Category: thiazole

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Methoxybenzyl chloride (2.72 mL, 20.09 mmol) was added to a solution of terEbutyl (4-bromothiazol- 2-yl)carbamate (5.10 g, 18.26 mmol) and CS2CO3 (11.90 g, 36.53 mmol) in DMF (40 mL) and the mixture was stirred at 80 C for 1 h. The reaction mixture was cooled to 25 C, quenched with water (100 mL), and extracted with EtOAc (3 x 300 mL). The organic extracts were dried over MgSCL, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (hexane: EtOAc; 1 :0 to 9.5:0.5) to afford the product (7.20 g, 99%) as a pale yellow wax. (0183) NMR (500 MHz, CDCL) (ppm) 7.36 – 7.31 (m, 2H), 6.85 – 6.81 (m, 2H), 6.81 (s, 1H), 5.21 (s, 2H), 3.78 (s, 3H), 1.52 (s, 9H); 13C NMR (126 MHz, CDCl3) (ppm) 161.9, 159.1, 153.0, 129.7, 129.6, 120.5, 113.8, 112.1, 84.1, 55.4, 49.7, 28.3; (0184) HRMS calcd for ( VJ hoBr^CkS [M+H]+ 401.0353, found 401.0359, 944804-88-0

944804-88-0 tert-Butyl 4-bromothiazol-2-ylcarbamate 45117837, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MASARYKOVA UNIVERZITA; PARUCH, Kamil; CARBAIN, Benoit; HAVEL, Stepan; VSIANSKY, Vit; NIKULENKOV, Fedor; KREJCI, Lumir; (133 pag.)WO2019/201867; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78502-71-3,Ethyl 2-(bromomethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,78502-71-3

To a solution of 6-fluoro-5-methoxy-2-phenylindole (200 mg) in N,N-dimethylformamide (4.1 mL) was added sodium hydride (dispersed in liquid paraffin, minimum 55%, 54 mg) under cooling with ice, and the mixture was stirred at room temperature for 70 minutes. Then a solution of ethyl 2-bromomethylthiazole-4-carboxylate (249 mg) in N,N-dimethylformamide (0.2 mL) was added, and the mixture was stirred at 80 C. for 25 hours. The reaction mixture was allowed to cool to ambient temperature. A saturated aqueous ammonium chloride solution-water (2/1) were added to the reaction mixture and this resulting mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (125 mg).In addition, structural formula and spectrum data of the title compound are shown in Table 29

As the paragraph descriping shows that 78502-71-3 is playing an increasingly important role.

Reference£º
Patent; KISSEI PHARMACEUTICAL CO., LTD.; US2012/129890; (2012); A1;,
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Thiazole | chemical compound | Britannica

1383816-29-2, rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The previously described Example 1- lB, 2-(3-((5-cyclopropyl-3-(2- (trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4- fluorobenzo[d]thiazole-6-carboxylic acid (20 mg, 0.033 mmol), was suspended in methylene chloride (0.6 mL), cooled to 0 C and treated with Nu,Nu-diisopropylethylamine (aprox. 10 uL, 0.07 mmol) and oxalyl chloride (10 uL, 0.10 mmol). After 20 minutes the reaction was concentrated in vacuo to a reddish colored residue, suspended in THF (0.5 mL) and then treated with 10 N ammonium hydroxide. After 1 hr of stirring, the reaction was diluted with ethyl acetate (1 mL), and water washed (2 x 0.5 mL). The resulting organic extract were concentrated to dryness, re-diluted with MeOH (2 mL), and directly purified using mass-directed reverse phase HPLC, using gradient of 30 to 90 % acetonitrile/water, and 0.05 % TFA as modifier. All product fractions were cold vacuum concentrated and free-based using an SPE polymer support cartridge and MeOH (2 mL) mobilizing solvent (product SPE PLHC03 MP part no PL3540- C603). All resulting methanol effluent was concentrated to furnish the title compound as a white powder, 14 mg (70 %). MS m/z 603.1 (M + 1)., 1383816-29-2

The synthetic route of 1383816-29-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRM LLC; TULLY, David C.; RUCKER, Paul Vincent; ALPER, Phillip B.; MUTNICK, Daniel; CHIANELLI, Donatella; WO2012/87519; (2012); A1;,
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Thiazole | chemical compound | Britannica

78364-55-3,78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93-85-6,2-Aminobenzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

93-85-6, General procedure: In a flask charged with 50 mL of CH3CN was added2.5 mmol of compound 5 andappropriate benzothiazole derivatives (2a-r,1.5 eq.) and the reaction mixture was refluxed for 10-38 h until the completeconsumption of starting material as detected by TLC.After the completion of the reaction, the reactionmixture was treated with ice and the resulting solid was filtered and washedwith water (2 x 25 mL). The residue was purifiedby a silica gel column chromatography andwas eluted with dichloromethane: methanol (40:1) to afford correspondingproducts 6a-r in 49-82% of yields.

As the paragraph descriping shows that 93-85-6 is playing an increasingly important role.

Reference£º
Article; Mistry, Bhupendra M.; Patel, Rahul V.; Keum, Young-Soo; Kim, Doo Hwan; Bioorganic and Medicinal Chemistry Letters; vol. 25; 23; (2015); p. 5561 – 5565;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, 476 ml of a 1.2 molar solution of DIBAH in toluene is slowly added in drops at -75 C. under nitrogen to a solution that consists of 60 g of 2-methylthiazole-4-carboxylic acid ethyl ester in 1070 ml of methylene chloride. It is stirred for 2 more hours. Then, 150 ml of isopropanol, and then 230 ml of water are slowly added in drops to it, the cold bath is removed and stirred vigorously at 25 C. for 2 more hours. The precipitate that is produced is suctioned off and rewashed with ethyl acetate. The filtrate is concentrated by evaporation in a vacuum, and the residue that is thus obtained is purified by chromatography on silica gel. 35.6 g of the title compound is obtained with hexane/ether 1:1 as a colorless oil.1H-NMR (CDCl3): delta=2.8 (3H), 8.05 (1H), 10.0 (1H) ppm.

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Schering, AG; US7001916; (2006); B1;,
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Thiazole | chemical compound | Britannica

62266-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62266-82-4,6-Bromobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.

tert-butyl 4-[(6-bromo-2-oxo-l ,3-benzothiazol-3(2H)-yl)methyl]piperidine-l- carboxylate (11-1) , ,To a round bottom flask was added 6-bromo-l,3-benzothiazol-2(3H)-one (0.300 g, 1.304 mmol), tert-butyl 4-(hydroxymethyl)piperidine-l -carboxylate (0.365 g, 1.695 mmol), triphenylphosphine (0.455 g, 1.695 mmol), diisopropyl (E)-diazene-l,2-dicarboxylate (DIAD) (0.330 mL, 1.695 mmol), and NMP (5 mL). The reaction mixture was then permitted to stir at room temperature for two hours. The crude reaction mixture was then diluted with methanol, filtered and concentrated. Purification of crude reaction mixture by reverse phasechromatography (Waters Sunfire MSC18, 30% acetonitrile / 0.1% trifluoroacetic acid / water? 100% acetonitrile / 0.1 % trifluoroacetic acid / water) fer/-butyl 4-[(6-bromo-2-oxo-l,3- benzothiazol-3(2H)-yl)methyl]piperidine-l -carboxylate (11-1) as a tan solid. HRMS (M+H)+: observed = 427.0691 , calculated – 427.0686.

62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.; WO2011/137046; (2011); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

Step 6: Intermediate 5-h: To a solution of intermediate 5-g (1.0 g, 105.0 mmol) and intermediate 5-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature and the reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 5-h as yellow oil., 56012-38-5

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; WO2014/29007; (2014); A1;,
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Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(Trifluoromethyl)benzo[d]thiazol-2-amine (6.8 g, 31.16 mmol)was dissolved in THF (60 mL) under N2. Isoamyl nitrite (8.03 g,68.55 mmol) was added dropwise and the mixture was refluxed for1.5 h. Then the mixture was poured into ice-H2O (60 mL) andextracted with EtOAc. The organic layer was washed by saturatedaqueous NaCl and dried over Na2SO4. It was then concentrated andpurified via flash chromatography on silica gel to get 6 g (Yield43.2%) of 6-(trifluoromethyl)benzo[d]thiazole (21n) as a yellow oil.ES-LCMS m/z: 204.0 (MH).

777-12-8, The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cao, Hengyi; Zhu, Guangya; Sun, Lin; Chen, Ge; Ma, Xinxin; Luo, Xiao; Zhu, Jidong; European Journal of Medicinal Chemistry; vol. 183; (2019);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111600-83-0,5-Bromo-4-methylthiazole,as a common compound, the synthetic route is as follows.

Compound 47b (300 mg, 1.69 mmol) under nitrogen,B2pin2 (861 mg, 3.39 mmol), Pd(dppf)Cl2 (30 mg, 0.04 mmol) and KOAc (332 mg, 3.39 mmol) were placed in a reaction flask.Add 20mL of ethylene glycol dimethyl ether,Heat to 80 C for 8 h.After the reaction was cooled to room temperature, filtered and the filtrate washed with water, EtOAc. The combined organic phase was dried over anhydrous sodium sulfate, filtered and the solvent was distilled off under reduced pressure, purified by silica gel column chromatography to give compound 47c (400mg).

111600-83-0, As the paragraph descriping shows that 111600-83-0 is playing an increasingly important role.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Zhu Jiawang; Cai Jiaqiang; Li Guiying; You Zejin; Wu Yongyong; Han Runfeng; Ge Yong; Wang Lichun; Wang Jingyi; (49 pag.)CN109928979; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica