Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-80-5,Thiazole-4-carboxaldehyde,as a common compound, the synthetic route is as follows.

A stirred mixture of 2-amino-4-methyl-pentanoic acid tert-butyl ester, hydrochloride (2. 1G, 9.38 mmol), 1, 3-thiazole-4-carboxaldehyde (Intermediate b) (1. 06 g, 9.38 MMOL) and triethylamine (1.31 mL, 9.38 MMOL) in dichloromethane (25 mL) was heated under reflux under nitrogen for 20 hours. The reaction mixture was allowed to cool to room temperature, washed twice with water, dried over NA2SO4 and evaporated to give the title compound as an oil. ‘H NMR (CDCI3) : 5 8.84 (s, 1H), 8.49 (d, 1 H), 8.01 (s, 1H), 4.00 (dd, 1 H), 1.90-1. 70 (m, 2H), 1.64-1. 56 (m, 1H), 1.47 (s, 9H), 0.96 (d, 3H) and 0.91 (d, 3H)., 3364-80-5

3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/60889; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

A solution of (S)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine (0.200 g, 1.18 mmol) and Na2CO3 (1.18 mmol) in N,N-dimethylformamide (10 mL) was stirred at room temperature for 15 min. Then 2,2,2-trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-one (0.438 g, 1.18 mmol) was added and the mixture stirred at 40 C for 2.5 h. Solvent was removed under reduced pressure and purified by column chromatography using dichloromethane/methanol (20:1) as eluent. Yield: 340 mg (68%); white crystals; mp 129-130C; [alpha]D -23.0 (c 0.18, MeOH); 1H NMR (400 MHz, DMSO-d6) delta 1.73-1.83 (m, 1H, HA-7), 1.89-1.96 (m, 1H, HB-7), 2.43-2.54 (m, 3H, signal overlapped with DMSO-d5, H-5, HA-4), 2.79 (dd, 1H, J = 5.5, 14.7 Hz, HB-4), 4.08-4.17 (m, 1H, CHNH), 6.69 (s, 2H, 2-NH2), 7.00 (s, 1H, Ar-H-3), 8.07 (d, 1H, J = 7.8 Hz, NH-C=O), 12.69 (s, 1H, Ar-NH) ppm; 13C NMR (101 MHz, DMSO-d6) delta 24.9, 28.7, 28.8, 45.5, 97.8, 104.5, 112.3, 112.9, 128.1, 144.2, 158.3, 166.2 ppm.

106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various.

Reference£º
Article; Campos, Ludmila E.; Garibotto, Francisco M.; Angelina, Emilio; Kos, Jiri; Toma?i?, Tihomir; Zidar, Nace; Kikelj, Danijel; Gonec; Marvanova, Pavlina; Mokry, Petr; Jampilek; Alvarez, Sergio E.; Enriz, Ricardo D.; Bioorganic Chemistry; vol. 91; (2019);,
Thiazole | C3H3NS – PubChem
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55690-60-3, 5-Methoxybenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55690-60-3, Sulfuryl chloride (10 mL) was added to 5-methoxy-2- mercaptobenzothiazole at 0 0C. After complete addition, the reaction mixture was allowed to warm to it. After 2 h, the reaction mixture was poured into ice water (100 mL). This was allowed to warm to rt and was extracted with EtOAc (3 x). The combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure. The material was used without further purification. LC-MS: RT = 9.08 min., [M+H]+ = 234.0.

55690-60-3 5-Methoxybenzo[d]thiazole-2-thiol 2830679, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CRITICAL THERAPEUTICS, INC.; WO2007/146066; (2007); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66947-92-0,Methyl 2-amino-1,3-benzothiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

2-Bromo-benzothiazole-6-carboxylic acid; [00105] To a solution of 2-bromo-benzothiazole-6-carboxylic acid methyl ester (1.256 g, 4.39 mmol) in THF (60 mL) and H2O (20 mL) is added lithium hydroxide monohydrate (920 mg, 21.9 mmol) at 0 0C. The mixture is stirred at rt overnight. The mixture is treated with IN HCl solution to adjust pH to 2 and extracted with ethyl acetate. The organic phase is washed with brine. The solvent is removed in vacuo and the crude product is used for next step without further purification. MS(ESI) m/z: 257.9 (M+l) +., 66947-92-0

The synthetic route of 66947-92-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRM LLC; WO2008/124393; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.682342-65-0,5-Iodo-4-(trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,682342-65-0

2-Amino-5-iodo-4-trifluoromethylthiazole (1.2 g) was dissolved in pyridine (2 ml) and thiophene-2-carbonyl chloride (0.80 g) was added at room temperature with stirring. The mixture was stirred for 6 hr at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The chloroform layer was dried over magnesium sulfate and the solvent was removed under reduced pressure. The solid thus obtained was recrystallized from methanol to give N-(5-iodo-4-trifluoromethylthiazol-2-yl)thiophene-2-carboxamide (1.2 g), m. p. 184-185 C.

682342-65-0 5-Iodo-4-(trifluoromethyl)thiazol-2-amine 22717671, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Nippon Soda Co., Ltd.; US2004/82629; (2004); A1;,
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88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88982-82-5

Intermediate 14 (1.98g, 9.5 mmol) was dissolved in methanol (50 ml) and N-(3- dimethylaminopropyl)-iV-ethylcarbodiimide hydrochloride (2.73g, 14.3mmol), 1- hydroxybenzotriazole (1.93g, 14.3mmol), and diisopropylethylamine (2.5ml, 14.3mmol) added. The resulting mixture was stirred at room temperature for 17 hours. The mixture was evaporated, and the resulting residue partitioned between CH2Cl2 and water. The organic layer was washed30 with IN HCl, sat. NaHCO3, sat. NaCl, dried over Na2SO4, filtered and evaporated to give the title compound. 1HNMR (500 MHz, CDCl3) delta: 7.57 (s, IH), 4.04 (s, 3H).

88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various.

Reference£º
Patent; MERCK & CO., INC.; WO2008/57336; (2008); A2;,
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79836-78-5,79836-78-5, Ethyl 2-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 0¡ã C. solution of ethyl 2-methyl-thiazole-5-carboxylate (15 g, 88 mmol) in tetrahydrofuran (50 mL) was added aqueous sodium hydroxide solution (5 N, 50 mL) over 10 minutes, and the resulting solution was stirred at room temperature for another 2 hours. It was then acidified with hydrochloric acid (2 N) to pH=1 and extracted with tetrahydrofuran (3¡Á100 mL). The combined organic layers were washed with brine (30 mL) and dried over sodium sulfate. Most of the solvents were removed under reduced pressure and the residue was lyophilized to afford Compound (E) (14 g).

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; CHUNG, John Inn; PIRJANIAN, Armen; ALVAREZ-NUNEZ, Fernando Antonio; KATZ, Jeffrey Michael; DAURIO, Dominick Paul; LA, Stevedat; KENNEDY, Michael T.; (52 pag.)US2018/161279; (2018); A1;,
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10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-Boc-piperazine (1.42 g, 7.6 mmol, 1.1 eq) was dissolved in 1,2-DCE (20 mL). To this solution, 2-thiazolecarboxaldehyde (0.780 g, 6.91 mmol, 1 eq) in 1,2-DCE (4 mL) was added followed by the portionwise addition of sodium triacetoxyborohydride (2.05 g, 9.68 mmol, 1.4 eq). The mixture was stirred at room temperature for 3 h and then washed with an aqueous saturated solution of NaHCO3. The organic layer was dried (MgSO4), the solvent removed in vacuo and the crude product was purified by column chromatography on a Biotage SP1 system (hexanes/EtOAc; v/v 6:4) to give the title compound (1.95 g, 100percent); 1H-NMR (500 MHz, CDCl3): delta 1.47 (s, 9H, C(CH3)3), 2.54 (t, 4H, J=4.7 Hz, piperazine N(CH2)2), 3.48 (t, 4H, J=5.0 Hz, piperazine N(CH2)2), 3.89 (s, 2H, NCH2), 7.30 (d, J=3.5 Hz, 1H, thiazole 5-H), 7.72 (d, J=3.5 Hz, 1H, thiazole 4-H); LC (Method B)-MS (ESI, m/z): Rt=2.84 min-306 [(M+Na)+, 100percent].

10200-59-6, 10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; THE INSTITUTE OF CANCER RESEARCH; US2009/247507; (2009); A1;,
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57268-16-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57268-16-3,5-Bromo-2-methylthiazole,as a common compound, the synthetic route is as follows.

STEP 3 : To a solution of 4- {5-[(4-fluorophenyl)methyl]-6-methylpyrimidin- 4-yl}-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (46 mg, 0.096 mmol) and 5-bromo-2-methyl-l,3-thiazole (17 mg, 0.096 mmol) in dioxane (5 rnL) was added potassium carbonate (66 mg, 0.48 mmol) and [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium (II) dichloromethane adduct (8 mg, 0.0096 mmol). The reaction mixture was stirred at 100 0C for 20 h, and then cooled to room temperature. The reaction mixture was concentrated, and then partitioned between ethyl acetate (100 mL) and water (50 mL). The layers were separated and the organic layer was washed with brine, dried over magnesium sulfate then filtered and concentrated. The residue was taken up in a minimum of acetonitrile and purified by preparative reverse phase HPLC to afford 4-{5-[(4-fluorophenyl)methyl]-6- methylpyrimidin-4-yl}-7-(2-methyl-l,3-thiazol-5-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (18 mg) as a white powder. 1H NMR (400 MHz, DMSO-D6): 8.47 (s, IH), 7.77 (s, IH), 7.41 (dd, IH), 7.19-7.05 (m, 4H), 6.96 (d, IH), 6.83 (d, IH), 4.47 (s, 2H), 4.27 (t, 2H), 3.93 (s, 2H), 3.74 (t, 2H), 2.67 (s, 3H), 2.14 (s, 3H); MS (EI) for C25H23FN4OS: 446 (M+).

As the paragraph descriping shows that 57268-16-3 is playing an increasingly important role.

Reference£º
Patent; EXELIXIS, INC.; ANAND, Neel, Kumar; BAIK, Tae-Gon; BLAZEY, Charles, M.; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen; JOSHI, Anagha; KIM, Angie, Inyoung; MANALO, Jean-Claire, Limun; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WO2010/135568; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29947-24-8,2-Bromo-4,5-dimethylthiazole,as a common compound, the synthetic route is as follows.

29947-24-8, To a microwave tube equipped with a stifling bar, (R)-4-((R)-1-((1-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-7-yl)oxy)ethyl)pyrrolidin-2-one (120 mg, 0.292 mmol), 2-bromo-4,5-dimethylthiazole (112.1 mg, 0.584 mmol), 1,2-dimethoxyethane (2 mL), 1 N Na2CO3 aqueous solution (0.73 mL, 0.73 mmol) were added, the mixture was bubbled N2 for 5 minutes before Pd(PPh3)4 (14.0 mg, 0.012 mmol) were added. The tube was sealed and heated in an oil bath at 100 C. for 2 hrs. DCM (200 mL) was added and the resulting mixture was washed with saturated NaHCO3 aqueous solution (20 mL¡Á4), brine (20 mL¡Á1), dried over anhydrous Na2SO4, filtered, removed solvents in vacuo. The resulting residue was passed a ISCO silica gel column (MeOH:DCM=5:95) to give off-white solids, 56.0 mg (yield 48.4%).

29947-24-8 2-Bromo-4,5-dimethylthiazole 9942366, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Gilead Scientific Systems, Inc.; Cory, Kevin S; Doo, Jimin; Farrand, Julie; Guerrero, Juan A; Katana, Ashley A; Cato, Daryl; Laisaweed, Scott I; Lee, Jiayao; Lingco, John O; Nicolaus, May; Notte, Gregory; Phyen, Hyeoung-Jung; Sangy, Michael; Sumit, Arun C; Adam J, Surayyah; Stephens, Cork L; Venkatraman, Chandrasekar; Watkins, William J; Yang, Jong Yu; Jabloki, Jeff; Jifel, Shiela; Ro, Jennifer; Lee, Sung H; Jao, Chung Dong; Grove, Jeffery; Su, Jianjun; Blomgren, Peter; Mitchell, Scott A; Shyung, Jin Ming; Chandrasekar, Jayaraman; (460 pag.)KR2016/37198; (2016); A;,
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