Category: thiazole

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The intermediate (3) (0.5 g, 0.00217 mol), EDCl (0.622 g, 0.00325 mol), DMAP (0.345 g, 0.0028 mol) were stirred in dichloromethane (6 mL) at 0 C, and the substituted acid (0.00217 mol) were dissolved in (4 mL) of dichloromethane and charged to the reaction mixture and stirred at room temperature for 8 h. The reaction completion was monitored by TLC. Reaction was completed. The reaction mixture was diluted with (10 mL) of dichloromethane, and was washed with 10% NaHCO3 (10 mL). Separated the organic layer and was washed with saturated brine solution (10 mL). The organic layer was dried over sodium sulfate and concentrated the organic layer under reduced pressure to afford compounds 4a-t. The spectral data of compounds 4(a-t) are given below.

494769-44-7, The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh; Rishikesan; Kumari, N. Suchetha; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 172 – 182;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.464192-28-7,2-Bromo-5-formylthiazole,as a common compound, the synthetic route is as follows.,464192-28-7

Intermediate 103 (16.34 g, 0.086 mol) was dissolved in methanol (300 mL) and cooled to 10C. Sodium borohydride (1.63 g, 0.043 mol) was added portionwise over 15 min. The cooling bath was removed and the reaction allowed to warm to room temperature and stirred for 3 hours. The solvent was evaporated. Water (100 mL) was added followed by 1N HCI (200 mL). Ethyl acetate (450 mL) was added and the phases were separated. The organic layer was washed with brine (450 mL), dried (MgS04) and concentrated to give a brown liquid. The crude product was purified by chromatography on silica, using cyclohexane-ethyl acetate (80: 20 v/v) as eluent to give the title compound. ‘H NMR (CDCI3) : 8 7.4 (1H, s), 4.82 (2H, d), 2.96 (1H, t)

The synthetic route of 464192-28-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/37818; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7210-76-6,Ethyl 2-amino-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,7210-76-6

General procedure: A solution of 2-amino-5-substituted-4-methylthiazole (1) (0.01 mol) (1a:1.2 g, 1b:1.3 g, 1c:1.6 g, 1d:1.9 g, 1e:1.9 g)[29, 30] and triethylamine (0.01 mol) (1.5 mL) was prepared by stirring in THF (50 mL) at room temperature. After cooling the mixture in an ice bath, chloroacetyl chloride (0.01mol) (0.8 mL) was added drop wise with constant stirring. Before evaporation of the solvent under reduced pressure,the reaction mixture was further stirred for 1 hour at room temperature. The precipitate formed was crystallised from ethanol [31, 12].

As the paragraph descriping shows that 7210-76-6 is playing an increasingly important role.

Reference£º
Article; Gundogdu-Karaburun, Nalan; Letters in drug design and discovery; vol. 11; 6; (2014); p. 814 – 823;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,78364-55-3

General procedure: Equimolar amounts of appropriate 2-hydrazinobenzothiazole1a-b, alpha-cyanoacetophenone 2a-c, and PTSA were mixed thoroughly in pestle mortar and heated on water bath for 4-5 min and then equimolar amount of appropriate trifluoromethyl beta-diketones 3a-d was added to it and mixed thoroughly. The reaction mixture was again heated 80-90 ¡ã C for 15 min on water bath. The solid was obtained by addition of aq. ethanol, filtered and crystallized from the mixture of ethanol and chloroform to give pure 4.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Aggarwal, Ranjana; Kumar, Virender; Bansal, Anshul; Sanz, Dionisia; Claramunt, Rosa M.; Journal of Fluorine Chemistry; vol. 140; (2012); p. 31 – 37;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5A 2-Amino-6-sulphanyl-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile 1.14 g (9.539 mmol) of 5-thiazolecarboxaldehyde and 1.91 g (19.077 mmol) of cyanothioacetamide are initially charged in 20 ml of ethanol, 2.097 ml (19.077 mmol) of 4-methylmorpholine are added and the mixture is heated under reflux for 4 hours. The mixture is then stirred at room temperature for 20 hours. The reaction mixture is concentrated and the residue is purified on silica gel (mobile phase: methylene chloride/methanol 100:0?10:1). The product-containing fractions are concentrated and the residue is triturated with acetonitrile. The solid is filtered off and dried under high vacuum. This gives 920 mg (37% of theory) of the target compound. 1H-NMR (400 MHz, DMSO-d6): delta=9.31 (s, 1H), 8.16 (s, 1H), 7.50-6.99 (s br, 2H). LC-MS (Method 2): Rt=1.29 min; MS (ESIpos): m/z=260 [M+H]+., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER SCHERING AKTIENGESELLSCHAFT; US2011/136871; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. A solution of 2-amino-4-ethoxycarbonylthiazole (1 mmole) in 1,4-dioxane (5 ML) was treated with di-tert-butyl dicarbonate (1.2 mmole), TMEDA (0.1 mmole) and DMAP (0.1 mmole) at room temperature.. After the reaction was stirred for 20 h, it was evaporated to dryness.. The residue was subjected to extraction to give 2-[N-Boc(amino)]-4-ethoxycarbonyl thiazole as a yellow solid., 5398-36-7

As the paragraph descriping shows that 5398-36-7 is playing an increasingly important role.

