Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7238-62-2,Ethyl 2-chloro-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 39 Preparation of Ethyl 2-(2′,4′-Dichlorophenoxy)-4-Methyl-5-Thiazolecarboxylate. A mixture of 6.24 g (0.03 mole) of ethyl 2-chloro-4-methyl-5-thiazolecarboxylate, 4.89 g (0.03 mole) of 2,4-dichlorophenol, 4.14 g (0.03 mole) of potassium carbonate and 40 ml. of acetone was held at reflux for 89 hours. Acetone was removed under reduced pressure. The residue was treated with 50 ml. of water and extracted with ether. The ether solution was washed successively with saturated sodium bicarbonate, 30 ml. of 10% sodium hydroxide and 50 ml. of water. The ether solution was dried (MgSO4) and concentrated. The residue was recrystallized from hexane to give 5.8 g (58%) of ethyl 2-(2′,4′-dichlorophenoxy)-4-methyl-5-thiazolecarboxylate as a white solid, m.p. 71-73 C. Anal. Calc’d. for C13 H11 Cl2 NO3 S: C, 47.00; H, 3.34; N, 4.22; Cl, 21.34. Found: C, 47.04; H, 3.34; N, 4.21; Cl, 21.36., 7238-62-2

As the paragraph descriping shows that 7238-62-2 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US4199506; (1980); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,5198-88-9

Compound 134 (0.96 g, 3.85 mmol) was dried in the tared reaction flask and weighed. This was dissolved in 30 mL dichloromethane, and 10 mL dimethylformamide was added along with a magnetic stir bar. 2-Bromothiazole-4-carboxylic acid (800.6 mg, 3.85 mmol) was weighed out and added. Diisopropylethylamine (1.0 mL, 5.7 mmol) was added followed by HATU (1.901 g, 5.00 mmol) and the reaction was stirred at room temperature overnight. This was concentrated directly onto silica and purified by column chromatography. Concentrating, then drying the pure fractions on high vacuum afforded 1.158 g of the title compound 136 (69% yield). 1H NMR (300 MHz, DMSO-d6) delta 12.14 (s, 1H), 8.57- 8.48 (m, 2H), 8.44 (s, 1H), 7.91 (ddd, J = 11.5, 8.4, 1.3 Hz, 1H), 7.52 (ddd, J = 8.4, 4.6, 3.8 Hz, 1H), 5.34 (d, J = 6.9 Hz, 1H), 4.52 (tt, J = 9.1, 7.3 Hz, 1H), 4.05 – 3.91 (m, 1H), 2.86- 2.72 (m, 2H), 2.39 (qd, J = 8.6, 2.8 Hz, 2H). m/z = 438/440 (M+H)+ (bromine isotopes).

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; KELLEY, Ryan; LI, Hui; HECKRODT, Thilo; CHEN, Yan; MCMURTRIE, Darren; TSO, Kin; TAYLOR, Vanessa; SINGH, Rajinder; YEN, Rose; MAUNG, Jack; (256 pag.)WO2016/172560; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a 250-mL round-bottom flask, 2-chloro-6-trifluoromethoxy-1,3-benzothiazole (5.36 g, 21.14 mmol) and 4-bromo-2-fluoroaniline (4.82 g, 25.36 mmol) were combined in 100 mL n-butanol containing 1% 4.0 M HCl in dioxane, and heated at 90 C. overnight. The mixture was cooled to rt and the solvent was removed under reduced pressure. Ethyl acetate (50 mL) was added, and the mixture was ultrasonicated by suspending the flask in an ultrasonication bath for 30 minutes. The mixture was filtered, and the filtrate was concentrated under reduced pressure. Acetonitrile (50 mL) was added to the mixture, which was then ultrasonicated for 30 minutes and then filtered to provide the product as a white solid (5 g, 58%). LC-MS m/z 409.1 (MH+), ret. time 4.02 min.

133840-96-7, The synthetic route of 133840-96-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US2004/224997; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

556-90-1, General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28620-12-4,6-Nitro-2-benzothiazolinone,as a common compound, the synthetic route is as follows.

Compound 47 (0.5?mmol) was dissolved in 1?mL dry DMF. Potassium carbonate (0.75?mmol) and 1-bromopentyl chloride (1.2?mmol) were added to the solution. The mixture was stirred at 80?C overnight. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (10?mL) and washed with water (2?*?10?mL). The organic layer was dried over MgSO4 and evaporated under reduced pressure. The product was purified by silica gel column chromatography (dichloromethane/petroleum ether 50:50, v/v). A yellow powder was obtained: yield 69%; mp 55?+-?1?C; 1H NMR (CDCl3) delta 8.37 (d, J?=?2.3?Hz, 1H), 8.25 (dd, J?=?2.3; 8.9?Hz, 1H), 7.14 (d, J?=?8.9?Hz, 1H), 4.01 (t, J?=?7.5?Hz, 2H), 1.75 (m, 2H), 1.40 (m, 4H), 0.90 (t, J?=?7.0?Hz, 3H); LC-MS (APCI+) m/z 267.1 (MH+).

28620-12-4, 28620-12-4 6-Nitro-2-benzothiazolinone 641571, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Leleu-Chavain, Natascha; Baudelet, Davy; Heloire, Valeria Moas; Rocha, Diana Escalante; Renault, Nicolas; Barczyk, Amelie; Djouina, Madjid; Body-Malapel, Mathilde; Carato, Pascal; Millet, Regis; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 347 – 362;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.,1477-42-5

Step 1: 4-methyl-3H-benzothiazol-2-one 5.00 g (30.5 mmol) 2-amino-4-methylbenzothiazole in 15.0 mL formic acid, 6.10 mL glacial acetic acid and 112 mL conc. hydrochloric acid were cooled to -5 C. with stirring and slowly combined with a solution of 2.10 g (30.5 mmol) sodium nitrite in 5.0 mL water. The reaction mixture was stirred for 20 min at this temperature, then heated to RT and then refluxed overnight. The cooled mixture was then mixed with water and extracted several times with EtOAc. The combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulphate, filtered and the filtrate was evaporated down. Yield: 3.70 g (74% of theoretical) ESI-MS: m/z=164 (M-H)-

The synthetic route of 1477-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/59954; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

(5- (4-Bromophenoxy) pyridin-2-yl) carbamic acid tert-butyl ester (1.460 g, 4 mmol) was dissolved in 12 mL DMFStir at room temperature, add sodium hydride (0.24g, 10mmol),After the addition was complete, the reaction was continued for 30 minutes.Then, chloromethylthiazole (1.344 g, 8 mmol) in DMF solvent (5 mL) was slowly added dropwise, and the temperature was raised to 50 C for reaction overnight.Then, 15 mL of ice water was added to the reaction, and the mixture was extracted with ethyl acetate.Combined organic phasesThe organic phase was washed with saturated brine,Dried over magnesium sulfate,Concentrated to give an oil.The oil obtained above was dissolved in 15 mL of dichloromethane.Trifluoroacetic acid (0.912g, 8mmol) was slowly added dropwise at room temperature.After the dropwise addition was completed, the mixture was stirred at 40 C and reacted overnight;The reaction was then concentrated and an aqueous potassium carbonate solution was added,Adjust the pH to 8, extract with ethyl acetate, and wash the organic phase with water.Dried, concentrated,Column chromatography [petroleum ether / ethyl acetate (v / v) = 6/4],The target compound was obtained (0.852 g, yield: 54%)., 3364-78-1

As the paragraph descriping shows that 3364-78-1 is playing an increasingly important role.

Reference£º
Patent; Dongguan Dongyangguang Pesticide Research And Development Co., Ltd.; Li Yitao; Lin Jian; Xu Junxing; Xiao Yu; Yao Wenqiang; Liu Xinshuo; (44 pag.)CN110452238; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

Step 1: ethyl 2-(2-((3-(trifluoromethyl)benzoyl)imino)-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)acetate To a solution of 4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine (200 mg, 1.297 mmol) in tetrahydrofuran (4.3 mL) were added 3-(trifluoromethyl)benzoyl chloride (324 mg, 1.56 mmol) and potassium carbonate (359 mg, 2.59 mmol). The reaction mixture was stirred at 80 C. for 5 hours and then concentrated under reduced pressure. To the resulting intermediate (0.43 mmol) were added N,N-dimethylformamide (1.5 mL) and ethyl bromoacetate (93 mg, 0.559 mmol). The reaction mixture was stirred at 80 C. for 3 hours and then cooled to room temperature. The reaction mixture was quenched with water and then extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=41) to give 103 mg of the titled compound as a white solid (Yield: 58%). 1H NMR (CDCl3, 400 MHz) delta 12.40 (brs, 1H), 8.54 (s, 1H), 8.43 (d, 1H), 7.71 (d, 1H), 7.54 (dd, 1H), 4.90 (s, 2H), 4.24-4.30 (m, 2H), 2.59 (brs, 2H), 2.50 (brs, 2H), 1.87-1.92 (m, 4H), 1.30 (t, 3H).

2933-29-1, The synthetic route of 2933-29-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38585-74-9,Thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

L. ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate. A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0 C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl3, washed successively with 1N HCl, saturated aqueous NaHCO3, and saturated brine, dried over NaSO4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl3, Rf=0.5 in 4% MeOH/CHCl3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl3) delta5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US5484801; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1603-91-4, 4-Methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 45Synthesis of (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (VIl-I) To a round bottom flask containing 40 mL CH2Cl2 was added I (695 mg, 6.09 mmol), 4-DMAP (52.3 mg, 0.43 mmol), and BoC2O (1.374 g, 6.29 mmol). The reaction mixture was stirred overnight at room temperature. Concentration of the solution in vacuo was followed by purification by column chromatography (silica gel, hexanes:EtOAc, 10: 1), affording the product as white crystals (54%).

1603-91-4, The synthetic route of 1603-91-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica