Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-58-2,2,4-Dimethylthiazole,as a common compound, the synthetic route is as follows.,541-58-2

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

The synthetic route of 541-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133046-46-5,Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (80 mg) in ethanol (1 ml) was treated with 2N sodium hydroxide (0.706 ml) and the solution stirred at room temperature for 18 h. 2M Hydrochloric acid (0.54 ml) was added and the mixture blown down to dryness. The residue was dried under vacuum over phosphorous pentoxide and was then suspended in dry dichloromethane (1 ml) and treated at room temperature with oxalyl chloride (0.032 ml) and DMF (1 drop). The mixture was stirred at room temperature for 30 mins and then added dropwise to a solution of Intermediate 16 (98 mg) in acetonitrile (2 ml) and the mixture was stirred at room temperature for 22 h. The mixture was diluted with dichloromethane (15 ml), washed with brine (2¡Á15 ml) and blown down to dryness. The residue was purified by mass directed autoprep HPLC followed by SPE cartridge (5 g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 339 as a brown gum (96 mg). LCMS showed MH+=483; TRET=2.57 min.

133046-46-5, The synthetic route of 133046-46-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Edlin, Christopher David; Holman, Stuart; Jones, Paul Spencer; Keeling, Suzanne Elaine; Lindvall, Mika Kristian; Mitchell, Charlotte Jane; Trivedi, Naimisha; US2009/131431; (2009); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-32-3,Thiazole-5-carboxyaldehyde,as a common compound, the synthetic route is as follows.

A solution of (2,6-di-tert-butyl-4H-pyran-4yl)tributylphosphonium perchlorate 1b (607 mg, 1.23 mmol) in anhydrous THF (10 mL) was prepared, purged with argon and cooled to -78 C. To this solution, n-BuLi (1.6 M in hexanes) (0.77 mL, 1.59 mmol) was added dropwise and the resulting mixture was stirred for 15 min. Then thiazole-5-carbaldehyde 4 (86 mg, 0.94 mmol) in anhydrous THF (7 mL) was added dropwise and the mixture was progressively heated to reach 0 C during 4 h. Saturated NH4Cl solution was added to quench the reaction and the solvent was evaporated under reduce pressure. The organic layer was extracted with dichloromethane, washed with water and dried over anhydrous MgSO4. After removal of the solvent, the product was purified by alumina column chromatography (30% ethyl acetate in hexanes). Yield: orange solid (219 mg, 0.75 mmol; 88%). Mp 60-61 C. IR (KBr): cm-1 1577 (C=C). 1H NMR (300 MHz, CD2Cl2): delta (ppm) 8.52 (s, 1H), 7.63 (s, 1H), 6.23 (d, J = 2.0 Hz, 1H), 5.81 (s, 1H), 5.69 (d, J = 2.0 Hz, 1H), 1.24 (s, 9H), 1.20 (s, 9H). 13C NMR (75 MHz, CD2Cl2): delta (ppm) 165.7, 163.2, 148.8, 140.2, 137.2, 131.9, 104.6, 99.9, 98.9, 36.2, 35.7, 28.2, 28.1. HRMS (ESI+): m/z calcd for [C17H24NOS]+: 290.1573, found: 290.1577., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Perez Tejada, Raquel; Pelleja, Laia; Palomares, Emilio; Franco, Santiago; Orduna, Jesus; Garin, Javier; Andreu, Raquel; Organic electronics; vol. 15; 11; (2014); p. 3237 – 3250;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235406-28-6,3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide,as a common compound, the synthetic route is as follows.

General procedure: A 0.2M solution in DMSO of the compound of formula (IV) (500 muL, 100 mumol) was added to a 0.2M solution in DMSO of the compound of formula (II) (500 muL, 100 mumol) followed by anhydrous potassium phosphate (64 mg, 300 mumol). The reaction mixture was heated to 80 C. for 16 hours before concentrating in vacuo. The residue was dissolved in DMSO (1 mL) and purified using preparative HPLC as described below to afford the desired compound of formula (I). The compounds of the Examples in the table belowwere prepared from the appropriate sulphonamide and: (a)3-cyano-4-fluorophenol; (b) 3,4-difluorophenol or (c)3-chioro-4-cyanophenol; according to Library Protocol 3.1., 1235406-28-6

1235406-28-6 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide 58042268, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; Owen, Robert McKenzie; Storer, Robert Ian; US2014/315933; (2014); A1;,
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Thiazole | chemical compound | Britannica

615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

615-21-4, 2.00 g of the compound represented by the formula (C-3-1) and 20 mL of tetrahydrofuran were placed in a reaction vessel under a nitrogen atmosphere.While cooling with ice, 0.69 g of sodium methoxide was added, and the mixture was stirred at room temperature for 2 hours.A solution obtained by dissolving 3.17 g of the compound represented by the formula (C-3-2) in 5 mL of tetrahydrofuran was added dropwise.After stirring at room temperature for 5 hours, it was diluted with 100 mL of dichloromethane and poured into water.The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated.By subjecting column chromatography (ruthenium gel, dichloromethane) and recrystallization (dichloromethane/hexane), 2.67 g of the compound of formula (C-3) was obtained.The yield of the compound represented by the formula (C-3-1) was 80%. The reaction solution after the reaction showed a light coloration.