Reference£º
Patent; Metabasis Therapeutics, Inc.; US6756360; (2004); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-58-2,2,4-Dimethylthiazole,as a common compound, the synthetic route is as follows.

General procedure: Typically, (hetero)aryl bromide (1.0 mmol), thiazole derivatives(2.0 mmol), Pd-PEPPSI complexes (0.01e0.5 mol%), base (2 mmol),acid additive (0.3 mmol), and 3mL of DMAc solvent were addedinto a parallel reactor. After heating at 130 C for 4 h, the resultingmixture was cooled to room temperature. Subsequently, 25mL ofwater and 20 mL of dichloromethane were added into the reactor,and the mixture was stirred for another several minutes, followedby extraction three times with dichloromethane (3 x 5 mL). Theorganic layer was then combined, dried over anhydrous sodiumsulfate, filtered, and evaporated under reduced pressure to give thecrude products. The crude products were then purified by silica-gelcolumn chromatography using petroleum etheredichloromethane(15/1) as the eluent. The obtained pure products were characterizedby 1H NMR and 13C NMR spectroscopy, and the spectra can be foundin the Supporting Information. And the isolated yields of productswere obtained based on the amounts of (hetero)aryl bromides.

541-58-2, 541-58-2 2,4-Dimethylthiazole 10934, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Ma, Bei-Bei; Lan, Xiao-Bing; Shen, Dong-Sheng; Liu, Feng-Shou; Xu, Chang; Journal of Organometallic Chemistry; vol. 897; (2019); p. 13 – 22;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of compound fert-butyl 4-(4-((4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate (1 equiv), K3PO4 (2 equiv), 5-bromothiazole (1 equiv) and Pd(dppf)Cl2 (0.1 equiv) in dioxane water was stirred at 100C under N2 for 16 hrs. The reaction mixture was cooled down to room temperature and quenched by the addition of water, extracted with EtOAc. The combined organics were dried with Na2S04, filtered and solvent removed under reduced pressure. The residue was purified by silica gel chromatography to afford tert-butyl 4-(4-((4-(thiazol-5- yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate.

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Patent; KADMON CORPORATION, LLC; SKUCAS, Eduardas; LIU, Kevin, G.; KIM, Ji-In; POYUROVSKY, Masha, V.; MO, Rigen; (345 pag.)WO2019/45824; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of VIII-3 (200 mg, 0.738 mmol), VIII-4 (400 mg, 0.88 mmol), and Na2CO3 (233 mg, 2.198 mmol) in DME (6 mL) and H2O (2 mL) was added Pd(dppf)Cl2 (53.9 mg, 0.0738 mmol). The reaction mixture was flushed with nitrogen and heated to 80 C. overnight. The mixture was diluted with EtOAc (40 mL), washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (PE:EA=10:1) to give VIII-5 (50 mg, yield: 13.15%). MS (ESI) m/z (M+H)+514.1., 1024583-33-2

As the paragraph descriping shows that 1024583-33-2 is playing an increasingly important role.

Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

To a stirred solution of 2-(chloromethyl)thiazole (D) (0.97 g, 6.46 mmol), tert-butyl 4-9(4,4,5 ,5-tetramethyl- 1 ,3 ,2-dioxaborolan-2-yl)-5 ,6-dihydropyridine- 1 (2H)-carboxylate (E) (1 g, 3.23 mmol) in dry DMF (10 mL) was added K2C03 (1.33 g, 9.69 mmol) at 20- 35C and the mixture was degassed with N2 for 10 minutes. Then Pd(dppf)2Ci2 (260 mg, 0.32 mmol) was added, again degassed with N2 for another 10 minutes and heated at 110C for 14 h. Then the reaction mixture was cooled to 20-35C, diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic layer was washed with brine (100 mL), dried over anhydrous Na2S04 and filtered. The filtrate was rotary evaporated under vacuum to get residue which was purified by column chromatography using a mixture of 30% ethyl acetate/hexane as an eluent to get the desired compound as a light brown liquid (400 mg, 44%); NMR (400MHz, DMSO-<) delta 7.70 (d, J=3.4 Hz, 1H), 7.60 (d, J=3.5 Hz, 1H), 5.60 (s, 1H), 3.82 (s, 2H), 3.71 (s, 2H), 3.38 (t, J=5.9 Hz, 2H), 2.06-1.96 (m, 2H), 1.40 (s, 9H). 3364-78-1, The synthetic route of 3364-78-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/195844; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica