Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromothiazole (200 mg, 1.2 mmol), (2-nitrophenyl)boronic acid (306 mg, 1.8 mmol), Na2CO3 (259 mg, 2.4 mmol) and Pd(PPh3)4(141 mg, 0.1 mmol) in DMA (5 mL) was degassed with nitrogen, heated to 150 C. and stirred for 2 hours under nitrogen atmosphere and microwave. The reaction was cooled to r.t, filtered and concentrated in vacuo. The residue was diluted with water, extracted with EA. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to give 5-(2-nitrophenyl)thiazole (130 mg, 52% yield) as a yellow solid. LC/MS (ESI, m/z): [M+1]+=207.2

3034-55-7, 3034-55-7 5-Bromothiazole 546059, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
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2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.11 2-(2-(2-Chlorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (15) Compound 15 was prepared through 2-chlorophenylacetic acid, obtained a white solid in 79% yield. Mp 171.3-172.5 C. 1H NMR (400 MHz, DMSO-d6) delta 8.00 (dd, J = 8.0, 3.6 Hz, 2H), 7.83 (t, J = 8.0 Hz, 1H), 7.53-7.45 (m, 3H), 7.38-7.34 (m, 2H), 4.62 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.3, 163.8, 141.5, 135.2, 134.3, 132.79, 132.77, 129.6, 129.5, 127.7, 127.6, 126.7, 125.5, 122.7, 41.8. IR (KBr, cm-1): 1700, 1685. HRMS-ESI (m/z) calcd for C15H10ClNO2S [M+H+] 304.0199, found 304.0197., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

intermediate 69:6-bromo-W-[2-chloro-6-{4-morpholinylmeth^amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 2-ch.oro-6-(4- morpholinylmethyl)-4-pyrimidinamine (1.356 g, 5.93 mmol) and 6-bromo-2-chloro-1 ,3- benzothiazo.e (1 ,474 g, 5.93 mmol) in dry A/,A/-dimethy.forrnamide (30 mL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in mineral oil, 0.474 g, 1 1.86 mmol). The reaction mixture was stirred with cooling for 1 hour and at ambient temperature for a further 1 hour. The mixture was treated cautiously with saturated ammonium chloride (7.5 mL). Saturated aqueous sodium carbonate was added (aqueous pH=11 ) and the product was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried using a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica using a gradient elution from 0 to 100 % ethyl acetate in cyciohexane followed by 0 to 30 % methanol in dichloromethane to afford the title compound (1.7 g, 3.86 mmol, 65 % yield). LCMS (Method D): Rt 1.19 minutes; m/z 440, 442 (MH+).

The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David; WO2012/35055; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56012-38-5,56012-38-5, (2-Methylthiazol-5-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.066 mL, 0.85 mmol) was added to (2-methylthiazol-5-yl)methanol (100mg, 0.77 mmol) and triethylamine (0.215 mL, 1.55 mmol) in DCM (3mL) at 0C over a period of 1 minute under nitrogen. The resulting solution was stirred at 0 C for 1 hour, then evaporated, redissolved in DCM (5m1) and washed with water (5m1). The organic phase was dried using a phase separator cartridge, evaporated and dried under vacuum to give (2-methylthiazol-5 -yl)methyl methanesulfonate (124 mg, 77 %) as animpure colourless gum which was used crude in the next stage. m/z: ES+ [M+H]+ not seen.

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
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886361-30-4, Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an inert atmosphere, copper(II)bromide (47.3 mmol, 1.0 eq) was suspended in MeCN (200 mL) and cooled to 5-10 C. followed by the addition of 3-methylbutylnitrite (71 mmol, 1.45 eq) over 15 min. To this reaction mixture the respective 2-aminothiazole derivative (47.3 mmol, 1 eq) was added in portions over 35 min at 5-10 C. The reaction mixture was then carefully heated to 65 C. and stirring continued for 2 h. The volatiles were removed under reduced pressure and the black residue was purified by FC (heptane/EtOAc, as the appropriate mixture) to give the products as slightly yellow oils or solids

886361-30-4, 886361-30-4 Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate 2782963, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Aissaoui, Hamed; Boss, Christoph; Gude, Markus; Koberstein, Ralf; Sifferlen, Thierry; US2010/222328; (2010); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a black solution of Copper (II) bromide (149 mg, 0.666 mmol) in Acetonitrile(1 mL) was added t-Butyl nitrite (0.095 mL, 0.72 1 mmol) at room temperature followedby 6-methoxybenzo[d]thiazol-2-amine (100mg, 0.555 mmol). Immediate bubbling and amild exotherm was observed upon benzothiazole addition. After 3 hours, the reactionmixture was diluted with EtOAc and washed with 1.0 M HC1, saturated NaHCO3, andthen Brine. The organic phase was dried over Mg504, filtered and concentrated to areddish-brown solid. The crude material was purified by ISCO flash chromatography (0-15% EtOAc/Hex over 20 mm, 12 g silica gel cartridge, Product at 5%). The desiredfractions were combined and concentrated to yield Intermediate 253A (84 mg, 0.344mmol, 62.0 % yield) as an off-white solid. LC-MS. Method H, RT = 1.12 mm, MS (ESI)m/z: 244.0, 246.0 (M+H). ?H NMR (400MHz, CHLOROFORM-d) 7.89 (d, J9.0 Hz,1H), 7.28 (1H under CDC13), 7.09 (dd, J9.0, 2.6 Hz, 1H), 3.90 (s, 3H)

1747-60-0, The synthetic route of 1747-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example No. 149Preparation of (4 , 5 -Dimethyl-thiazol-2-yl) – (8-methoxy-2H- pyrazolo [3 , 4-c] quinolin-4 -yl) -amine4 , 5-dimethylthiazol-2 -amine (0.4 mmol 2 eq. , ) was dissolved in THF (dry, 3mL) in a microwave vial (2-5mL) LiHMDS 2M in THF(0.6 mmol 4eq.) was added. The mixture was stirred for 20 min at r.t. and then added to a solution of 4-chloro-8-methoxy-2-(4 -methoxybenzyl) -2H-pyrazolo [3 , 4-c] quinoline (0.16 mmol, leq.) in pyridine (2mL) . The reaction mixture was irradiated in a microwave reactor for 20 min at 200 C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 325.1205 g/molHPLC-MS: analytical method Brt: 2.397 min – found mass: 326.1 (m/z+H), 2289-75-0

The synthetic route of 2289-75-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; KOESTLER, Roland; YEHIA, Nasser; WO2012/143143; (2012); A1;,
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541-58-2, 2,4-Dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

541-58-2, The 2,4-dimethylthiazol-5-ylsulphonyl chloride used as a starting material is commercially available and is also described in J. Het. Chem., 1981, 18., 997. The material may also be prepared as follows :- o Chlorosulphonic acid (20 ml) was cooled to 15C in an ice/methanol bath.2,4-Dimethylthiazole (11.32 g) was added dropwise over 45 minutes, with the evolution of hydrogen chloride gas during the addition. The mixture so obtained was heated to 140-1500C for 16 hours. The resultant mixture was cooled to 110-120C and finely powdered phosphorus pentachloride (41.6 g) was added in small portions, with the evolution of further hydrogen 5 chloride gas during the addition. The mixture so obtained was heated to 12O0C for 1 hour. The mixture was cooled to ambient temperature and poured slowly into a vigorously stirred mixture of ice (200 g) and water (200 ml). The mixture so obtained was stirred for 30 minutes. The mixture was extracted with methylene chloride. The organic extract was dried over magnesium sulphate and purified by chromatography on silica using increasingly polar Q mixtures of isohexane and diethyl ether as eluent. There was thus obtained2,4-dimethylthiazol-5-ylsulphonyl chloride as a yellow oil (18.4 g); 1H NMR Spectrum: (CDCl3) 2.76 (3H, s), 2.77 (3H, s).

As the paragraph descriping shows that 541-58-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/129052; (2007); A1;,
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Thiazole | chemical compound | Britannica

14527-41-4, 5-Thiazolecarboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example IX.1 (general route) (R)-Benzyl 3-(4-((S)-1 -(thiazole-5-carboxamido)ethyl)phenoxy)pyrrolidine-1 – carboxylate _ – 86 – 3.80 g (10.1 mmol) of example VIII in 20 ml_ DMF are charged with 5.15 ml_ (29.9 mmol) DIPEA, 3.80 g (11.5 mmol) TBTU and finally after 10 min with 1.29 g (9.99 mmol) thiazole-5-carboxylic acid. The reaction mixture is stirred at r.t. over night. The next day water is added and the mixture is extracted with EtOAc (3x). The organic layers are combined, dried over MgS04, filtered and the solvent is removed in vacuo. The crude product is purified by flash chromatography (silica gel, EtOAc). Then the product is added to EtOAc and washed with a saturated aq. NaHCO3 solution (3x), dried over MgSO4, filtered and the solvent is removed in vacuo. C24H25N3O4S (M= 451.5 g/mol) ESI-MS: 452 [M+Hf Rt (HPLC):0.92 min (method D), 14527-41-4

14527-41-4 5-Thiazolecarboxylic acid 84494, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEIMANN, Annekatrin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/170197; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1759-28-0,4-Methyl-5-vinylthiazole,as a common compound, the synthetic route is as follows.

At room temperature, (Rs) imine 2 (0.3 mmol) and the additive (0.315 mmol) was dissolved in 3 mL THF with vigorous stirring for about half an hour. The resulted clear solution was added to the priorly prepared benzothiazol-2-yl metallic reagent (0.45 mmol in 3 mL THF) at -78 C. The reaction was accomplished rapidly within 10 min (monitored by TLC). Then the reaction was quenched with aqueous saturated NH4Cl, extracted with DCM (10 mL ¡Á 3), washed by brine (10 mL), dried over Na2SO4, and concentrated under vacuum. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate 3:1-1:1). The diastereoselectivity was determined by 1H NMR analysis of the crude product., 1759-28-0

The synthetic route of 1759-28-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhang, Jinlong; Yang, Yuhong; Wang, Mei; Lin, Li; Wang, Rui; Tetrahedron Letters; vol. 53; 51; (2012); p. 6893 – 6896;,
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Thiazole | chemical compound | Britannica