Category: thiazole

3034-57-9, 2-Amino-5-bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i) 4-Methyl-5-methylsulfanyl-thiazol-2-ylamine 5-Bromo-4-methyl-thiazol-2-ylamine (1.35 g, 7 mmol,) was dissolved in methanol abs. (13.5mL) and sodium methanethiolate (0.6g, 7.7 mmol) 1.1 equiv.) was added portionwise at rt. After stirring overnight, the dark colored mixture was concentrated under reduced pressure and purified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent. The desired fractions were evaporated to give the title compound as a light yellow solid: 180 mg, MS (ISP): m/e 161.1 (M+H)+, 3034-57-9

3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Hebeisen, Paul; Kitas, Eric A.; Minder, Rudolf E.; Mohr, Peter; Wessel, Hans Peter; US2009/143448; (2009); A1;,
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65872-41-5, 2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: Preparation OF 2A : (7R)-7-[(Z)-2-(2-Amino-5-chlorothiazol-4-yl)-2- (METHOXVIMINO) ACETAMIDO]-3- [ (4- (AMINOMETHYI)-1-PYDDINIO) METHYL]-3- CEPHEM-4-CARBOXYLATE Bis-trifluoroacetic Acid Salt (see Fig. 2) A. Preparation of 2-AMINO-5-CHLORO-A- .-4-THIAZOLEACETIC Acid (6) To 500mL OF DMF WERE ADDED 50.0 g (250MUNOL) OF 2-AMINO-A-(METHOXYIMINO)-4- THIAZOLEACETIC acid and 35g (260 mmol) OF N-CHLOROSUCCINIMIDE. The mixture was stirred at room temperature OVERNIGHT, after which time mass spectral analysis showed no more starting material to be present. The light brown solution was used without further purification., 65872-41-5

65872-41-5 2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetic acid 5486924, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THERAVANCE, INC.; WO2005/5436; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.

2-azidomethyl thiazole Diphenylphosphoryl azide (3.25 mL, 0.015 mol) and 1,8-diazabicyclo[5.4.0] undec-7-ene (2.25 mL, 0.025 mol) were added to a solution of thiazol-2-yl-methanol (1.44 g, 0.013 mol) in toluene (20 mL) at 0 C. After 1 hour, the reaction was warmed to room temperature and stirred overnight. The mixture was diluted with toluene (20 mL) and washed with H2 O (3*) brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The residue was purified by flash chromatography (30% ethyl acetate/hexanes) to afford the azide as a tan oil (1.1 g, 63%). IR: 2098 cm-1. 1 H NMR (250 MHz, CDCl3) delta7.8 (d, 1H, J=2.0 Hz); 7.4 (d, 1H, J=2.0 Hz); 4.7 (s, 2H).

14542-12-2, As the paragraph descriping shows that 14542-12-2 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5698526; (1997); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50850-93-6,Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

Commercially available ester 1 (1.0g, 4.5mmol) was dissolved in anhydrous THF and the RB flask was cooled to 0C. Then LiAlH4 was added slowly and the flask was stirred at 0C for additional 10min. The flask was then stirred at room temperature for 24h. The reaction was then cooled, quenched with methanol, NH4Cl Rochelle’s salt and diluted with ethyl acetate (10ml). The organic layer was separated and the aqueous layer was extracted with additional ethyl acetate (3¡Á10ml). The organic layers were combined, dried over Na2SO4 and concentrated under vacuo on a rotary evaporator to obtain a yellow solid. The crude product was purified via gradient silica gel column chromatography using a mixture of CH2Cl2 and methanol (100:1 to 5:1) to obtain the desired alcohol as yellow solid 2 (420mg, 52%). (0009) 1H NMR (500MHz, CDCl3): delta 7.57 (d, J=0.9Hz, 1H), 7.35-7.46 (m, 1H), 7.25 (dd, J=8.2, 1.8Hz, 1H), 6.45 (br s, 1H), 4.53 (s, 2H), 4.0 (br s, 1H). (0010) 13C NMR (125MHz, CDCl3): delta 167.6, 150.5, 134.9, 130.6, 125.1, 119.4, 117.7, 64.2,., 50850-93-6

The synthetic route of 50850-93-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Dutta, Aloke K.; Santra, Soumava; Harutyunyan; Das, Banibrata; Lisieski, Michael J.; Xu, Liping; Antonio, Tamara; Reith, Maarten E.A.; Perrine, Shane A.; European Journal of Pharmacology; vol. 862; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73150-67-1,2-(2-Aminothiazol-4-yl)-2-oxoacetic acid,as a common compound, the synthetic route is as follows.

This compound was then treated at 20C with a solution of 2-amino-4-thiazoleglyoxylic acid (2.61 g, 15.2 mmole) in dimethylformamide (50 ml), followed by 5 ml of water. The reaction was stirred at 20C for 20 hours, and was then chilled and diluted with 250 ml of water. Stirring of the resulting gum gave a granular solid which was filtered, washed with water, and then azeotroped with acetonitrile to dryness. The dry solid was slurried with 100 ml of acetonitrile, filtered, and finally washed sequentially with acetonitrile, ethyl ether, and hexane. Drying in air gave 1.97 g of the title compound., 73150-67-1

As the paragraph descriping shows that 73150-67-1 is playing an increasingly important role.

