPh3)4(13 mg, 0.012 mmol) and K2CO3 (48 mg, 0.349 mmol) in THF (3 mL) and water (1 mL) was heated in a microwave reactor at 130 C. for 20 min. under Ar, then was cooled to rt. The reaction was diluted with water (5 mL), and extracted with EtOAc (4¡Á10 mL). The combined organic fractions were dried over MgSO4, and concentrated in vacuo to give the crude title compound. This material was used directly for the next step without further purification. LCMS, [M+H]+=392.1., 78502-81-5

The synthetic route of 78502-81-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Shi, Yan; Cheng, Peter T.W.; Wang, Ying; Jusuf, Sutjano; Tao, Shiwei; Zhang, Hao; Wu, Shung C.; Robl, Jeffrey A.; (87 pag.)US2017/253554; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 18: 4-METHYL-2-HYDRAZINOBENZOTHIAZOLE To a suspension of 4-methyl-2-aminobenzothiazole (5.0 g., 0.03 mole) in 20 ml. of ethylene glycol was added 5.4 g. of 85% hydrazine hydrate (0.09 mole) and 2.75 g. (0.046 mole) acetic acid. The mixture was heated to 126C. under N2 atmosphere for 3 hours. On cooling and dilution with about 1/2 volume of water the product crystallized.

1477-42-5, As the paragraph descriping shows that 1477-42-5 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US3937714; (1976); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3855-95-6,2-Chloro-6-benzothiazolecarboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of di-tert-butyl dicarbonate (1.2 mL, 5.0 mmol) and 2-chlorobenzo[d]thiazole-6-carboxylic acid (0.53 g, 2.5 mmol) in anhydrous t-butanol (10 mL) was added dimethylaminopyridine (91 mg, 0.74 mmol) and the mixture stirred for 1 h. The reaction was concentrated under reduced pressure and purified by silica gel chromatography eluting with 0-50% EtOAc/hexanes to give Compound 1 88a (0.56 g, 84% yield) as a clear oil. LCMS = 2.22 mm using analytical method (B), 270.0 (M+H).1H NMR (400MHz, CDC13) oe 8.45 (d, J=1.5 Hz, 1H), 8.12 (dd, J8.6, 1.8 Hz, 1H), 7.97 (d, J8.6 Hz, 1H), 1.55 – 1.42 (m, 9H)., 3855-95-6

The synthetic route of 3855-95-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; JIANG, Ji; KIM, Soong-Hoon; PI, Zulan; QIAO, Jennifer X.; TORA, George O.; WANG, Tammy C.; FINLAY, Heather; WO2014/11513; (2014); A1;,
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