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; MAMIYA, JUNICHI; (100 pag.)TW2019/14995; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5398-36-7,Ethyl 2-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,5398-36-7

Thiazole 4b (0.439 g 2.5 mmol) was dissolved in a mixture ofCH2Cl2:THF (1:1) (10 mL). (Boc)2O (0.577 g, 2.65 mmol) and TEA (0.744 g, 7.36 mmol) were added. The mixture was refluxed for 72 h and then concentrated under reduced pressure. The residue was disolved in AcOEt, washed with HCl 5% v/v (3 x 15 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica flash cromatography AcOEt:EP (3:7). White solid. Yield 74%. 1H NMR ((CD3)2CO, 400 MHz): delta 1.33 (t, 3H,J =7.2 Hz), 1.54 (s, 9H), 4.30 (q, 2H, J = 7.2 Hz), 7.22 (s, 1H), 10.33 (s,1H). 13C NMR ((CD3)2CO, 100 MHz): delta 14.6, 28.2, 61.1, 82.2, 122.4,143.0, 160.4, 161.8.

The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Franco, Jaime; Medeiros, Andrea; Benitez, Diego; Perelmuter, Karen; Serra, Gloria; Comini, Marcelo A.; Scarone, Laura; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 776 – 788;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, As the paragraph descriping shows that 348-40-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To 2-methyl-1 ,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80 ¡ãC for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80 ¡ãC. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound, 1 .12 g.1H NMR (DSMO) delta 8.34 (s, 1 H), 2.80 (s, 3H), 35272-15-2

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; BALDWIN, Ian Robert; DOWN, Kenneth David; FAULDER, Paul; GAINES, Simon; HAMBLIN, Julie Nicole; JONES, Katherine Louise; LE, Joelle; LUNNISS, Christopher James; PARR, Nigel James; RITCHIE, Timothy John; ROBINSON, John Edward; SMETHURST, Christian Alan Paul; WO2011/67366; (2011); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53266-94-7,Ethyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,53266-94-7

A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl) acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190 ¡ãC for 5 h and then cooled at RT and diluted with 100 mL of CH2CL2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDC13) : 81. 26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7. 86 (m, 10 H) ; Mass Spectrum (NH3-CI): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2005/14537; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.349-49-5,4-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

(Example 48) 4-Hydroxy-4-(trifluoromethyl)-3-{1-[4-(trifluoromethyl)1,3-thiazol-2-yl]piperidin-4-yl}-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (hereinafter, referred to as compound 48-a)[0476] Copper(II) chloride (2.90 g, 21.57 mmol) was added to a solution of 2-amino-4-(trifluoromethyl)thiazole (3.05 g, 18.14 mmol) in acetonitrile (80 mL), then isoamyl nitrite (3.60 mL, 27.04 mmol) was added dropwise thereto at 0¡ãC, and the mixture was stirred at room temperature for 1 hour and at 50¡ãC for 2 hours. Then, the solvent in the reaction solution was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 100/0 – 70/30 (gradient)] to obtain an oil (1.12 g)._: [0478] 4-Hydroxy-3-(piperidin-4-yl)-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (62 mg, 0.18 mmol) produced in Reference Example 60 and N,N-diisopropylethylamine (40 muL, 0.24 mmol) were added to a solution of the obtained oil (55 mg) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature for 5 hours and further at 0¡ãC for 2 hours and 30 minutes. The reaction solution was diluted with ethyl acetate, washed with water and brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 70/30 – 10/90 (gradient)] to obtain the title compound 48-a (6 mg, yield: 6percent) and compound 48-b (18 mg, yield: 16percent). Compound 48-a 1H-NMR (400 MHz, DMSO-d6) delta: 12.29 (1H, s), 10.53 (1H, s), 7.54 (1H, s), 6.79 (1H, s), 4.05-3.96 (2H, m), 3.40-3.20 (1H, m), 3.14 (2H, t, J = 12 Hz), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.94-1.74 (4H, m); MS (ESI) m/z: 456 (M+H)+.Compound 48-b 1H-NMR (400 MHz, DMSO-d6) delta: 12.27 (1H, s), 10.54 (1H, s), 8.61 (1H, s), 6.80 (9H, s), 4.10 (2H, d, J = 13 Hz), 3.33-3.18 (3H, m), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.99-1.74 (4H, m); MS (ESI) m/z: 607 (M+H)+., 349-49-5

As the paragraph descriping shows that 349-49-5 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; KOBAYASHI, Hideki; OHKAWA, Nobuyuki; TAKANO, Daisuke; KUBOTA, Hideki; ONODA, Toshio; KANEKO, Toshio; ARAI, Masami; TERASAKA, Naoki; EP2862861; (2015); A1;,
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