Reference£º
Patent; E.R. Squibb & Sons, Inc.; EP229012; (1991); B1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a 4-neck reactor equipped with a thermometer, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 100 ml of DMF in a nitrogen stream.To this solution, 41.8 g (304 mmol) of potassium carbonate and 10.34 g (60.6 mmol) of 5-bromovaleronitrile were added and the whole of the mixture was stirred at 60 C. for 8 hours.After completion of the reaction, the reaction solution was cooled to 20 C., poured into 1000 ml of water, and extracted with 1000 ml of ethyl acetate.After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate by a rotary evaporator to obtain a yellow solid.This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40)As a white solid, 6.82 g of Intermediate T was obtained (yield: 45.7%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP6191793; (2017); B1;,
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440100-94-7,440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromothiazole-5-carbonitrile (200 mg, 1.05 mmol), tert-butylpiperazine-1-carboxylate (800 mg, 4.3 mmol), potassium phosphate tribasic (260 mg, 1.22mmol), palladium acetate trimer (40 mg, 0.06 mmol), tri-tert-butylphosphinetetrafluoroborate (20 mg, 0.06 mmol) in toluene (4 mL), taken in a microwave vial underargon atmosphere was irradiated for 30 min at 80 C (TLC indicated complete consumptionof starting material). The reaction mixture was diluted with water (10 mL) and extracted withEtOAc (3 x 30 mL). The combined organic extracts were washed with brine (10 mL), driedover N a2S04 and concentrated under reduced pressure. The crude product obtained waspurified by column chromatography (100-200 silica gel, 20 g, 10-30% EtOAc-Hexane) toafford tert-butyl 4-(5-cyanothiazol-2-yl)piperazine-1-carboxylate (200 mg, 64%) as a whitesolid LCMS (ESI+): m/z: 295.60 [M+Ht.

The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: 2-Bromo-1,3-thiazole-5-carboxamide Into a 2 L round-bottom flask was added ethyl 2-bromothiazole-5-carboxylate (50.0 g, 212 mmol), THF (500 mL) and MeOH (250 mL). To this was added concentrated ammonium hydroxide in water (590 mL) and the reaction mixture was stirred at room temperature for 4 h. The solvents were removed under reduced pressure and the crude mixture poured into a separatory funnel containing brine (1 L). The aqueous layer was extracted with EtOAc (4*500 mL) and the combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure.

41731-83-3, The synthetic route of 41731-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A:4-bromothiazole-2-carboxylic acid (1,1.0 g, 4.8 mmol)Dissolved in ethylene glycol dimethyl ether (12mL)And water (4mL),Add 4-fluorophenylboronic acid (17, 1.0 g, 7.2 mmol)And anhydrous potassium carbonate (994 mg, 7.2 mmol),Then tetrakis(triphenylphosphine)palladium (277 mg, 0.24 mmol) was added.The resulting mixture was heated to 98 C under nitrogen for 24 hours.TLC analysis indicated the end of the reaction.The reaction solution was cooled to room temperature.Then add water (40 mL),The pH was adjusted to 2-3 with 6M hydrochloric acid.Filtered, the filter cake was dissolved in 20 mL of dichloromethane.The dichloromethane layer was washed with a saturated sodium bicarbonate solution.Divide the water layer,Adjust the pH of the water layer to 2-3,Filter the suspension,The filter cake was dried to give compound 18 (906 mg).Yield: 84.7%.

88982-82-5, 88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Wang Haibo; Zheng Xiaohe; Cai Zhengjiang; Zheng Shan; Ye Zhengchun; Ma Huidan; Lin Haiming; (54 pag.)CN108623532; (2018); A;,
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Thiazole | chemical compound | Britannica

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.5 M solution of nBuLi (2.0 eq) in hexane was added under argon to a solution of 2,2-dimethoxyethanamine (2.0 eq) in THF at -78C. After stirring for 30 min, thiazole-2-carbonitrile (2-Im-2, 3.0 g, 1.0 eq) was added and the resulting solution was stirred at 0 C for 2h, then quenched with 20 mL of 5% MeOH in water. The volatiles were removed and 6N HC1 was added to adjust to pH=l. The acidic solution was refluxed overnight, cooled to rt then poured into a mixture of ice and aqueous a2C03. This was extracted with EtOAc and the organic layer was concentrated to give Imadazole 2. LCMS (0.01% Ammonia): 152.1 m/z (M+H)+; ?-NMR (DMSO-d6, 500MHz): delta: 13.19 (bs, 1H), 7.98 (d, 1H, J=3.0Hz), 7.82 (d, 1H, J=3.0Hz), 7.36 (s, 1H), 7.14 (s, 1H)., 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
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Thiazole | chemical compound | Britannica